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Background Pemphigus is an autoimmune intraepidermal blistering disease mediated by autoantibodies targeting desmosomes. It can be induced by many triggers, such as ionizing radiation. Methods We report a case of radiotherapy-induced pemphigus (RIP) with a review of the published cases in the English and French literature. Results A 61-year old man was diagnosed to have epidermoid carcinoma of the piriform sinus and then received a 70 Gy radiation therapy. One month after the treatment completion, multiple blisters and erosions occurred initially on the site of irradiation, then in other skin areas. Histological examination showed an intraepidermal blister with acantholysis and necrosis of individual keratinocytes. Direct immunofluorescence and indirect immunofluorescence were typical of pemphigus. Immunoblot revealed antibodies reacting with a 110 kDa antigen. This feature was consistent with the diagnosis of RIP. Less than 20 cases of RIP have been reported previously. Mean age at diagnosis was 64.2 years, and there is a slight female preponderance. RIP occurred, in most cases, initially within the area of irradiation. Conclusion Our patient showed some distinctive findings never reported previously in RIP: a histological focal keratinocyte necrosis, and the presence of autoantibodies reacting with a 110 kDa keratinocytic protein in immunoblot analysis. Because of a different prognosis, it is important to differentiate RIP and paraneoplastic pemphigus (PNP), although cases of ionizing radiation-induced PNP had also been described. As in our patient, RIP seems to respond well to systemic corticosteroids and immunosuppressive therapy, which induce remission within a few months.

L\'hemangiome larynge de l\'adulte est extremement rare et presente des specificites histologiques et evolutives. Il peut representer un veritable defi therapeutique. Les auteurs rapportent 9 cas d\'hemangiomes larynges de l\'adulte colliges retrospectivement sur une periode de 20 ans (1984- 2004). Il s\'agissait de 6 hommes et 3 femmes, âges en moyenne de 46 ans (17 a 75 ans). Les signes d\'appel etaient la dysphonie dans tous les cas, associee a des hemorragies de sang rouge exteriorisees par voie buccale chez 3 patients. Le diagnostic reposait dans tous les cas sur la laryngoscopie directe qui retrouvait une tumefaction glottique de couleur bleutee, a surface lisse. Une biopsie avec examen anatomo-pathologique a ete systematique. Tous les patients ont beneficie d\'une exerese instrumentale de la masse par voie endoscopique, avec hemostase locale. Deux recidives ont ete notees, pour lesquels une seconde exerese instrumentale par voie endoscopique a ete realisee avec une evolution favorable. Le recul moyen etait de 9 ans. The adult laryngeal hemangioma is extremely rare and presents histological and evolutionary particularities. It can represent a real therapeutic challenge. The authors report 9 cases of adult laryngeal hemangiomas over a period of 20 years (1984-2004). It was about 6 man and 3 women, old on average of 46 years ( 17 - 75 years). The signs of appeal were the dysphonia in every case, associated to bleedings of red blood exteriorized with oral way in 3 cases. Diagnosis based in every case on the direct laryngoscopy which found a glottic tumefaction of bluish colour, in smooth surface. A biopsy with anatomo-pathological exam was realized in every case. All the patients benefited from an instrumental excision of the mass by endoscopic way, with local haemostasis. Two recurrences were noted, which benefited from a second endoscopic instrumental excision, with a favorable evolution. Average follow up was of 9 years. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 16 2006: pp. 5-7

L\'amylose localisee est caracterisee par un depot de proteines fibrillaires dans un site de l\'organisme sans atteinte systemique. La localisation laryngee est tres rare. Ce diagnostic doit etre evoque devant toute lesion d\'allure benigne du larynx. Les auteurs rapportent un cas d\'amylose laryngee collige sur une periode de 10 ans. Localized amyloidosis is characterized by the deposition of amyloid fibres in a particular site or organ system in the absence of systemic involvement. The laryngeal location of amylosis is rare. The diagnosis must be suspected in front of any tumor of benign speed of the larynx. Authors report a case of laryngeal amyloidosis brought during a period of 10 years. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 16 2006: pp. 30-31