Author: "A. Anders" / Topic: medicine - Searchworks@Jio Institute Digital Library Search Results

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51,264 results on '"A. Anders"'

1. CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial

Author: Montagne, Janelle M., Mitchell, Jacob T., Tandurella, Joseph A., Christenson, Eric S., Danilova, Ludmila V., Deshpande, Atul, Loth, Melanie, Sidiropoulos, Dimitrios N., Davis-Marcisak, Emily, Bergman, Daniel R., Zhu, Qingfeng, Wang, Hao, Kagohara, Luciane T., Engle, Logan L., Green, Benjamin F., Favorov, Alexander V., Ho, Won Jin, Lim, Su Jin, Zhang, Rui, Li, Pan, Gai, Jessica, Mo, Guanglan, Mitchell, Sarah, Wang, Rulin, Vaghasia, Ajay, Hou, Wenpin, Xu, Yao, Zimmerman, Jacquelyn W., Elisseeff, Jennifer H., Yegnasubramanian, Srinivasan, Anders, Robert A., Jaffee, Elizabeth M., Zheng, Lei, and Fertig, Elana J.
Published: 2025
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2. Cerebrospinal fluid and plasma concentrations of the inflammatory marker soluble CD27 in a large surgical population

Author: Tigchelaar, Celien, Cunningham, Janet L., Rasmusson, Annica J., Thulin, Måns, Burman, Joachim, Kema, Ido P., Larsson, Anders, and Absalom, Anthony R.
Published: 2024
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3. Electric field causes volumetric changes in the human brain.

Author: Argyelan, Miklos, Oltedal, Leif, Deng, Zhi-De, Wade, Benjamin, Bikson, Marom, Joanlanne, Andrea, Sanghani, Sohag, Bartsch, Hauke, Cano, Marta, Dale, Anders M, Dannlowski, Udo, Dols, Annemiek, Enneking, Verena, Espinoza, Randall, Kessler, Ute, Narr, Katherine L, Oedegaard, Ketil J, Oudega, Mardien L, Redlich, Ronny, Stek, Max L, Takamiya, Akihiro, Emsell, Louise, Bouckaert, Filip, Sienaert, Pascal, Pujol, Jesus, Tendolkar, Indira, van Eijndhoven, Philip, Petrides, Georgios, Malhotra, Anil K, and Abbott, Christopher
Subjects: Amygdala, Hippocampus, Temporal Lobe, Humans, Antidepressive Agents, Magnetic Resonance Imaging, Organ Size, Brain Mapping, Depression, Electroconvulsive Therapy, Adult, Aged, Middle Aged, Female, Male, Electromagnetic Radiation, ECT, depression, electric field modeling, human, human biology, medicine, neuroimaging, volume change, Biochemistry and Cell Biology
Abstract: Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p
Published: 2019

4. Practical guideline on obesity care in patients with gastrointestinal and liver diseases - Joint ESPEN/UEG guideline

Author: Stephan C. Bischoff, Johann Ockenga, Ahad Eshraghian, Rocco Barazzoni, Luca Busetto, Marjo Campmans-Kuijpers, Vincenzo Cardinale, Irit Chermesh, Haluk Tarik Kani, Wafaa Khannoussi, Laurence Lacaze, Miguel Léon-Sanz, Juan M. Mendive, Michael W. Müller, Frank Tacke, Anders Thorell, Darija Vranesic Bender, Arved Weimann, Cristina Cuerda, and Bischoff S. C., Ockenga J., Eshraghian A., Barazzoni R., Busetto L., Campmans-Kuijpers M., Cardinale V., Chermesh I., KANİ H. T., Khannoussi W., et al.
Subjects: Internal Diseases, Tarımsal Bilimler, Yoğun Bakım Tıbbı, NUTRITION & DIETETICS, Beslenme ve Diyetetik, Yoğun Bakım, Sağlık Bilimleri, Critical Care and Intensive Care Medicine, Gastroesophageal reflux disease, İç Hastalıkları, Clinical Medicine (MED), Inflammatory bowel disease, BESLENME VE DİYETETİK, Ziraat, Health Sciences, Tarım Bilimleri, Beslenme ve Dietetik, Klinik Tıp (MED), Tarım ve Çevre Bilimleri (AGE), Obesity, Irritable bowel syndrome, celiac disease, Internal Medicine Sciences, Nutrition and Dietetics, Sarcopenic obesity, Klinik Tıp, Agricultural Sciences, Intensive Care, Agriculture, Dahili Tıp Bilimleri, Agriculture & Environment Sciences (AGE), CLINICAL MEDICINE, Tıp, Irritable bowel syndrome, Pancreatitis, YOĞUN BAKIM, Medicine, CRITICAL CARE MEDICINE, celiac disease
Abstract: BACKGROUND: Patients with chronic gastrointestinal disease such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, gastroesophageal reflux disease (GERD), pancreatitis, and chronic liver disease (CLD) often suffer from obesity because of coincidence (IBD, IBS, celiac disease) or related pathophysiology (GERD, pancreatitis and CLD). It is unclear if such patients need a particular diagnostic and treatment that differs from the needs of lean gastrointestinal patients. The present guideline addresses this question according to current knowledge and evidence.OBJECTIVE: The present practical guideline is intended for clinicians and practitioners in general medicine, gastroenterology, surgery and other obesity management, including dietitians and focuses on obesity care in patients with chronic gastrointestinal diseases.METHODS: The present practical guideline is the shortened version of a previously published scientific guideline developed according to the standard operating procedure for ESPEN guidelines. The content has been re-structured and transformed into flow-charts that allow a quick navigation through the text.RESULTS: In 100 recommendations (3× A, 33× B, 24 × 0, 40× GPP, all with a consensus grade of 90% or more) care of gastrointestinal patients with obesity - including sarcopenic obesity - is addressed in a multidisciplinary way. A particular emphasis is on CLD, especially metabolic associated liver disease, since such diseases are closely related to obesity, whereas liver cirrhosis is rather associated with sarcopenic obesity. A special chapter is dedicated to obesity care in patients undergoing bariatric surgery. The guideline focuses on adults, not on children, for whom data are scarce. Whether some of the recommendations apply to children must be left to the judgment of the experienced pediatrician.CONCLUSION: The present practical guideline offers in a condensed way evidence-based advice how to care for patients with chronic gastrointestinal diseases and concomitant obesity, an increasingly frequent constellation in clinical practice.
Published: 2023

5. Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

Author: Lorinda Simms, Shehkar Patil, David R. Gandara, Anders Mellemgaard, Raghunadharao Digumarti, Bonne Biesma, Johan Vansteenkiste, Mauro Zukin, Joachim von Pawel, Katherine P. Sugarman, Keunchil Park, Christian Manegold, Filippo de Marinis, Tuncay Göksel, Janusz Rolski, Piotr Serwatowski, Jin S. Lee, Giorgio V. Scagliotti, Ulrich Gatzemeier, and Purvish M. Parikh
Subjects: Male, Oncology, medicine.medical_specialty, Cancer Research, Guanine, Lung Neoplasms, medicine.medical_treatment, Kaplan-Meier Estimate, Pemetrexed, Deoxycytidine, chemistry.chemical_compound, Glutamates, Carcinoma, Non-Small-Cell Lung, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Lung cancer, Aged, Cisplatin, Chemotherapy, business.industry, Middle Aged, medicine.disease, Gemcitabine, Surgery, Regimen, chemistry, Female, business, medicine.drug, Necitumumab
Abstract: PURPOSE Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non–small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting. PATIENTS AND METHODS This noninferiority, phase III, randomized study compared the overall survival between treatment arms using a fixed margin method (hazard ratio [HR] < 1.176) in 1,725 chemotherapy-naive patients with stage IIIB or IV NSCLC and an Eastern Cooperative Oncology Group performance status of 0 to 1. Patients received cisplatin 75 mg/m2 on day 1 and gemcitabine 1,250 mg/m2 on days 1 and 8 (n = 863) or cisplatin 75 mg/m2 and pemetrexed 500 mg/m2 on day 1 (n = 862) every 3 weeks for up to six cycles. RESULTS Overall survival for cisplatin/pemetrexed was noninferior to cisplatin/gemcitabine (median survival, 10.3 v 10.3 months, respectively; HR = 0.94; 95% CI, 0.84 to 1.05). Overall survival was statistically superior for cisplatin/pemetrexed versus cisplatin/gemcitabine in patients with adenocarcinoma (n = 847; 12.6 v 10.9 months, respectively) and large-cell carcinoma histology (n = 153; 10.4 v 6.7 months, respectively). In contrast, in patients with squamous cell histology, there was a significant improvement in survival with cisplatin/gemcitabine versus cisplatin/pemetrexed (n = 473; 10.8 v 9.4 months, respectively). For cisplatin/pemetrexed, rates of grade 3 or 4 neutropenia, anemia, and thrombocytopenia ( P ≤ .001); febrile neutropenia ( P = .002); and alopecia ( P < .001) were significantly lower, whereas grade 3 or 4 nausea ( P = .004) was more common. CONCLUSION In advanced NSCLC, cisplatin/pemetrexed provides similar efficacy with better tolerability and more convenient administration than cisplatin/gemcitabine. This is the first prospective phase III study in NSCLC to show survival differences based on histologic type.
Published: 2023
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6. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE)

Author: Pham, Tài, Heunks, Leo, Bellani, Giacomo, Madotto, Fabiana, Aragao, Irene, Beduneau, Gaëtan, Goligher, Ewan C, Grasselli, Giacomo, Laake, Jon Henrik, Mancebo, Jordi, Peñuelas, Oscar, Piquilloud, Lise, Pesenti, Antonio, Wunsch, Hannah, van Haren, Frank, Brochard, Laurent, Laffey, John G, Abrough, Fekri, Acharya, Subhash P, Amin, Pravin, Arabi, Yaseen, Bauer, Philippe, Beitler, Jeremy, Berkius, Johan, Bugedo, Guillermo, Camporota, Luigi, Cerny, Vladimir, Cho, Young-Jae, Clarkson, Kevin, Estenssoro, Elisa, Goligher, Ewan, Gritsan, Alexey, Hashemian, Seyed Mohammadreza, Hermans, Greet, Heunks, Leo M, Jovanovic, Bojan, Kurahashi, Kiyoyasu, Matamis, Dimitrios, Moerer, Onnen, Molnar, Zsolt, Ozyilmaz, Ezgi, Panka, Bernardo, Papali, Alfred, Peñuelas, Óscar, Perbet, Sébastien, Qiu, Haibo, Razek, Assem Abdel, Rittayamai, Nuttapol, Roldan, Rollin, Serpa Neto, Ary, Szuldrzynski, Konstanty, Talmor, Daniel, Tomescu, Dana, Van Haren, Frank, Villagomez, Asisclo, Zeggwagh, Amine Ali, Abe, Toshikazu, Aboshady, Abdelrhman, Acampo-de Jong, Melanie, Acharya, Subhash, Adderley, Jane, Adiguzel, Nalan, Agrawal, Vijay Kumar, Aguilar, Gerardo, Aguirre, Gaston, Aguirre-Bermeo, Hernan, Ahlström, Björn, Akbas, Türkay, Akker, Mustafa, Al Sadeh, Ghamdan, Alamri, Sultan, Algaba, Angela, Ali, Muneeb, Aliberti, Anna, Allegue, Jose Manuel, Alvarez, Diana, Amador, Joaquin, Andersen, Finn H, Ansari, Sharique, Apichatbutr, Yutthana, Apostolopoulou, Olympia, Arellano, Daniel, Arica, Mestanza, Arikan, Huseyin, Arinaga, Koichi, Arnal, Jean-Michel, Asano, Kengo, Asín-Corrochano, Marta, Avalos Cabrera, Jesus Milagrito, Avila Fuentes, Silvia, Aydemir, Semih, Aygencel, Gulbin, Azevedo, Luciano, Bacakoglu, Feza, Badie, Julio, Baedorf Kassis, Elias, Bai, Gabriela, Balaraj, Govindan, Ballico, Bruno, Banner-Goodspeed, Valerie, Banwarie, Preveen, Barbieri, Rosella, Baronia, Arvind, Barrett, Jonathan, Barrot, Loïc, Barrueco-Francioni, Jesus Emilio, Barry, Jeffrey, Bawangade, Harshal, Beavis, Sarah, Beck, Eduardo, Beehre, Nina, Belenguer Muncharaz, Alberto, Belliato, Mirko, Bellissima, Agrippino, Beltramelli, Rodrigo, Ben Souissi, Asma, Benitez-Cano, Adela, Benlamin, Mohamed, Benslama, Abdellatif, Bento, Luis, Benvenuti, Daniela, Bernabe, Laura, Bersten, Andrew, Berta, Giacomo, Bertini, Pietro, Bertram-Ralph, Elliot, Besbes, Mohamed, Bettini, Lisandro Roberto, Beuret, Pascal, Bewley, Jeremy, Bezzi, Marco, Bhakhtiani, Lakshay, Bhandary, Rakesh, Bhowmick, Kaushik, Bihari, Shailesh, Bissett, Bernie, Blythe, David, Bocher, Simon, Boedjawan, Narain, Bojanowski, Christine M, Boni, Elisa, Boraso, Sabrina, Borelli, Massimo, Borello, Silvina, Borislavova, Margarita, Bosma, Karen J, Bottiroli, Maurizio, Boyd, Owen, Bozbay, Suha, Briva, Arturo, Bruel, Cédric, Bruni, Andrea, Buehner, Ulrike, Bulpa, Pierre, Burt, Karen, Buscot, Mathieu, Buttera, Stefania, Cabrera, Jorge, Caccese, Roberta, Caironi, Pietro, Canchos Gutierrez, Ivan, Canedo, Nancy, Cani, Alma, Cappellini, Iacopo, Carazo, Jesus, Cardonnet, Luis Pablo, Carpio, David, Carriedo, Demetrio, Carrillo, Ramón, Carvalho, João, Caser, Eliana, Castelli, Antonio, Castillo Quintero, Manuel, Castro, Heloisa, Catorze, Nuno, Cengiz, Melike, Cereijo, Enrique, Ceunen, Helga, Chaintoutis, Christos, Chang, Youjin, Chaparro, Gustavogcha, Chapman, Carmel, Chau, Simon, Chavez, Cecilia Eugenia, Chelazzi, Cosimo, Chelly, Jonathan, Chemouni, Frank, Chen, Kai, Chena, Ariel, Chiarandini, Paolo, Chilton, Phil, Chiumello, Davide, Chou-Lie, Yvette, Chudeau, Nicolas, Cinel, Ismail, Cinnella, Gilda, Clark, Michele, Clark, Thomas, Clementi, Stefano, Coaguila, Luis, Codecido, Alexis Jaspe, Collins, Amy, Colombo, Riccardo, Conde, Juan, Consales, Guglielmo, Cook, Tim, Coppadoro, Andrea, Cornejo, Rodrigo, Cortegiani, Andrea, Coxo, Cristina, Cracchiolo, Andrea Neville, Crespo Ramirez, Mónica, Crova, Philippe, Cruz, José, Cubattoli, Lucia, Çukurova, Zafer, Curto, Francesco, Czempik, Piotr, D'Andrea, Rocco, da Silva Ramos, Fernando, Dangers, Laurence, Danguy des Déserts, Marc, Danin, Pierre-Eric, Dantas, Fabianne, Daubin, Cédric, Dawei, Wu, de Haro, Candelaria, de Jesus Montelongo, Felipe, De Mendoza, Diego, de Pablo, Raúl, De Pascale, Gennaro, De Rosa, Silvia, Decavèle, Maxens, Declercq, Pierre-Louis, Deicas, Alberto, del Carmen Campos Moreno, María, Dellamonica, Jean, Delmas, Benjamin, Demirkiran, Oktay, Demirkiran, Hilmi, Dendane, Tarek, di Mussi, Rossella, Diakaki, Chrysi, Diaz, Anatilde, Diaz, Willy, Dikmen, Yalim, Dimoula, Aikaterini, Doble, Patricia, Doha, Nagwa, Domingos, Guilherme, Dres, Martin, Dries, David, Duggal, Abhijit, Duke, Graeme, Dunts, Pavel, Dybwik, Knut, Dykyy, Maksym, Eckert, Philippe, Efe, Serdar, Elatrous, Souheil, Elay, Gülseren, Elmaryul, Abubaker S, Elsaadany, Mohamed, Elsayed, Hany, Elsayed, Samar, Emery, Malo, Ena, Sébastien, Eng, Kevin, Englert, Joshua A, Erdogan, Elif, Ergin Ozcan, Perihan, Eroglu, Ege, Escobar, Miguel, Esen, Figen, Esen Tekeli, Arzu, Esquivel, Alejandro, Esquivel Gallegos, Helbert, Ezzouine, Hanane, Facchini, Alberto, Faheem, Mohammad, Fanelli, Vito, Farina, Maria Fernanda, Fartoukh, Muriel, Fehrle, Lutz, Feng, Feng, Feng, Yufeng, Fernandez, Irene, Fernandez, Borja, Fernandez-Rodriguez, Maria Lorena, Ferrando, Carlos, Ferreira da Silva, Maria João, Ferreruela, Mireia, Ferrier, Janet, Flamm Zamorano, Matias Jesús, Flood, Laura, Floris, Leda, Fluckiger, Martin, Forteza, Catalina, Fortunato, Antonella, Frans, Eric, Frattari, Antonella, Fredes, Sebastian, Frenzel, Tim, Fumagalli, Roberto, Furche, Mariano Andres, Fusari, Maurizio, Fysh, Edward, Galeas-Lopez, Juan Luis, Galerneau, Louis-Marie, Garcia, Analía, Garcia, María Fernanda, Garcia, Elisabet, Garcia Olivares, Pablo, Garlicki, Jaroslaw, Garnero, Aude, Garofalo, Eugenio, Gautam, Prabha, Gazenkampf, Andrey, Gelinotte, Stéphanie, Gelormini, Domenico, Ghrenassia, Etienne, Giacomucci, Angelo, Giannoni, Robert, Gigante, Andrea, Glober, Nancy, Gnesin, Paolo, Gollo, Yari, Gomaa, Dina, Gomero Paredes, Rosita, Gomes, Rui, Gomez, Raúl Alejandro, Gomez, Oscar, Gomez, Aroa, Gondim, Louise, Gonzalez, Manuel, Gonzalez, Isabel, Gonzalez-Castro, Alejandro, Gordillo Romero, Orlando, Gordo, Federico, Gouin, Philippe, Graf Santos, Jerónimo, Grainne, Rooney, Grando, Matilde, Granov Grabovica, Sanja, Grasso, Salvatore, Grasso, Rinaldo, Grimmer, Lisa, Grissom, Colin, Gu, Qing, Guan, Xiang-Dong, Guarracino, Fabio, Guasch, Neus, Guatteri, Luca, Gueret, Renaud, Guérin, Claude, Guerot, Emmanuel, Guitard, Pierre-Gildas, Gül, Fethi, Gumus, Ayca, Gurjar, Mohan, Gutierrez, Patricia, Hachimi, Abdelhamid, Hadzibegovic, Adi, Hagan, Samantha, Hammel, Clare, Han Song, Joo, Hanlon, Gabrielle, Heines, Serge, Henriksson, Johanna, Herbrecht, Jean-Etienne, Heredia Orbegoso, Gabriel Omar, Hermon, Andrew, Hernandez, Rosana, Hernandez, Carmen, Herrera, Luis, Herrera-Gutierrez, Manuel, Hidalgo, Juan, Hill, Dianne, Holmquist, Dagmar, Homez, Marcela, Hongtao, Xia, Hormis, Anil, Horner, Daniel, Hornos, M Carmen, Hou, Meihong, House, Stacy, Housni, Brahim, Hugill, Keith, Humphreys, Sally, Humbert, Louis, Hunter, Stephanie, Hwa Young, Lee, Iezzi, Nicolas, Ilutovich, Santiago, Inal, Volkan, Innes, Richard, Ioannides, Panagiotis, Iotti, Giorgio Antonio, Ippolito, Mariachiara, Irie, Hiromasa, Iriyama, Hiroki, Itagaki, Taiga, Izura, Javier, Izza, Santiago, Jabeen, Rakhshanda, Jamaati, Hamidreza, Jamadarkhana, Sunil, Jamoussi, Amira, Jankowski, Milosz, Jaramillo, Luis Alberto, Jeon, Kyeongman, Jeong Lee, Seok, Jeswani, Deepak, Jha, Simant, Jiang, Liangyan, Jing, Chen, Jochmans, Sébastien, Johnstad, Bror Anders, Jongmin, Lee, Joret, Aurélie, Junhasavasdikul, Detajin, Jurado, Maria Teresa, Kam, Elisa, Kamohara, Hidenobu, Kane, Caroline, Kara, Iskender, Karakurt, Sait, Karnjanarachata, Cherdkiat, Kataoka, Jun, Katayama, Shinshu, Kaushik, Shuchi, Kelebek Girgin, Nermin, Kerr, Kathryn, Kerslake, Ian, Khairnar, Prakash, Khalid, Abidi, Khan, Akram, Khanna, Ashish K, Khorasanee, Reza, Kienhorst, Dieneke, Kirakli, Cenk, Knafelj, Rihard, Kol, Mark Kol, Kongpolprom, Napplika, Kopitko, Csaba, Korkmaz Ekren, Pervin, Kubisz-Pudelko, Agnieszka, Kulcsar, Zoltan, Kumasawa, Junji, Kuriyama, Akira, Kutchak, Fernanda, Labarca, Eduardo, Labat, Françoise, Laborda, César, Laca Barrera, Manuel Alberto, Lagache, Laurie, Landaverde Lopez, Antonio, Lanspa, Michael, Lascari, Valeria, Le Meur, Matthieu, Lee, Su Hwan, Lee, Young Ju, Lee, Jinwoo, Lee, Won-Yeon, Lee, Jarone, Legernaes, Terje, Leiner, Tamaas, Lemiale, Virginie, Leonor, Tiago, Lepper, Philipp M, Li, Dahuan, Li, Hongbin, Li, Oleg, Lima, Ana Raquel, Lind, Dan, Litton, Edward, Liu, Ning, Liu, Ling, Liu, Jialin, Llitjos, Jean-François, Llorente, Beatriz, Lopez, Rodolfo, Lopez, Claudia Elizabeth, Lopez Nava, Claudia, Lovazzano, Pablo, Lu, Min, Lucchese, Francesca, Lugano, Manuela, Lugo Goytia, Gustavo, Luo, Hua, Lynch, Ceri, Macheda, Sebastiano, Madrigal Robles, Victor Hugo, Maggiore, Salvatore Maurizio, Magret Iglesias, Mònica, Malaga, Peter, Mallapura Maheswarappa, Harish, Malpartida, Guillermo, Malyarchikov, Andrey, Mansson, Helena, Manzano, Anaid, Marey, Ismael, Marin, Nathalie, Marin, Maria del Carmen, Markman, Eliana, Martin, Felix, Martin, Alex, Martin Dal Gesso, Cristina, Martinez, Felipe, Martínez-Fidalgo, Conchita, Martin-Loeches, Ignacio, Mas, Arantxa, Masaaki, Sakuraya, Maseda, Emilio, Massa, Eleni, Mattsson, Anna, Maugeri, Jessica, McCredie, Victoria, McCullough, James, McGuinness, Shay, McKown, Andrew, Medve, László, Mei, Chengqing, Mellado Artigas, Ricard, Mendes, Vitor, Mervat, Mohamed Khalaf Ebraheim, Michaux, Isabelle, Mikhaeil, Michael, Milagros, Olga, Milet, Igor, Millan, Maria Teresa, Minwei, Zhang, Mirabella, Lucia, Mishra, Sanghamitra, Mistraletti, Giovanni, Mochizuki, Katsunori, Moghal, Arif, Mojoli, Francesco, Molin, Alexandre, Montiel, Raquel, Montini, Luca, Monza, Gianmario, Mora Aznar, Maria, Morakul, Sunthiti, Morales, Maria, Moreno Torres, Daniel, Morocho Tutillo, Diego Rolando, Motherway, Catherine, Mouhssine, Doumiri, Mouloudi, Eleni, Muñoz, Tapia, Munoz de Cabo, Carlos, Mustafa, Mohamed, Muthuchellappan, Radhakrishnan, Muthukrishnan, Muraleekrishnan, Muttini, Stefano, Nagata, Isao, Nahar, Dick, Nakanishi, Misuzu, Nakayama, Izumi, Namendys-Silva, Silvio Antonio, Nanchal, Rahul, Nandakumar, Sivakumar, Nasi, Alessandra, Nasir, Kamal, Navalesi, Paolo, Naz Aslam, Tayyba, Nga Phan, Thuy, Nichol, Alistair, Niiyama, Shuhei, Nikolakopoulou, Sofia, Nikolic, Elena, Nitta, Kenichi, Noc, Marko, Nonas, Stephanie, Nseir, Saad, Nur Soyturk, Ayse, Obata, Yukako, Oeckler, Richard, Oguchi, Moe, Ohshimo, Shinichiro, Oikonomou, Marina, Ojados, Agueda, Oliveira, Maria Teresa, Oliveira Filho, Wilson, Oliveri, Carlo, Olmos, Aitor, Omura, Kazuya, Orlandi, Maria Cristina, Orsenigo, Francesca, Ortiz-Ruiz De Gordoa, Laura, Ota, Kei, Ovalle Olmos, Rainier, Öveges, Nándo, Oziemski, Peter, Ozkan Kuscu, Ozlem, Özyilmaz, Ezgi, Pachas Alvarado, Fernando, Pagella, Gonzalo, Palaniswamy, Vijayanand, Palazon Sanchez, Eugenio Luis, Palmese, Salvatore, Pan, Guojun, Pan, Wensen, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Parekh, Ameet, Parke, Rachael, Parrilla, Francisco J, Parrilla, Dácil, Pasha, Taha, Pasin, Laura, Patão, Luis, Patel, Mayur, Patel, Grisma, Pati, Basanta Kumar, Patil, Jayaprakash, Pattnaik, Saroj, Paul, Daniel, Pavesi, Maurizio, Pavlotsky, Vanesa Alejandra, Paz, Graciela, Paz, Enrique, Pecci, Elisabetta, Pellegrini, Carlos, Peña Padilla, Andrea Gabriela, Perchiazzi, Gaetano, Pereira, Tiago, Pereira, Vera, Perez, Manuel, Perez Calvo, Cesar, Perez Cheng, Meisy, Perez Maita, Ronald, Pérez-Araos, Rodrigo, Perez-Teran, Purificación, Perez-Torres, David, Perkins, Gavin, Persona, Paolo, Petnak, Tananchai, Petrova, Marina, Pham, Tai, Philippart, François, Picetti, Edoardo, Pierucci, Elisabetta, Piervincenzi, Edoardo, Pinciroli, Riccardo, Pintado, Maria-Consuelo, Piraino, Thomas, Piras, Stephanie, Piras, Claudio, Pirompanich, Pattarin, Pisani, Luigi, Platas, Enrique, Plotnikow, Gustavo, Porras, Willy, Porta, Virginia, Portilla, Mariana, Portugal, José, Povoa, Pedro, Prat, Gwenael, Pratto, Romina, Preda, Gabriel, Prieto, Isidro, Prol-Silva, Estefania, Pugh, Richard, Qi, Yupeng, Qian, Chuanyun, Qin, Tiehe, Qu, Hongping, Quintana, Teobaldo, Quispe Sierra, Rosari, Quispe Soto, Rocio, Rabbani, Raihan, Rabee, Mohamed, Rabie, Ahmed, Rahe Pereira, Maria Augusta, Rai, Ashish, Raj Ashok, Sundar, Rajab, Mostafa, Ramdhani, Navin, Ramey, Elizabeth, Ranieri, Marco, Rathod, Darshana, Ray, Banambar, Redwanul Huq, Shihan Mahmud, Regli, Adrian, Reina, Rosa, Resano Sarmiento, Natalia, Reynaud, Faustine, Rialp, Gemma, Ricart, Pilar, Rice, Todd, Richardson, Angus, Rieder, Marcelo, Rinket, Martin, Rios, Fernando, Risso Vazquez, Alejandro, Riva, Ivano, Rivette, Monaly, Roca, Oriol, Roche-Campo, Ferran, Rodriguez, Covadonga, Rodriguez, Gabriel, Rodriguez Gonzalez, Daniel, Rodriguez Tucto, Xandra Yanina, Rogers, Angela, Romano, María Elena, Rørtveit, Linda, Rose, Alastair, Roux, Damien, Rouze, Anahita, Rubatto Birri, Paolo Nahuel, Ruilan, Wang, Ruiz Robledo, Aldana, Ruiz-Aguilar, Antonio Luis, Sadahiro, Tomohito, Saez, Ignacio, Sagardia, Judith, Saha, Rajnish, Saha, Rohit, Saiphoklang, Narongkorn, Saito, Shigeki, Salem, Maie, Sales, Gabriele, Salgado, Patricia, Samavedam, Srinivas, Sami Mebazaa, Mhamed, Samuelsson, Line, San Juan Roman, Nandyelly, Sanchez, Patricia, Sanchez-Ballesteros, Jesus, Sandoval, Yazcitk, Sani, Emanuele, Santos, Martin, Santos, Carla, Sanui, Masamitsu, Saravanabavan, Lakshmikanthcharan, Sari, Sema, Sarkany, Agnes, Sauneuf, Bertrand, Savioli, Monica, Sazak, Hilal, Scano, Riccardo, Schneider, Francis, Schortgen, Frédérique, Schultz, Marcus J, Schwarz, Gabriele Leonie, Seçkin Yücesoy, Faruk, Seely, Andrew, Seiler, Frederik, Seker Tekdos, Yasemin, Seok Chan, Kim, Serano, Luca, Serednicki, Wojciech, Setten, Mariano, Shah, Asim, Shah, Bhagyesh, Shang, You, Shanmugasundaram, Pradeep, Shapovalov, Konstantin, Shebl, Eman, Shiga, Takuya, 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Nobuaki, Shin, Phil, Short, Jack, Shuhua, Chen, Siddiqui, Sughrat, Silesky Jimenez, Juan Ignacio, Silva, Daniel, Silva Sales, Betania, Simons, Koen, Sjøbø, Brit Ågot, Slessor, David, Smiechowicz, Jakub, Smischney, Nathan, Smith, Paul, Smith, Tim, Smith, Mark, Snape, Sarah, Snyman, Lindi, Soetens, Filiep, Sook Hong, Kyung, Sosa Medellin, Miguel Ángel, Soto, Giovanna, Souloy, Xavier, Sousa, Elsa, Sovatzis, Stefania, Sozutek, Didem, Spadaro, Savino, Spagnoli, Marco, Spångfors, Martin, Spittle, Nick, Spivey, Mike, Stapleton, Andrew, Stefanovic, Branislava, Stephenson, Lorraine, Stevenson, Elizabeth, Strand, Kristian, Strano, Maria Teresa, Straus, Slavenka, Sun, Chenliang, Sun, Rongqing, Sundaram, Venkat, SunPark, Tai, Surlemont, Elisabeth, Sutherasan, Yuda, Szabo, Zsuzsanna, Tainter, Christopher, Takaba, Akihiro, Tallott, Mandy, Tamasato, Tamasato, Tang, Zhanhong, Tangsujaritvijit, Viratch, Taniguchi, Leandro, Taniguchi, Daisuke, Tarantino, Fabio, Teerapuncharoen, Krittika, Temprano, Susana, Terragni, Pierpaolo, Terzi, Nicola, Thakur, Anand, Theerawit, Pongdhep, Thille, Arnaud W, Thomas, Matt, Thungtitigul, Poungrat, Thyrault, Martial, Tilouch, Nejla, Timenetsky, Karina, Tirapu, Juna, Todeschini, Manuel, Tomas, Roser, Tomaszewski, Christian, Tonetti, Tommaso, Tonnelier, Alexandre, Trinder, John, Trongtrakul, Konlawij, Truwit, Jonathon, Tsuei, Betty, Tulaimat, Aiman, Turan, Sema, Turkoglu, Melda, Tyagi, Sanjeev, Ubeda, Alejandro, Vagginelli, Federica, Valenti, María Florencia, Vallverdu, Imma, Van Axel, Alisha, van den Hul, Ingrid, van der Hoeven, Han, Van Der Meer, Nardo, Vanhoof, Marc, Vargas-Ordoñez, Mónica, Vaschetto, Rosanna, Vascotto, Ettore, Vatsik, Maria, Vaz, Ana, Vazquez-Sanchez, Antonia, Ventura, Sara, Vermeijden, Jan Wytze, Vidal, Anxela, Vieira, Jocyelle, Vilela Costa Pinto, Bruno, Villagra, Ana, Villegas Succar, Cristina, Vinorum, Ole Georg, Vitale, Giovanni, Vj, Ramesh, Vochin, Ana, Voiriot, Guillaume, Volta, Carlo Alberto, von Seth, Magnu, Wajdi, Maazouzi, Walsh, Don, Wang, Shouhong, Wardi, Gabriel, Ween-Velken, Nils Christian, Wei, Bi-Lin, Weller, Dolf, Welsh, Deborah, Welters, Ingeborg, Wert, Michael, Whiteley, Simon, Wilby, Elizabeth, Williams, Erin, Williams, Karen, Wilson, Antoinette, Wojtas, Jadwiga, Won Huh, Jin, Wrathall, David, Wright, Christopher, Wu, Jian-Feng, Xi, Guo, Xing, Zheng-Jiang, Xu, Hongyang, Yamamoto, Kotaro, Yan, Jie, Yáñez, Julio, Yang, Xiaobo, Yates, Elliot, Yazicioglu Mocin, Ozlem, Ye, Zhenglong, Yildirim, Fatma, Yoshida, Norifumi, Yoshido, Hector Higo Leon, Young Lee, Bo, Yu, Rongguo, Yu, Gong, Yu, Tao, Yuan, Boyun, Yuangtrakul, Nadwipa, Yumoto, Tetsuya, Yun, Xie, Zakalik, Graciela, Zaki, Ahmad, Zalba-Etayo, Begoña, Zambon, Massimo, Zang, Bin, Zani, Gianluca, Zarka, Jonathan, Zerbi, Simone Maria, Zerman, Avsar, Zetterquist, Harald, Zhang, Jiuzhi, Zhang, Hongwen, Zhang, Wei, Zhang, Guoxiu, Zhang, Weixin, Zhao, Hongsheng, Zheng, Jia, Zhu, Bin, Zumaran, Ronald, Pham T., Heunks L., Bellani G., Madotto F., Aragao I., Beduneau G., Goligher E. C., Grasselli G., Laake J. H., Mancebo J., et al., Intensive Care Medicine, ACS - Diabetes & metabolism, ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, Intensive Care, Econometrics, Neurosurgery, Cardiothoracic Surgery, and Internal Medicine
Subjects: Pulmonary and Respiratory Medicine, Internal Medicine Sciences, Klinik Tıp, RESPIRATORY SYSTEM, Dahili Tıp Bilimleri, Göğüs Hastalıkları ve Allerji, CLINICAL MEDICINE, Sağlık Bilimleri, Clinical Medicine (MED), Tıp, SOLUNUM SİSTEMİ, Mechanical ventilation, N/A, Health Sciences, Settore MED/41 - ANESTESIOLOGIA, Akciğer ve Solunum Tıbbı, Medicine, Klinik Tıp (MED), Chest Diseases and Allergy
Abstract: Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2–6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital. Interpretation: In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. Funding: European Society of Intensive Care Medicine, European Respiratory Society.
Published: 2023

