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Aim. To study the features of lipid peroxidation of biological membranes and accumulation of toxic metabolites in the body of patients with psoriasis, depending on the presence of concomitant chronic viral hepatitis C.Materials and methods. In the survey, participated 56 patients with a vulgar form of psoriasis who received in-patient treatment at the Nalchik skin clinic in 2016–2017, divided into 2 groups, depending on the presence of concomitant chronic viral hepatitis C. In patients, the content of malonic dialdehyde in blood was determined as an indicator of the state of the prooxidant system, ceruloplasmin and erythrocyte catalase, as indicators of antioxidant protection, and also for the evaluation of the Intoxication Syndrome; the level of substances of low and medium molecular mass and oligopeptides in the biological environments of the organism in different periods of the disease.Results. It was found that the presence of concomitant chronic viral hepatitis C in patients with psoriasis was characterized by a more pronounced increase in the concentration of lipid peroxidation products than in the group of patients with hepatitis without psoriasis, accompanied by a decrease in the activity of antioxidant enzymes in the blood plasma and an increase in the activity of catalase in erythrocytes. Simultaneously, the presence of chronic hepatitis C led to a significantly higher content in the body fluids of patients with low and medium molecular weight substances and oligopeptides.

The emergence of superbugs and antibiotic resistance bacteria nowadays make a limited choice of antibiotic available for treatment. This circumstance is an alarming to public health. Thus, public knowledge and attitude towards antibiotic usage play an important role in the success of treatment process. This study aimed to evaluate public knowledge and attitude towards antibiotic utilization and the association of knowledge with demographic variables. A self-administered cross-sectional survey was conducted involving 380 respondents by using a pre-validate questionnaire at public places in Shah Alam, Malaysia from January 2014 to April 2014. From this study, it was analyzed that 43% of respondents have good knowledge towards antibiotic. Majority of the respondents knew antibiotic is used for bacterial infection. However, 40% of respondents misunderstood that antibiotic is indicated for viral infection. Half of the respondents know how to differentiate antibiotic with other drugs. High number of respondents, 63.2% knows that they need to complete full course of antibiotic, however in the attitude statement; only 57.9% of respondents complete their antibiotic course.Based on the percentage of correct response on the attitude statement positive attitude was observed. However, 57.4% still expect antibiotic to be prescribed for common cold. Demographic characteristics such as gender, race, educational level and healthcare occupation were found significant association with knowledge of antibiotic usage. It has been concluded that although knowledge of public is good, public should be stressed out of the importance of correct usage of antibiotic and promote changes in their attitude towards antibiotic usage.