7. High Self-Reported Satisfaction After Top Surgery in Gender-Affirming Surgery: A Single-Center Study

Author: Rikke Holmgaard, Deborah-Leigh Day, Mathias Kvist Mejdahl, Christian Lyngsaa Lang, and Anders Klit
Subjects: Gender Studies, medicine.medical_specialty, Quality of life (healthcare), business.industry, education, Transgender, Medicine (miscellaneous), Medicine, business, Single Center, human activities, humanities, Surgery
Abstract: Purpose: Top surgery, or masculinization of the chest, is often the first and sometimes only procedure in gender-affirming surgery for transgender- and gender-diverse persons assigned female at bir...
Published: 2023
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8. Measurements of W+W−+ ≥ 1 jet production cross-sections in pp collisions at √s = 13 TeV with the ATLAS detector

Author: Aaboud, M, Aad, G, Abbott, B, Abdinov, O, Abeloos, B, Abhayasinghe, DK, Abidi, SH, AbouZeid, OS, Abraham, NL, Abramowicz, H, Abreu, H, Abulaiti, Y, Acharya, BS, Adachi, S, Adamczyk, L, Adelman, J, Adersberger, M, Adiguzel, A, Adye, T, Affolder, AA, Afik, Y, Agheorghiesei, C, Aguilar-Saavedra, JA, Ahmadov, F, Aielli, G, Akatsuka, S, Akesson, TPA, Akilli, E, Akimov, AV, Alberghi, GL, Albert, J, Albicocco, P, Verzini, MJA, Alderweireldt, S, Aleksa, M, Aleksandrov, IN, Alexa, C, Alexopoulos, T, Alhroob, M, Ali, B, Alimonti, G, Alison, J, Alkire, SP, Allaire, C, Allbrooke, BMM, Allen, BW, Allport, PP, Aloisio, A, Alonso, A, Alonso, F, Alpigiani, C, Alshehri, AA, Alstaty, MI, Gonzalez, BA, Alvarez Piqueras, D, Alviggi, MG, Amadio, BT, Coutinho, YA, Ambroz, L, Amelung, C, Amidei, D, Amor Dos Santos, SP, Amoroso, S, Amrouche, CS, Anastopoulos, C, Ancu, LS, Andari, N, Andeen, T, Anders, CF, Anders, JK, Anderson, KJ, Andreazza, A, Andrei, V, Anelli, CR, Angelidakis, S, Angelozzi, I, Angerami, A, Anisenkov, AV, Annovi, A, Antel, C, Anthony, MT, Antonelli, M, Antrim, DJA, Anulli, F, Aoki, M, Aparisi Pozo, JA, Aperio Bella, L, Arabidze, G, Araque, JP, Araujo Ferraz, V, Araujo Pereira, R, Arce, ATH, Ardell, RE, Arduh, FA, Arguin, J-F, Argyropoulos, S, Armbruster, AJ, Armitage, LJ, Armstrong, A, Arnaez, O, Arnold, H, Arratia, M, Arslan, O, Artamonov, A, Artoni, G, Artz, S, Asai, S, Asbah, N, Ashkenazi, A, Asimakopoulou, EM, Asquith, L, Assamagan, K, Astalos, R, Atkin, RJ, Atkinson, M, Atlay, NB, Augsten, K, Avolio, G, Avramidou, R, Ayoub, MK, Azuelos, G, Baas, AE, Baca, MJ, Bachacou, H, Bachas, K, Backes, M, Bagnaia, P, Bahmani, M, Bahrasemani, H, Bailey, AJ, Baines, JT, Bajic, M, Bakalis, C, Baker, OK, Bakker, PJ, Gupta, DB, Baldin, EM, Balek, P, Balli, F, Balunas, WK, Balz, J, Banas, E, Bandyopadhyay, A, Banerjee, S, Bannoura, AAE, Barak, L, Barbe, WM, Barberio, EL, Barberis, D, Barbero, M, Barillari, T, Barisits, M-S, Barkeloo, J, Barklow, T, Barlow, N, Barnea, R, 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Schulte, A, Schultz-Coulon, H-C, Schumacher, M, Schumm, BA, Schune, P, Schwartzman, A, Schwarz, TA, Schweiger, H, Schwemling, P, Schwienhorst, R, Sciandra, A, Sciolla, G, Scornajenghi, M, Scuri, F, Scutti, F, Scyboz, LM, Searcy, J, Sebastiani, CD, Seema, P, Seidel, SC, Seiden, A, Seiss, T, Seixas, JM, Sekhniaidze, G, Sekhon, K, Sekula, SJ, Semprini-Cesari, N, Sen, S, Senkin, S, Serfon, C, Serin, L, Serkin, L, Sessa, M, Severini, H, Sforza, F, Sfyrla, A, Shabalina, E, Shahinian, JD, Shaikh, NW, Shan, LY, Shang, R, Shank, JT, Shapiro, M, Sharma, AS, Sharma, A, Shatalov, PB, Shaw, K, Shaw, SM, Shcherbakova, A, Shen, Y, Sherafati, N, Sherman, AD, Sherwood, P, Shi, L, Shimizu, S, Shimmin, CO, Shimojima, M, Shipsey, IPJ, Shirabe, S, Shiyakova, M, Shlomi, J, Shmeleva, A, Saadi, DS, Shochet, MJ, Shojaii, S, Shope, DR, Shrestha, S, Shulga, E, Sicho, P, Sickles, AM, Sidebo, PE, Haddad, ES, Sidiropoulou, O, Sidoti, A, Siegert, F, Sijacki, D, Silva, J, Jr, SM, Oliveira, MVS, Silverstein, SB, 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B, Stapnes, S, Starchenko, EA, Stark, GH, Stark, J, Stark, SH, Staroba, P, Starovoitov, P, Staerz, S, Staszewski, R, Stegler, M, Steinberg, P, Stelzer, B, Stelzer, HJ, Stelzer-Chilton, O, Stenzel, H, Stevenson, TJ, Stewart, GA, Stockton, MC, Stoicea, G, Stolte, P, Stonjek, S, Straessner, A, Strandberg, J, Strandberg, S, Strauss, M, Strizenec, P, Stroehmer, R, Strom, DM, Stroynowski, R, Strubig, A, Stucci, SA, Stugu, B, Stupak, J, Styles, NA, Su, D, Su, J, Suchek, S, Sugaya, Y, Suk, M, Sulin, VV, Sultan, DMS, Sultansoy, S, Sumida, T, Sun, S, Sun, X, Suruliz, K, Suster, CJE, Sutton, MR, Suzuki, S, Svatos, M, Swiatlowski, M, Swift, SP, Sydorenko, A, Sykora, I, Sykora, T, Ta, D, Tackmann, K, Taenzer, J, Taffard, A, Tafirout, R, Tahirovic, E, Taiblum, N, Takai, H, Takashima, R, Takasugi, EH, Takeda, K, Takeshita, T, Takubo, Y, Talby, M, Talyshev, AA, Tanaka, J, Tanaka, M, Tanaka, R, Tannenwald, BB, Araya, ST, Tapprogge, S, Mohamed, ATA, Tarem, S, Tarna, G, Tartarelli, GF, Tas, P, Tasevsky, M, Tashiro, T, Tassi, E, Delgado, AT, Tayalati, Y, Taylor, AC, Taylor, AJ, Taylor, GN, Taylor, PTE, Taylor, W, Tee, AS, Teixeira-Dias, P, Ten Kate, H, Teng, PK, Teoh, JJ, Tepel, F, Terada, S, Terashi, K, Terron, J, Terzo, S, Testa, M, Teuscher, RJ, Thais, SJ, Theveneaux-Pelzer, T, Thiele, F, Thomas, DW, Thomas, JP, Thompson, AS, Thompson, PD, Thomsen, LA, Thomson, E, Tian, Y, Torres, RET, Tikhomirov, VO, Tikhonov, YA, Timoshenko, S, Tipton, P, Tisserant, S, Todome, K, Todorova-Nova, S, Todt, S, Tojo, J, Tokar, S, Tokushuku, K, Tolley, E, Tomiwa, KG, Tomoto, M, Tompkins, L, Toms, K, Tong, B, Tornambe, P, Torrence, E, Torres, H, Pastor, ET, Tosciri, C, Toth, J, Touchard, F, Tovey, DR, Treado, CJ, Trefzger, T, Tresoldi, F, Tricoli, A, Trigger, IM, Trincaz-Duvoid, S, Tripiana, MF, Trischuk, W, Trocme, B, Trofymov, A, Troncon, C, Trovatelli, M, Trovato, F, Truong, L, Trzebinski, M, Trzupek, A, Tsai, F, Tseng, JC-L, Tsiareshka, PV, Tsirigotis, A, Tsirintanis, N, Tsiskaridze, V, Tskhadadze, 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Vetterli, MC, Maira, NV, Pinto, MVB, Vichou, I, Vickey, T, Boeriu, OEV, Viehhauser, GHA, Viel, S, Vigani, L, Villa, M, Perez, MV, Vilucchi, E, Vincter, MG, Vinogradov, VB, Vishwakarma, A, Vittori, C, Vivarelli, I, Vlachos, S, Vogel, M, Vokac, P, Volpi, G, von Buddenbrock, SE, Von Toerne, E, Vorobel, V, Vorobev, K, Vos, M, Vossebeld, JH, Vranjes, N, Milosavljevic, MV, Vrba, V, Vreeswijk, M, Sfiligoj, T, Vuillermet, R, Vukotic, I, Zenis, T, Zivkovic, L, Wagner, P, Wagner, W, Wagner-Kuhr, J, Wahlberg, H, Wahrmund, S, Wakamiya, K, Walbrecht, VM, Walder, J, Walker, R, Walker, SD, Walkowiak, W, Wallangen, V, Wang, AM, Wang, C, Wang, F, Wang, H, Wang, J, Wang, P, Wang, Q, Wang, R-J, Wang, R, Wang, SM, Wang, WT, Wang, W, Wang, WX, Wang, Y, Wang, Z, Wanotayaroj, C, Warburton, A, Ward, CP, Wardrope, DR, Washbrook, A, Watkins, PM, Watson, AT, Watson, MF, Watts, G, Watts, S, Waugh, BM, Webb, AF, Webb, S, Weber, C, Weber, MS, Weber, SA, Weber, SM, Weidberg, AR, Weinert, B, Weingarten, J, Weirich, 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Yeletskikh, I, Yigitbasi, E, Yildirim, E, Yorita, K, Yoshihara, K, Young, CJS, Young, C, Yu, J, Yue, X, Yuen, SPY, Zabinski, B, Zacharis, G, Zaffaroni, E, Zaidan, R, Zaitsev, AM, Zakareishvili, T, Zakharchuk, N, Zalieckas, J, Zambito, S, Zanzi, D, Zaripovas, DR, Zeissner, SV, Zeitnitz, C, Zemaityte, G, Zeng, JC, Zeng, Q, Zenin, O, Zerwas, D, Zgubic, M, Zhang, DF, Zhang, D, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, L, Zhang, M, Zhang, P, Zhang, R, Zhang, X, Zhang, Y, Zhang, Z, Zhao, P, Zhao, X, Zhao, Y, Zhao, Z, Zhemchugov, A, Zhou, B, Zhou, C, Zhou, L, Zhou, MS, Zhou, M, Zhou, N, Zhou, Y, Zhu, CG, Zhu, HL, Zhu, H, Zhu, J, Zhu, Y, Zhuang, X, Zhukov, K, Zhulanov, V, Zibell, A, Zieminska, D, Zimine, NI, Zimmermann, S, Zinonos, Z, Zinser, M, Ziolkowski, M, Zobernig, G, Zoccoli, A, Zoch, K, Zorbas, TG, Zou, R, Nedden, MZ, Zwalinski, L, Collaboration, ATLAS, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2885, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), ATLAS (IHEF, IoP, FNWI), XENON (IHEF, IoP, FNWI), Other Research IHEF (IoP, FNWI), UAM. Departamento de Física Teórica, Aad, G. [0000-0002-6665-4934], Abbott, B. [0000-0002-5888-2734], Abbott, D. C. [0000-0002-7248-3203], Abed Abud, A. [0000-0002-2788-3822], Abeling, K. [0000-0002-1002-1652], Abhayasinghe, D. K. [0000-0002-2987-4006], Abidi, S. H. [0000-0002-8496-9294], AbouZeid, O. S. [0000-0002-8279-9324], Abramowicz, H. [0000-0001-5329-6640], Abreu, H. [0000-0002-1599-2896], Abulaiti, Y. [0000-0003-0403-3697], Abusleme Hoffman, A. C. [0000-0003-0762-7204], Acharya, B. S. [0000-0002-8588-9157], Achkar, B. [0000-0002-0288-2567], Adam, L. [0000-0001-6005-2812], Adam Bourdarios, C. [0000-0002-2634-4958], Adamczyk, L. [0000-0002-5859-2075], Adamek, L. [0000-0003-1562-3502], Adelman, J. [0000-0002-1041-3496], Adiguzel, A. [0000-0001-6644-0517], Adorni, S. [0000-0003-3620-1149], Adye, T. [0000-0003-0627-5059], Affolder, A. A. [0000-0002-9058-7217], Afik, Y. [0000-0001-8102-356X], Agapopoulou, C. [0000-0002-2368-0147], Agaras, M. N. [0000-0002-4355-5589], Aggarwal, A. [0000-0002-1922-2039], Agheorghiesei, C. [0000-0003-3695-1847], Aguilar-Saavedra, J. A. [0000-0002-5475-8920], Ahmad, A. [0000-0001-8638-0582], Ahmadov, F. [0000-0003-3644-540X], Ahmed, W. S. [0000-0003-0128-3279], Ai, X. [0000-0003-3856-2415], Aielli, G. [0000-0002-0573-8114], Akatsuka, S. [0000-0002-1681-6405], Akbiyik, M. [0000-0002-7342-3130], Åkesson, T. P. A. [0000-0003-4141-5408], Akilli, E. [0000-0003-1309-5937], Akimov, A. V. [0000-0002-2846-2958], Al Khoury, K. [0000-0002-0547-8199], Alberghi, G. L. [0000-0003-2388-987X], Albert, J. [0000-0003-0253-2505], Alconada Verzini, M. J. [0000-0003-2212-7830], Alderweireldt, S. [0000-0002-8224-7036], Aleksa, M. [0000-0002-1936-9217], Aleksandrov, I. N. [0000-0001-7381-6762], Alexa, C. [0000-0003-0922-7669], Alexopoulos, T. [0000-0002-8977-279X], Alfonsi, A. [0000-0001-7406-4531], Alfonsi, F. [0000-0002-0966-0211], Alhroob, M. [0000-0001-7569-7111], Ali, B. [0000-0001-8653-5556], Ali, S. [0000-0001-5216-3133], Aliev, M. [0000-0002-9012-3746], Alimonti, G. [0000-0002-7128-9046], Allaire, C. [0000-0003-4745-538X], Allbrooke, B. M. M. [0000-0002-5738-2471], Allport, P. P. [0000-0001-7303-2570], Aloisio, A. [0000-0002-3883-6693], Alonso, F. [0000-0001-9431-8156], Alpigiani, C. [0000-0002-7641-5814], Alvarez Estevez, M. [0000-0002-8181-6532], Alviggi, M. G. [0000-0003-0026-982X], Amaral Coutinho, Y. [0000-0002-1798-7230], Ambler, A. [0000-0003-2184-3480], Ambroz, L. [0000-0002-0987-6637], Amidei, D. [0000-0002-6814-0355], Amor Dos Santos, S. P. [0000-0001-7566-6067], Amoroso, S. [0000-0001-5450-0447], Anastopoulos, C. [0000-0003-1587-5830], Andari, N. [0000-0002-4935-4753], Andeen, T. [0000-0002-4413-871X], Anders, J. K. [0000-0002-1846-0262], Andrean, S. Y. [0000-0002-9766-2670], Andreazza, A. [0000-0001-5161-5759], Angelidakis, S. [0000-0002-8274-6118], Angerami, A. [0000-0001-7834-8750], Anisenkov, A. V. [0000-0002-7201-5936], Annovi, A. [0000-0002-4649-4398], Antel, C. [0000-0001-9683-0890], Anthony, M. T. [0000-0002-5270-0143], Antipov, E. [0000-0002-6678-7665], Antonelli, M. [0000-0002-2293-5726], Antrim, D. J. A. [0000-0001-8084-7786], Anulli, F. [0000-0003-2734-130X], Aoki, M. [0000-0001-7498-0097], Aparisi Pozo, J. A. [0000-0001-7401-4331], Aparo, M. A. [0000-0003-4675-7810], Aperio Bella, L. [0000-0003-3942-1702], Aranzabal, N. [0000-0001-9013-2274], Araujo Ferraz, V. [0000-0003-1177-7563], Arcangeletti, C. [0000-0001-8648-2896], Arce, A. T. H. [0000-0002-7255-0832], Arena, E. [0000-0001-5970-8677], Arguin, J-F. [0000-0003-0229-3858], Argyropoulos, S. [0000-0001-7748-1429], Arling, J.-H. [0000-0002-1577-5090], Armbruster, A. J. [0000-0002-9007-530X], Armstrong, A. [0000-0001-8505-4232], Arnaez, O. [0000-0002-6096-0893], Arnold, H. [0000-0003-3578-2228], Artoni, G. [0000-0002-3477-4499], Asada, H. [0000-0003-1420-4955], Asai, S. [0000-0001-5279-2298], Asbah, N. A. [0000-0001-8381-2255], Asimakopoulou, E. M. [0000-0003-2127-373X], Asquith, L. 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G., Zou, R., Zou, W., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Franchini , M., Romano , M., Valentinetti , S., Alberghi , G. L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., and ATLAS collaboration
Subjects: Plus Plus, 13000 GeV-cms, ((n)jet dilepton) [final state], QC770-798, transverse momentum [jet], 01 natural sciences, Subatomär fysik, Hadron-Hadron scattering (experiments), scattering [p p], Nuclear Experiment, Settore FIS/01, Electroweak interaction, hadronic [jet], mass dependence, upper limit [coupling constant], CERN LHC Coll, kinematics, Distributions, colliding beams [p p], p p: scattering, Astrophysics::High Energy Astrophysical Phenomena, coupling constant: upper limit, jet: multiplicity, Nuclear physics, phase space, Atlas (anatomy), quantum chromodynamics, muon: pair, coupling: (3gauge boson), TeV, ddc:530, Rapidity, High Energy Physics, 010306 general physics, Particle Physics, Particle Physics, LHC, ATLAS, Parton Distributions, final state: ((n)jet dilepton), 010308 nuclear & particles physics, jet: hadronic, Hadron Colliders, Automatic Keywords, dependence [multiplicity], Experimental High Energy Physics, p p: colliding beams, electron, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Atlas detector, (3gauge boson) [coupling], Hadron, jet: transverse momentum, GeV, transverse momentum dependence, High Energy Physics - Experiment, gauge [coupling], W: pair production, High Energy Physics - Experiment (hep-ex), Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Pair Production, Quantum chromodynamics, Physics, Jet (fluid), mass: transverse, multiplicity: dependence, lepton: transverse momentum, ATLAS, Zz Production, Nuclear and elementary particle physics: 431 [VDP], medicine.anatomical_structure, jet: production, pair production [W], Subtraction, differential cross section, LHC, multiplicity [jet], anomaly [coupling], Particle Physics - Experiment, perturbation theory [quantum chromodynamics], Nuclear and High Energy Physics, topology, Regular Article - Experimental Physics, 530 Physics, coupling: gauge, jet: associated production, interference, FOS: Physical sciences, differential cross section: measured, measured [differential cross section], Nuclear and particle physics. Atomic energy. Radioactivity, electron muon, 0103 physical sciences, medicine, associated production [jet], quantum chromodynamics: perturbation theory, coupling: anomaly, electroweak interaction, background, High Energy Physics::Phenomenology, Física, W bosons, production [jet], pair [muon], rapidity, Pair production, transverse [mass], High Energy Physics::Experiment, Hadron-hadron collisions, transverse momentum [lepton], experimental results
Abstract: We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Beijing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom., Fiducial and differential cross-section measurements of W+W− production in association with at least one hadronic jet are presented. These measurements are sensitive to the properties of electroweak-boson self-interactions and provide a test of perturbative quantum chromodynamics and the electroweak theory. The analysis is performed using proton-proton collision data collected at p s = 13TeV with the ATLAS experiment, corresponding to an integrated luminosity of 139 fb−1. Events are selected with exactly one oppositely charged electron-muon pair and at least one hadronic jet with a transverse momentum of pT > 30 GeV and a pseudorapidity of | | < 4.5. After subtracting the background contributions and correcting for detector effects, the jet-inclusive W+W−+ 1 jet fiducial cross-section and W+W−+ jets differential cross-sections with respect to several kinematic variables are measured. These measurements include leptonic quantities, such as the lepton transverse momenta and the transverse mass of the W+W− system, as well as jet-related observables such as the leading jet transverse momentum and the jet multiplicity. Limits on anomalous triple-gauge-boson couplings are obtained in a phase space where interference between the Standard Model amplitude and the anomalous amplitude is enhanced., ANPCyT, YerPhI, Armenia, Australian Research Council, BMWFW, Austria, Austrian Science Fund (FWF), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), NRC, Canada, Canada Foundation for Innovation, CERN, ANID, Chile, Chinese Academy of Sciences, Ministry of Science and Technology, China, National Natural Science Foundation of China (NSFC), Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government Czech Republic Government, DNRF, Denmark Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS) CEA-DRF/IRFU, France, SRNSFG, Georgia, Federal Ministry of Education & Research (BMBF), HGF, Germany Max Planck Society, Greek Ministry of Development-GSRT, RGC, China Hong Kong SAR, China, Israel Science Foundation Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland NCN, Poland, Portuguese Foundation for Science and Technology European Commission, MNE/IFA, Romania, JINR, Russian Federation NRC KI, Russian Federation, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia MIZS, Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden Wallenberg Foundation, Sweden, SERI, Switzerland Swiss National Science Foundation (SNSF), Canton of Bern, Switzerland Canton of Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC), United States Department of Energy (DOE) National Science Foundation (NSF), BCKDF, Canada CANARIE, Canada Compute Canada, Canada CRC, Canada IVADO, Canada, Beijing Municipal Science AMP; Technology Commission, China, COST, European Union European Research Council (ERC) ERDF, European Union Horizon 2020, European Union Marie Sklodowska-Curie Actions, European Union, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, Herakleitos programme - EU-ESF, Greece Thales Group Aristeia programme - EU-ESF, Greece Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain CERCA Programme Generalitat de Catalunya, Spain PROMETEO Programme Generalitat Valenciana, Spain GenT Programme Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust, Azerbaijan National Academy of Sciences (ANAS), SSTC, Belarus, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
Published: 2021
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9. Nonmicroradical Resection Margin as a Predictor of Recurrence in Patients With Stage III Colon Cancer Undergoing Complete Mesocolic Excision: A Prospective Cohort Study

Author: Anna Sofie Friis Olsen, Birgitte Bols, Peter Ingeholm, Jakob Kleif, Claus Anders Bertelsen, and Anders Kierkegaard Gundestrup
Subjects: medicine.medical_specialty, Rectal Neoplasms, business.industry, Gastroenterology, Margins of Excision, General Medicine, Surgery, Stage III Colon Cancer, Cohort Studies, Colonic Neoplasms, Resection margin, Humans, Medicine, Prospective Studies, business, Prospective cohort study, Neoplasm Staging, Retrospective Studies
Abstract: The prognostic value of the present definition of microradicality in colon cancer is poorly understood, especially considering the vast influence it has in rectal cancer prognosis.This study aimed to investigate whether the risk of recurrence after complete mesocolic excision for stage III colon cancer is associated with the distance from tumor tissue to resection margin and whether the location of the involved margin is of any significance.A prospective cohort of patients was stratified into 2 groups to distinguish between direct margin invasion (0-mm resection margin) and a ≤1-mm resection margin without direct invasion or 3 groups to distinguish between the location of margin involvement (lateral tumor resection margin, central vascular ligation margin, and nonperitonealized mesocolic resection margin). Patients with microradical resections were used as a control group.We included all patients undergoing elective complete mesocolic excision for International Union Against Cancer stage III colon cancer at Nordsjællands Hospital between January 1, 2008, and December 31, 2016.A total of 276 patients met all inclusion criteria and none of the exclusion criteria.Primary outcome was risk of recurrence after 3.2 years.A total of 41 patients (15%) had a nonmicroradical resection. The 3.2-year cumulative incidence of recurrence for a 0-mm margin was 43% and 24% for a ≤1-mm margin without direct invasion, corresponding with an HR of 4.3 (p = 0.0146) and 1.3 (p = 0.474). The location of the involved margin showed no significant differences.This was a single-center study containing a limited number of patients with a nonmicroradical resection with a risk of type II error.We found no increased risk of recurrence for a ≤1-mm margin without direct invasion, indicating that the present classification of microradicality might not be justified if an intact posterior mesocolic fascia without invasion of tumor tissue is present. See Video Abstract at http://links.lww.com/DCR/B625.ANTECEDENTES:El valor pronóstico de la definición actual de microrradicalidad en el cáncer de colon es poco conocido, especialmente considerando la gran influencia que tiene en el pronóstico del cáncer de recto.OBJETIVO:Este estudio tiene como objetivo investigar si el riesgo de recurrencia después de la escisión mesocólica completa (CME) para el cáncer de colon en estadio III está asociado con la distancia desde el tejido tumoral hasta el margen de resección y si la localización del margen afectado tiene alguna importancia.DISEÑO:Una cohorte prospectiva de pacientes se estratificó en dos grupos para distinguir entre la invasión del margen directo (margen de resección de 0 mm) y un margen de resección ≤1 mm sin invasión directa, o tres grupos para distinguir entre la localización de la afectación del margen (resección lateral del margen del tumor, margen de ligadura vascular central y margen de resección mesocólica no peritonizada). Los pacientes con resecciones microrradicales se utilizaron como grupo control.ENTORNO CLÍNICO:Incluimos a todos los pacientes sometidos a CME electiva por cáncer de colon en estadio III de la UICC en el Hospital Nordsjællands, Dinamarca, entre el 1 de enero de 2008 y el 31 de diciembre de 2016.PACIENTES:Un total de 276 pacientes cumplieron todos los criterios de inclusión y ninguno de los criterios de exclusión.PRINCIPALES MEDIDAS DE RESULTADO:El resultado primario fue el riesgo de recurrencia después de 3 · 2 años.RESULTADOS:Un total de 41 (15%) pacientes tuvieron una resección no microrradical. La incidencia acumulada de recurrencia a los 3,2 años para un margen de 0 mm fue del 43% y del 24% para un margen ≤1 mm sin invasión directa, lo que corresponde a un cociente de riesgo de 4,3 (p = 0,0146) y 1,3 (p = 0,474) respectivamente. La localización del margen afectado no mostró diferencias significativas.LIMITACIONES:Estudio unicéntrico con un número limitado de pacientes con resección no microrradical con riesgo de error tipo II.CONCLUSIONES:No encontramos un mayor riesgo de recurrencia para un margen ≤1 mm sin invasión directa, lo que indica que la clasificación actual de microrradicalidad podría no estar justificada si está presente una fascia mesocólica posterior intacta sin invasión del tejido tumoral. Consulte Video Resumen en http://links.lww.com/DCR/B625. (Traducción-Dr Yazmin Berrones-Medina).
Published: 2022
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10. Effects of working memory load and CS-US intervals on delay eyeblink conditioning

Author: Leila Etemadi, Anders Rasmussen, Dan-Anders Jirenhed, and Neurosciences
Subjects: Linear mixed effect model, medicine.medical_specialty, genetic structures, Working memory, Interstimulus interval, Cerebellar function, Stimulus (physiology), Audiology, behavioral disciplines and activities, Education, Eyeblink conditioning, Developmental Neuroscience, medicine, Conditioning, Psychology, Motor learning, psychological phenomena and processes
Abstract: Background: Eyeblink conditioning is used in many different species to study motor learning and make inferences about cerebellar function. However, considerable discrepancies in performance between different species combined with evidence that awareness of stimulus contingencies affects performance indicates that eyeblink conditioning in part reflects activity in non-cerebellar regions. This questions whether eyeblink conditioning can be used as a pure measure of cerebellar function in humans. Methods: Here we explored two ways to reduce non-cerebellar influences on performance in eyeblink conditioning: (1) using a short interstimulus interval, and (2) having participants do working memory tasks during the conditioning. Data were analyzed, and the influence of the interstimulus interval and working memory tasks was assessed using a linear mixed effects model. Results: Our results show that subjects trained with a short interstimulus interval (150ms and 250ms) produce few conditioned responses after 100 trials. For subjects trained with a longer interstimulus interval (500ms), those who did working memory tasks produced fewer conditioned responses and had a more gradual learning curve, more akin to those reported in the animal literature. Conclusions: Our results suggest that having subjects perform working memory tasks during eyeblink conditioning can be a viable strategy to reduce non-cerebellar interference in the learning.
Published: 2023
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11. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Author: Niamh Mullins, JooEun Kang, Adrian I. Campos, Jonathan R.I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark Adams, Swapnil Awasthi, Michael Gandal, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Stephan Ripke, Erin B. Ware, Andrew W. Bergen, Wade H. Berrettini, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi-Chung Chen, Steven Crawford, Scott Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernández-Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai-Gwo Hwu, Sonia Jain, Stéphane Jamain, Susana Jiménez-Murcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Kelly L. Klump, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Chih-Min Liu, Pierre J. Magistretti, Christian R. Marshall, James E. Mitchell, Eric T. Monson, Richard M. Myers, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Michael Strober, Laura M. Thornton, Janet Treasure, Ming T. Tsuang, Stephanie H. Witt, D. Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Tracy M. Air, Martin Alda, Lars Alfredsson, Ole A. Andreassen, Adebayo Anjorin, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M. Helena Azevedo, Nicholas Bass, Claiton H.D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, Rosa Bosch, David L. Braff, Richard Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Miguel Casas, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Sven Cichon, Aiden Corvin, Nicholas Craddock, David Craig, Franziska Degenhardt, Srdjan Djurovic, Howard J. Edenberg, Ayman H. Fanous, Jerome C. Foo, Andreas J. Forstner, Mark Frye, Janice M. Fullerton, Justine M. Gatt, Pablo V. Gejman, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugenio H. Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Steven P. Hamilton, Marian L. Hamshere, Annette Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A. Jones, Lina Jonsson, René S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Bettina Konte, Marie-Odile Krebs, Mikael Landén, Jacob Lawrence, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Susanne Lucae, Fermin Mayoral, Susan L. McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Sarah E. Medland, Divya Mehta, Ingrid Melle, Yuri Milaneschi, Philip B. Mitchell, Esther Molina, Gunnar Morken, Preben Bo Mortensen, Bertram Müller-Myhsok, Caroline Nievergelt, Vishwajit Nimgaonkar, Markus M. Nöthen, Michael C. O’Donovan, Roel A. Ophoff, Michael J. Owen, Carlos Pato, Michele T. Pato, Brenda W.J.H. Penninx, Jonathan Pimm, Giorgio Pistis, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A. Rouleau, Diego L. Rovaris, Dan Rujescu, Cristina Sánchez-Mora, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Stanley I. Shyn, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund J.S. Sonuga-Barke, Gianfranco Spalletta, John S. Strauss, Beata Świątkowska, Maciej Trzaskowski, Gustavo Turecki, Laura Vilar-Ribó, John B. Vincent, Henry Völzke, James T.R. Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Allison E. Ashley-Koch, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser, Nathan A. Kimbrel, Jennifer H. Lindquist, Benjamin McMahon, David W. Oslin, Xuejun Qin, Esben Agerbo, Anders D. Børglum, Gerome Breen, Annette Erlangsen, Tõnu Esko, Joel Gelernter, David M. Hougaard, Ronald C. Kessler, Henry R. Kranzler, Qingqin S. Li, Nicholas G. Martin, Andrew M. McIntosh, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David Porteous, Robert J. Ursano, Danuta Wasserman, Thomas Werge, David C. Whiteman, Cynthia M. Bulik, Hilary Coon, Ditte Demontis, Anna R. Docherty, Po-Hsiu Kuo, Cathryn M. Lewis, J. John Mann, Miguel E. Rentería, Daniel J. Smith, Eli A. Stahl, Murray B. Stein, Fabian Streit, Virginia Willour, Douglas M. Ruderfer, Manuel Mattheisen, Abdel Abdellaoui, Mark J. Adams, Till F.M. Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T.F. Beekman, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Jane Hvarregaard Christensen, Toni-Kim Clarke, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Eske M. Derks, Nese Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Valentina Escott-Price, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Josef Frank, Héléna A. Gaspar, Michael Gill, Fernando S. Goes, Scott D. Gordon, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Yang Wu, Hualin S. Xi, Jian Yang, Futao Zhang, Volker Arolt, Dorret I. Boomsma, Udo Dannlowski, E.J.C. de Geus, J. Raymond Depaulo, Enrico Domenici, Katharina Domschke, Jakob Grove, Lynsey S. Hall, Christine Søholm Hansen, Thomas F. Hansen, Stefan Herms, Ian B. Hickie, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M. Howard, Rick Jansen, Eric Jorgenson, James A. Knowles, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Donald J. MacIntyre, Dean F. MacKinnon, Robert M. Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Christel M. Middeldorp, Evelin Mihailov, Lili Milani, Francis M. Mondimore, Grant W. Montgomery, Sara Mostafavi, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Paul F. O’Reilly, Hogni Oskarsson, Caroline Hayward, Andrew C. Heath, Glyn Lewis, Pamela A.F. Madden, Patrik K. Magnusson, Andres Metspalu, Sara A. Paciga, Nancy L. Pedersen, Jodie N. Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E. Peterson, Wouter J. Peyrot, Danielle Posthuma, Jorge A. Quiroz, Per Qvist, John P. Rice, Brien P. Riley, Saira Saeed Mirza, Robert Schoevers, Eva C. Schulte, Ling Shen, Engilbert Sigurdsson, Grant C.B. Sinnamon, Johannes H. Smit, Hreinn Stefansson, Stacy Steinberg, Jana Strohmaier, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G. Uitterlinden, Daniel Umbricht, Albert M. van Hemert, Alexander Viktorin, Peter M. Visscher, Yunpeng Wang, Bradley T. Webb, Roy H. Perlis, David J. Porteous, Catherine Schaefer, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Patrick F. Sullivan, Kevin S. O’Connell, Brandon Coombes, Zhen Qiao, Thomas D. Als, Sigrid Børte, Alexander W. Charney, Ole Kristian Drange, Michael J. Gandal, Saskia P. Hagenaars, Masashi Ikeda, Nolan Kamitaki, Kristi Krebs, Georgia Panagiotaropoulou, Brian M. Schilder, Laura G. Sloofman, Bendik S. Winsvold, Hong-Hee Won, Liliya Abramova, Kristina Adorjan, Mariam Al Eissa, Diego Albani, Ney Alliey-Rodriguez, Verneri Antilla, Anastasia Antoniou, Ji Hyun Baek, Michael Bauer, Eva C. Beins, Sarah E. Bergen, Armin Birner, Erlend Bøen, Murielle Brum, Ben M. Brumpton, Nathalie Brunkhorst-Kanaan, William Byerley, Murray Cairns, Miquel Casas, Pablo Cervantes, Cristiana Cruceanu, Alfredo Cuellar-Barboza, Julie Cunningham, David Curtis, Piotr M. Czerski, Anders M. Dale, Nina Dalkner, Friederike S. David, Amanda L. Dobbyn, Athanassios Douzenis, Torbjørn Elvsåshagen, I. Nicol Ferrier, Alessia Fiorentino, Tatiana M. Foroud, Liz Forty, Oleksandr Frei, Nelson B. Freimer, Louise Frisén, Katrin Gade, Julie Garnham, Ian R. Gizer, Katherine Gordon-Smith, Tiffany A. Greenwood, José Guzman-Parra, Kyooseob Ha, Magnus Haraldsson, Martin Hautzinger, Urs Heilbronner, Dennis Hellgren, Peter A. Holmans, Laura Huckins, Jessica S. Johnson, Janos L. Kalman, Yoichiro Kamatani, Sarah Kittel-Schneider, Maria Koromina, Thorsten M. Kranz, Michiaki Kubo, Ralph Kupka, Steven A. Kushner, Catharina Lavebratt, Markus Leber, Heon-Jeong Lee, Shawn E. Levy, Catrin Lewis, Martin Lundberg, Sigurdur H. Magnusson, Adam Maihofer, Dolores Malaspina, Eirini Maratou, Lina Martinsson, Nathaniel W. McGregor, James D. McKay, Helena Medeiros, Vincent Millischer, Jennifer L. Moran, Derek W. Morris, Thomas W. Mühleisen, Niamh O’Brien, Claire O’Donovan, Loes M. Olde Loohuis, Lilijana Oruc, Sergi Papiol, Antonio F. Pardiñas, Amy Perry, Andrea Pfennig, Evgenia Porichi, Towfique Raj, Mark H. Rapaport, J. Raymond DePaulo, Eline J. Regeer, Fabio Rivas, Julian Roth, Panos Roussos, Fanny Senner, Sally Sharp, Paul D. Shilling, Claire Slaney, Janet L. Sobell, Maria Soler Artigas, Anne T. Spijker, Dan J. Stein, Chikashi Terao, Claudio Toma, Paul Tooney, Evangelia-Eirini Tsermpini, Marquis P. Vawter, Helmut Vedder, Simon Xi, Wei Xu, Jessica Mei Kay Yang, Allan H. Young, Hannah Young, Peter P. Zandi, Hang Zhou, null HUNT All-In Psychiatry, Gulja Babadjanova, Lena Backlund, Susanne Bengesser, Douglas H.R. Blackwood, Vaughan J. Carr, Stanley Catts, Dimitris Dikeos, Bruno Etain, Panagiotis Ferentinos, Micha Gawlik, Elliot S. Gershon, Frans Henskens, Jan Hillert, Kyung Sue Hong, Christina M. Hultman, Kristian Hveem, Nakao Iwata, Assen V. Jablensky, George Kirov, Christine Lochner, Carmel Loughland, Carol A. Mathews, Francis J. McMahon, Patricia Michie, Bryan Mowry, Benjamin M. Neale, Caroline M. Nievergelt, Ketil J. Oedegaard, Tomas Olsson, Chris Pantelis, George P. Patrinos, Eva Z. Reininghaus, Takeo Saito, Ulrich Schall, Martin Schalling, Rodney J. Scott, Eystein Stordal, Arne E. Vaaler, Eduard Vieta, Irwin D. Waldman, John-Anker Zwart, John I. Nurnberger, Arianna Di Florio, Roger A.H. Adan, Tetsuya Ando, Harald Aschauer, Jessica H. Baker, Vladimir Bencko, Andreas Birgegård, Joseph M. Boden, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Laura Carlberg, Matteo Cassina, Maurizio Clementi, Roger D. Cone, Philippe Courtet, James J. Crowley, Unna N. Danner, Oliver S.P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo Martinez, Laramie E. Duncan, Karin Egberts, Morten Mattingsdal, Sara McDevitt, Ingrid Meulenbelt, Nadia Micali, James Mitchell, Karen Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Melissa A. Munn-Chernoff, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K. O’Toole, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Richard Parker, John F. Pearson, Stefan Ehrlich, Geòrgia Escaramís, Thomas Espeseth, Xavier Estivill, Anne Farmer, Angela Favaro, Krista Fischer, James A.B. Floyd, Manuel Föcker, Lenka Foretova, Monica Forzan, Christopher S. Franklin, Giovanni Gambaro, Johanna Giuranna, Paola Giusti-Rodríquez, Fragiskos Gonidakis, Scott Gordon, Monica Gratacos Mayora, Sébastien Guillaume, Ken B. Hanscombe, Konstantinos Hatzikotoulas, Johannes Hebebrand, Sietske G. Helder, Anjali K. Henders, Beate Herpertz-Dahlmann, Wolfgang Herzog, Anke Hinney, L. John Horwood, Christopher Hübel, Liselotte V. Petersen, Kirstin L. Purves, Anu Raevuori, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Filip Rybakowski, Paolo Santonastaso, André Scherag, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P. Eline Slagboom, Margarita C.T. Slof-Op ‘t Landt, Agnieszka Slopien, Nicole Soranzo, Sandro Sorbi, Lorraine Southam, Vidar W. Steen, Laura M. Huckins, James I. Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Jennifer Jordan, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Jaakko Kaprio, Leila Karhunen, Andreas Karwautz, Martien J.H. Kas, Martin A. Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Katherine M. Kirk, Lars Klareskog, Gun Peggy S. Knudsen, Janne T. Larsen, Stephanie Le Hellard, Virpi M. Leppä, Paul Lichtenstein, Bochao Danae Lin, Astri Lundervold, Jurjen Luykx, Mario Maj, Katrin Mannik, Sara Marsal, Garret D. Stuber, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A. van Elburg, Eric F. van Furth, Tracey D. Wade, Gudrun Wagner, Esther Walton, H. Erich Wichmann, Elisabeth Widen, Shuyang Yao, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Martin Jungkunz, Lydie Dietl, Cornelia E. Schwarze, Norbert Dahmen, Björn H. Schott, Arian Mobascher, Silvia Crivelli, Michelle F. Dennis, Phillip D. Harvey, Bruce W. Carter, Jennifer E. Huffman, Daniel Jacobson, Ravi Madduri, Maren K. Olsen, John Pestian, J. Michael Gaziano, Sumitra Muralidhar, Rachel Ramoni, Jean Beckham, Kyong-Mi Chang, Christopher J. O’Donnell, Philip S. Tsao, James Breeling, Grant Huang, J.P. Casas Romero, Jennifer Moser, Stacey B. Whitbourne, Jessica V. Brewer, Mihaela Aslan, Todd Connor, Dean P. Argyres, Brady Stephens, Mary T. Brophy, Donald E. Humphries, Luis E. Selva, Nhan Do, Shahpoor Shayan, Kelly Cho, Saiju Pyarajan, Elizabeth Hauser, Yan Sun, Hongyu Zhao, Peter Wilson, Rachel McArdle, Louis Dellitalia, Kristin Mattocks, John Harley, Clement J. Zablocki, Jeffrey Whittle, Frank Jacono, Salvador Gutierrez, Gretchen Gibson, Kimberly Hammer, Laurence Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark Hamner, Roy Mathew, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair Ballas, Douglas Ivins, Stephen Mastorides, Jonathan Moorman, Saib Gappy, Jon Klein, Nora Ratcliffe, Hermes Florez, Olaoluwa Okusaga, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Neeraj Tandon, Darshana Jhala, Samuel Aguayo, David Cohen, Satish Sharma, Suthat Liangpunsakul, Kris Ann Oursler, Mary Whooley, Sunil Ahuja, Joseph Constans, Paul Meyer, Jennifer Greco, Michael Rauchman, Richard Servatius, Melinda Gaddy, Agnes Wallbom, Timothy Morgan, Todd Stapley, Scott Sherman, George Ross, Philip Tsao, Patrick Strollo, Edward Boyko, Laurence Meyer, Samir Gupta, Mostaqul Huq, Joseph Fayad, Adriana Hung, Jack Lichy, Robin Hurley, Brooks Robey, Robert Striker, Dietl, Lydie, Schwarze, Cornelia E., Dahmen, Norbert, Schott, Björn H., Nöthen, Markus M., Ripke, Stephan, Mobascher, Arian, Rujescu, Dan, Lieb, Klaus, Roepke, Stefan, Schmahl, Christian, Bohus, Martin, Rietschel, Marcella, Crivelli, Silvia, Dennis, Michelle F., Harvey, Phillip D., Carter, Bruce W., Huffman, Jennifer E., Jacobson, Daniel, Madduri, Ravi, Olsen, Maren K., Pestian, John, Gaziano, J. Michael, Muralidhar, Sumitra, Ramoni, Rachel, Beckham, Jean, Chang, Kyong-Mi, O'Donnell, Christopher J., Tsao, Philip S., Breeling, James, Huang, Grant, Romero, J. P. Casas, Moser, Jennifer, Whitbourne, Stacey B., Brewer, Jessica V., Aslan, Mihaela, Connor, Todd, Argyres, Dean P., Stephens, Brady, Brophy, Mary T., Humphries, Donald E., Selva, Luis E., Do, Nhan, Shayan, Shahpoor, Cho, Kelly, Pyarajan, Saiju, Hauser, Elizabeth, Sun, Yan, Zhao, Hongyu, Wilson, Peter, McArdle, Rachel, Dellitalia, Louis, Mattocks, Kristin, Harley, John, Zablocki, Clement J., Whittle, Jeffrey, Jacono, Frank, Gutierrez, Salvador, Gibson, Gretchen, Hammer, Kimberly, Kaminsky, Laurence, Villareal, Gerardo, Kinlay, Scott, Xu, Junzhe, Hamner, Mark, Mathew, Roy, Bhushan, Sujata, Iruvanti, Pran, Godschalk, Michael, Ballas, Zuhair, Ivins, Douglas, Mastorides, Stephen, Moorman, Jonathan, Gappy, Saib, Klein, Jon, Ratcliffe, Nora, Florez, Hermes, Okusaga, Olaoluwa, Murdoch, Maureen, Sriram, Peruvemba, Yeh, Shing Shing, Tandon, Neeraj, Jhala, Darshana, Aguayo, Samuel, Cohen, David, Sharma, Satish, Liangpunsakul, Suthat, Oursler, Kris Ann, Whooley, Mary, Ahuja, Sunil, Constans, Joseph, Meyer, Paul, Greco, Jennifer, Rauchman, Michael, Servatius, Richard, Gaddy, Melinda, Wallbom, Agnes, Morgan, Timothy, Stapley, Todd, Sherman, Scott, Ross, George, Tsao, Philip, Strollo, Patrick, Boyko, Edward, Meyer, Laurence, Gupta, Samir, Huq, Mostaqul, Fayad, Joseph, Hung, Adriana, Lichy, Jack, Hurley, Robin, Robey, Brooks, Striker, Robert, Wray, Naomi R., Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R. I., Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor V., Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Hassan Kiadeh, Farnush Farhadi, Finucane, Hilary K., Foo, Jerome C., Forstner, Andreas J., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T., Berger, Klaus, Boomsma, Dorret I., Cichon, Sven, Dannlowski, Udo, de Geus, E. J. C., DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J., Hamilton, Steven P., Grove, Jakob, Hall, Lynsey S., Hansen, Christine Søholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M., Howard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O'Reilly, Paul F., Oskarsson, Hogni, Hayward, Caroline, Heath, Andrew C., Kendler, Kenneth S., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A. F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nordentoft, Merete, O'Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Peterson, Roseann E., Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Penninx, Brenda W. J. H., Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Lewis, Cathryn M., Levinson, Douglas F., Breen, Gerome, Børglum, Anders D., Sullivan, Patrick F., O'Connell, Kevin S., Coombes, Brandon, Qiao, Zhen, Als, Thomas D., Børte, Sigrid, Charney, Alexander W., Drange, Ole Kristian, Gandal, Michael J., Hagenaars, Saskia P., Ikeda, Masashi, Kamitaki, Nolan, Kim, Minsoo, Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M., Sloofman, Laura G., Winsvold, Bendik S., Won, Hong-Hee, Abramova, Liliya, Adorjan, Kristina, Al Eissa, Mariam, Albani, Diego, Alliey-Rodriguez, Ney, Anjorin, Adebayo, Antilla, Verneri, Antoniou, Anastasia, Awasthi, Swapnil, Baek, Ji Hyun, Bass, Nicholas, Bauer, Michael, Beins, Eva C., Bergen, Sarah E., Birner, Armin, Bøen, Erlend, Boks, Marco P., Bosch, Rosa, Brum, Murielle, Brumpton, Ben M., Brunkhorst-Kanaan, Nathalie, Budde, Monika, Byerley, William, Cairns, Murray, Casas, Miquel, Cervantes, Pablo, Cruceanu, Cristiana, Cuellar-Barboza, Alfredo, Cunningham, Julie, Curtis, David, Czerski, Piotr M., Dale, Anders M., Dalkner, Nina, David, Friederike S., Djurovic, Srdjan, Dobbyn, Amanda L., Douzenis, Athanassios, Elvsåshagen, Torbjørn, Ferrier, I. Nicol, Fiorentino, Alessia, Foroud, Tatiana M., Forty, Liz, Frei, Oleksandr, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Garnham, Julie, Gelernter, Joel, Gizer, Ian R., Gordon-Smith, Katherine, Greenwood, Tiffany A., Guzman-Parra, José, Ha, Kyooseob, Haraldsson, Magnus, Hautzinger, Martin, Heilbronner, Urs, Hellgren, Dennis, Holmans, Peter A., Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Kalman, Janos L., Kamatani, Yoichiro, Kennedy, James L., Kittel-Schneider, Sarah, Kogevinas, Manolis, Koromina, Maria, Kranz, Thorsten M., Kranzler, Henry R., Kubo, Michiaki, Kupka, Ralph, Kushner, Steven A., Lavebratt, Catharina, Lawrence, Jacob, Leber, Markus, Lee, Heon-Jeong, Lee, Phil H., Levy, Shawn E., Lewis, Catrin, Liao, Calwing, Lundberg, Martin, Magnusson, Sigurdur H., Maihofer, Adam, Malaspina, Dolores, Maratou, Eirini, Martinsson, Lina, McGregor, Nathaniel W., McKay, James D., Medeiros, Helena, Millischer, Vincent, Moran, Jennifer L., Morris, Derek W., Mühleisen, Thomas W., O'Brien, Niamh, O'Donovan, Claire, Olde Loohuis, Loes M., Oruc, Lilijana, Papiol, Sergi, Pardiñas, Antonio F., Perry, Amy, Pfennig, Andrea, Porichi, Evgenia, Quested, Digby, Raj, Towfique, Rapaport, Mark H., Regeer, Eline J., Rivas, Fabio, Roth, Julian, Roussos, Panos, Ruderfer, Douglas M., Sánchez-Mora, Cristina, Senner, Fanny, Sharp, Sally, Shilling, Paul D., Sirignano, Lea, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Artigas, Maria Soler, Spijker, Anne T., Stein, Dan J., Strauss, John S., Świątkowska, Beata, Terao, Chikashi, Toma, Claudio, Tooney, Paul, Tsermpini, Evangelia-Eirini, Vawter, Marquis P., Vedder, Helmut, Walters, James T. R., Xi, Simon, Xu, Wei, Kay Yang, Jessica Mei, Young, Allan H., Young, Hannah, Zandi, Peter P., Zhou, Hang, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Alfredsson, Lars, Babadjanova, Gulja, Backlund, Lena, Bellivier, Frank, Bengesser, Susanne, Berrettini, Wade H., Blackwood, Douglas H. R., Boehnke, Michael, Carr, Vaughan J., Catts, Stanley, Corvin, Aiden, Craddock, Nicholas, Dikeos, Dimitris, Etain, Bruno, Ferentinos, Panagiotis, Frye, Mark, Fullerton, Janice M., Gawlik, Micha, Gershon, Elliot S., Green, Melissa J., Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Henskens, Frans, Hillert, Jan, Hong, Kyung Sue, Hultman, Christina M., Hveem, Kristian, Iwata, Nakao, Jablensky, Assen V., Kahn, René S., Kelsoe, John R., Kirov, George, Landén, Mikael, Leboyer, Marion, Lissowska, Jolanta, Lochner, Christine, Loughland, Carmel, Mathews, Carol A., Mayoral, Fermin, McElroy, Susan L., McMahon, Francis J., Melle, Ingrid, Michie, Patricia, Mitchell, Philip B., Morken, Gunnar, Mowry, Bryan, Myers, Richard M., Neale, Benjamin M., Nievergelt, Caroline M., Oedegaard, Ketil J., Olsson, Tomas, Pantelis, Chris, Pato, Carlos, Pato, Michele T., Patrinos, George P., Ramos-Quiroga, Josep Antoni, Reif, Andreas, Reininghaus, Eva Z., Ribasés, Marta, Rouleau, Guy A., Saito, Takeo, Schall, Ulrich, Schalling, Martin, Schofield, Peter R., Scott, Laura J., Scott, Rodney J., Serretti, Alessandro, Weickert, Cynthia Shannon, Stordal, Eystein, Turecki, Gustavo, Vaaler, Arne E., Vieta, Eduard, Vincent, John B., Waldman, Irwin D., Weickert, Thomas W., Zwart, John-Anker, Biernacka, Joanna M., Nurnberger, John I., Edenberg, Howard J., Stahl, Eli A., McQuillin, Andrew, Di Florio, Arianna, Ophoff, Roel A., Andreassen, Ole A., Adan, Roger A. H., Ando, Tetsuya, Aschauer, Harald, Baker, Jessica H., Bencko, Vladimir, Bergen, Andrew W., Birgegård, Andreas, Boden, Joseph M., Boehm, Ilka, Boni, Claudette, Perica, Vesna Boraska, Brandt, Harry, Buehren, Katharina, Bulik, Cynthia M., Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Clementi, Maurizio, Cone, Roger D., Courtet, Philippe, Crawford, Steven, Crow, Scott, Crowley, James J., Danner, Unna N., Davis, Oliver S. P., de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E., Dick, Danielle M., Dina, Christian, Dmitrzak-Weglarz, Monika, Martinez, Elisa Docampo, Duncan, Laramie E., Egberts, Karin, Marshall, Christian R., Mattingsdal, Morten, McDevitt, Sara, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, James, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Munn-Chernoff, Melissa A., Nacmias, Benedetta, Navratilova, Marie, Ntalla, Ioanna, Olsen, Catherine M., O'Toole, Julie K., Padyukov, Leonid, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Parker, Richard, Pearson, John F., Ehrlich, Stefan, Escaramís, Geòrgia, Espeseth, Thomas, Estivill, Xavier, Farmer, Anne, Favaro, Angela, Fernández-Aranda, Fernando, Fichter, Manfred M., Fischer, Krista, Floyd, James A. B., Föcker, Manuel, Foretova, Lenka, Forzan, Monica, Franklin, Christopher S., Gallinger, Steven, Gambaro, Giovanni, Giegling, Ina, Giuranna, Johanna, Giusti-Rodríquez, Paola, Gonidakis, Fragiskos, Gordon, Scott, Gorwood, Philip, Mayora, Monica Gratacos, Guillaume, Sébastien, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine A., Hanscombe, Ken B., Hatzikotoulas, Konstantinos, Hebebrand, Johannes, Helder, Sietske G., Henders, Anjali K., Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hinney, Anke, Horwood, L. John, Hübel, Christopher, Petersen, Liselotte V., Pinto, Dalila, Purves, Kirstin L., Raevuori, Anu, Ramoz, Nicolas, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Scherer, Stephen W., Schmidt, Ulrike, Schork, Nicholas J., Schosser, Alexandra, Seitz, Jochen, Slachtova, Lenka, Slagboom, P. Eline, Slof-Op 't Landt, Margarita C. T., Slopien, Agnieszka, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar W., Strober, Michael, Huckins, Laura M., Hudson, James I., Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimir, Jiménez-Murcia, Susana, Johnson, Craig, Jordan, Jennifer, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Kaplan, Allan S., Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien J. H., Kaye, Walter H., Kennedy, Martin A., Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Kirk, Katherine M., Klareskog, Lars, Klump, Kelly L., Knudsen, Gun Peggy S., Larsen, Janne T., Le Hellard, Stephanie, Leppä, Virpi M., Li, Dong, Lichtenstein, Paul, Lilenfeld, Lisa, Lin, Bochao Danae, Lundervold, Astri, Luykx, Jurjen, Magistretti, Pierre J., Maj, Mario, Mannik, Katrin, Marsal, Sara, Stuber, Garret D., Szatkiewicz, Jin P., Tachmazidou, Ioanna, Tenconi, Elena, Thornton, Laura M., Tortorella, Alfonso, Tozzi, Federica, Treasure, Janet, Tsitsika, Artemis, Tyszkiewicz-Nwafor, Marta, Tziouvas, Konstantinos, van Elburg, Annemarie A., van Furth, Eric F., Wade, Tracey D., Wagner, Gudrun, Walton, Esther, Watson, Hunna J., Whiteman, David C., Wichmann, H. Erich, Widen, Elisabeth, Woodside, D. Blake, Yao, Shuyang, Yilmaz, Zeynep, Zeggini, Eleftheria, Zerwas, Stephanie, Zipfel, Stephan, Jungkunz, Martin, Mullins, N., Kang, J., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., Su, M. -H., Watson, H. J., Adams, M., Awasthi, S., Gandal, M., Hafferty, J. D., Hishimoto, A., Kim, M., Okazaki, S., Otsuka, I., Ripke, S., Ware, E. B., Bergen, A. W., Berrettini, W. H., Bohus, M., Brandt, H., Chang, X., Chen, W. J., Chen, H. -C., Crawford, S., Crow, S., Diblasi, E., Duriez, P., Fernandez-Aranda, F., Fichter, M. M., Gallinger, S., Glatt, S. J., Gorwood, P., Guo, Y., Hakonarson, H., Halmi, K. A., Hwu, H. -G., Jain, S., Jamain, S., Jimenez-Murcia, S., Johnson, C., Kaplan, A. S., Kaye, W. H., Keel, P. K., Kennedy, J. L., Klump, K. L., Li, D., Liao, S. -C., Lieb, K., Lilenfeld, L., Liu, C. -M., Magistretti, P. J., Marshall, C. R., Mitchell, J. E., Monson, E. T., Myers, R. M., Pinto, D., Powers, A., Ramoz, N., Roepke, S., Rozanov, V., Scherer, S. W., Schmahl, C., Sokolowski, M., Strober, M., Thornton, L. M., Treasure, J., Tsuang, M. T., Witt, S. H., Woodside, D. B., Yilmaz, Z., Zillich, L., Adolfsson, R., Agartz, I., Air, T. M., Alda, M., Alfredsson, L., Andreassen, O. A., Anjorin, A., Appadurai, V., Soler Artigas, M., Van der Auwera, S., Azevedo, M. H., Bass, N., Bau, C. H. D., Baune, B. T., Bellivier, F., Berger, K., Biernacka, J. M., Bigdeli, T. B., Binder, E. B., Boehnke, M., Boks, M. P., Bosch, R., Braff, D. L., Bryant, R., Budde, M., Byrne, E. M., Cahn, W., Casas, M., Castelao, E., Cervilla, J. A., Chaumette, B., Cichon, S., Corvin, A., Craddock, N., Craig, D., Degenhardt, F., Djurovic, S., Edenberg, H. J., Fanous, A. H., Foo, J. C., Forstner, A. J., Frye, M., Fullerton, J. M., Gatt, J. M., Gejman, P. V., Giegling, I., Grabe, H. J., Green, M. J., Grevet, E. H., Grigoroiu-Serbanescu, M., Gutierrez, B., Guzman-Parra, J., Hamilton, S. P., Hamshere, M. L., Hartmann, A., Hauser, J., Heilmann-Heimbach, S., Hoffmann, P., Ising, M., Jones, I., Jones, L. A., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kendler, K. S., Kloiber, S., Koenen, K. C., Kogevinas, M., Konte, B., Krebs, M. -O., Landen, M., Lawrence, J., Leboyer, M., Lee, P. H., Levinson, D. F., Liao, C., Lissowska, J., Lucae, S., Mayoral, F., Mcelroy, S. L., Mcgrath, P., Mcguffin, P., Mcquillin, A., Medland, S. E., Mehta, D., Melle, I., Milaneschi, Y., Mitchell, P. B., Molina, E., Morken, G., Mortensen, P. B., Muller-Myhsok, B., Nievergelt, C., Nimgaonkar, V., Nothen, M. M., O'Donovan, M. C., Ophoff, R. A., Owen, M. J., Pato, C., Pato, M. T., Penninx, B. W. J. H., Pimm, J., Pistis, G., Potash, J. B., Power, R. A., Preisig, M., Quested, D., Ramos-Quiroga, J. A., Reif, A., Ribases, M., Richarte, V., Rietschel, M., Rivera, M., Roberts, A., Roberts, G., Rouleau, G. A., Rovaris, D. L., Rujescu, D., Sanchez-Mora, C., Sanders, A. R., Schofield, P. R., Schulze, T. G., Scott, L. J., Serretti, A., Shi, J., Shyn, S. I., Sirignano, L., Sklar, P., Smeland, O. B., Smoller, J. W., Sonuga-Barke, E. J. S., Spalletta, G., Strauss, J. S., Swiatkowska, B., Trzaskowski, M., Turecki, G., Vilar-Ribo, L., Vincent, J. B., Volzke, H., Walters, J. T. R., Shannon Weickert, C., Weickert, T. W., Weissman, M. M., Williams, L. M., Wray, N. R., Zai, C. C., Ashley-Koch, A. E., Beckham, J. C., Hauser, E. R., Hauser, M. A., Kimbrel, N. A., Lindquist, J. H., Mcmahon, B., Oslin, D. W., Qin, X., Mattheisen, M., Abdellaoui, A., Adams, M. J., Agerbo, E., Andlauer, T. F. M., Bacanu, S. -A., Baekvad-Hansen, M., Beekman, A. T. F., Bryois, J., Buttenschon, H. N., Bybjerg-Grauholm, J., Cai, N., Christensen, J. H., Clarke, T. -K., Colodro-Conde, L., Couvy-Duchesne, B., Crawford, G. E., Davies, G., Derks, E. M., Direk, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Escott-Price, V., Hassan Kiadeh, F. F., Finucane, H. K., Frank, J., Gaspar, H. A., Gill, M., Goes, F. S., Gordon, S. D., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Boomsma, D. I., Dannlowski, U., Depaulo, J. R., Domenici, E., Domschke, K., Esko, T., Grove, J., Hall, L. S., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Homuth, G., Horn, C., Hottenga, J. -J., Hougaard, D. M., Howard, D. M., Jansen, R., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Kutalik, Z., Li, Y., Lind, P. A., Macintyre, D. J., Mackinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., Middeldorp, C. M., Mihailov, E., Milani, L., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O'Reilly, P. F., Oskarsson, H., Hayward, C., Heath, A. C., Lewis, G., Li, Q. S., Madden, P. A. F., Magnusson, P. K., Martin, N. G., Mcintosh, A. M., Metspalu, A., Mors, O., Nordentoft, M., Paciga, S. A., Pedersen, N. L., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Peyrot, W. J., Posthuma, D., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Mirza, S. S., Schoevers, R., Schulte, E. 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P., Stephens, B., Brophy, M. T., Humphries, D. E., Selva, L. E., Do, N., Shayan, S., Cho, K., Pyarajan, S., Hauser, E., Sun, Y., Zhao, H., Wilson, P., Mcardle, R., Dellitalia, L., Mattocks, K., Harley, J., Zablocki, C. J., Whittle, J., Jacono, F., Gutierrez, S., Gibson, G., Hammer, K., Kaminsky, L., Villareal, G., Kinlay, S., Xu, J., Hamner, M., Mathew, R., Bhushan, S., Iruvanti, P., Godschalk, M., Ballas, Z., Ivins, D., Mastorides, S., Moorman, J., Gappy, S., Klein, J., Ratcliffe, N., Florez, H., Okusaga, O., Murdoch, M., Sriram, P., Yeh, S. S., Tandon, N., Jhala, D., Aguayo, S., Cohen, D., Sharma, S., Liangpunsakul, S., Oursler, K. A., Whooley, M., Ahuja, S., Constans, J., Meyer, P., Greco, J., Rauchman, M., Servatius, R., Gaddy, M., Wallbom, A., Morgan, T., Stapley, T., Sherman, S., Ross, G., Tsao, P., Strollo, P., Boyko, E., Meyer, L., Gupta, S., Huq, M., Fayad, J., Hung, A., Lichy, J., Hurley, R., Robey, B., Striker, R., Erlangsen, A., Kessler, R. C., Porteous, D., Ursano, R. J., Wasserman, D., Coon, H., Demontis, D., Docherty, A. R., Kuo, P. -H., Mann, J. J., Renteria, M. E., Stein, M. B., Willour, V., Psychiatry, Biological Psychology, APH - Methodology, APH - Mental Health, APH - Health Behaviors & Chronic Diseases, AMS - Sports, AMS - Ageing & Vitality, APH - Personalized Medicine, Amsterdam Neuroscience - Complex Trait Genetics, Complex Trait Genetics, Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, HUS Psychiatry, Department of Public Health, Clinicum, Nuorisopsykiatria, Faculty Common Matters (Faculty of Social Sciences), Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Biostatistics Helsinki, Anna Keski-Rahkonen / Principal Investigator, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation, Internal medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Mullins N., Kang J., Campos A.I., Coleman J.R.I., Edwards 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E.Z., Saito T., Schall U., Schalling M., Scott R.J., Weickert C.S., Stordal E., Vaaler A.E., Vieta E., Waldman I.D., Zwart J.-A., Nurnberger J.I., Stahl E.A., Di Florio A., Adan R.A.H., Ando T., Aschauer H., Baker J.H., Bencko V., Birgegard A., Boden J.M., Boehm I., Boni C., Perica V.B., Buehren K., Bulik C.M., Burghardt R., Carlberg L., Cassina M., Clementi M., Cone R.D., Courtet P., Crowley J.J., Danner U.N., Davis O.S.P., de Zwaan M., Dedoussis G., Degortes D., DeSocio J.E., Dick D.M., Dina C., Dmitrzak-Weglarz M., Martinez E.D., Duncan L.E., Egberts K., Mattingsdal M., McDevitt S., Meulenbelt I., Micali N., Mitchell J., Mitchell K., Monteleone P., Monteleone A.M., Munn-Chernoff M.A., Nacmias B., Navratilova M., Ntalla I., Olsen C.M., O'Toole J.K., Padyukov L., Palotie A., Pantel J., Papezova H., Parker R., Pearson J.F., Ehrlich S., Escaramis G., Espeseth T., Estivill X., Farmer A., Favaro A., Fischer K., Floyd J.A.B., Focker M., Foretova L., Forzan M., Franklin C.S., Gambaro G., Giuranna J., Giusti-Rodriquez P., Gonidakis F., Gordon S., Mayora M.G., Guillaume S., Hanscombe K.B., Hatzikotoulas K., Hebebrand J., Helder S.G., Henders A.K., Herpertz-Dahlmann B., Herzog W., Hinney A., Horwood L.J., Hubel C., Petersen L.V., Purves K.L., Raevuori A., Reichborn-Kjennerud T., Ricca V., Ripatti S., Ritschel F., Roberts M., Rybakowski F., Santonastaso P., Scherag A., Schmidt U., Schork N.J., Schosser A., Seitz J., Slachtova L., Slagboom P.E., Slof-Op 't Landt M.C.T., Slopien A., Soranzo N., Sorbi S., Southam L., Steen V.W., Huckins L.M., Hudson J.I., Imgart H., Inoko H., Janout V., Jordan J., Julia A., Kalsi G., Kaminska D., Kaprio J., Karhunen L., Karwautz A., Kas M.J.H., Kennedy M.A., Keski-Rahkonen A., Kiezebrink K., Kim Y.-R., Kirk K.M., Klareskog L., Knudsen G.P.S., Larsen J.T., Le Hellard S., Leppa V.M., Lichtenstein P., Lin B.D., Lundervold A., Luykx J., Maj M., Mannik K., Marsal S., Stuber G.D., Szatkiewicz J.P., Tachmazidou I., Tenconi E., Tortorella A., Tozzi F., Tsitsika A., Tyszkiewicz-Nwafor M., Tziouvas K., van Elburg A.A., van Furth E.F., Wade T.D., Wagner G., Walton E., Whiteman D.C., Wichmann H.E., Widen E., Yao S., Zeggini E., Zerwas S., Zipfel S., Jungkunz M., Dietl L., Schwarze C.E., Dahmen N., Schott B.H., Mobascher A., Crivelli S., Dennis M.F., Harvey P.D., Carter B.W., Huffman J.E., Jacobson D., Madduri R., Olsen M.K., Pestian J., Gaziano J.M., Muralidhar S., Ramoni R., Beckham J., Chang K.-M., O'Donnell C.J., Tsao P.S., Breeling J., Huang G., Romero J.P.C., Moser J., Whitbourne S.B., Brewer J.V., Aslan M., Connor T., Argyres D.P., Stephens B., Brophy M.T., Humphries D.E., Selva L.E., Do N., Shayan S., Cho K., Pyarajan S., Hauser E., Sun Y., Zhao H., Wilson P., McArdle R., Dellitalia L., Mattocks K., Harley J., Zablocki C.J., Whittle J., Jacono F., Gutierrez S., Gibson G., Hammer K., Kaminsky L., Villareal G., Kinlay S., Xu J., Hamner M., Mathew R., Bhushan S., Iruvanti P., Godschalk M., Ballas Z., Ivins D., Mastorides S., Moorman J., Gappy S., Klein J., Ratcliffe N., Florez H., Okusaga O., Murdoch M., Sriram P., Yeh S.S., Tandon N., Jhala D., Aguayo S., Cohen D., Sharma S., Liangpunsakul S., Oursler K.A., Whooley M., Ahuja S., Constans J., Meyer P., Greco J., Rauchman M., Servatius R., Gaddy M., Wallbom A., Morgan T., Stapley T., Sherman S., Ross G., Tsao P., Strollo P., Boyko E., Meyer L., Gupta S., Huq M., Fayad J., Hung A., Lichy J., Hurley R., Robey B., Striker R., Erlangsen A., Kessler R.C., Porteous D., Ursano R.J., Wasserman D., Coon H., Demontis D., Docherty A.R., Kuo P.-H., Mann J.J., Renteria M.E., Stein M.B., and Willour V.
Subjects: LD SCORE REGRESSION, Genome-wide association study, Suicide, Attempted, 3124 Neurology and psychiatry, 0302 clinical medicine, Risk Factors, Insomnia, Suicide attempt, GWAS, Suïcidi, Depression (differential diagnoses), Cause of death, Psychiatry, 0303 health sciences, Factors de risc en les malalties, Mental Disorders, Genetic Correlation, Genome-wide Association Study, Pleiotropy, Polygenicity, Suicide, Suicide Attempt, DEPRESSION, 3. Good health, Genetic correlation, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Depressive Disorder, Major, Mental illness, Cohort, SEX, medicine.symptom, Human, medicine.medical_specialty, Risk factors in diseases, BF, Locus (genetics), BEHAVIORS, Psykiatri, EVENTS, 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, ddc:610, GENOME-WIDE ASSOCIATION, IDEATION, Socioeconomic status, METAANALYSIS, Biological Psychiatry, 030304 developmental biology, business.industry, Risk Factor, Genetic architecture, THOUGHTS, RC0321, business, Malalties mentals, 030217 neurology & neurosurgery
Abstract: Statistical analyses were carried out on the NL Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and the Mount Sinai high performance computing cluster (http://hpc.mssm.edu), which is supported by the Office of Research Infrastructure of the National Institutes of Health (Grant Nos. S10OD018522 and S10OD026880). This work was conducted in part using the resources of the Advanced Computing Center for Research and Education at Vanderbilt University, Nashville, TN. This work was funded by the National Institutes of Health (Grant Nos. R01MH116269 and R01MH121455 [to DMR]), NIGMS of the National Institutes of Health (Grant No. T32GM007347 [to JK]), and the Brain & Behavior Research Foundation (NARSAD Young Investigator Award No. 29551 [to NM])., BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders., Office of Research Infrastructure of the National Institutes of Health S10OD018522 S10OD026880, United States Department of Health & Human Services, National Institutes of Health (NIH) - USA R01MH116269 R01MH121455, NIH National Institute of General Medical Sciences (NIGMS) T32GM007347 NARSAD 29551
Published: 2022
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12. Bleeding complications in patients on new oral anticoagulants for venous thromboembolism in Kenya

Author: Anders Barasa, Jasmit Shah, Ahmed Sokwala, Mzee Ngunga, and Antonina Obayo
Subjects: Male, medicine.medical_specialty, Aspirin, business.industry, General surgery, Cardiovascular Topics, Administration, Oral, Anticoagulants, Hemorrhage, Venous Thromboembolism, General Medicine, Middle Aged, Kenya, Dabigatran, Text mining, Rivaroxaban, Medicine, Humans, In patient, Female, business, Cardiology and Cardiovascular Medicine, Venous thromboembolism, Aged
Abstract: BACKGROUND: The incidence of bleeding complications in patients with venous thromboembolism (VTE) on new oral anticoagulants (NOACs) has not been widely studied in contemporary clinical practice in Africa. The purpose of this study was to determine the rates of major bleeding, clinically relevant non-major bleeding (CRNM) and minor bleeding associated with NOAC use METHODS: A retrospective review was carried out of patients diagnosed with venous thromboembolism and treated with NOACs at the Aga Khan University Hospital, Nairobi, from January 2014 to December 2019. Clinical and outcome data were collected from medical records and the hospital mortality database. All patients with VTE aged > 18 years and initiated on NOACS were recruited. Patients with missing information were excluded. They were followed up from the time of commencement of oral anticoagulation to completion of therapy, or to the time of the first major bleed, CRNM or minor bleeding. Data on bleeding were obtained from the hospital database and through telephone interviews. Unadjusted rates of the first major bleeding event or CRNM were calculated as the number of bleeding events per 100 person-years. RESULTS: Two hundred and forty-three patients with VTE were recruited and 222 (91.4%) were initiated on rivaroxaban, 12 (4.9%) on dabigatran and nine (3.7%) on apixaban, with a median follow up of 213 [interquartile range (IQR): 119–477] days. The median age of the patients was 57 (IQR: 45–71) years. A total of 64 bleeding events were identified in 50 (20.6%) patients. Overall, the incidence rate for bleeding events was 17.24 per 100 patient-years. The incidence rate of major bleeding was 3.79 per 100 person-years. Gastrointestinal bleeding was the most common major bleeding site. There were more females with bleeding events (70.7%) compared to males. Anaemia and the use of aspirin and other antiplatelets were associated with a higher incidence of major and CRNM bleeding [relative risk (RR) = 3.77, confidence interval (CI) = 1.37–10.39, p = 0.005 and RR = 8.89, CI = 2.06–38.33, p = 0.0003, respectively]. CONCLUSIONS: Most of these bleeds were minor, with the gastrointestinal tract being the most common source of major bleeding and menorrhagia being the commonest cause of bleeding. Anaemia and the use of aspirin were associated with a higher incidence of major bleeding.
Published: 2022
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13. European guideline on obesity care in patients with gastrointestinal and liver diseases - Joint European Society for Clinical Nutrition and Metabolism / United European Gastroenterology guideline

Author: Stephan C. Bischoff, Rocco Barazzoni, Luca Busetto, Marjo Campmans‐Kuijpers, Vincenzo Cardinale, Irit Chermesh, Ahad Eshraghian, Haluk Tarik Kani, Wafaa Khannoussi, Laurence Lacaze, Miguel Léon‐Sanz, Juan M. Mendive, Michael W. Müller, Johann Ockenga, Frank Tacke, Anders Thorell, Darija Vranesic Bender, Arved Weimann, Cristina Cuerda, and Bischoff S. C. , Barazzoni R., Busetto L., Campmans-Kuijpers M., Cardinale V., Chermesh I., Eshraghian A., KANİ H. T. , Khannoussi W., Lacaze L., et al.
Subjects: Internal Diseases, Sarcopenia, obesity, gastroesophageal reflux disease, pancreatitis, Y GASTRIC BYPASS, GASTROESOPHAGEAL-REFLUX DISEASE, EXOCRINE PANCREATIC INSUFFICIENCY, Sağlık Bilimleri, İç Hastalıkları, Clinical Medicine (MED), sarcopenic obesity, celiacdisease, Klinik Tıp (MED), NONALCOHOLIC FATTY LIVER, Child, Klinik Tıp, gastroesophagealrefluxdisease, Liver Diseases, Gastroenterology, GASTROENTEROLOJİ VE HEPATOLOJİ, Tıp, Hepatoloji, Oncology, LIFE-STYLE INTERVENTION, Gastroesophageal Reflux, Medicine, Adult, bariatric surgery, CONTROLLED ATTENUATION PARAMETER, Gastroenterology and Hepatology, celiac disease, cirrhosis, inflammatory bowel disease, irritable bowel syndrome, non-alcoholic fatty liver disease, Gastroenteroloji-(Hepatoloji), non‐alcoholicfattyliverdisease, Health Sciences, Humans, inflammatoryboweldisease, GLUTEN-FREE DIET, Internal Medicine Sciences, Hepatology, GASTROENTEROLOGY & HEPATOLOGY, irritablebowelsyndrome, sarcopenicobesity, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Inflammatory Bowel Diseases, POST-BARIATRIC SURGERY, Gastroenteroloji, BODY-MASS INDEX, bariatricsurgery, INFLAMMATORY-BOWEL-DISEASE
Abstract: Background Patients with chronic gastrointestinal (GI) disease such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, gastroesophageal reflux disease (GERD), pancreatitis, and chronic liver disease (CLD) often suffer from obesity because of coincidence (IBD, IBS, celiac disease) or related pathophysiology (GERD, pancreatitis and CLD). It is unclear if such patients need a particular diagnostic and treatment that differs from the needs of lean GI patients. The present guideline addresses this question according to current knowledge and evidence. Objective The objective of the guideline is to give advice to all professionals working in the field of gastroenterology care including physicians, surgeons, dietitians and others how to handle patients with GI disease and obesity. Methods The present guideline was developed according to the standard operating procedure for European Society for Clinical Nutrition and Metabolism guidelines, following the Scottish Intercollegiate Guidelines Network grading system (A, B, 0, and good practice point [GPP]). The procedure included an online voting (Delphi) and a final consensus conference. Results In 100 recommendations (3x A, 33x B, 24x 0, 40x GPP, all with a consensus grade of 90% or more) care of GI patients with obesity - including sarcopenic obesity - is addressed in a multidisciplinary way. A particular emphasis is on CLD, especially fatty liver disease, since such diseases are closely related to obesity, whereas liver cirrhosis is rather associated with sarcopenic obesity. A special chapter is dedicated to obesity care in patients undergoing bariatric surgery. The guideline focuses on adults, not on children, for whom data are scarce. Whether some of the recommendations apply to children must be left to the judgment of the experienced pediatrician. Conclusion The present guideline offers for the first time evidence-based advice how to care for patients with chronic GI diseases and concomitant obesity, an increasingly frequent constellation in clinical practice.
Published: 2022

14. Randomised clinical trials in critical care: past, present and future

Author: Naomi E Hammond, Rob Mac Sweeney, Waleed Alhazzani, Anders Granholm, Morten Hylander Møller, Kathryn M Rowan, Derek C. Angus, Elie Azoulay, Fernando G. Zampieri, Lennie P. G. Derde, Paul J Young, Sheila Nainan Myatra, and Anders Perner
Subjects: Flexibility (engineering), medicine.medical_specialty, Standardization, business.industry, Gold standard, Confounding, Review, Critical Care and Intensive Care Medicine, law.invention, Bayesian statistics, Clinical trial, Critical care, Clinical trials, Randomized controlled trial, law, Intensive care, medicine, Humans, Randomized clinical trials, Intensive care medicine, business, Randomized Controlled Trials as Topic
Abstract: Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of intervention effects. Here, we provide an overview of the history of RCTs and discuss the major challenges and limitations of current critical care RCTs, including overly optimistic effect sizes; unnuanced conclusions based on dichotomization of results; limited focus on patient-centred outcomes other than mortality; lack of flexibility and ability to adapt, increasing the risk of inconclusive results and limiting knowledge gains before trial completion; and inefficiency due to lack of re-use of trial infrastructure. We discuss recent developments in critical care RCTs and novel methods that may provide solutions to some of these challenges, including a research programme approach (consecutive, complementary studies of multiple types rather than individual, independent studies), and novel design and analysis methods. These include standardization of trial protocols; alternative outcome choices and use of core outcome sets; increased acceptance of uncertainty, probabilistic interpretations and use of Bayesian statistics; novel approaches to assessing heterogeneity of treatment effects; adaptation and platform trials; and increased integration between clinical trials and clinical practice. We outline the advantages and discuss the potential methodological and practical disadvantages with these approaches. With this review, we aim to inform clinicians and researchers about conventional and novel RCTs, including the rationale for choosing one or the other methodological approach based on a thorough discussion of pros and cons. Importantly, the most central feature remains the randomisation, which provides unparalleled restriction of confounding compared to non-randomised designs by reducing confounding to chance.
Published: 2021
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15. Snapping thumb: a rare case of stenosing tenosynovitis of the extensor pollicis longus tendon

Author: Maiken Stilling, Pelle Hanberg, Andrea Lund, and Anders Ditlev Foldager-Jensen
Subjects: musculoskeletal diseases, medicine.medical_specialty, Case Report, Wrist, Thumb, 030218 nuclear medicine & medical imaging, Tendons, 03 medical and health sciences, 0302 clinical medicine, Extensor pollicis longus tendon, Rare case, Medicine, Humans, Stenosing tenosynovitis, 030222 orthopedics, Tenosynovitis, business.industry, musculoskeletal and joint disorders, Tendon Entrapment, General Medicine, musculoskeletal system, medicine.disease, Surgery, body regions, tendonopathies, medicine.anatomical_structure, Orthopedic surgery, Tendinopathy, business, orthopaedics
Abstract: Tenosynovitis of the extensor pollicis longus (EPL) is rarely reported in patients without rheumatoid arthritis but may lead to thumb snapping as a consequence of EPL stenosing tenosynovitis.This case presents painful thumb snapping that developed after a wrist trauma and repetitive loading. Ultrasound and MRI were used as diagnostic tools, before surgical release of the EPL in the third extensor compartment was performed. Neither EPL tenosynovitis nor thumb snapping were found at follow-up.
Published: 2023
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16. Measurements of the inclusive and differential production cross sections of a top-quark-antiquark pair in association with a Z boson at √s = 13 TeV with the ATLAS detector

Author: Aad, Georges, Abbott, Braden Keim, Abbott, Dale, Abed Abud, Adam, Abeling, Kira, Abhayasinghe, Deshan Kavishka, Abidi, Haider, Abouzeid, Hass, Abouzeid, Ossama, Abraham, Nicola Louise, Abramowicz, Halina, Abreu, Henso, Abulaiti, Yiming, Acharya, Bobby Samir, Achkar, Baida, Adam, Lennart, Adam Bourdarios, Claire, Adamczyk, Leszek, Adamek, Lukas, Adelman, Jahred, Adiguzel, Aytul, Adorni Braccesi Chiassi, Sofia, Adye, Tim, Adye, Timothy John, Affolder, Tony, Affolder, Anthony, Afik, Yoav, Agapopoulou, Christina, Agaras, Merve Nazlim, Aggarwal, Anamika, Agheorghiesei, Catalin, Aguilar Saavedra, Juan Antonio, Ahmad, Ammara, Ahmadov, Faig, Ahmed, Waleed Syed, Ai, Xiaocong, Aielli, Giulio, Akatsuka, Shunichi, Akbiyik, Melike, Akesson, Torsten, Akilli, Ece, Akimov, Andrei, Al Khoury, Konie, Alberghi, Gian Luigi, Albert, Justin, Verzini, M.J. Alconada, Alderweireldt, Sara, Aleksa, Martin, Aleksandrov, I.N., Alexa, Calin, Alexopoulos, Theodoros, Alfonsi, Alice, Alfonsi, Fabrizio, Alhroob, Muhammad, Ali, Babar, Ali, Shahzad, Aliev, Malik, Alimonti, Gianluca, Allaire, Corentin, Allbrooke, Benedict, Allen, Benjamin William, Allport, Philip Patrick, Aloisio, Alberto, Alonso, Francisco, Alpigiani, Cristiano, Alunno Camelia, Elio, Alvarez Estevez, Manuel, Alviggi, Mariagrazia, Do Amaral Coutinho, Yara, Ambler, Alessandro, Ambroz, Luca, Amelung, Christoph, Amidei, Dante, Amor dos Santos, Susana Patricia, Amoroso, Simone, Amrouche, Cherifa Sabrina, An, Fenfen, Anastopoulos, Christos, Andari, Nansi, Andeen, Timothy Robert, Anders, John Kenneth, Andrean, Stefio Yosse, Andreazza, Attilio, Andrei, Victor, Anelli, Christopher Ryan, Angelidakis, Stylianos, Angerami, Aaron, Anisenkov, Alexey, Annovi, Alberto, Antel, Claire, Anthony, Matthew Thomas, Antipov, Egor, Antonelli, Mario, Antrim, Daniel Joseph, Anulli, Fabio, Aoki, Masato, Aparisi Pozo, Javier Alberto, Aparo, Marco, Aperio Bella, Ludovica, Aranzabal Barrio, Nordin, Araujo Ferraz, Victor, Pereira, R.Araujo, Arcangeletti, Chiara, Arce, Ayana Tamu, Arguin, Jean-Francois, Argyropoulos, Spyros, Argyropoulos, Spyridon, Arling, Jan-Hendrik, Armbruster, Aaron James, Armstrong, Alexander, Arnaez, Olivier, Arnold, Hannah, Arrubarrena Tame, Zulit Paola, Artoni, Giacomo, Asada, Haruka, Asai, Kanae, Asai, Shoji, Asawatavonvanich, Thanawat, Asbah, Nedaa Alexandra, Asimakopoulou, Eleni Myrto, Asquith, Lily, Assahsah, Jihad, Assamagan, Ketevi Adikle, Astalos, Robert, Atkin, Ryan Justin, Atkinson, Markus Julian, Atlay, Naim Bora, Atmani, Hicham, Atmasiddha, Prachi, Augsten, Kamil, Austrup, Volker Andreas, Avolio, Giuseppe, Ayoub, Mohamad Kassem, Azuelos, Georges, Babal, Dominik, Bachacou, Henri, Bachas, Dinos, Bachas, Konstantinos, Backman, Karl Filip, Bagnaia, Paolo, Bahrasemani, H., Bahrasemani, Sina, Bailey, Adam, Bailey, Virginia, Baines, John, Bakalis, Christos, Baker, Keith, Bakker, Pepijn Johannes, Bakos, Evelin, Bakshi Gupta, Debottam, Balaji, Shyam, Balasubramanian, Rahul, Baldin, Evgenii, Balek, Petr, Balli, Fabrice, Balunas, William Keaton, Balz, Johannes, Banas, Elzbieta, Bandieramonte, Marilena, Bandyopadhyay, Anjishnu, Banerjee, Sw., Banerjee, Swagato, Barak, Liron, Barbe, William Mickael, Barberio, Elisabetta, Barberis, Dario, Barbero, Marlon Benoit, Barbour, Gregory, Barillari, Teresa, Barisits, Martin, Barkeloo, Jason Tyler Colt, Barklow, Tim, Barklow, Timothy Laurence, Barnea, Rotem, Barnett, Bruce M, Barnett, Michael, Barnovska-Blenessy, Z., Baroncelli, Toni, Baroncelli, Antonio, Barone, Gaetano, Barr, Alan, Barranco Navarro, Laura, Barreiro Alonso, Fernando, Barreiro Guimaraes da Costa, Joao, Barron, Uriel, Barsov, Sergey, Bartels, Falk, Bartoldus, Rainer, Bartolini, Giovanni, Barton, Adam Edward, Bartos, Pavol, Basalaev, Artem, Basan, Alexander, Bassalat, Ahmed, Basso, Matthew Joseph, Bates, Richard, Batlamous, Souad, Batley, Richard, Batool, Binish, Battaglia, Marco, Bauce, Matteo, Bauer, Florian, Bauer, Patrick, Bawa, Harinder Singh, Bayirli, Arif, Beacham, James, Beau, Tristan, Beauchemin, Pierre-Hugues, Becherer, Fabian, Bechtle, Philip, Beck, Helge Christoph, Beck, Hans Peter, Beck, Hanspeter, Becker, Kathrin, Becot, Cyril Pascal, Beddall, Ayda, Beddall, Andrew, Bednyakov, Vadim, Bedognetti, Matteo, Bee, Chris, Bee, Christopher Peter, Beermann, Thomas, Begalli, Marcia, Begel, Michael, Behera, Arabinda, Behr, Janna Katharina, Beisiegel, Florian, Belfkir, Mohamed, Bell, Andrew Stuart, Bella, Gideon, Bellagamba, Lorenzo, Bellerive, Alain, Bellos, Panagiotis, Beloborodov, Konstantin, Belotskiy, Konstantin, Belyaev, Nikita, Benchekroun, Driss, Benekos, Nectarios, Benhammou, Yan, Benjamin, Doug, Benjamin, Douglas Paul, Benoit, Mathieu, Bensinger, Jim, Bensinger, James, Bentvelsen, Stan, Bentvelsen, Stanislaus, Beresford, Lydia Audrey, Beretta, Matteo Mario, Berge, David, Bergeaas Kuutmann, Elin, Berger, Nicolas, Bergmann, Benedikt Ludwig, Bergsten, Laura Jean, Beringer, Juerg, Berlendis, Simon, Bernardi, Gregorio, Bernius, Catrin, Bernlochner, Florian Urs, Berry, Tracey, Berta, Peter, Berthold, Anne-Sophie, Bertram, Iain, Bessidskaia Bylund, Olga, Besson, Nathalie, Bethke, Siegfried, Betti, Alessandra, Bevan, Adrian, Beyer, Julien-Christopher, Bhatta, Somadutta, Bhattacharya, Deb Sankar, Bhattarai, Prajita, Bhopatkar, Vallary Shashikant, Bi, Runyu, Bianchi, Riccardo Maria, Biebel, Otmar, Biedermann, Dustin, Bielski, Rafal, Bierwagen, Katharina, Biesuz, Nicolo Vladi, Biglietti, Michela, Billoud, T.R. V., Bindi, Marcello, Bingul, Ahmet, Bini, Cesare, Biondi, Silvia, Birch-Sykes, Callum Jacob, Birman, Mattias, Bisanz, Tobias, Biswal, Jyoti Prakash, Biswas, Diptaparna, Bitadze, Alexander, Bittrich, Carsten, Bjoerke, Kristian, Blazek, Tomas, Bloch, Ingo, Blocker, Craig, Blue, Andrew James, Blumenschein, Ulla, Blumenschein, Heidrun, Bobbink, Gerjan, Bobbink, Gerard, Bobrovnikov, Viktor, Bocchetta, Simona, Bogavac, Danijela, Bogdanchikov, Alexander, Bohm, Christian, Boisvert, Veronique, Bokan, Petar, Bold, Tomasz, Bolz, Arthur Eugen, Bomben, Marco, Bona, Marcella, Bonilla, Johan Sebastian, Boonekamp, Maarten, Booth, Callum Dale, Borbely, Albert Gyorgy, Borecka-Bielska, Hanna Maria, Borgna, Lucas Santiago, Borisov, Anatoli, Borissov, Guennadi, Bortoletto, Daniela, Boscherini, Davide, Fernandez-Bosman, Martine, Sola, J.D. Bossio, Bouaouda, Khalil, Boudreau, Joseph, Bouhova-Thacker, E.V., Bouhova-Thacker, Evelina Vassileva, Boumediene, Djamel Eddine, Boveia, Antonio, Boyd, Jamie, Boyd, James, Boye, Diallo, Boyko, Igor, Bozson, Adam, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Brau, Benjamin Paul, Brau, J.E., Brau, James Edward, Breaden Madden, Will, Breaden Madden, William Dmitri, Brendlinger, Kurt, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Britton, David, Britzger, Daniel Andreas, Brock, Ian, Brock, Raymond, Brooijmans, Gustaaf, Brooks, William King, Brost, Elizabeth, Bruckman de Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Bruni, Alessia, Bruni, Graziano, Bruschi, Marco, Bruscino, Nello, Bryngemark, Lene Kristian, Buanes, Trygve, Buat, Quentin, Buchholz, Peter, Buckley, Andy, Budagov, Ioulian, Buckley, Andrew Gordon, Budagov, Yulian, Bugge, Magnar Kopangen, Bulekov, Oleg, Bullard, Brendon, Burch, Tyler James, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, Jon, Burr, Jonathan, Burton, Charles, Burzynski, Jackson Carl, Buescher, Volker, Buschmann, Eric, Bussey, Peter John, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan, Butti, Pierfrancesco, Buttinger, Will, Buttinger, William, Buxo Vazquez, Carlos Josue, Buzatu, Adrian, Buzykaev, Alexey, Buzykaev, Aleksey, Cabras, Grazia, Cabrera Urban, Susana, Caforio, Davide, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Calderini, Giovanni, Calfayan, Philippe, Callea, Giuseppe, Caloba, Luiz, Caltabiano, Alessandro, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel, Calvet, Thomas Philippe, Calvetti, Milene, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Camerlingo, Maria Teresa, Cameron, David, Camincher, Clement, Campana, Simone, Campanelli, Mario, Camplani, Alessandra, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, Tingting, Cao, Yumeng, Garrido, M.D. M.Capeans, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, Ina, Carli, Tancredi, Carlino, Giampaolo, Carlson, B.T., Carlson, Benjamin Taylor, Carlson, Evan Michael, Carminati, Leonardo, Carney, Rebecca, Caron, Sascha, Carquin Lopez, Edson, Carra, Sonia, Carratta, Giuseppe, Carter, J.W. S., Carter, Thomas Michael, Casado Lechuga, Pilar, Casha, Albert Francis, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Castillo Gimenez, Victoria, Castro, Nuno, Catinaccio, Andrea, Catmore, James, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Celebi, Emre, Celli, Federico, Cerny, Karel, Santiago Cerqueira, Augusto, Cerri, Alex, Cerri, Alessandro, Cerrito, Lucio, Cerutti, Fabio, Cervelli, Alberto, Cetin, Serkant, Chadi, Zakaria, Chakraborty, Dhiman, Chan, Jay, Chan, Chen-Hsun, Chan, Terry Ws, Chan, Wing Sheung, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, Dave, Charlton, David, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Che, Siinn, Chekanov, Sergei, Chekulaev, Sergey, Chelkov, G.A., Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Chen, Hucheng, Chen, Jing, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Chen, Xin, Chen, Ye, Chen, Yu-Heng, Cheng, Hok Chuen, Cheng, Huajie, Cheplakov, Alexander, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott, Cheung, Kingman, Chevalerias, Thibault, Chevalier, Laurent, Chiarella, Vitaliano, Chiarelli, Giorgio, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Chiu, I-Huan, Chiu, Justin, Chiu, Y.H., Chizhov, Mihail, Choi, Kyungeon, Chomont, Arthur, Chou, Yuan-Tang, Chow, Edwin, Chow, Yun Sang, Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Chudoba, Jiri, Chwastowski, Janusz, Chytka, Ladislav, Cieri, Davide, Ciesla, Krzysztof, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Cirotto, Francesco, Citron, Z.H., Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Clark, Philip, Clawson, Savannah, Clement, Christophe, Coadou, Yann, Cobal, Marina, Coccaro, Andrea, Cochran, James Herbert, Coelho Lopes de Sa, Rafael, Cohen, Hadar, Coimbra, A.E. C., Cole, Brian, Colijn, Auke-Pieter, Collot, Johann, Conde Muino, Patricia, Connell, Simon, Connelly, Ian Allan, Constantinescu, Serban, Conventi, Francesco, Cooper-Sarkar, A.M., Cormier, Felix, Cormier, Kyle James Read, Corpe, Louie Dartmoor, Corradi, Massimo, Corrigan, Eric Edward, Corriveau, Francois, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Creager, Rachael Ann, Crepe-Renaudin, Sabine, Crescioli, Francesco, Cristinziani, Markus, Croft, Vincent Alexander, Crosetti, Giovanni, Dandoy, Jeffrey Rogers, Crosetti, Nanni, Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Cui, Han, Cukierman, Aviv Ruben, Cunningham, William Reilly, Cunningham, Liam, Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Czurylo, Marta Maja, da Cunha Sargedas de Sousa, M.J., da Fonseca Pinto, Joao Victor, da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, Florian, Dado, Tomas, Dahbi, Salah-Eddine, Dai, Tiesheng, Dallapiccola, Carlo, Dam, Mogens, d'Amen, Gabriele, d'Amico, Valerio, Damp, Johannes Frederic, Dandoy, Jeff, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Giovanni, Darbo, Nanni, Dartsi, Olympia, Dattagupta, Aparajita, Daubney, Thomas, d'Auria, Saverio, David, Claire, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, De, Kaushik, de Asmundis, Riccardo, de Beurs, Marcus, de Castro, Stefano, de Groot, Nicolo, de Jong, Paul, de la Torre Perez, Hector, de Maria, Antonio, de Pedis, Daniele, de Salvo, Alessandro, de Sanctis, Umberto, de Santis, Maurizio, de Santo, Antonella, de Vivie de Regie, Jean-Baptiste, Dedovich, Dmitri, Deiana, Allison Mccarn, del Peso, Jose, Delabat Diaz, Yasiel, Delgove, David, Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'Acqua, Andrea, Dell'Asta, Lidia, Delmastro, Marco, Delporte, Charles Eliaz, Delsart, Pierre Antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Demontigny, Gabriel, Denisov, Serguei, d'Eramo, Louis, Derendarz, Dominik Karol, Derkaoui, Jamal, Derue, Frederic, Dervan, Paul, Desch, Klaus, Dette, Karola, Deutsch, Christopher, Devesa, Maria Roberta, Deviveiros, Pier-Olivier, Di Bello, Francesco Armando, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Clemente, William Kennedy, Di Clemente, Will, Di Donato, Camilla, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Di Petrillo, Karri Folan, Di Sipio, Riccardo, Diaconu, Cristinel, de Almeida Dias, Flavia, Vale, T.Dias Do, Diaz Gutierrez, Marco Aurelio, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward, Dietrich, Janet, Diez Cornell, Sergio, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Dittmeier, Sebastian, Dittus, Fridolin, Dittus, Fido, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Barros Do Vale, Aline, Dobre, Monica, Dodsworth, David Michael, Doglioni, Caterina, Dolejsi, Jiri, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Donini, Julien Noce, d'Onofrio, Adelina, d'Onofrio, Monica, Dopke, Jens, Doria, Alessandra, Dova, Maria Teresa, Doyle, Anthony Terence, Doyle, Tony, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Drobac, Alec Swenson, Du, Dongshuo, Du Pree, Tristan Arnoldus, Duan, Yanyun, Dubinin, Filipp, Dubovsky, Michal, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Guenter, Ducu, Otilia Anamaria, Duda, Dominik, Dudarev, Alexey, Dudder, Andreas Christian, Duffield, Emily Marie, d'Uffizi, Matteo, Duflot, Laurent, Duehrssen-Debling, Michael, Dulsen, Carsten, Dumancic, Mirta, Dumitriu, Ana Elena, Dunford, Monica, Dungs, Sascha, Duperrin, Arnaud, Yildiz, H.Duran, Ellis, Nicolas, Yildiz, Duran, Dueren, Michael Johannes, Durglishvili, Archil, Duschinger, Dirk Uwe, Dutta, Baishali, Duvnjak, Damir, Dyckes, G.I., Dyndal, Mateusz, Dysch, Samuel Dezso, Dziedzic, Bartosz Sebastian, Eggleston, Michael Glenn, Eifert, Till, Eigen, Gerald, Einsweiler, Kevin Frank, Ekelof, Tord Johan Carl, El Jarrari, Hassnae, Ellajosyula, Venugopal, Ellert, Mattias, Ellinghaus, Frank, Elliot, Alison, Emerman, Alexander Zack, Evans, Harold, Ellis, Nick, Elmsheuser, Johannes, Elsing, Markus, Emeliyanov, Dmitry, Emerman, Alex, Enari, Yuji, Epland, Matthew, Erdmann, Johannes, Ereditato, Antonio, Erland, Paula Agnieszka, Errenst, Martin, Escalier, Marc, Escobar Ibanez, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Gaspar de Andrade Evans, Guiomar, Evans, Hal, Evans, Meirin Oan, Ezhilov, Aleksei, Fabbri, Federica, Fabbri, Laura, Fabiani, Veronica, Facini, Gabriel, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Fanti, Marcello, Faraj, Mohammed, Farbin, Amir, Farilla, Addolorata, Fedorko, Wojciech Tadeusz, Fell, Alexandra, Farilla, Ada, Farina, Edoardo Maria, Farooque, Trisha, Farrington, Sinead, Farthouat, Philippe, Fassi, Farida, Fassnacht, Patrick, Fassouliotis, Dimitris, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Fedorko, Wojtek, Fehr, Armin, Feickert, Matthew Carl, Feligioni, Lorenzo, Fell, Alix, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Fenyuk, Alexandre, Ferguson, Sarah Whitney, Ferrando, James Edward, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferreira de Lima, Danilo Enoque, Ferrer Soria, Antonio, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank, Filipcic, Andrej, Filthaut, Frank, Finelli, Kevin Daniel, Castro Nunes Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian, Fischer, Julian, Fisher, Wade Cameron, Fitschen, Tobias, Fleck, Ivor, Fleischmann, Philipp, Flick, Tobias, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis Roberto, Follega, Francesco Maria, Fomin, Nikolai, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Forland, Blake Christopher, Formica, Andrea, Forster, Fabian Alexander, Forti, Alessandra, Fortin, Etienne Marie, Foti, Maria Giovanna, Fournier, Daniel, Fox, Harald, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Franco, Luca, Franconi, Laura, Franklin, Melissa, Frattari, Guglielmo, Fray, Antony, Freeman, Patrick Moriishi, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Frizzell, Dylan Cooper, Froidevaux, Daniel, Frost, James, Fujimoto, Minori, Fukunaga, Chikara, Fullana Torregrosa, Esteban, Fusayasu, Takahiro, Fuster Verdu, Juan, Gabrielli, Alessandro, Gabrielli, Andrea, Gadatsch, Stefan, Gadow, Paul Philipp, Gagliardi, Guido, Gagnon, Louis-Guillaume, Gallardo, Gabriel, Gallas, Elizabeth, Gallop, Bruce Joseph, Gamboa Goni, Rodrigo, Gan, Kock Kiam, Ganguly, Sanmay, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garay Walls, Francisca, Garcia, Carmen, Garcia Navarro, Jose Enrique, Garcia Pascual, Juan Antonio, Garcia, Juanan, Garcia Argos, Carlos, Garcia-Sciveres, Maurice, Gardner, Robert William, Garelli, Nicoletta, Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Gaudiello, Andrea, Gaudio, Gabriella, Gauzzi, Paolo, Gavrilenko, Igor, Gavriliuk, Aleksandr, Gay, Colin Warren, Gaycken, Goetz, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn, Gee, C.N. P., Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-Helene, Geng, Cong, Gentile, Simonetta, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Gessinger-Befurt, Paul, Gessner, Gregor, Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza, Ghosh, Aishik, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Giannini, Antonio, Giannini, Giulia, Gibson, Stephen, Gignac, Matthew, Gil, Damian Tomasz, Gilbert, Benjamin Jacob, Gillberg, Dag, Gilles, Geoffrey, Gillwald, N.E. K., Gingrich, Douglas, Giordani, Mario, Gingrich, Doug, Giordani, Mapo, Giraud, Pierre-Francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, Evangelos Leonidas, Gkougkousis, Vagelis, Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Glatzer, Julian, Glaysher, P.C. F., Glazov, Alexander, Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-Kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Golling, Tobias, Golubkov, Dmitry, da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Gonzalez de la Hoz, Santiago, Gonzalez Fernandez, Sergio, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Goshaw, Alfred Thomas, Goshaw, A.T., Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-Bold, Iwona, Graham, Emily Charlotte, Gramling, Johanna, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Grachev, Vadim, Gravila, Paul, Gravili, Francesco Giuseppe, Gray, Chloe, Gray, Heather, Grefe, Christian, Gregersen, Kristian Damlund, Gregor, Ingrid, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Grieser, Nathan Allen, Grillo, Alex, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-Francois, Groh, Sabrina, Gross, Eilam, Grosse-Knetter, Joern, Grout, Zara Jane, Grud, Christopher Ryan, Grummer, Aidan, Grundy, James Cameron, Guan, Liang, Guan, Wen, Gubbels, Christopher, Hance, Michael, Gubbels, Chris, Guenther, Jaroslav, Guerguichon, Antinea, Rojas, J.G. R.Guerrero, Guescini, Francesco, Guest, Daniel Hay, Guest, Dan, Gugel, Ralf, Guida, Alessandro, Guillemin, Thibault, Guindon, Stefan, Guo, Jun, Guo, Wen, Guo, Yicheng, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Gwilliam, Carl, Haaland, Even Simonsen, Haas, Andrew, Haber, Carl, Hadavand, Haleh, Hadef, Asma, Haleem, Mahsana, Haley, Joseph, Hall, Jack Joseph, Halladjian, Garabed, Hallewell, Gregory, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Han, Kunlin, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hawkes, Christopher, Hays, Christopher Paul, Hance, Mike, Handl, David Michael, Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Hansen, Jorgen Beck, Hansen, Dines, Hansen, Maike Christina, Hansen, Peter, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Hartmann, Nikolai, Hasegawa, Yoji, Hasib, Ahmed, Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Chris, Hawkings, Richard, Hayashida, Shota, Hayden, Daniel, Hayes, Christopher Robyn, Hayes, Robin, Hays, Chris, Hays, Jonathan, Hayward, Helen, Haywood, Stephen, He, Fudong, He, Yunjian, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Hehir, Natasha, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten, Helsens, Clement, Henderson, R.C. W., Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Hertenberger, Ralf, Hervas, Luis, Herwig, Christian, Hesketh, Gavin, Hessey, Nigel, Hibi, Hiroaki, Higashino, Satoshi, Higon-Rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karlheinz, Hillier, Stephen, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Hodgkinson, Mark, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova, Holzbock, Michael, Hommels, L.B. A.H., Hong, Tae Min, Honig, Jan Cedric, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Hou, Suen, Hoummada, Abdeslam, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, Hrivnac, Julius, Hrynevich, Aliaksei, Hrynova, Tetiana, Hsu, Pai-Hsien, Hsu, Shih-Chieh, Hu, Qipeng, Hu, Shuyang, Hu, Yifan, Huang, Danping, Huang, Xiaozhong, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Hubner, Michael, Huegging, Fabian, Huffman, Todd Brian, Huhtinen, Mika, Hulsken, Raphael, Hunter, Robert Francis, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel Jordan, Hyrych, Sofiia, Iacobucci, Giuseppe, Iakovidis, Georgios, Iakovidis, George, Ibragimov, Iskander, Iconomidou-Fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ikeno, Masahiro, Ilic, Nikolina, Iltzsche, Franziska, Imam, Hajar, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Istin, Serhat, Ponce, J.M. Iturbe, Iuppa, Roberto, Ivina, Anna, Izen, Joseph Michael, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Jain, Vivek, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof, Jansky, Roland, Janus, Michel, Janus, Piotr Andrzej, Jarlskog, Goran, Jaspan, Adam Elliott, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jenni, Peter, Jeong, Namgyun, Jezequel, Stephane, Jia, Jiangyong, Jia, Zihang, Jiang, Hai, Jiang, Yi, Jiang, Zihao, Jiggins, Stephen, Jimenez Morales, Fabricio Andres, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per Daniel Conny, Johns, Kenneth, Johnson, Christian, Jones, Eleanor, Jones, R.W. L., Jones, Samuel David, Jones, Timothy John, Jones, T.J., Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Kaczmarska, Anna, Kado, Marumi, Kagan, Harris, Kagan, Michael Aaron, Kahn, Alan Mathew, Kahra, Christian, Kaji, Toshiaki, Kajomovitz Must, Enrique, Kalderon, Charles William, Kartvelishvili, Vakhtang, Kastanas, Konstantinos, Kalderon, Will, Kaluza, Adam, Kamenshchikov, Andrey, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kano, Yuya, Kanzaki, Junichi, Kaplan, Laser Seymour, Kar, Deepak, Karava, Kla, Kareem, Mohammad, Karkanias, Ioannis, Karpov, Sergey, Karpova, Zoya, Kartvelishvili, Vato, Karyukhin, Andrei, Kasimi, Eirini, Kastanas, Alex, Kato, Chikuma, Katzy, Judith, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawamoto, Tatsuo, Kawamura, Gen, Kay, Ellis, Kaya, Fikriye Idil, Kaya, Colette, Kazakos, Stergios, Kazanin, Vassili, Keaveney, James Michael, Keeler, Richard, Keller, John Stakely, Kellermann, Edgar, Kelsey, Daniel Christopher, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Kersten, Susanne, Kersevan, Borut Paul, Haghighat, S.Ketabchi, Khalil-Zada, Farhad, Khandoga, Mykola, Khanov, Alexander, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khoo, Teng Jian, Khoriauli, Gia, Khramov, Evgeny, Khubua, J., Khubua, Djemal, Kido, Shogo, Kiehn, Moritz, Kim, Eunchong, Kim, Young-Kee, Kimura, Naoki, Kirchhoff, Andreas, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrei, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Kitsaki, Chara, Kivernyk, Oleh, Klapdor-Kleingrothaus, Thorwald, Klassen, Martin, Klein, Christoph Thomas, Klein, Matthew Henry, Klein, Max, Klein, Uta, Kleinknecht, Konrad, Klimek, Pawel Jan, Klimentov, Alexei, Klimpel, Fabian, Klingl, Tobias, Klioutchnikova, Tatiana, Klitzner, Felix Fidelio, Kluit, Peter, Kluth, Stefan, Kneringer, Emmerich, Knoops, E.B. F.G., Knue, Andrea Helen, Kobayashi, Dai, Kobel, Michael, Kocian, Martin, Kodama, Takafumi, Kodys, Peter, Koeck, D.M., Kock, Daniela, Konig, Philipp, Koffas, Thomas, Koehler, Nicolas, Kolb, Mathis, Koletsou, Iro, Komarek, Tomas, Kondo, Takahiko, Kordas, Konstantinos, Kondo, Taka, Koeneke, Karsten, Kong, A.X. Y., Konig, Adriaan Clemens, Kono, Takanori, Konstantinides, Vasilis, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan Zenon, Korcyl, Krzysztof Marian, Kordas, Kostas, Koren, Guy, Korn, Andreas, Korolkov, Ilya, Korolkova, Elena, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Kotwal, Ashutosh, Koulouris, Aimilianos, Kourkoumeli-Charalampidi, Athina, Kourkoumelis, Christine, Kourlitis, Evangelos, Kouskoura, Vasiliki, Kowalewski, Robert Victor, Kowalewski, Bob, Kozanecki, Witold, Kozhin, Anatoli, Kramarenko, Viktor, Kramberger, Gregor, Krasnopevtsev, Dimitrii, Krasny, Mieczyslaw, Krasznahorkay, Attila, Krauss, Dominik, Kremer, Jakub, Kretzschmar, Jan, Kreul, Ken Matthias, Krieger, Peter, Krieter, Ferdinand, Krishnamurthy, Samyukta, Krishnan, Anjali, Krivos, Martin, Krizka, Karol, Kroeninger, Kevin Alexander, Kroha, Hubert, Kroll, Jiri, Kroll, Joseph Ira, Krowpman, Kyle Stuart, Kruchonak, Uladzimir, Krueger, Hans, Krumnack, Nils Erik, Kruse, Mark, Krzysiak, Janina Anna, Kubota, Arisa, Kuchinskaia, Olesia, Kuday, Sinan, Kuchler, Daniela, Kuechler, J.T., Kuehn, Susanne, Kuhl, Thorsten, Kukhtin, Victor, Kulchitsky, Y., Koultchitski, Iouri, Kuleshov, Sergey, Koultchitski, Yuri, Kuleshov, Serguei, Kulinich, Yakov Petrovich, Kuna, Marine, Kupco, Alexander, Kupfer, Tobias, Kuprash, Oleg, Kurashige, Hisaya, Kurchaninov, Leonid, Kurochkin, Yurii, Kurova, Anastasia, Kurth, Matthew Glenn, Kuwertz, Emma Sian, Kuze, Masahiro, Kvam, Audrey Katherine, Kvita, Jiri, Kwan, Tony, Lacasta Llacer, Carlos, Lacava, Francesco, Lack, David Philip John, Lacker, Heiko Markus, Lacour, Didier, Ladygin, Evgeny, Lai, Stanley Tsai-Ting, Ladygin, Evgueni, Lafaye, Remi, Laforge, Bertrand, Lagouri, Theodota, Lai, Stan, Lakomiec, Inga Katarzyna, Lambert, Joseph Earl, Lammers, Sabine Wedam, Lampl, Walter, Lampoudis, Christos, Lancon, Eric Christian, Landgraf, Ulrich, Landon, Murrough, Lang, Valerie, Lange, Joern, Langenberg, Robert Johannes, Lankford, Andrew James, Lanni, Francesco, Lantzsch, Kerstin, Lanza, Agostino, Lapertosa, Alessandro, Laporte, Jean-Francois, Lari, Tommaso, Lasagni Manghi, Federico, Lassnig, Mario, Latonova, Vera, Lau, Tak Shun, Laudrain, Antoine, Laurier, Alexandre, Lavorgna, Marco, Lawlor, Sean Dean, Lazzaroni, Massimo, Le, Brian, Le Guirriec, Emmanuel, Lebedev, Alexandre, Lecompte, T., Leblanc, Matthew Edgar, Le Compte, Thomas Joseph, Leblanc, Matt, Le Compte, Tom, Ledroit-Guillon, F., Lee, Ava Chloe Audrey, Lee, Claire, Lee, Graham Richard, Lee, Lawrence, Lee, Shih-Chang, Lee, Songkyo, Lefebvre, Benoit, Lefebvre, Helena, Lefebvre, Michel, Leggett, Charles, Lehmann, Konstantin, Lehmann, Niklaus, Lehmann Miotto, Giovanna, Leight, William Axel, Leisos, Antonios, Lisboa Leite, Marco, Leitgeb, Clara Elisabeth, Leitner, Rupert, Leney, Katharine, Lenz, Tatjana, Leone, Sandra, Leonidopoulos, Christos, Leopold, Alexander, Leroy, Claude, Les, Robert, Lester, Christopher, Levchenko, Mikhail, Leveque, Jessica, Levin, Daniel Sheldon, Lloyd, Stephen, Levin, Dan, Levinson, Lorne, Lewis, Daniel James, Li, Boyang, Li, Bing, Li, Changqiao, Li, Fan, Li, Heng, Li, Haifeng, Li, Jing, Li, Ke, Li, Liang, Li, Mengran, Li, Quanyin, Li, Shu, Li, Xingguo, Li, Yichen, Li, Zhi, Li, Zhiying, Li, Zhelun, Li, Zhiyuan, Liang, Zhijun, Liberatore, Marianna, Liberti, Barbara, Lie, Ki, Lim, Sanghoon, Lin, Chiao-Ying, Lin, Kuan-Yu, Linck, Rebecca, Lindley, Rachel Elizabeth, Lindon, Jack, Linss, Arthur, Lionti, Anthony, Lipeles, Elliot, Lipniacka, Anna, Liss, Anthony Michael, Lister, Alison, Little, Jared, Liu, Bo, Liu, Bingxuan, Liu, Hongbin, Liu, Jianbei, Liu, J.K. K., Liu, Kun, Liu, Minghui, Liu, Mingyi, Liu, Peilian, Liu, Xiaotian, Liu, Yi, Liu, Yang, Liu, Yanlin, Liu, Yanwen, Livan, Michele, Lleres, Annick, Llorente Merino, Javier, Luehring, Frederick, Lloyd, Steve, Lo, Cheuk Yee, Lobodzinska, Ewelina Maria, Loch, Peter, Loffredo, Salvatore, Lohse, Thomas, Lohwasser, Kristin, Lokajicek, Milos, Long, Jonathan, Long, Robin Eamonn, Longarini, Iacopo, Longo, Luigi, Lopez Paz, Ivan, Lopez Solis, Alvaro, Lorenz, Jeanette Miriam, Lorenzo Martinez, Narei, Lory, Alexander, Loesle, Alena, Lou, Xuanhong, Lou, Xinchou, Lounis, Abdenour, Love, Jeremy Robert, Love, Peter, Lozano Bahilo, Julio, Lu, Miaoran, Lu, Yun-Ju, Lubatti, Henry, Luci, Claudio, Lucio Alves, Fabio Lucio, Lucotte, Arnaud, Luehring, Fred, Luise, Ilaria, Luminari, Lamberto, Lund-Jensen, Bengt, Luongo, Nicholas, Lutz, Margaret Susan, Lynn, David, Lyons, Harry John, Lysak, Roman, Lytken, Else, Lyu, Feng, Lyubushkin, Vladimir, Lyubushkina, Tatiana, Ma, Hong, Ma, Lianliang, Ma, Yanhui, Donell, D.M. Mac, Macdonell, Danika Marina, Maccarrone, Giovanni, Macdonald, Calum Michael, Macdonald, Jack, Machado Miguens, Joana, Madar, Romain, Mader, Wolfgang, Madugoda Ralalage Don, Madhuranga, Madysa, Nico, Maeda, Junpei, Maeno, Tadashi, Maerker, Max, Magerl, Veronika, Magini, Nicolo, Magro, Jacopo, Mahon, Devin, Maidantchik, Carmen, Maio, Amelia, Maj, Klaudia, Majersky, Oliver, Majewski, Stephanie, Makida, Yasuhiro, Makovec, Nikola, Malaescu, Bogdan, Malecki, Pa., Malecki, Pawel, Maleev, Victor, Malek, Fairouz, Malito, Davide, Mallik, Usha, Malone, Claire, Maltezos, Stavros, Malyukov, Sergey, Mamuzic, Judita, Mancini, Giada, Mandalia, Jesal, Mandic, Igor, Manhaes de Andrade Filho, Luciano, Maniatis, Ioannis Michail, Ramos, J.Manjarres, Mankinen, Katja Hannele, Mann, Alexander, Manousos, Athanasios, Marshall, Zachary Louis, Martin, Timothy, Maslennikov, Aleksei, Mcfayden, Joshua Angus, Manousos, Thanos, Mansoulie, Bruno, Manthos, Ioannis, Manzoni, Stefano, Marantis, Alexandros, Marceca, Gino, Marchese, Luigi, Marchiori, Giovanni, Marcisovsky, Michal, Marcoccia, Lorenzo, Marcon, Caterina, Marjanovic, Marija, Mc Kay, Madalyn Ann, Mcpherson, Robert Anthony, Marshall, Zach, Martensson, M.U. F., Marti I Garcia, Salvador, Martin, Christopher Blake, Martin, Tim, Martin, Victoria, Martin Dit Latour, Bertrand, Martinelli, Luca, Martinez-Perez, Mario, Martinez Agullo, Pablo, Martinez Outschoorn, Verena Ingrid, Martin-Haugh, Stewart, Martoiu, Sorin, Martyniuk, Alex Christopher, Marzin, Antoine, Maschek, Stefan Raimund, Masetti, Lucia, Mashimo, Tetsuro, Mashinistov, Ruslan, Masik, Jiri, Maslennikov, Alexei, Massa, Lorenzo, Massarotti, Paolo, Mastrandrea, Paolo, Mastroberardino, Anna, Masubuchi, Tatsuya, Matakias, Dimitrios, Matic, Andrea, Matsuzawa, Nobuo, Mattig, Peter, Maurer, Julien, Macek, Bostjan, Maximov, Dmitriy, Mazini, Rachid, Maznas, Ioannis, Mazza, Simone Michele, Mc Gowan, John Patrick, Mc Kee, Shawn, Mccarthy, Thomas, Mccormack, William Patrick, Mcdonald, Emily Frances, Mcdonald, Millie, Mcdougall, Ashley Ellen, Mcfayden, Josh, Mchedlidze, Gvantsa, Mc Kay, Maddie, Mclean, Kayla, Mcmahon, Stephen, Mcnamara, Peter Charles, Mcnicol, Christopher John, Mcpherson, R.A., Mdhluli, Joyful Elma, Meadows, Zachary Alden, Meehan, Samuel Ross, Megy, Theo, Mehlhase, Sascha, Mehta, Andrew, Meirose, Bernhard, Melini, Davide, Mellado Garcia, Bruce, Mellenthin, Johannes, Melo, Matej, Meloni, Federico, Melzer, Alexander, Gouveia, E.D. Mendes, Mendes Jacques da Costa, Antonio Manuel, Meng, Huan Yu, Meng, Lingxin, Meng, Xiangting, Menke, Sven, Meoni, Evelin, Mergelmeyer, Sebastian, Merkt, Sebastian Andreas, Merlassino, Claudia, Mermod, Philippe, Merola, Leonardo, Meroni, Chiara, Merz, Garrett William, Meshkov, Oleg, Meshreki, John Kamal Rizk, Metcalfe, Jessica, Mete, Alaettin Serhan, Meyer, Christopher John, Meyer, Jean-Pierre, Michetti, Michele, Middleton, Robin, Mijovic, Liza, Mikenberg, George, Mikestikova, Marcela, Mikuz, Marko, Mildner, Hannes, Milic, Adriana, Milke, Christopher Don, Milke, Chris, Miller, David, Miller, Laura Stephanie, Milov, Alexander, Milstead, David Anthony, Minaenko, Andrei, Minashvili, Irakli, Mince, Laurynas, Mincer, Allen Irving, Mindur, Bartosz, Mineev, Mikhail, Minegishi, Yuji, Mino, Yuya, Mir Martinez, Lluisa Maria, Mironova, Maria, Mistry, Khilesh Pradip, Mitani, Takashi, Mitrevski, Jovan, Mitsou, Vasiliki, Mittal, Monika, Miu, Ovidiu, Miucci, Antonio, Miyagawa, Paul, Mizukami, Atsushi, Mjoernmark, Jan-Ulf, Mkrtchyan, Tigran, Mlynarikova, Michaela, Moa, Torbjorn, Mobius, Silke, Mochizuki, Kazuya, Moder, Paul, Mogg, Philipp, Mohapatra, Soumya, Moles Valls, Regina, Monig, Klaus, Monnier, Emmanuel, Montalbano, Alyssa Rae, Montejo Berlingen, Javier, Montella, Marco, Monticelli, Fernando, Monzani, Simone, Morange, Nicolas, Moreira de Carvalho, Ana Luisa, Moreno Lopez, Deywis, Moreno Llacer, Maria, Moreno Martinez, Carlos, Morettini, Paolo, Morgenstern, Marcus Matthias, Morgenstern, Stefanie, Mori, Daniel, Morii, Masahiro, Morinaga, Masahiro, Morisbak, Vanja, Morley, Anthony, Mornacchi, Giuseppe, Morris, Alice, Morvaj, Ljiljana, Moschovakos, Paraschos, Myers, Gregory William, Nachman, Benjamin Philip, Moschovakos, Paris, Moser, Brian, Mosidze, Maia, Moskalets, Tetiana, Moskvitina, Polina, Moss, Joshua, Moyse, E.J. W., Muanza, Steve, Mueller, James Alfred, Muller, Ralph, Muenstermann, Daniel, Mullier, Geoffrey, Mungo, Davide Pietro, Munoz Martinez, Jose Luis, Munoz Sanchez, Francisca, Murin, Pavel, Murray, William John, Murray, Bill, Murrone, Alessia, Muse, Joseph M, Muskinja, Miha, Mwewa, Chilufya, Myagkov, Alexei, Myers, Ava Anne, Neep, Thomas James, Ntekas, Konstantinos, Myers, Greg, Myers, John, Myska, Miroslav, Nachman, B.P., Nackenhorst, Olaf, Nag, Abhishek, Nagai, Koichi, Nagano, Kunihiro, Nagasaka, Yasushi, Nagle, James Lawrence, Nagy, Elemer, Nairz, Armin, Higuchi, Yu Nakahama, Nakamura, Koji, Nakamura, Tomoaki, Nanjo, Hajime, Napolitano, Fabrizio, Garcia, R.F. Naranjo, Narayan, Rohin Thampilali, Naryshkin, Iurii, Naseri, Mohsen, Naumann, Thomas, Navarro, Gabriela Alejandra, Nechaeva, Polina, Nechansky, Filip, Ng, Yan Wing, Neep, T.J., Negri, Andrea, Negrini, Matteo, Nellist, Clara, Nelson, Christina, Nelson, Michael Edward, Nemecek, Stanislav, Nessi, Marzio, Neubauer, Mark, Neuhaus, Friedemann, Neumann, Manuel, Newhouse, Robin, Newman, Paul Richard, Ng, Chi Wing, Nikolaidou, Rodanthi, Nilsson, Paal Nils Bertil, Ng, Sam Yanwing, Ng, Ying Wun Yvonne, Ngair, Badr-Eddine, Nguyen, Hoang Dai Nghia, Nguyen Manh, Tuan, Nibigira, Emery, Nickerson, Richard, Nikolaidou, Rosy, Nielsen, Daniel, Nielsen, Jason, Niemeyer, Marcel, Nikiforou, Nikiforos, Nikolaenko, Vladimir, Nikolic-Audit, I., Nikolopoulos, Konstantinos, Nilsson, Paul, Nindhito, Herjuno Rah, Nisati, Aleandro, Nishu, Nishu, Nisius, Richard, Nitsche, Isabel, Nitta, Tatsumi, Nobe, Takuya, Noel, Daniel Louis, Noguchi, Yohei, Nomidis, Ioannis, Nomura, Marcelo Ayumu, Nordberg, Markus, Novak, Jakob, Novak, Tadej, Novgorodova, Olga, Novotny, Radek, Nozka, Libor, Ntekas, Kostas, Nurse, Emily Laura, Oakham, Gerald, Ocariz, Jose Humberto, Ochi, Atsuhiko, Ochoa, Ines, Ochoa, Jean-Pierre, O'Connor, Kelsey Shea, Oda, Susumu, Odaka, Shigeru, Ordek, Serhat, Ogrodnik, Agnieszka Ewa, Oh, Alexander, Ohm, Christian, Oide, Hideyuki, Oishi, Reiyo, Ojeda, Martina Laura, Okawa, Hideki, Okazaki, Yuta, O'Keefe, Michael William, Okumura, Yasuyuki, Olariu, Albert, Seabra, L.F. Oleiro, Olivares, Sebastian, Oliveira Damazio, Denis, Oliver, Jason, Olsson, Mats Joakim Robert, Olszewski, Andrzej, Olszowska, Jolanta, Oncel, Omer Ogul, O'Neil, Dugan, O'Neill, Aaron Paul, Onofre, Antonio, Onyisi, P.U. E., Oppen, Henrik, Oreamuno Madriz, Rafael Guillermo, Oreglia, Mark, Orellana, Gonzalo Enrique, Orestano, Domizia, Orlando, Nicola, Orr, Robert, O'Shea, Valentine, Ouellette, Jeffrey Cortlandt, Parker, Andrew Michael, O'Shea, Val, Ospanov, Rustem, Otero y Garzon, Gustavo, Otono, Hidetoshi, Ott, Philipp Sebastian, Ottino, Gregory James, Ouchrif, Mohamed, Ouellette, Jeff, Ould-Saada, Farid, Ouraou, Ahmimed, Ouyang, Qun, Owen, Mark Andrew, Owen, Rhys, Ozcan, Erkcan, Ozturk, Nurcan, Pacalt, Josef, Pacey, Holly, Pachal, Katherine, Pacheco Pages, Andreu, Padilla Aranda, Cristobal, Pagan Griso, Simone, Palacino, Gabriel, Palazzo, Serena, Palestini, Sandro, Palka, Marek, Palni, Prabhakar, Pandini, Carlo Enrico, Panduro Vazquez, Jose Guillermo, Panduro Vazquez, William, Pani, Priscilla, Panizzo, Giancarlo, Paolozzi, Lorenzo, Papadatos, Constantine, Papageorgiou, Konstantinos, Parajuli, Santosh, Paramonov, Alexander, Paraskevopoulos, Christos, Paredes Hernandez, Daniela Katherinne, Paredes Saenz, Santiago Rafael, Parida, Bibhuti, Park, Tae Hyoun, Parker, Adam Jackson, Pollard, Christopher Samuel, Parker, Andy, Parodi, Fabrizio, Parrish, Elliot, Parsons, John, Parzefall, Ulrich, Pascual Dominguez, Luis, Pascuzzi, Vincent, Pasner, Jacob Martin, Pasquali, Federica, Pasqualucci, Enrico, Passaggio, Stefano, Pastore, Francesca, Pasuwan, Patrawan, Pataraia, Sophio, Pater, Joleen, Pater, Jo, Pathak, Atanu, Patton, Joseph, Pauly, Thilo, Pearkes, Jannicke Andree, Pedersen, Maiken, Pedraza Diaz, Lucia, Costa Batalha Pedro, Rute, Peiffer, Thomas, Peleganchuk, Sergey, Penc, Ondrej, Peng, Chen, Peng, Haiping, Sotto-Maior Peralva, Bernardo, Perego, Marta Maria, Pereira Peixoto, A.P., Pereira Sanchez, Laura, Perepelitsa, Dennis, Perez Codina, Estel, Perini, Laura, Pernegger, Heinz, Perrella, Sabrina, Perrevoort, Ann-Kathrin, Peters, Krisztian, Peters, Reinhild, Petersen, Brian, Petersen, Troels, Petit, Elisabeth, Petousis, Vlasios, Petridou, Chariclia, Petrucci, Fabrizio, Pettee, Mariel, Pettersson, Nora Emilia, Petukhova, Krystsina, Raine, John Andrew, Rajagopalan, Srinivasan, Mihule, Kristina, Peyaud, Alan, Pezoa Rivera, Raquel, Pezzotti, Lorenzo, Pham, Le Ha Thu, Pham, Joni, Phillips, Peter, Phipps, Michael William, Piacquadio, Giacinto, Pianori, Elisabetta, Picazio, Attilio, Pickles, Rebecca Hayley, Piegaia, Ricardo, Pietreanu, Dorel, Pilcher, James, Pilcher, Jim, Pilkington, Andrew, Pinamonti, Michele, Pinfold, James, Pitman Donaldson, Charlie Bruno, Pitt, Michael, Pizzimento, Luca, Pizzini, Alessio, Pleier, Marc-Andre, Plesanovs, Vladislavs, Pleskot, Vojtech, Plotnikova, Elena, Podberezko, Pavel, Pottgen, Ruth, Poggi, Riccardo, Poggioli, Luc, Pogrebnyak, Ivan, Pohl, David-Leon, Pokharel, Ishan, Polesello, Giacomo, Poley, Anne-Luise, Policicchio, Antonio, Polifka, Richard, Polini, Alessandro, Pollard, Chris, Polychronakos, Venetios, Ponomarenko, Daniil, Pontecorvo, Ludovico, Popa, Stefan, Popeneciu, Gabriel, Portales, Louis, Portillo Quintero, Dilia Maria, 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A., Vigani, Luigi, Villa, Mauro, Perez, M.Villaplana, Villhauer, Elena Michelle, Vilucchi, Elisabetta, Vincter, Manuella, Virdee, Govindraj Singh, Vishwakarma, Akanksha, Vittori, Camilla, Vivarelli, Iacopo, Vogel, Marcelo, Vokac, Petr, von Ahnen, Janik, von Buddenbrock, Stefan, von Torne, Eckhard, Vorobel, Vit, Vorobev, Konstantin, Vos, Marcel, Vossebeld, Joost, Vozak, Matous, Vranjes, Nenad, Vranjes Milosavljevic, Marija, Vrba, Vaclav, Vreeswijk, Marcel, Vu, Ngoc Khanh, Vuillermet, Raphael, Vukotic, Ilija, Wada, Sayaka, Wagner, Peter, Wagner, Wolfgang, Wagner-Kuhr, Jeannine, Wahdan, Shayma, Wahlberg, Hernan Pablo, Wakasa, Rena, Walbrecht, Verena Maria, Walder, James William, Walker, Rodney, Walker, Stuart Derek, Walkowiak, Wolfgang, Wallangen, Veronica, Wang, Ann Miao, Wang, Alex Zeng, Wang, Chen, Wang, Chenliang, Wang, Haichen, Wang, Hulin, Wang, Jiawei, Wang, Peilong, Wang, Qing, Wang, Renjie, Wang, Rongkun, Wang, Rui, Wang, Song-Ming, Wang, Weitao, Wang, Wei, Wang, Wenxiao, Wang, Yufeng, Wang, Zirui, Wanotayaroj, Chaowaroj, Warburton, Andreas, Ward, Patricia, Ward, Robert James, Warrack, Neil, Watson, Alan, Watson, Miriam, Watts, Gordon, Waugh, Benedict Martin, Webb, Aaron, Weber, Christian, Weber, Michael Simon, Wells, Phillippa, Whalen, Kathleen Charlotte, Wyatt, Terence Richard, Weber, Michele, Weber, Stephen, Weber, Sebastian Mario, Wei, Yingjie, Weidberg, Anthony, Weingarten, Jens, Weirich, Marcel, Weiser, Christian, Wells, Pippa, Wenaus, Torre, Wendland, Bjoern, Wengler, Thorsten, Wenig, Siegfried, Wermes, Norbert, Wessels, Martin, Weston, Thomas, Whalen, Kate, Wharton, Andrew Mark, White, Aaron Stephen, White, Andrew, White, Martin John, Whiteson, Daniel, Whitmore, B.W., Wiedenmann, Werner, Wiel, Christian, Wielers, Monika, Wieseotte, Natalie, Wiglesworth, Craig, Wiik-Fuchs, L.A. M., Wilkens, Henric, Wilkins, Lewis, Williams, Daniel, Williams, Hugh, Williams, Sarah Louise, Willocq, Stephane, Windischhofer, Philipp, Wingerter, Isabelle, Winkels, Emma, Winklmeier, Frank, Winter, Benedict Tobias, Wittgen, Matthias, Wobisch, Markus, Wolf, Anton, Woelker, Ricardo, Wollrath, Julian, Wolter, Marcin, Wolters, Helmut, Wong, Vincent Wai Sum, Wongel, Alicia, Woods, Natasha Lee, Worm, Steven, Wosiek, Barbara Krystyna, Wozniak, Krzysztof Wieslaw, Wraight, Kenneth Gibb, Wu, Sau Lan, Wu, Xin, Wu, Yusheng, Wurzinger, Jonas, Young, Charles Chunghoi, Wyatt, Terry, Wynne, Benjamin Michael, Xella, Stefania, Xiang, Jianhuan, Xiao, Xiong, Xie, Xiangyu, Xiotidis, Ioannis, Xu, Da, Xu, Hanlin, Xu, Hao, Xu, Lailin, Xu, Riley, Xu, Tairan, Xu, Wenhao, Xu, Yue, Xu, Zhongyukun, Xu, Zijun, Yabsley, Bruce Donald, Yacoob, Sahal, Yallup, David, Yamaguchi, Naoki, Yamaguchi, Yohei, Yamamoto, Akira, Yamatani, Masahiro, Yamazaki, Tomohiro, Yamazaki, Yuji, Yan, Jun, Yan, Zhen, Yang, Haijun, Yang, Hongtao, Yang, Siqi, Yang, Tianyi, Yang, Xiao, Yang, Xuan, Yang, Yi-Lin, Yang, Zhe, Yao, Weiming, Yao, Wei-Ming, Yap, Yee Chinn, Ye, Hanfei, Ye, Jingbo, Ye, Shuwei, Yeletskikh, Ivan, Yexley, Melissa, Yigitbasi, Efe, Yin, Pengqi, Yorita, Kohei, Yoshihara, Keisuke, Young, Christopher, Young, Charlie, Yu, Jie, Yuan, Rui, Yue, Xiaoguang, Zaazoua, Mohamed, Zabinski, Bartlomiej Henryk, Zacharis, Georgios, Zaffaroni, Ettore, Zahreddine, Jad, Zaytsev, Alexandre, Zakareishvili, Tamar, Zakharchuk, Nataliia, Zambito, Stefano, Zanzi, Daniele, Zeissner, Sonja Verena, Zeitnitz, Christian, Zemaityte, Gabija, Zeng, Jiancong, Zenin, Oleg, Zenis, Tibor, Zerwas, Dirk, Zgubic, Miha, Zhang, Bowen, Zhang, Dengfeng, Zhang, Gang, Zhang, Jinlong, Zhang, Kaili, Zhang, Lei, Zhang, Liqing, Zhang, Matt, Zhang, Rui, Zhang, Shuzhou, Zhang, Xiangke, Zhang, Xueyao, Zhang, Yu, Zhang, Zhidong, Zhang, Zhiqing Philippe, Zhao, Pingchuan, Zhao, Yuzhan, Zhao, Zhengguo, Zhemchugov, Alexey, Zheng, Zhi, Zhong, Dewen, Zhou, Bing, Zhou, Chen, Zhou, Hao, Zhou, Mingliang, Zhou, Ning, Zhou, You, Zhu, Chengguang, Zhu, Chenzheng, Zhu, Heling, Zhu, Hongbo, Zhu, Junjie, Zhu, Yingchun, Zhuang, Xuai, Zhukov, Konstantin, Zhulanov, Vladimir, Zieminska, Daria, Zimine, Nikolai, Zimmermann, Stephanie Ulrike, Zinonos, Zinonas, Ziolkowski, Michal, Zivkovic, Lidija, Zobernig, Georg, Zobernig, Haimo, Zoccoli, Antonio, Zoch, Knut, Zorbas, Theodore, Zou, Rui, Zwalinski, Lukasz, De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Franchini , M., Romano , M., Valentinetti , S., Alberghi , G. L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., ATLAS collaboration, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aad, G. 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W., Shaked Renous, D., Shan, L. Y., Shapiro, M., Sharma, A., Sharma, A. S., Shatalov, P. B., Shaw, K., Shaw, S. M., Shehade, M., Shen, Y., Sherman, A. D., Sherwood, P., Shi, L., Shimmin, C. O., Shimogama, Y., Shimojima, M., Shinner, J. D., Shipsey, I. P. J., Shirabe, S., Shiyakova, M., Shlomi, J., Shmeleva, A., Shochet, M. J., Shojaii, J., Shope, D. R., Shrestha, S., Shrif, E. M., Shroff, M. J., Shulga, E., Sicho, P., Sickles, A. M., Sideras Haddad, E., Sidiropoulou, O., Sidoti, A., Siegert, F., Sijacki, Dj., Silva, M., Silva Oliveira, M. V., Silverstein, S. B., Simion, S., Simoniello, R., Simpson-allsop, C. J., Simsek, S., Sinervo, P., Sinetckii, V., Singh, S., Sioli, M., Siral, I., Sivoklokov, S. Yu., Sjölin, J., Skaf, A., Skorda, E., Skubic, P., Slawinska, M., Sliwa, K., Smakhtin, V., Smart, B. H., Smiesko, J., Smirnov, N., Smirnov, S. Yu., Smirnov, Y., Smirnova, L. N., Smirnova, O., Smith, E. A., Smith, H. A., Smizanska, M., Smolek, K., Smykiewicz, A., Snesarev, A. A., Snoek, H. L., Snyder, I. M., Snyder, S., Sobie, R., Soffer, A., Søgaard, A., Sohns, F., Solans Sanchez, C. A., Soldatov, E. Yu., Soldevila, U., Solodkov, A. A., Soloshenko, A., Solovyanov, O. V., Solovyev, V., Sommer, P., Son, H., Sonay, A., Song, W., Song, W. Y., Sopczak, A., Sopio, A. L., Sopkova, F., Sottocornola, S., Soualah, R., Soukharev, A. M., South, D., Spagnolo, S., Spalla, M., Spangenberg, M., Spanò, F., Sperlich, D., Spieker, T. M., Spigo, G., Spina, M., Spiteri, D. P., Spousta, M., Stabile, A., Stamas, B. L., Stamen, R., Stamenkovic, M., Stampekis, A., Stanecka, E., Stanislaus, B., Stanitzki, M. M., Stankaityte, M., Stapf, B., Starchenko, E. A., Stark, G. H., Stark, J., Staroba, P., Starovoitov, P., Stärz, S., Staszewski, R., Stavropoulos, G., Stegler, M., Steinberg, P., Steinhebel, A. L., Stelzer, B., Stelzer, H. J., Stelzer-Chilton, O., Stenzel, H., Stevenson, T. J., Stewart, G. A., Stockton, M. C., Stoicea, G., Stolarski, M., Stonjek, S., Straessner, A., Strandberg, J., Strandberg, S., Strauss, M., Strebler, T., Strizenec, P., Ströhmer, R., Strom, D. M., Stroynowski, R., Strubig, A., Stucci, S. A., Stugu, B., Stupak, J., Styles, N. A., Su, D., Su, W., Su, X., Suarez, N. B., Sulin, V. V., Sullivan, M. J., Sultan, D. M. S., Sultansoy, S., Sumida, T., Sun, S., Sun, X., Suster, C. J. E., Sutton, M. R., Suzuki, S., Svatos, M., Swiatlowski, M., Swift, S. P., Swirski, T., Sydorenko, A., Sykora, I., Sykora, M., Sykora, T., Ta, D., Tackmann, K., Taenzer, J., Taffard, A., Tafirout, R., Tagiev, E., Taibah, R. H. M., Takashima, R., Takeda, K., Takeshita, T., Takeva, E. P., Takubo, Y., Talby, M., Talyshev, A. A., Tam, K. C., Tamir, N. M., Tanaka, J., Tanaka, R., Tapia Araya, S., Tapprogge, S., Tarek Abouelfadl Mohamed, A., Tarem, S., Tariq, K., Tarna, G., Tartarelli, G. F., Tas, P., Tasevsky, M., Tassi, E., Tateno, G., Tavares Delgado, A., Tayalati, Y., Taylor, A. J., Taylor, G. N., Taylor, W., Teagle, H., Tee, A. S., Teixeira De Lima, R., Teixeira-Dias, P., Ten Kate, H., Teoh, J. J., Terashi, K., Terron, J., Terzo, S., Testa, M., Teuscher, R. J., Thais, S. J., Themistokleous, N., Theveneaux-Pelzer, T., Thomas, D. W., Thomas, J. P., Thompson, E. A., Thompson, P. D., Thomson, E., Thorpe, E. J., Tikhomirov, V. O., Tikhonov, Yu. A., Timoshenko, S., Tipton, P., Tisserant, S., Todome, K., Todorova-Nova, S., Todt, S., Tojo, J., Tokár, S., Tokushuku, K., Tolley, E., Tombs, R., Tomiwa, K. G., Tomoto, M., Tompkins, L., Tornambe, P., Torrence, E., Torres, H., Torró Pastor, E., Toscani, M., Tosciri, C., Toth, J., Tovey, D. R., Traeet, A., Treado, C. J., Trefzger, T., Tresoldi, F., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Trischuk, D. A., Trischuk, W., Trocmé, B., Trofymov, A., Troncon, C., Trovato, F., Truong, L., Trzebinski, M., Trzupek, A., Tsai, F., Tseng, J. C. -L., Tsiareshka, P. V., Tsirigotis, A., Tsiskaridze, V., Tskhadadze, E. G., Tsopoulou, M., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Tsybychev, D., Tu, Y., Tudorache, A., Tudorache, V., Tuna, A. N., Turchikhin, S., Turgeman, D., Turk Cakir, I., Turner, R. J., Turra, R., Tuts, P. M., Tzamarias, S., Tzovara, E., Uchida, K., Ukegawa, F., Unal, G., Unal, M., Undrus, A., Unel, G., Ungaro, F. C., Unno, Y., Uno, K., Urban, J., Urquijo, P., Usai, G., Uysal, Z., Vacek, V., Vachon, B., Vadla, K. O. H., Vafeiadis, T., Vaidya, A., Valderanis, C., Valdes Santurio, E., Valente, M., Valentinetti, S., Valero, A., Valéry, L., Vallance, R. A., Vallier, A., Valls Ferrer, J. A., Van Daalen, T. R., Van Gemmeren, P., Van Stroud, S., Van Vulpen, I., Vanadia, M., Vandelli, W., Vandenbroucke, M., Vandewall, E. R., Vannicola, D., Vari, R., Varnes, E. W., Varni, C., Varol, T., Varouchas, D., Varvell, K. E., Vasile, M. E., Vasquez, G. A., Vazeille, F., Vazquez Furelos, D., Vazquez Schroeder, T., Veatch, J., Vecchio, V., Veen, M. J., Veloce, L. M., Veloso, F., Veneziano, S., Ventura, A., Verbytskyi, A., Vercesi, V., Verducci, M., Vergel Infante, C. M., Vergis, C., Verkerke, W., Vermeulen, A. T., Vermeulen, J. C., Vernieri, C., Verschuuren, P. J., Vetterli, M. C., Viaux Maira, N., Vickey, T., Vickey Boeriu, O. E., Viehhauser, G. H. A., Vigani, L., Villa, M., Villaplana Perez, M., Villhauer, E. M., Vilucchi, E., Vincter, M. G., Virdee, G. S., Vishwakarma, A., Vittori, C., Vivarelli, I., Vogel, M., Vokac, P., Von Ahnen, J., von Buddenbrock, S. E., Von Toerne, E., Vorobel, V., Vorobev, K., Vos, M., Vossebeld, J. H., Vozak, M., Vranjes, N., Vranjes Milosavljevic, M., Vrba, V., Vreeswijk, M., Vu, N. K., Vuillermet, R., Vukotic, I., Wada, S., Wagner, P., Wagner, W., Wagner-Kuhr, J., Wahdan, S., Wahlberg, H., Wakasa, R., Walbrecht, V. M., Walder, J., Walker, R., Walker, S. D., Walkowiak, W., Wallangen, V., Wang, A. M., Wang, A. Z., Wang, C., Wang, H., Wang, J., Wang, P., Wang, Q., Wang, R. -J., Wang, R., Wang, S. M., Wang, W. T., Wang, W., Wang, W. X., Wang, Y., Wang, Z., Wanotayaroj, C., Warburton, A., Ward, C. P., Ward, R. J., Warrack, N., Watson, A. T., Watson, M. F., Watts, G., Waugh, B. M., Webb, A. F., Weber, C., Weber, M. S., Weber, S. A., Weber, S. M., Wei, Y., Weidberg, A. R., Weingarten, J., Weirich, M., Weiser, C., Wells, P. S., Wenaus, T., Wendland, B., Wengler, T., Wenig, S., Wermes, N., Wessels, M., Weston, T. D., Whalen, K., Wharton, A. M., White, A. S., White, A., White, M. J., Whiteson, D., Whitmore, B. W., Wiedenmann, W., Wiel, C., Wielers, M., Wieseotte, N., Wiglesworth, C., Wiik-Fuchs, L. A. M., Wilkens, H. G., Wilkins, L. J., Williams, D. M., Williams, H. H., Williams, S., Willocq, S., Windischhofer, P. J., Wingerter-Seez, I., Winkels, E., Winklmeier, F., Winter, B. T., Wittgen, M., Wobisch, M., Wolf, A., Wölker, R., Wollrath, J., Wolter, M. W., Wolters, H., Wong, V. W. S., Wongel, A. F., Woods, N. L., Worm, S. D., Wosiek, B. K., Woźniak, K. W., Wraight, K., Wu, S. L., Wu, X., Wu, Y., Wuerzinger, J., Wyatt, T. R., Wynne, B. M., Xella, S., Xiang, J., Xiao, X., Xie, X., Xiotidis, I., Xu, D., Xu, H., Xu, L., Xu, R., Xu, T., Xu, W., Xu, Y., Xu, Z., Yabsley, B., Yacoob, S., Yallup, D. P., Yamaguchi, N., Yamaguchi, Y., Yamamoto, A., Yamatani, M., Yamazaki, T., Yamazaki, Y., Yan, J., Yan, Z., Yang, H. J., Yang, H. T., Yang, S., Yang, T., Yang, X., Yang, Y., Yang, Z., Yao, W-M., Yap, Y. C., Ye, H., Ye, J., Ye, S., Yeletskikh, I., Yexley, M. R., Yigitbasi, E., Yin, P., Yorita, K., Yoshihara, K., Young, C. J. S., Young, C., Yu, J., Yuan, R., Yue, X., Zaazoua, M., Zabinski, B., Zacharis, G., Zaffaroni, E., Zahreddine, J., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zambito, S., Zanzi, D., Zeißner, S. V., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zenin, O., Ženiš, T., Zerwas, D., Zgubič, M., Zhang, B., Zhang, D. F., Zhang, G., Zhang, J., Zhang, K., Zhang, L., Zhang, M., Zhang, R., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, P., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Ziolkowski, M., Živković, L., Zobernig, G., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, and Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2936
Subjects: electron, Top quark, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Physics and Astronomy (miscellaneous), 13000 GeV-cms, measured [channel cross section], Parton, pair production [top], 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Subatomic Physics, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], parton, associated production [Z0], Nuclear Experiment, Settore FIS/01, Physics, Luminosity (scattering theory), Large Hadron Collider, 4. Education, ATLAS, 16. Peace & justice, Nuclear and elementary particle physics: 431 [VDP], CERN LHC Coll, medicine.anatomical_structure, kinematics, colliding beams [p p], top: pair production, channel cross section: measured, Particle Physics - Experiment, data analysis method, p p: scattering, Particle physics, Z boson, CERN Lab, Regular Article - Experimental Physics, 530 Physics, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, differential cross section: measured, Cross section (physics), Atlas (anatomy), measured [differential cross section], muon, 0103 physical sciences, medicine, ddc:530, High Energy Physics, 010306 general physics, Engineering (miscellaneous), top quark, Muon, hep-ex, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Física, leptonic decay [Z0], Z0: associated production, Z0: leptonic decay, LHC, Particle Physics, Top physics, High Energy Physics::Experiment, Hadron-hadron collisions, p p: colliding beams, experimental results, Lepton
Abstract: We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Au CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANIstralia; BMWFW and FWF, Austria; ANAXS, Azerbaijan; SSTC, Belarus;D, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MESofRussia andNRCKI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOEandNSF, USA. In addition, individual groups andmembers have received support fromBCKDF, CANARIE, ComputeCanada, CRC and IVADO, Canada; Beijing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), theY Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in Ref. [91]., Measurements of both the inclusive and differential production cross sections of a top-quark-antiquark pair in association with a Z boson (t (t) over barZ) are presented. The measurements are performed by targeting final states with three or four isolated leptons (electrons or muons) and are based on root s = 13 TeV proton-proton collision data with an integrated luminosity of 139 fb(-1), recorded from 2015 to 2018 with the ATLAS detector at the CERN Large Hadron Collider. The inclusive cross section is measured to be a sigma(t (t) over barZ)= 0.99 +/- 0.05 (stat.) +/- 0.08 (syst.) pb, in agreement with the most precise theoretical predictions. The differential measurements are presented as a function of a number of kinematic variables which probe the kinematics of the t (t) over barZ system. Both absolute and normalised differential crosssection measurements are performed at particle and parton levels for specific fiducial volumes and are compared with theoretical predictions at different levels of precision, based on a chi(2)/ndf and p value computation. Overall, good agreement is observed between the unfolded data and the predictions., CERN, ANPCyT, YerPhI, Armenia, Australian Research Council, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), NRC, Canada, Canada Foundation for Innovation, SSTC, Belarus, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government, Czech Republic Government, DNRF, Denmark, Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS), CEA-DRF/IRFU, France, SRNSFG, Georgia, Federal Ministry of Education & Research (BMBF), HGF, Germany, Max Planck Society, Greek Ministry of Development-GSRT, RGC, China, Hong Kong SAR, China, Israel Science Foundation, Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland, NCN, Poland, Portuguese Foundation for Science and Technology European Commission, MNE/IFA, Romania, JINR, MESofRussia, Russian Federation, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia, MIZS, Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden, Wallenberg Foundation, Sweden, SERI, Switzerland, Swiss National Science Foundation (SNSF), Cantons of Bern and Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC), DOEandNSF, USA, BCKDF, Canada, CANARIE, Canada, ComputeCanada, Canada, CRC, Canada, IVADO, Canada, Beijing Municipal Science & Technology Commission, COST, France, ERC, France, ERDF, France, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union, France, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, Thales Group, Aristeia programmes, EU-ESF, Greece, Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain, CERCA Programme Generalitat de Catalunya, Spain, GenT Programmes Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust, BMWFW, Austria, Austrian Science Fund (FWF), Azerbaijan National Academy of Sciences (ANAS), D, Chile, Minciencias, Colombia
Published: 2021
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17. Radiological identification of the globus pallidus motor subregion in Parkinson’s disease

Author: Anders Sondergaard, Francesco Sammartino, Barbara Changizi, Vibhor Krishna, Rachel Marsh, and Fang-Cheng Yeh
Subjects: medicine.medical_specialty, Parkinson's disease, business.industry, medicine.medical_treatment, Healthy subjects, General Medicine, medicine.disease, Focused ultrasound, Globus pallidus, medicine, In patient, Pallidotomy, Radiology, business, Diffusion MRI, Tractography
Abstract: OBJECTIVE Globus pallidus (GP) lesioning improves motor symptoms of Parkinson’s disease (PD) and is occasionally associated with nonmotor side effects. Although these variable clinical effects were shown to be site-specific within the GP, the motor and nonmotor subregions have not been distinguished radiologically in patients with PD. The GP was recently found to have a distinct radiological signature on diffusion MRI (dMRI), potentially related to its unique cellular content and organization (or tissue architecture). In this study, the authors hypothesize that the magnitude of water diffusivity, a surrogate for tissue architecture, will radiologically distinguish motor from nonmotor GP subregions in patients with PD. They also hypothesize that the therapeutic focused ultrasound pallidotomy lesions will preferentially overlap the motor subregion. METHODS Diffusion MRI from healthy subjects (n = 45, test-retest S1200 cohort) and PD patients (n = 33) was parcellated based on the magnitude of water diffusivity in the GP, as measured orientation distribution function (ODF). A clustering algorithm was used to identify GP parcels with distinct ODF magnitude. The individual parcels were used as seeds for tractography to distinguish motor from nonmotor subregions. The locations of focused ultrasound lesions relative to the GP parcels were also analyzed in 11 patients with PD. RESULTS Radiologically, three distinct parcels were identified within the GP in healthy controls and PD patients: posterior, central, and anterior. The posterior and central parcels comprised the motor subregion and the anterior parcel was classified as a nonmotor subregion based on their tractography connections. The focused ultrasound lesions preferentially overlapped with the motor subregion (posterior more than central). The hotspots for motor improvement were localized in the posterior GP parcel. CONCLUSIONS Using a data-driven approach of ODF-based parcellation, the authors radiologically distinguished GP motor subregions in patients with PD. This method can aid stereotactic targeting in patients with PD undergoing surgical treatments, especially focused ultrasound ablation.
Published: 2022
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18. Strong evidence for parasympathetic sinoatrial reinnervation after heart transplantation

Author: J. Philip Saul, Katrine Rolid, Kari Nytrøen, Sissel Nygaard, Gaute Døhlen, Lars Gullestad, Arnt E. Fiane, Anders Haugom Christensen, Erik Thaulow, and Vegard Bruun Wyller
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Baroreceptor, Supine position, medicine.medical_treatment, Hemodynamics, Blood Pressure, Autonomic Nervous System, Heart Rate, Internal medicine, Heart rate, Valsalva maneuver, medicine, Humans, Heart rate variability, Heart transplantation, Transplantation, Hand Strength, business.industry, Heart, medicine.anatomical_structure, Cardiology, Heart Transplantation, Surgery, Cardiology and Cardiovascular Medicine, business, Reinnervation
Abstract: Background Heart transplantation (HTx) surgically denervates the heart. We examined indices of sinoatrial reinnervation, with emphasis on (1) the occurrence and timing of parasympathetic reinnervation, and (2) the consequences of reinnervation for heart rate (HR) responsiveness and arterial baroreceptor sensitivity. Methods Fifty HTx recipients were prospectively followed for 36 months after surgery. Hemodynamic variables and heart rate variability were continuously recorded at supine rest, 60 degrees head-up-tilt, during the Valsalva maneuver and during handgrip isometric exercise. Results Suggesting parasympathetic reinnervation: at baseline rest, root of the mean squared differences of successive RR intervals increased from median 3.9(5.9) to 7.1(5.1) ms (p < 0.001); high-frequency power increased from 4.0(12) to 5.7(18.9) ms2 (p = 0.018); and baroreceptor sensitivity increased from 0.04(0.36) to 1.3(2.4) ms/mmHg (p < 0.001). Suggesting sympathetic reinnervation: at baseline rest low-frequency power increased from 0.49(2.5) to 7.5(18.1) ms2 (p < 0.001); and HR responses to sympathetic stimulation during (1) head-up tilt increased from 1.9(4.2) to 9.1(8.2) bpm (p < 0.001), (2) Valsalva increased from 1.6(1.4) to 8.3(10.8) bpm (p < 0.001) and (3) handgrip increased from 0.3(0.6) to 1.9(5.1) bpm (p < 0.001). Signs of sympathetic reinnervation emerged within 6 months, while signs of parasympathetic reinnervation emerged by 24 months. Conclusions Root of the mean squared differences of successive RR intervals, high-frequency and low-frequency variability, HR responsiveness and arterial baroreflex sensitivity all increased after HTx, suggesting functional parasympathetic and sympathetic sinoatrial reinnervation. Accordingly, the pathological regulatory state present in heart transplant recipients, which is responsible for a host of functional and clinical abnormalities, is being partially offset over time by restored autonomic control of the heart in many heart transplant recipients.
Published: 2022
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19. Evolution of Coronavirus Disease 2019 (COVID-19) Symptoms During the First 12 Months After Illness Onset

Author: Amy Matser, Godelieve J. de Bree, Neeltje A. Kootstra, Anders Boyd, Marije R. de Wit, Menno D. de Jong, Joost G. van den Aardweg, Hugo D.G. van Willigen, Tjalling Leenstra, Marit J. van Gils, Maria Prins, Maartje Dijkstra, Elke Wynberg, Graduate School, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Infectious diseases, Experimental Immunology, APH - Aging & Later Life, Pulmonology, ACS - Pulmonary hypertension & thrombosis, AMS - Ageing & Vitality, AMS - Tissue Function & Regeneration, APH - Methodology, APH - Global Health, AII - Inflammatory diseases, ACS - Diabetes & metabolism, and Pulmonary medicine
Subjects: Microbiology (medical), medicine.medical_specialty, Long COVID, Coronavirus disease 2019 (COVID-19), Proportional hazards model, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Disease, medicine.disease, Obesity, recovery, Infectious Diseases, Disease severity, Internal medicine, medicine, symptoms, Who criteria, business, Prospective cohort study
Abstract: Background Few robust longitudinal data on long-term coronavirus disease 2019 (COVID-19) symptoms are available. We evaluated symptom onset, severity and recovery across the full spectrum of disease severity, up to one year after illness onset. Methods The RECoVERED Study is a prospective cohort study based in Amsterdam, the Netherlands. Participants aged ≥18 years were enrolled following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis via the local public health service and from hospitals. Standardized symptom questionnaires were completed at enrollment, 1 week and month later, and monthly thereafter. Clinical severity was defined according to World Health Organization (WHO) criteria. Kaplan-Meier methods were used to compare time from illness onset to symptom recovery, by clinical severity. We examined determinants of time to recovery using multivariable Cox proportional hazards models. Results Between 11 May 2020 and 1 May 2021, 342 COVID-19 patients (192 [56%] male) were enrolled, of whom 99/342 (29%) had mild, 145/342 (42%) moderate, 56/342 (16%) severe, and 42/342 (12%) critical disease. The proportion of participants who reported at least 1 persistent symptom at 12 weeks after illness onset was greater in those with severe/critical disease (86.7% [95% confidence interval {CI} = 76.5–92.7%]) compared to those with mild or moderate disease (30.7% [95% CI = 21.1–40.9%] and 63.8% [95% CI = 54.8–71.5%], respectively). At 12 months after illness onset, two-fifths of participants (40.7% [95% CI = 34.2–7.1]) continued to report ≥1 symptom. Recovery was slower in female compared to male participants (adjusted hazard ratio [aHR] 0.65 [95% CI = .47–.92]) and those with a body mass index [BMI] ≥30kg/m2 compared to BMI Conclusions COVID-19 symptoms persisted for one year after illness onset, even in some individuals with mild disease. Female sex and obesity were the most important determinants of speed of recovery from symptoms.
Published: 2022
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20. Genetics and voice production in childhood and adolescence – a review

Author: Christian F. Larsen, Anders Overgård Jønsson, and Mette Merete Pedersen
Subjects: Genetics, 050402 sociology, business.industry, 05 social sciences, Growth hormone, Voice production, Voice analysis, 03 medical and health sciences, 0302 clinical medicine, 0504 sociology, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Voice, Medicine, In patient, Voice change, business
Abstract: Adolescence is a challenging time of change in voicing, normally and in pathology. An increased focus on voice production in relation to genetics can expand our knowledge of the onset of puberty and voice change. Our aim with this review was to connect research of genetics to voice production in adolescence. We need further understanding of the developmental background of voice in childhood and adolescence, because many genetic multi handicaps include voice production. Genetic development related to voice production was the focus in a search made by the Royal English Society of Medicine, with only a few results. We supplemented with references to genetic studies of adults and animals as well as adjacent areas of voice production. The genetic development of voice production is steered from the hypothalamus probably related to growth hormone. The genetic voice production in adults form the basis for understanding development. Some research results were found related to the pubertal steps. The findings are important in the future, using advanced voice analysis and artificial intelligence methods in patients with Multi handicaps.
Published: 2022
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21. MR-proANP and NT-proBNP During Targeted Temperature Management Following Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the TTH48 Trial

Author: Hans Kirkegaard, Henriette Michelsen Bach, Christophe Henri Valdemar Duez, Eldar Søreide, Kristian Strand, Anders Morten Grejs, and Anni Nørgaard Jeppesen
Subjects: medicine.medical_specialty, natriuretic peptide, business.industry, Mr proanp, medicine.drug_class, medicine.medical_treatment, cardiac arrest, Targeted temperature management, Critical Care and Intensive Care Medicine, targeted temperature management, Out of hospital cardiac arrest, MR-proANP, Anesthesiology and Pain Medicine, NT-proBNP, Internal medicine, Post-hoc analysis, cardiovascular system, Natriuretic peptide, Cardiology, Medicine, In patient, prognostication, business
Abstract: We aimed to evaluate the effect of prolonged targeted temperature management (TTM) in patients with out-of-hospital cardiac arrest (OHCA) on the levels of midregional pro-atrial natriuretic peptide (MR-proANP) and N-terminal pro b-type natriuretic peptide (NT-proBNP) and assess their potential as prognostic biomarkers. A preplanned post hoc analysis of "Targeted temperature management for 48 h vs 24 h and neurologic outcome after out-of-hospital cardiac arrest: A randomized clinical trial (TTH48 trial)," where patients were randomized to TTM at 33°C ± 1°C of standard duration (24 hours) versus prolonged (48 hours). Blood samples were drawn from patients with OHCA at two Scandinavian university hospitals at admission to the ICU and at 24, 48, and 72 hours after reaching the target temperature. Primary outcome was levels of MR-proANP and NT-proBNP. Secondary outcome was cerebral performance category (CPC 1-5) at 6 months. Samples from 114 patients were analyzed. Prolonged TTM significantly decreased the levels of MR-proANP and NT-proBNP at 48 hours compared with standard 24 hours-TTM (p
Published: 2022
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22. Risk of Local Recurrence After Complete Mesocolic Excision for Right-Sided Colon Cancer: Post-Hoc Sensitivity Analysis of a Population-Based Study

Author: Anders Ulrich Neuenschwander, Jakob Kleif, and Claus Anders Bertelsen
Subjects: medicine.medical_specialty, education.field_of_study, Post hoc, business.industry, Colorectal cancer, Causal effect, Population, Gastroenterology, Absolute risk reduction, General Medicine, medicine.disease, Surgery, Population based study, Cohort, Medicine, Cumulative incidence, business, education
Abstract: BACKGROUND A causal treatment effect of complete mesocolic excision for right-sided colon cancer on the risk of recurrence has been shown, but it is still unclear whether this is caused solely by a risk reduction of local recurrence. OBJECTIVE To assess to what extent complete mesocolic excision attributes to the risk of local recurrence. DESIGN Post-hoc analyses of data from a population-based cohort. Inverse probability of treatment weighting and competing risk analyses were used to estimate the possible causal effects of complete mesocolic excision. SETTING Data from the four public colorectal cancer centers in the Capital Region of Denmark. PATIENTS Patients undergoing elective colon resections for right-sided colon cancer without distant metastases during the period 2010-2013. One center performed complete mesocolic excision, the remainder conventional resections. MAIN OUTCOME MEASURES The primary outcome was the cumulative incidence of solely local recurrence 5.2 years after surgery. Secondary outcomes were solely distant recurrence and both local and distant recurrence diagnosed within 180 days. RESULTS A total of 807 patients were included with 186 undergoing complete mesocolic excision and 621 conventional resections. The 5.2-year cumulative incidence of a solely local recurrence was 3.7% (95% CI: 0.5-6.1) after complete mesocolic excision compared with 7.0% (5.0-8.9) in the control group, and the absolute risk reduction of complete mesocolic excision was 3.7% (2.5-7.1; p=0.035). The absolute risk reduction on local and distant recurrence was 3.4% (1.3-5.6; p=0.0019) and on solely distant recurrence 3.1% (0.0-6.2; p=0.0516). LIMITATIONS The recurrence risk after conventional resection might under estimated by the use of inappropriate modalities to diagnose local recurrence for some patients and the shorter duration in this group. CONCLUSION This study shows a causal treatment effect of complete mesocolic excision on the risk of a solely local recurrence and of distant recurrence with or without local recurrence. See Video Abstract at http://links.lww.com/DCR/B832 .
Published: 2021
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23. Outstanding Response to Sorafenib in a Patient with Metastatic Gastrointestinal Stromal Tumour

Author: Tim Svenstrup Poulsen, Gina Al-Farra, Anders Krarup-Hansen, Marie Dehnfeld, Estrid Høgdall, Charlotte Brinch, Magnus Bergenfeldt, and Anders Toxværd
Subjects: Sorafenib, Multidisciplinary approach, Stromal cell, Gastrointestinal stromal tumour, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Case Report, gastrointestinal stromal tumour, digestive system diseases, Oncology, medicine, Cancer research, multidisciplinary approach, sorafenib, PDGFRA mutation, business, pdgfra mutation, neoplasms, RC254-282, medicine.drug
Abstract: Gastrointestinal stromal tumour (GIST) is the most common sarcoma and can be seen in any part of the gastrointestinal tract. The effect of tyrosine kinase inhibitors varies with mutation status in receptor tyrosine kinase KIT and in platelet-derived growth factor receptor A (PDGFRA). This case presents a 61-year-old man, diagnosed with an 11-cm GIST located at the stomach with a high risk of recurrence. The patient showed intolerance to imatinib shortly after introduction and subsequently progressed on sunitinib and nilotinib. The patient started fourth-line treatment with sorafenib with an impressive response to a point at which metastases intra-abdominally and in the liver could be resected. After surgery, sorafenib was restarted. Due to toxicity, sorafenib dose was reduced over time. The dose was insufficient to control the disease since a new recurrence was detected. Mutation analyses revealed a GIST harbouring a deletion of codon p.I843_D846del, located at PDGFRA exon 18, right next to the codon D842 where mutations are known leading to imatinib resistance. In this case, the GIST was highly sensitive to sorafenib, and the response was dose related. It is mandatory to perform mutation analyses on primary tumour and at recurrence in the decision-making of the correct treatment for the patient. In March 2021, the patient had been in treatment with sorafenib for 12.5 years and was still without signs of recurrence. A multidisciplinary approach was essential for the long-term survival of the patient in this case.
Published: 2021
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24. The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation analyses

Author: Marju Orho-Melander, Isabel Drake, Lena Strindberg, Per-Anders Jansson, Emanuel Fryk, Emma Ahlqvist, Anders Rosengren, Leif Groop, Annika Lundqvist, and Jan Borén
Subjects: Male, medicine.medical_specialty, Galectin 1, Endocrinology, Diabetes and Metabolism, Population, Renal function, 030209 endocrinology & metabolism, Type 2 diabetes, Population-based, Article, Diabetic nephropathy, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Diabetes mellitus, Chronic kidney disease, Galectin-1, Internal Medicine, medicine, Humans, Renal Insufficiency, Chronic, education, Mendelian randomisation, ANDIS, 030304 developmental biology, 0303 health sciences, education.field_of_study, business.industry, Middle Aged, medicine.disease, Obesity, 3. Good health, Prospective, Malmö Diet Cancer, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Cohort, Female, business, Kidney disease, Human, Genome-Wide Association Study, Glomerular Filtration Rate
Abstract: Aims/hypothesis Galectin-1 modulates inflammation and angiogenesis, and cross-sectional studies indicate that galectin-1 may be a uniting factor between obesity, type 2 diabetes and kidney function. We examined whether circulating galectin-1 can predict incidence of chronic kidney disease (CKD) and type 2 diabetes in a middle-aged population, and if Mendelian randomisation (MR) can provide evidence for causal direction of effects. Methods Participants (n = 4022; 58.6% women) in the Malmö Diet and Cancer Study–Cardiovascular Cohort enrolled between 1991 and 1994 (mean age 57.6 years) were examined. eGFR was calculated at baseline and after a mean follow-up of 16.6 ± 1.5 years. Diabetes status was ascertained through registry linkage (mean follow-up of 18.4 ± 6.1 years). The associations of baseline galectin-1 with incident CKD and type 2 diabetes were assessed with Cox regression, adjusting for established risk factors. In addition, a genome-wide association study on galectin-1 was performed to identify genetic instruments for two-sample MR analyses utilising the genetic associations obtained from the Chronic Kidney Disease Genetics (CKDGen) Consortium (41,395 cases and 439,303 controls) and the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (74,124 cases and 824,006 controls). One genome-wide significant locus in the galectin-1 gene region was identified (sentinel SNP rs7285699; p = 2.4 × 10−11). The association between galectin-1 and eGFR was also examined in individuals with newly diagnosed diabetes from the All New Diabetics In Scania (ANDIS) cohort. Results Galectin-1 was strongly associated with lower eGFR at baseline (p = 2.3 × 10−89) but not with incident CKD. However, galectin-1 was associated with increased risk of type 2 diabetes (per SD increase, HR 1.12; 95% CI 1.02, 1.24). Two-sample MR analyses could not ascertain a causal effect of galectin-1 on CKD (OR 0.92; 95% CI 0.82, 1.02) or type 2 diabetes (OR 1.05; 95% CI 0.98, 1.14) in a general population. However, in individuals with type 2 diabetes from ANDIS who belonged to the severe insulin-resistant diabetes subgroup and were at high risk of diabetic nephropathy, genetically elevated galectin-1 was significantly associated with higher eGFR (p = 5.7 × 10−3). Conclusions/interpretation Galectin-1 is strongly associated with lower kidney function in cross-sectional analyses, and two-sample MR analyses suggest a causal protective effect on kidney function among individuals with type 2 diabetes at high risk of diabetic nephropathy. Future studies are needed to explore the mechanisms by which galectin-1 affects kidney function and whether it could be a useful target among individuals with type 2 diabetes for renal improvement. Graphical abstract
Published: 2021

25. Intracranial Pressure Variability: A New Potential Metric of Cerebral Ischemia and Energy Metabolic Dysfunction in Aneurysmal Subarachnoid Hemorrhage?

Author: Anders Hånell, Elisabeth Ronne-Engström, Anders Lewén, Per Enblad, Teodor Svedung Wettervik, and Timothy Howells
Subjects: medicine.medical_specialty, Subarachnoid hemorrhage, business.industry, Ischemia, medicine.disease, Anesthesiology and Pain Medicine, Internal medicine, Metric (mathematics), medicine, Cardiology, Surgery, Neurology (clinical), business, Intracranial pressure
Published: 2021
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26. The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study

Author: Anders Grubb, Martin Magnusson, Erasmus Bachus, Liana Xhakollari, Margret Leosdottir, Peter M. Nilsson, Anders Christensson, and Amra Jujic
Subjects: Quality of life, medicine.medical_specialty, Cardiorenal syndrome, education, Renal function, Original Research Articles, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Original Research Article, Cystatin C, Mortality, Aged, Shrunken pore, Heart Failure, Proportional hazards model, business.industry, Hazard ratio, Odds ratio, Prognosis, medicine.disease, Confidence interval, Heart failure, Creatinine, RC666-701, Female, Cardiology and Cardiovascular Medicine, business, Glomerular Filtration Rate, Kidney disease
Abstract: AIMS: This study aimed to investigate the association between the 'Shrunken pore syndrome' (SPS) and risk of death, 30 day rehospitalization, and health-related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C /eGFRcreatinine ratio.METHODS AND RESULTS: A total of 373 patients hospitalized for HF [mean age 74.8 (±12.1) years; 118 (31.6%) women] were retrieved from the HeARt and brain failure inVESTigation trial (HARVEST-Malmo). Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas were used for estimation of glomerular filtration rate (eGFR). Presence of SPS was defined as eGFRcystatin C ≤ 60% of eGFRcreatinine . In Cox regression multivariate models, associations between SPS, risk of death (median follow-up time 1.8 years), and risk of 30 day rehospitalization were studied. Associations between SPS and impaired QoL were studied using multivariate logistic regressions. In multivariate models, SPS was associated with all-cause mortality [124 events; hazard ratio (HR) 1.99; 95% confidence interval (95% CI) 1.23-3.21; P = 0.005] and with 30 day rehospitalization (70 events; HR 1.82; CI 95% 1.04-3.18; P = 0.036). Analyses of QoL, based on a Kansas City Cardiomyopathy Questionnaire overall score < 50, revealed that SPS was associated with higher risk of low health-related QoL (odds ratios 2.15; CI 95% 1.03-4.49; P = 0.042).CONCLUSIONS: The results of this observational study show for the first time an association between SPS and poor prognosis in HF. Further studies are needed to confirm the results in HF cohorts and experimental settings to identify pathophysiological mechanisms. (Less)
Published: 2021

27. Risk factors and treatment of oxygenator high-pressure excursions during cardiopulmonary bypass

Author: Martin Lindgren, Anders Jeppsson, Lukas Lannemyr, and Anders Hjärpe
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, business.industry, General Medicine, law.invention, law, Inlet pressure, High pressure, Internal medicine, Cardiopulmonary bypass, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Safety Research, Oxygenator
Abstract: Introduction: A high-pressure excursion (HPE) is a sudden increase in oxygenator inlet pressure during cardiopulmonary bypass (CPB). The aims of this study were to identify factors associated with HPE, to describe a treatment protocol utilizing epoprostenol in severe cases, and to assess early outcome in HPE patients. Methods: Patients who underwent cardiac surgery with cardiopulmonary bypass at Sahlgrenska University Hospital 2016–2018 were included in a retrospective observational study. Pre- and post-operative data collected from electronic health records, local databases, and registries were compared between HPE and non-HPE patients. Factors associated with HPE were identified with logistic regression models. Results: In total, 2024 patients were analyzed, and 37 (1.8%) developed HPE. Large body surface area (adjusted Odds Ratio (aOR): 1.43 per 0.1 m2; 95% confidence interval (CI): 1.16–1.76, p < 0.001), higher hematocrit during CPB (aOR: 1.20 per 1%; (1.09–1.33), p < 0.001), acute surgery (aOR: 2.98; (1.26–6.62), p = 0.018), and previous stroke (aOR: 2.93; (1.03–7.20), p = 0.027) were independently associated with HPE. HPE was treated with hemodilution ( n = 29, 78.4%), and/or extra heparin ( n = 23, 62.2%), and/or epoprostenol ( n = 12, 32.4%). No oxygenator change-out was necessary. While there was no significant difference in 30-day mortality (2.7% vs 3.2%, p = 1.0), HPE was associated with a higher perioperative stroke rate (8.1% vs 1.8%, aOR 5.09 (1.17–15.57), p = 0.011). Conclusions: Large body surface area, high hematocrit during CPB, previous stroke and acute surgery were independently associated with HPE. A treatment protocol including epoprostenol appears to be a safe option. Perioperative stroke rate was increased in HPE patients.
Published: 2021
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28. Dextran‐based priming solution during cardiopulmonary bypass attenuates renal tubular injury—A secondary analysis of randomized controlled trial in adult cardiac surgery patients

Author: Anders Thorén, Kerstin Björk, Sven-Erik Ricksten, Anders Jeppsson, Anna Corderfeldt, Oscar Kolsrud, Göran Dellgren, and Mikael Barbu
Subjects: Adult, medicine.medical_specialty, Diuresis, Renal function, Kidney, law.invention, chemistry.chemical_compound, Randomized controlled trial, law, medicine, Cardiopulmonary bypass, Humans, Cardiac Surgical Procedures, Creatinine, Cardiopulmonary Bypass, business.industry, Acute kidney injury, Dextrans, General Medicine, Acute Kidney Injury, medicine.disease, Cardiac surgery, Anesthesiology and Pain Medicine, chemistry, Anesthesia, Complication, business
Abstract: BACKGROUND Acute kidney injury (AKI) is a well-known complication after cardiac surgery and cardiopulmonary bypass (CPB). In the present secondary analysis of a blinded randomized controlled trial, we evaluated the effects of a colloid-based versus a conventional crystalloid-based prime on tubular injury and postoperative renal function in patients undergoing cardiac surgery with CPB. METHODS Eighty-four adult patients undergoing cardiac surgery with CPB were randomized to receive either a crystalloid- or colloid- (dextran 40) based CPB priming solution. The crystalloid solution was based on Ringer-Acetate plus mannitol. The tubular injury biomarker, N-acetyl-b-D-glucosaminidase (NAG), serum creatinine and diuresis were measured before, during and after CPB. The incidence of AKI was assessed according to the KDIGO criteria. RESULTS The urinary-NAG/urinary-creatinine ratio rose in both groups during and after CPB, with a more pronounced increase in the crystalloid group (p = .038). One hour after CPB, the urinary-NAG/urinary-creatinine ratio was 88% higher in the crystalloid group (4.7 ± 6.3 vs. 2.5 ± 2.7, p = .045). Patients that received the dextran 40-based priming solution had a significantly lower intraoperative diuresis (p
Published: 2021
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29. An Artificial Intelligence–based Support Tool for Automation and Standardisation of Gleason Grading in Prostate Biopsies

Author: Ida Arvidsson, Agnieszka Krzyzanowska, Athanasios Simoulis, Kalle Åström, Anders Heyden, Felicia Elena Marginean, Niels Christian Overgaard, and Anders Bjartell
Subjects: Male, Prostate biopsy, medicine.diagnostic_test, business.industry, Intraclass correlation, Biopsy, Urology, Prostate, Gleason grading, Prostatic Neoplasms, Cancer, medicine.disease, Automation, Prostate cancer, medicine.anatomical_structure, Artificial Intelligence, Image Interpretation, Computer-Assisted, medicine, Humans, Artificial intelligence, Neoplasm Grading, business
Abstract: Background Gleason grading is the standard diagnostic method for prostate cancer and is essential for determining prognosis and treatment. The dearth of expert pathologists, the inter- and intraobserver variability, as well as the labour intensity of Gleason grading all necessitate the development of a user-friendly tool for robust standardisation. Objective To develop an artificial intelligence (AI) algorithm, based on machine learning and convolutional neural networks, as a tool for improved standardisation in Gleason grading in prostate cancer biopsies. Design, setting, and participants A total of 698 prostate biopsy sections from 174 patients were used for training. The training sections were annotated by two senior consultant pathologists. The final algorithm was tested on 37 biopsy sections from 21 patients, with digitised slide images from two different scanners. Outcome measurements and statistical analysis Correlation, sensitivity, and specificity parameters were calculated. Results and limitations The algorithm shows high accuracy in detecting cancer areas (sensitivity: 100%, specificity: 68%). Compared with the pathologists, the algorithm also performed well in detecting cancer areas (intraclass correlation coefficient [ICC]: 0.99) and assigning the Gleason patterns correctly: Gleason patterns 3 and 4 (ICC: 0.96 and 0.94, respectively), and to a lesser extent, Gleason pattern 5 (ICC: 0.82). Similar results were obtained using two different scanners. Conclusions Our AI-based algorithm can reliably detect prostate cancer and quantify the Gleason patterns in core needle biopsies, with similar accuracy as pathologists. The results are reproducible on images from different scanners with a proven low level of intraobserver variability. We believe that this AI tool could be regarded as an efficient and interactive tool for pathologists. Patient summary We developed a sensitive artificial intelligence tool for prostate biopsies, which detects and grades cancer with similar accuracy to pathologists. This tool holds promise to improve the diagnosis of prostate cancer.
Published: 2021
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30. A Cost-Consequence Analysis of Different Screening Procedures in Alzheimer’s Disease: Results from the MOPEAD Project

Author: Wimo, Anders, Belger, Mark, Sannemann, Lena, Stoekenbroek, Malou, Gurruchaga Telleria, Miren, Valero, Sergi, Vermunt, Lisa, Waterink, Lisa, Winblad, Bengt, Visser, Peter Jelle, Zwan, Marissa, Boada, Mercè, Bon, Jaka, Collaborators, consortium, members of the MOPEAD, Escher, Claus, Müller, Theresa, Bogdanovic, Nenad, Andersen, Pia, Spulber, Gabriela, Sundström, Maria, Westman, Eric, Ferreira, Daniel, Jessen, Frank, Jelic, Vesna, Haglund, Anders, Stomrud, Erik, Nelvig, Anders, Saha, Samir, Petek, Davorina, Serné, Erik, Dumas, Annette, Kramberger, Milica G, Jamilis, Laura, Johansson, Gunilla, Rodrigo Salas, Adrián, Rodríguez Gómez, Octavio, Clinical chemistry, Neurology, and Amsterdam Neuroscience - Neurodegeneration
Subjects: medicine.medical_specialty, Referral, statistics & numerical data [Internet], Cost consequences, diagnosis, Cost-Benefit Analysis, Population, costs, Primary care, Disease, cost analysis, Alzheimer Disease, Diabetes mellitus, medicine, Diabetes Mellitus, Dementia, Humans, Mass Screening, ddc:610, education, Screening procedures, education.field_of_study, Internet, Primary Health Care, business.industry, General Neuroscience, economics [Primary Health Care], screening, diagnosis [Alzheimer Disease], General Medicine, medicine.disease, Europe, Psychiatry and Mental health, Clinical Psychology, Family medicine, cost-consequence analysis, statistics & numerical data [Primary Health Care], diagnostic work-up, Geriatrics and Gerontology, Patient Participation, business, economics [Internet], Alzheimer’s disease, Research Article, dementia
Abstract: Background: For care planning and support, under-detection and late diagnosis of Alzheimer’s disease (AD) is a great challenge. Models of Patient-Engagement for Alzheimer’s Disease (MOPEAD) is an EU-funded project aiming at testing different strategies to improve this situation. Objective: To make a cost-consequence analysis of MOPEAD. Methods: Four screening strategies were tested in five countries (Germany, the Netherlands, Slovenia, Spain, and Sweden): 1) a web-approach; 2) Open-House initiative; 3) in primary care; and 4) by diabetes specialists. Persons-at-risk of AD in all strategies were offered referral to a hospital-based specialist. The primary health-economic outcome was the cost per true-positive case (TP) of AD from the screened population. Results: Of 2,847 screened persons, 1,121 screened positive (39%), 402 were evaluated at memory clinics (14%), and 236 got an AD diagnosis (8%). The cost per TP of those screened was €3,115 with the web-approach, €2,722 with the Open-House, €1,530 in primary care, and €1,190 by diabetes specialists. Sensitivity analyses that more likely reflect the real-world situation confirmed the results. The number-needed-to-screen was 30 with the web-approach, 8 with the Open-House and primary care, and 6 with the diabetes specialists. There were country differences in terms of screening rates, referrals to memory clinics, staff-types involved, and costs per TP. Conclusion: In primary care and by the diabetes specialist, the costs per TP/screened population were lowest, but the capacity of such settings to identify cases with AD-risk must be discussed. Hence new diagnostic strategies such as web-solutions and Open-House initiatives may be valuable after modifications.
Published: 2021
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31. Acute kidney injury and risk of cardiovascular outcomes: A nationwide cohort study

Author: Gunnar Gislason, Anders Bonde Nissen, Paul Blanche, Philip Andreas Schytz, Nicholas Carlson, Karl Emil Nelveg-Kristensen, Christian Torp-Pedersen, and Kristine Hommel
Subjects: medicine.medical_specialty, Creatinine, business.industry, medicine.medical_treatment, Acute kidney injury, Renal function, medicine.disease, Transplantation, chemistry.chemical_compound, chemistry, Nephrology, Internal medicine, Heart failure, medicine, business, Stroke, Dialysis, Cohort study
Abstract: BACKGROUND: Acute kidney injury (AKI) has been associated with cardiovascular disease, but this is sparsely studied in non-selected populations and with little attention to the effect in age and renal function. Using nationwide administrative data, we investigated the hypothesis of increased one-year risk of cardiovascular event or death associated with AKI.METHODS: In a cohort study, we identified all admissions in Denmark between 2008 and 2018. AKI was defined as ≥1.5 times increase from baseline to peak creatinine during admission, or dialysis. We excluded patients with age RESULTS: Among 565,056 hospital admissions, 39,569 (7.0%) cases of AKI were present. In total, 18,642 patients sustained a cardiovascular outcome. AKI was significantly associated with cardiovascular outcome with an adjusted OR [CI] of 1.33 [1.16-1.53], 1.43 [1.33-1.54], 1.23 [1.14-1.34], 1.38 [1.18-1.62] for eGFR ≥90, 60-89, 30-59 and 15-29ml/min/1.73m 2, respectively. When omitting the outcome heart failure, these results were 1.24 [1.06-1.45], 1.22 [1.11-1.33], 1.05 [0.95-1.16], 1.25 [1.02-1.54]. Results did not change substantially in strata of age groups, in AKI stages and in the subcohort adjusted for proteinuria. CONCLUSION: Non-selected patients aged 50 years or above with AKI during admission had significantly higher one-year risk of cardiovascular event or death, especially, but not only due to heart failure, independent of age and eGFR.
Published: 2022
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32. Different Responses to Neoadjuvant Chemotherapy in Urothelial Carcinoma Molecular Subtypes

Author: Hans Olsson, Gottfrid Sjödahl, Gunilla Chebil, Mattias Höglund, Petter Kollberg, Kristina Lövgren, Johan Abrahamsson, Pontus Eriksson, Anders Ullén, Karin Holmsten, Carina Bernardo, Claes Lindh, Fredrik Liedberg, Iva Johansson, and Nour Al Dain Marzouka
Subjects: Oncology, medicine.medical_specialty, Urology, medicine.medical_treatment, Transcriptome, Cystectomy, Basal (phylogenetics), Internal medicine, medicine, Osteopontin, Stage (cooking), Cisplatin, Cancer och onkologi, Chemotherapy, Bladder cancer, biology, business.industry, Hazard ratio, Retrospective cohort study, medicine.disease, Urothelial carcinoma, Molecular subtypes, Luminal, Basal, squamous, Neoadjuvant, Response, Survival, SPP1, Signature, Cancer and Oncology, biology.protein, Immunohistochemistry, business, Immunostaining, medicine.drug
Abstract: Background For muscle-invasive bladder cancer (MIBC), no tissue biomarkers are available for clinical use to predict response to neoadjuvant chemotherapy. Objective To investigate how molecular subtypes impact pathological response and survival in patients receiving preoperative cisplatin-based chemotherapy. Design, setting, and participants Classification of a retrospective cohort of 149 patients was performed by tumor transcriptomic profiling and immunostaining. A cohort treated with radical cystectomy alone and public data sets were used for comparison and external validation. Outcome measurements and statistical analysis Complete pathological response in the cystectomy specimen (ypT0N0) and survival were compared in predefined molecular subtypes. Differential gene expression and chemotherapy response were explored beyond molecular subtypes. Results and limitations Patients with genomically unstable (GU) and urothelial-like (Uro) tumors had higher proportions of complete pathological response (16/31 [52%] and 17/54 [31%]), versus five out of 24 (21%) with the basal/squamous (Ba/Sq) subtype following neoadjuvant chemotherapy and radical cystectomy. Molecular subtype was independently associated with improved survival for patients with GU tumors (hazard ratio [HR] 0.29, 95% confidence interval [CI]: 0.11–0.79) and UroC tumors (HR 0.37, 95% CI: 0.14–0.94) compared with Ba/Sq tumors, adjusting for clinical stage. In addition, expression of the gene coding for osteopontin (SPP1) showed a subtype-dependent effect on chemotherapy response. Conclusions Urothelial cancer of the luminal-like (GU and Uro) subtypes is more responsive to cisplatin-based neoadjuvant chemotherapy. A second-generation of subtype-specific biomarkers, for example, SPP1, may be a way forward to develop a more precision-based treatment approach for neoadjuvant chemotherapy in MIBC. Patient summary This study shows that tumor classification by gene expression profiling and molecular subtyping can identify patients who are more likely to benefit from chemotherapy before radical cystectomy for muscle-invasive bladder cancer. Together with other markers for response, molecular subtypes could have a role in selective administration of such chemotherapy.
Published: 2022
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33. The effects of blood flow restriction resistance training on indices of delayed onset muscle soreness and peak power

Author: Richard J. Schmidt, Christopher E. Proppe, Ethan C. Hill, John Paul V. Anders, Cory M. Smith, Glen O. Johnson, Paola M. Rivera, Joshua L. Keller, Joel T. Cramer, and Terry J. Housh
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Delayed onset muscle soreness, Biophysics, Cardiology, medicine, Resistance training, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, medicine.symptom, business, Blood flow restriction
Abstract: BACKGROUND: Low-load resistance training with blood flow restriction (LL + BFR) attenuated delayed onset muscle soreness (DOMS) under some conditions. OBJECTIVE: The purpose of this study examined the effects of reciprocal concentric-only elbow flexion-extension muscle actions at 30% of peak torque on indices of DOMS. METHODS: Thirty untrained women (mean ± SD; 22 ± 2.4 years) were randomly assigned to 6 training days of LL + BFR (n= 10), low-load non-BFR (LL) (n= 10), or control (n= 10). Participants completed 4 sets (1 × 30, 3 × 15) of submaximal (30% of peak torque), unilateral, isokinetic (120∘s-1) muscle actions. Indices of DOMS including peak power, resting elbow joint angle (ROM), perceived muscle soreness (VAS), and pain pressure threshold (PPT) were assessed. RESULTS: There were no changes in peak power, ROM, or VAS. There was a significant interaction for PPT. Follow-up analyses indicated PPT increased for the LL + BFR condition (Day 5 > Day 2), but did not decrease below baseline. The results of the present study indicated LL + BFR and LL did not induce DOMS for the elbow extensors in previously untrained women. CONCLUSION: These findings suggested LL + BFR and LL concentric-only resistance training could be an effective training modality to elicit muscular adaptation without inducing DOMS.
Published: 2022
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34. Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls

Author: Emily de Coursey, Jesper Magnusson, Susannah Leach, Seema Baid-Agrawal, Carin Wallquist, Andreas Schult, Kristjan Karason, Lars-Magnus Andersson, Inger Holm Gunnarsson, Jan-Åke Liljeqvist, John Mackay Søfteland, Jan Stenström, Hanna Jacobsson, Magnus Gisslén, Mats Bemark, Marie Felldin, Jan Ekelund, Vanda Friman, and Anders Bergdahl
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), media_common.quotation_subject, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, Antibodies, Viral, Gastroenterology, Disease severity, Internal medicine, Humans, Immunology and Allergy, Medicine, Pharmacology (medical), Longitudinal Studies, media_common, Transplantation, biology, SARS-CoV-2, business.industry, Longevity, COVID-19, Immunosuppression, Organ Transplantation, Transplant Recipients, biology.protein, Antibody, business, Solid organ transplantation, Paired Analysis
Abstract: Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n = 65) were matched with controls (n = 65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG antibodies against N and S antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti-N-IgG at all time points (1 month p = .007, 3 months p .001, 6 months p = .019, and 9 months p = .021) but not anti-S-IgG at any time points. A mixed-model analysis confirmed these findings except for anti-S-IgG at 1 month (p = .005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S-specific, but not N-specific, antibody responses to SARS-CoV-2 infection compared to immunocompetent controls.
Published: 2022
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35. In vitro Inhibition of respiratory pathogens by lactobacillus and alpha haemolytic streptococci from Aboriginal and Torres Strait Islander children

Author: Julian Zaugg, Kyra Cottrell, Anders Cervin, Andrea Coleman, Seweryn Bialasiewicz, Alexander Håkansson, and Eva Grahn Håkansson
Subjects: biology, medicine.drug_class, Antibiotics, Australia, Streptococcus, General Medicine, Amoxicillin, medicine.disease_cause, biology.organism_classification, Applied Microbiology and Biotechnology, Anti-Bacterial Agents, Microbiology, Haemophilus influenzae, Moraxella catarrhalis, Lactobacillus, Otitis Media, Antibiotic resistance, Ampicillin, Clavulanic acid, Streptococcus pneumoniae, medicine, Humans, Biotechnology, medicine.drug
Abstract: Aims To explore the in vitro ability of alpha haemolytic streptococcus (AHS) and lactobacilli (LBs), from Indigenous Australian children, to inhibit the growth of respiratory pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis), also from Indigenous Australian children. Methods and Results The bacterial interference of 91 isolates, from Indigenous Australian children both with and without otitis media (OM) or rhinorrhoea, was investigated using agar overlay and cell-free supernatant. Promising isolates underwent whole genome sequencing to investigate upper respiratory tract tropism, antibiotic resistance and virulence. Antibiotic susceptibility was examined for ampicillin, amoxicillin +clavulanic acid and azithromycin. Differences in the strength of bacterial inferences in relation to OM was examined using a case series of three healthy and three children with OM. LBs readily inhibited the growth of pathogens. AHS were less effective, although several isolates inhibited S. pneumoniae. One L. rhamnosus had genes coding for pili to adhere to epithelial cells. We detected antibiotic resistance genes coding for antibiotic efflux pump and ribosomal protection protein. LBs were susceptible to antimicrobials in vitro. Screening for virulence detected genes encoding for two putative capsule proteins. Healthy children had AHS and LB that were more potent inhibitors of respiratory pathogens in vitro than children with OM. Conclusions L. rhamnosus from remote Indigenous Australian children are potent inhibitors of respiratory pathogens in vitro. Significance and Impact of Study Respiratory/ear disease are endemic in Indigenous Australians. There is an urgent call for more effective treatment/prevention; beneficial microbes have not been explored. L. rhamnosus investigated in this study are potent inhibitors of respiratory pathogens in vitro and require further investigation.
Published: 2022
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36. The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden

Author: Charlotta Edlund, Anders Ternhag, Gunilla Skoog Ståhlgren, Petra Edquist, Åse Östholm Balkhed, Simon Athlin, Emeli Månsson, Maria Tempé, Jakob Bergström, Christian G Giske, Håkan Hanberger, Daniel Holmström, Anna-Karin Lindgren, Gisela Otto, Maria Furberg, Johan Fält, and Elin Hedman
Subjects: Adult, Male, medicine.medical_specialty, Cefotaxime, medicine.drug_class, Antibiotics, Penicillins, Internal medicine, medicine, Clinical endpoint, Humans, Dysuria, Temocillin, Adverse effect, Sweden, business.industry, Anti-Bacterial Agents, Gastrointestinal Microbiome, Ciprofloxacin, Infectious Diseases, Urinary Tract Infections, Female, medicine.symptom, business, Cefixime, medicine.drug
Abstract: Summary Background Use of third-generation cephalosporins, such as cefotaxime, is associated with an increased risk of selection for antimicrobial resistance, so alternative antibiotics need to be considered. The aim of the present study was to evaluate intestinal colonisation with third-generation cephalosporin-resistant pathogens following use of temocillin—an alternative antibiotic to cefotaxime that is potentially less prone to disturbing the intestinal microbiota—in empirical treatment of febrile urinary tract infection (UTI). Methods We did a randomised, multicentre, superiority, open-label phase 4 trial in patients who had been admitted to inpatient care in 12 Swedish hospitals with suspected or diagnosed febrile UTI (complicated or uncomplicated). To meet inclusion criteria, a patient was required to have at least one sign or symptom of pyelonephritis (ie, flank pain; costovertebral angle tenderness; and changes to urinary frequency or urgency or dysuria), a fever of 38·0°C or higher, and a positive urine dipstick (for nitrites, white blood cells, or both). Participants were also required to have an indication for intravenous antibiotic treatment. Participants were randomly assigned (1:1) to receive either 2 g temocillin or 1–2 g cefotaxime, by local investigators opening consecutive sealed randomisation envelopes that were generated centrally in advance. Both drugs were administered intravenously every 8 h. The trial was open label for investigators and patients, but those doing the microbiological analyses were masked to the groups. Participants were treated with antibiotics for 7–10 days (or up to 14 days if they had bacteraemia), at least 3 days of which were on the study drug; at day 4 and later, participants who were showing improvement could be given an oral antibiotic (ciprofloxacin, ceftibuten, cefixime, or co-trimoxazole). Patients not showing improvement were regarded as having treatment failures. Rectal swabs were collected at three timepoints: at baseline (before the first dose), after the last dose of study drug, and 7–10 days after treatment stopped. The composite primary outcome was colonisation with Enterobacterales with reduced susceptibility to third-generation cephalosporins, or colonisation with toxin-producing Clostridioides difficile, or both, to evaluate disturbance of the intestinal microbiota. The study is registered in the EU Clinical Trials Register (EudraCT 2015-003898-15). Findings Between May 20, 2016, and July 31, 2019, 207 patients were screened for eligibility, of whom 55 patients were excluded. 152 participants were randomly assigned to groups: 77 (51%) patients received temocillin, 75 (49%) patients received cefotaxime. The composite primary endpoint was met by 18 (26%) of 68 participants receiving temocillin versus 30 (48%) of 62 patients receiving cefotaxime (risk difference −22% [95% CI −42% to −3%]), showing superiority of temocillin versus cefotaxime (ie, less disturbance of the intestinal microbiota). 43 adverse events were reported in 40 (52%) of 77 patients in the temocillin group, versus 46 adverse events in 34 (45%) of 75 patients in the cefotaxime group. Most events were of mild to moderate severity. 21 (27%) patients in the temocillin and 17 (23%) patients in the cefotaxime group had an adverse event that was considered to be associated with the study drug. Interpretation Temocillin was found to be less selective than cefotaxime of Enterobacterales with reduced susceptibility to third-generation cephalosporins, and it could therefore be a favourable alternative in the empirical treatment of febrile UTI. Use of this antibiotic could reduce hospital transmission and health-care-associated infections by these pathogens. Funding Public Health Agency of Sweden.
Published: 2022
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37. Safety and Glycemic Outcomes During the MiniMed™ Advanced Hybrid Closed-Loop System Pivotal Trial in Adolescents and Adults with Type 1 Diabetes

Author: Richard A.M. Jonkers, Robert A. Vigersky, John H. Shin, Toni L. Cordero, Anirban Roy, Dorothy I. Shulman, Rodica Pop-Busui, Melissa Vella, Athena Philis-Tsimikas, Mark Kipnes, Benyamin Grosman, John C. Reed, Xiaoxiao Chen, Andrew S. Rhinehart, Kevin B. Kaiserman, Mark P. Christiansen, Anders L. Carlson, James Thrasher, Bruce W. Bode, Robert H. Slover, Jennifer L. Sherr, Scott W. Lee, Ron Brazg, Satish K. Garg, and David R. Lilenquist
Subjects: Adult, Blood Glucose, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Young Adult, Insulin Infusion Systems, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Aged, Glycemic, Type 1 diabetes, business.industry, Blood Glucose Self-Monitoring, Middle Aged, medicine.disease, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Basal (medicine), Cardiology, Bolus (digestion), business, Closed loop
Abstract: Introduction: This trial assessed safety and effectiveness of an advanced hybrid closed-loop (AHCL) system with automated basal (Auto Basal) and automated bolus correction (Auto Correction) in adol...
Published: 2022
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38. Ursodeoxycholic acid and liver disease associated with cystic fibrosis: A multicenter cohort study

Author: Helen M. Evans, Elena Kondratyeva, Mark R. Oliver, Carla Colombo, Isabelle de Monestrol, F. Alghisi, Rita Padoan, Chee Y. Ooi, Grant A. Ramm, Nataliya Kashirskaya, Fabiola Corti, Gianfranco Alicandro, Peter Lewindon, Anders Lindblad, I. Asherova, and Birgitta Strandvik
Subjects: 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Incidence (epidemiology), medicine.disease, Gastroenterology, Cystic fibrosis, Ursodeoxycholic acid, 03 medical and health sciences, Liver disease, 030104 developmental biology, 0302 clinical medicine, 030228 respiratory system, Interquartile range, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Cumulative incidence, business, Liver Disease Associated with Cystic Fibrosis, Cohort study, medicine.drug
Abstract: Background The efficacy and safety of ursodeoxycholic acid (UDCA) for the treatment of liver disease associated with cystic fibrosis (CF) are under discussion, and clinical practice varies among centers. The study aimed at evaluating if the incidence of severe liver disease differs between CF centers routinely prescribing or not prescribing UDCA. Methods We carried out a retrospective multicenter cohort study including 1591 CF patients (1192 patients from UDCA-prescribing centers and 399 from non-prescribing centers) born between 1990 and 2007 and followed from birth up to 31 December 2016. We computed the crude cumulative incidence (CCI) of portal hypertension (PH) at the age of 20 years in the two groups and estimated the subdistribution hazard ratio (HR) through a Fine and Gray model. Results Over the observation period, 114 patients developed PH: 90 (7.6%) patients followed-up in UDCA prescribing centers and 24 (6.0%) in non-prescribing centers. The CCI of PH at 20 years was 10.1% (95% CI: 7.9-12.3) in UDCA-prescribing and 7.7% (95% CI: 4.6-10.7) in non-prescribing centers. The HR among patients followed in prescribing centers indicated no significant difference in the rate of PH either in the unadjusted model (HR: 1.21, 95% CI: 0.69-2.11) or in the model adjusted for pancreatic insufficiency (HR: 1.28, 95% CI: 0.77-2.12). Conclusions CF patients followed-up in UDCA prescribing centers did not show a lower incidence of PH as compared to those followed in centers not prescribing UDCA. These results question the utility of UDCA in reducing the occurrence of severe liver disease in CF.
Published: 2022
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39. Association of alcohol-induced loss of consciousness and overall alcohol consumption with risk for dementia

Author: Marie Zins, May A. Beydoun, Jane E. Ferrie, Séverine Sabia, Lars Alfredsson, Gill Livingston, Markus Jokela, Pyry N Sipilä, Mika Kivimäki, Solja T. Nyberg, Aki Koskinen, Marcel Goldberg, G. David Batty, Jaana Pentti, Archana Singh-Manoux, Peter Westerholm, Timo E. Strandberg, Anders Knutsson, Sakari Suominen, Jussi Vahtera, Ari Väänänen, Andrew Sommerlad, Joni V Lindbohm, Sarah Floud, Department of Public Health, Clinicum, Faculty of Medicine, University of Helsinki, Department of Psychology and Logopedics, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, and Helsinki University Hospital Area
Subjects: Male, Unconsciousness, SWEDISH, Cohort Studies, 0302 clinical medicine, Risk Factors, 030212 general & internal medicine, Finland, Original Investigation, DAMAGE, education.field_of_study, Hazard ratio, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Middle Aged, Alcoholism, Online Only, Female, France, Public Health, medicine.symptom, MIDLIFE, Cohort study, Adult, Adolescent, Population, Binge drinking, 03 medical and health sciences, mental disorders, medicine, Dementia, Humans, CORONARY-HEART-DISEASE, Risk factor, education, BINGE DRINKING, METAANALYSIS, Aged, Proportional Hazards Models, Sweden, DECLINE, Ethanol, Proportional hazards model, business.industry, Research, Klinisk medicin, medicine.disease, COGNITIVE IMPAIRMENT, LIFE-STYLE FACTORS, United Kingdom, Featured, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 3121 General medicine, internal medicine and other clinical medicine, Clinical Medicine, business, FOLLOW-UP, 030217 neurology & neurosurgery, Demography
Abstract: Key Points Question Are alcohol-induced loss of consciousness and heavy weekly alcohol consumption associated with increased risk of future dementia? Findings In this multicohort study of 131 415 adults, a 1.2-fold excess risk of dementia was associated with heavy vs moderate alcohol consumption. Those who reported having lost consciousness due to alcohol consumption, regardless of their overall weekly consumption, had a 2-fold increased risk of dementia compared with people who had not lost consciousness and were moderate drinkers. Meaning The findings of this study suggest that alcohol-induced loss of consciousness is a long-term risk factor for dementia among both heavy and moderate drinkers., Importance Evidence on alcohol consumption as a risk factor for dementia usually relates to overall consumption. The role of alcohol-induced loss of consciousness is uncertain. Objective To examine the risk of future dementia associated with overall alcohol consumption and alcohol-induced loss of consciousness in a population of current drinkers. Design, Setting, and Participants Seven cohort studies from the UK, France, Sweden, and Finland (IPD-Work consortium) including 131 415 participants were examined. At baseline (1986-2012), participants were aged 18 to 77 years, reported alcohol consumption, and were free of diagnosed dementia. Dementia was examined during a mean follow-up of 14.4 years (range, 12.3-30.1). Data analysis was conducted from November 17, 2019, to May 23, 2020. Exposures Self-reported overall consumption and loss of consciousness due to alcohol consumption were assessed at baseline. Two thresholds were used to define heavy overall consumption: greater than 14 units (U) (UK definition) and greater than 21 U (US definition) per week. Main Outcomes and Measures Dementia and alcohol-related disorders to 2016 were ascertained from linked electronic health records. Results Of the 131 415 participants (mean [SD] age, 43.0 [10.4] years; 80 344 [61.1%] women), 1081 individuals (0.8%) developed dementia. After adjustment for potential confounders, the hazard ratio (HR) was 1.16 (95% CI, 0.98-1.37) for consuming greater than 14 vs 1 to 14 U of alcohol per week and 1.22 (95% CI, 1.01-1.48) for greater than 21 vs 1 to 21 U/wk. Of the 96 591 participants with data on loss of consciousness, 10 004 individuals (10.4%) reported having lost consciousness due to alcohol consumption in the past 12 months. The association between loss of consciousness and dementia was observed in men (HR, 2.86; 95% CI, 1.77-4.63) and women (HR, 2.09; 95% CI, 1.34-3.25) during the first 10 years of follow-up (HR, 2.72; 95% CI, 1.78-4.15), after excluding the first 10 years of follow-up (HR, 1.86; 95% CI, 1.16-2.99), and for early-onset (, This cohort study examines the association of overall consumption of alcohol and resultant loss of consciousness with risk for dementia.
Published: 2023
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40. Sex differences in the genetics of sarcoidosis across European and African ancestry populations

Author: Vasiliki Vasila, Nathan Pezant, Lori Garman, Joachim Müller-Quernheim, Stefan Schreiber, Susanna Kullberg, Leonid Padyukov, Benjamin A. Rybicki, Anders Eklund, Johan Grunewald, David Ellinghaus, Michael C. Iannuzzi, Courtney G. Montgomery, Natalia V. Rivera, and Ying Xiong
Subjects: Evolutionary biology, medicine, Sarcoidosis, General Medicine, Biology, medicine.disease
Abstract: BackgroundSex differences in the susceptibility of sarcoidosis are unknown. The study aims to identify sex-dependent genetic variations in two clinical sarcoidosis phenotypes: Löfgren’s syndrome (LS) and non-Löfgren’s syndrome (non-LS).MethodsA meta-analysis of genome-wide association studies was conducted on Europeans and African Americans, totaling 10,103 individuals from three population-based cohorts, Sweden (n = 3,843), Germany (n = 3,342), and the United States (n = 2,918), followed by an SNP lookup in the UK Biobank (UKB, n = 387,945). A genome-wide association study based on Immunochip data consisting of 141,000 single nucleotide polymorphisms (SNPs) was conducted in the sex groups. The association test was based on logistic regression using the additive model in LS and non-LS sex groups independently. Additionally, gene-based analysis, gene expression, expression quantitative trait loci (eQTL) mapping, and pathway analysis were performed to discover functionally relevant mechanisms related to sarcoidosis and biological sex.ResultsWe identified sex-dependent genetic variations in LS and non-LS sex groups. Genetic findings in LS sex groups were explicitly located in the extended Major Histocompatibility Complex (xMHC). In non-LS, genetic differences in the sex groups were primarily located in the MHC class II subregion and ANXA11. Gene-based analysis and eQTL enrichment revealed distinct sex-specific gene expression patterns in various tissues and immune cell types. In LS sex groups, a pathway map related to antigen presentation machinery by IFN-gamma. In non-LS, pathway maps related to immune response lectin-induced complement pathway in males and related to maturation and migration of dendritic cells in skin sensitization in females were identified.ConclusionOur findings provide new evidence for a sex bias underlying sarcoidosis genetic architecture, particularly in clinical phenotypes LS and non-LS. Biological sex likely plays a role in disease mechanisms in sarcoidosis.
Published: 2023
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41. Involuntary treatment in patients with anorexia nervosa:utilization patterns and associated factors

Author: Liselotte Petersen, Benjamin Mac Donald, Loa Clausen, Janne Tidselbak Larsen, Cynthia M. Bulik, and Anders Helles Carlsen
Subjects: Male, coercion, Pediatrics, medicine.medical_specialty, epidemiological factors, compulsory treatment, business.industry, Anorexia Nervosa/therapy, eating disorders, anorexia nervosa, Cohort Studies, Hospitalization, Psychiatry and Mental health, severe and enduring anorexia nervosa, Anorexia nervosa (differential diagnoses), Involuntary treatment, Humans, Medicine, Female, In patient, involuntary treatment, business, Applied Psychology, Retrospective Studies
Abstract: BackgroundA subgroup of patients with anorexia nervosa (AN) undergoing involuntary treatment (IT) seems to account for most of the IT events. Little is known about these patients and their treatment including the temporal distribution of IT events and factors associated with subsequent utilization of IT. Hence, this study explores (1) utilization patterns of IT events, and (2) factors associated with subsequent utilization of IT in patients with AN.MethodsIn this nationwide Danish register-based retrospective exploratory cohort study patients were identified from their first (index) hospital admission with an AN diagnosis and followed up for 5 years. We explored data on IT events including estimated yearly and total 5-year rates, and factors associated with subsequent increased IT rates and restraint, using regression analyses and descriptive statistics.ResultsIT utilization peaked in the initial few years starting at or following the index admission. A small percentage (1.0%) of patients accounted for 67% of all IT events. The most frequent measures reported were mechanical and physical restraint. Factors associated with subsequent increased IT utilization were female sex, lower age, previous admissions with psychiatric disorders before index admission, and IT related to those admissions. Factors associated with subsequent restraint were lower age, previous admissions with psychiatric disorders, and IT related to these.ConclusionsHigh IT utilization in a small percentage of individuals with AN is concerning and can lead to adverse treatment experiences. Exploring alternative approaches to treatment that reduce the need for IT is an important focus for future research.
Published: 2023
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42. Associations between depression and cardiometabolic health: A 27-year longitudinal study

Author: Anders M. Dale, Amy J. Jak, Kristy Cuthbert, Michael C. Neale, Lisa T. Eyler, Carol E. Franz, William S. Kremen, Richard L. Hauger, Xin Tu, Richard Vandiver, McKenna E. Williams, Chandra A. Reynolds, Ole A. Andreassen, Daniel E. Gustavson, Jeremy A. Elman, Mark W. Logue, Matthew S. Panizzon, Michael J. Lyons, Nathan A. Gillespie, Christine Fennema-Notestine, Nathan Whitsel, Ruth E. McKenzie, Rosemary Toomey, Mark Sanderson-Cimino, Graham M L Eglit, Hillary L. Ditmars, and Hong Xian
Subjects: Male, Adult, Aging, medicine.medical_specialty, Longitudinal study, Hypercholesterolemia, Cardiovascular, Article, 03 medical and health sciences, 0302 clinical medicine, Sleep Apnea Syndromes, Erectile Dysfunction, Clinical Research, Risk Factors, Internal medicine, Behavioral and Social Science, History of depression, medicine, Psychology, Humans, Longitudinal Studies, Stroke, Applied Psychology, Depression (differential diagnoses), 030304 developmental biology, Aged, Psychiatry, 0303 health sciences, business.industry, Depression, Prevention, Cardiometabolic health, Neurosciences, Sleep apnea, medicine.disease, Twin study, Brain Disorders, Substance abuse, Polygenic risk scores, Psychiatry and Mental health, Mental Health, Good Health and Well Being, Hypertension, Public Health and Health Services, Sleep Research, business, Body mass index, 030217 neurology & neurosurgery
Abstract: BackgroundClarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems.MethodsThe study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse (‘baseline’) and the longitudinal Vietnam Era Twin Study of Aging (‘follow-up’). Depression symptoms were assessed at baseline [mean age 41.42 years (s.d. = 2.34)] using the Diagnostic Interview Schedule, Version III, Revised. The onset of eight cardiometabolic conditions (atrial fibrillation, diabetes, erectile dysfunction, hypercholesterolemia, hypertension, myocardial infarction, sleep apnea, and stroke) was assessed via self-reported doctor diagnosis at follow-up [mean age 67.59 years (s.d. = 2.41)].ResultsTotal depression symptoms were longitudinally associated with incident diabetes (OR 1.29, 95% CI 1.07–1.57), erectile dysfunction (OR 1.32, 95% CI 1.10–1.59), hypercholesterolemia (OR 1.26, 95% CI 1.04–1.53), and sleep apnea (OR 1.40, 95% CI 1.13–1.74) over 27 years after controlling for age, alcohol consumption, smoking, body mass index, C-reactive protein, and polygenic risk for specific health conditions. In sensitivity analyses that excluded somatic depression symptoms, only the association with sleep apnea remained significant (OR 1.32, 95% CI 1.09–1.60).ConclusionsA history of depression symptoms by early midlife is associated with an elevated risk for subsequent development of several self-reported health conditions. When isolated, non-somatic depression symptoms are associated with incident self-reported sleep apnea. Depression symptom history may be a predictor or marker of cardiometabolic risk over decades.
Published: 2023

43. Effect of intracorneal ring segment implantation on high order aberrations comparing patients with eccentric versus central keratoconus

Author: Samer Hamada, Berthold Seitz, Zisis Gatzioufas, Mohamed Elalfy, Lisa-Marie Anders, and Philipp Anders
Subjects: Keratoconus, medicine.medical_specialty, genetic structures, Corneal Stroma, media_common.quotation_subject, Refraction, Ocular, Prosthesis Implantation, Ophthalmology, medicine, Humans, Eccentric, Eccentricity (behavior), High order, Intracorneal ring segment, media_common, medicine.diagnostic_test, business.industry, Corneal Topography, Prostheses and Implants, General Medicine, Corneal tomography, medicine.disease, Corneal topography, business
Abstract: Purpose: To assess potential differences between central and eccentric cones in the aberrometric corneal profile and in visual and keratometric outcomes 6 months after intracorneal ring segment (ICRS) implantation for keratoconus. Methods: This study compared two groups consisting of 12 patients each, with central or eccentric keratoconus who were treated with femtosecond laser-assisted Keraring implantation. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, keratometric readings and higher order aberrations (HOAs) including high order aberrations root mean square (HOARMS), coma, spherical aberration and trefoil were measured preoperatively and 6 months after ICRS implantation. Results: Trefoil and spherical aberration were significantly reduced after ICRS implantation compared to preoperative values in eccentric keratoconus (Trefoil, p = 0.0049; Spherical aberration, p < 0.0001). In central keratoconus spherical aberration was reduced not significantly after ICRS implantation compared to preoperative values ( p = 0.087). Coma showed a significant reduction in central ( p = 0.0001) and in eccentric keratoconus ( p = 0.0001). The reduction of spherical aberration in central keratoconus was significantly positively correlated to improvement in UDVA (Pearson’s correlation coefficient, r = −0.66; p = 0.02). In eccentric keratoconus there was a significant positive correlation between reduction of trefoil and improvement in UDVA (Spearmans R, r = −0.69; p = 0.01). Conclusion: Patients both with central and eccentric keratoconus benefit from ICRS implantation. Specifically, our data provide a slightly higher gain in visual performance for eccentric cones 6 month after ICRS implantation, which is accentuated by a greater reduction in spherical aberration and trefoil. Improvements in UDVA are positively correlated with reductions in HOAs.
Published: 2021
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44. Recurrence after complete mesocolic excision for right‐sided colon cancer: post hoc sensitivity analyses—early recurrence, surgery by specialist and dissection in the mesocolic plane

Author: Anders Ulrich Neuenschwander, Jakob Kleif, and Claus Anders Bertelsen
Subjects: medicine.medical_specialty, Post hoc, Early Recurrence, Colorectal cancer, medicine.medical_treatment, Population, medicine, Humans, Disseminated disease, education, Colectomy, education.field_of_study, business.industry, Dissection, Gastroenterology, Absolute risk reduction, medicine.disease, Surgery, Treatment Outcome, Colonic Neoplasms, Lymph Node Excision, Laparoscopy, Lymphadenectomy, Neoplasm Recurrence, Local, business, Mesocolon
Abstract: Aim The aim was to investigate whether the previously reported causal treatment effect of complete mesocolic excision on the risk of recurrence was biased by inclusion of patients with potentially undiagnosed disseminated disease at the time of surgery, by non-specialist surgery, or caused by mesocolic plane dissection. Method A population of 1069 patients, 813 undergoing conventional resection and 256 complete mesocolic excision for colon cancer during the period 2008-2013, was stepwise reduced in the following order by excluding patients with recurrence diagnosed within 6 months of the resection, having surgery performed by a non-specialist without supervision, and specimens assessed as not being mesocolic plane dissection. The primary outcome measure was risk of recurrence after 5.2 years using competing risk analyses. Results The absolute risk reduction of complete mesocolic excision was 6.0% (95% CI 1.8-10.2; P = 0.0049) after excluding patients with recurrence within 6 months of resection, 6.1% (95% CI 1.9-10.4; P = 0.0045) after excluding non-specialist surgery, and 7.5% (95% CI 2.9-12.0; P = 0.0013) after the exclusion of patients whose specimens were assessed as dissections not being performed in the mesocolic plane. Conclusion The absolute risk reduction of recurrence after complete mesocolic excision for right-sided colon cancer in our previous study was not biased by potentially undiagnosed disseminated disease at the time of surgery or non-specialist surgery, and was not solely caused by dissection in the mesocolic plane. Central vascular dissection with central lymphadenectomy seems a major factor for better oncological results.
Published: 2021
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45. CD8+tissue‐resident memory T cells recruit neutrophils that are essential for flare‐ups in contact dermatitis

Author: Veronika Mraz, Julie Friis Weber, Anders Woetmann, Charlotte M. Bonefeld, Niels Ødum, Anne-Sofie Østergaard Gadsbøll, Jeanne D. Johansen, Mia H. Jee, Anders B. Funch, and Carsten Geisler
Subjects: integumentary system, medicine.diagnostic_test, Epidermis (botany), Chemistry, Immunology, medicine.disease, Flow cytometry, CXCL1, Chemokine receptor, CXCL2, medicine, Immunology and Allergy, Infiltration (medical), Allergic contact dermatitis, CD8
Abstract: Background Allergic contact dermatitis (ACD) is classically described as a delayed-type hypersensitivity reaction. However, patients often experience flare-ups characterized by itching erythema, edema, and often vesicles occurring within hours after re-exposure of previously sensitized skin to the specific contact allergen. Recent studies have indicated that skin-resident memory T (TRM ) cells play a central role in ACD. However, the pathogenic role of TRM cells in allergen-induced flare-ups is not known. Methods By the use of various mouse models and cell depletion protocols, we investigated the role of epidermal TRM cells in flare-up reactions to the experimental contact allergen 1-fluoro-2,4-dinitrobenzene. The inflammatory response was measured by changes in ear thickness, and the cellular composition in epidermis was determined by flow cytometry and confocal microscopy. Finally, adaptive transfer and inhibitors were used to determine the role of TRM cells, neutrophils, and CXCL1/CXCL2 in the response. Results We show that CD8+ TRM cells initiate massive infiltration of neutrophils in the epidermis within 12 h after re-exposure to the contact allergen. Depletion of neutrophils before re-exposure to the allergen abrogated the flare-up reactions. Furthermore, we demonstrate that CD8+ TRM cells mediate neutrophil recruitment by inducing CXCL1 and CXCL2 production in the skin, and that blockage of the C-X-C chemokine receptor type 1 and 2 inhibits flare-up reactions and neutrophil infiltration. Conclusion As the first, we show that epidermal CD8+ TRM cells cause ACD flare-ups by rapid recruitment of neutrophils to the epidermis.
Published: 2021
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46. Temporary cessation of ibrutinib results in reduced grade 3‐4 infections and durable remissions—Interim analysis of an on‐off‐repeat Phase 1b/2 study in patients with chronic lymphocytic leukemia

Author: Tom A. Mulder, Tove Wästerlid, Anders Österborg, Kia Heimersson, Marzia Palma, Håkan Mellstedt, Lotta Hansson, Magdalena Kättström, Anders Uddevik, and Jeanette Lundin
Subjects: Oncology, medicine.medical_specialty, chemistry.chemical_compound, chemistry, business.industry, Chronic lymphocytic leukemia, Internal medicine, Ibrutinib, medicine, In patient, Interim analysis, medicine.disease, business
Abstract: Ibrutinib is used continuously in CLL. This phase 1b/2 study interim analysis explored on-off-repeat dosing to reduce toxicity. After 12 months, 16/22 patients (73%) remained in first off-phase irrespective if initial CR/PR or
Published: 2021
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47. Technological readiness and implementation of genomic‐driven precision medicine for complex diseases

Author: Christina Jern, Gunnel Nordmark, Anca I. Catrina, Erik Melén, Johan Sundström, Per Hall, Marju Orho-Melander, Matej Orešič, Tove Fall, Bo Jacobsson, Lars Rönnblom, D Repsilber, Melanie R. Benson, Kamila Czene, Maria F. Gomez, Paul W. Franks, Jonas Halfvarson, Sarah E. Bergen, Mia Wadelius, Anders Johansson, Patrick F. Sullivan, Lars Klareskog, Mikaela Friedman, Anders Mälarstig, Hannes Hagström, J. Gustav Smith, Sara Hägg, Catarina Almqvist, Richard Rosenquist, Ingrid Kockum, Claes Ohlsson, Kristina Johnell, and Beatrice Melin
Subjects: medicine.medical_specialty, Neurologi, precision medicine, Genomics, Disease, Environmental risk, precision prevention, Health care, genomics, Internal Medicine, medicine, Humans, Precision Medicine, Medicinsk genetik, precision diagnostics, business.industry, complex disease, Klinisk medicin, precision treatment, Precision medicine, Data science, Human genetics, Neurology, Medical genetics, Identification (biology), Clinical Medicine, business, Delivery of Health Care, Medical Genetics
Abstract: The fields of human genetics and genomics have generated considerable knowledge about the mechanistic basis of many diseases. Genomic approaches to diagnosis, prognostication, prevention and treatment - genomic-driven precision medicine (GDPM) - may help optimize medical practice. Here, we provide a comprehensive review of GDPM of complex diseases across major medical specialties. We focus on technological readiness: how rapidly a test can be implemented into health care. Although these areas of medicine are diverse, key similarities exist across almost all areas. Many medical areas have, within their standards of care, at least one GDPM test for a genetic variant of strong effect that aids the identification/diagnosis of a more homogeneous subset within a larger disease group or identifies a subset with different therapeutic requirements. However, for almost all complex diseases, the majority of patients do not carry established single-gene mutations with large effects. Thus, research is underway that seeks to determine the polygenic basis of many complex diseases. Nevertheless, most complex diseases are caused by the interplay of genetic, behavioural and environmental risk factors, which will likely necessitate models for prediction and diagnosis that incorporate genetic and non-genetic data. Funding Agencies|SciLifeLab; Swedish Research Council (Vetenskapsradet)Swedish Research Council [D0886501]; US National Institute of Mental HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [MH077139, MH1095320]; European UnionEuropean Commission [610307, 733161, 825843]; Swedish Cancer SocietySwedish Cancer Society; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2018-02837, 2014-03352, 2009-1039, 2018-03307]; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation; Karolinska Institutet, Karolinska University HospitalKarolinska Institutet; Radiumhemmets Forskningsfonder; European Research CouncilEuropean Research Council (ERC)European Commission [CoG-2015_681742_NASCENT]; Swedish Heart-Lung FoundationSwedish Heart-Lung Foundation [20160872]; Swedish Foundation for Strategic Research (IRC Center); Novo Nordisk FoundationNovo Nordisk FoundationNovocure Limited; ALF; Strategic Research Area Epidemiology at Karolinska Institutet; Swedish Rheumatism Association; Vth 80-year Foundation; Swedish Society of Medicine; Clinical Research Support (Avtal om Lakarutbildning och Forskning); Swedish government; county councils; ALF-agreement; Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [15-0067]; IMI2 Joint Undertaking [115974]; European Federation of Pharmaceutical Industries and Associations with JDRF; H2020 Program ERA PerMed JTC 2018 Call (VR) [2018-05619]
Published: 2021
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48. A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

Author: De Zhao Kong, Georgina Imberger, Jørn Wetterslev, Bao-Yong Lai, Geert Koster, Naqash J Sethi, Andreas Bender Jonsson, Steven Kwasi Korang, Rui-Xue Hu, Emilie C Risom, Bente Thoft Jensen, Anders Granholm, Morten Hylander Møller, Maria L. Fabritius, Sanam Safi, Mathias Maagaard, Anders Perner, Meint Volbeda, Susanne Vahr Lauridsen, Anja Geisler, Bart Hiemstra, Nico van Bakelen, Marie Warrer Munch, Ruben J. Eck, Oliver Karam, Eric Keus, Christian Gluud, Barzi Gareb, Emil Eik Nielsen, Søren Marker, A. K. Nørskov, Ning Liang, Thijs M. Koster, Sofie Louise Rygård, Willem Dieperink, Maria Cronhjort, Fredrik Sjövall, Tine Sylvest Meyhoff, Fredrike Blokzijl, Iwan C. C. van der Horst, Marija Barbateskovic, Josh Feinberg, Lars Hyldborg Lundstrøm, Arash Afshari, Craig French, RS: Carim - V04 Surgical intervention, Intensive Care, MUMC+: MA Medische Staf IC (9), MUMC+: MA Intensive Care (3), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), and Anesthesiology
Subjects: medicine.medical_specialty, Epidemiology, Population, Psychological intervention, Outcome assessment, GUIDELINES, 03 medical and health sciences, 0302 clinical medicine, Disease severity, Bias, Meta-Analysis as Topic, medicine, Humans, HETEROGENEITY, 030212 general & internal medicine, education, Reliability (statistics), Evidence, RISK, Diversity, education.field_of_study, business.industry, Reproducibility of Results, Quality, Meta-analysis, Research Design, AGREEMENT, Family medicine, Scale (social sciences), RELIABILITY, Research Design/statistics & numerical data, Systematic review, Tool, Heterogeneity, business, human activities, 030217 neurology & neurosurgery, REVIEWS, Diversity (business)
Abstract: Objective: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions. Study design and setting: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreement in three groups. Results: CDIM measures clinical diversity on a scale that includes four domains with 11 items overall: setting (time of conduct/country development status/units type); population (age, sex, patient inclusion criteria/baseline disease severity, comorbidities); interventions (intervention intensity/strength/duration of intervention, timing, control intervention, cointerventions); and outcome (definition of outcome, timing of outcome assessment). The CDIM is completed in two steps: first two authors independently assess clinical diversity in the four domains. Second, after agreeing upon scores of individual items a consensus score is achieved. Interrater scale reliability and agreement ranged from moderate to almost perfect depending on the type of raters. Conclusion: CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis. (c) 2021 Elsevier Inc. All rights reserved.
Published: 2021
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49. The importance of donor characteristics, post‐mortem time and preservation time for use and efficacy of donated corneas for posterior lamellar keratoplasty

Author: Niels Gram, Jesper Hjortdal, Anders Shehab, and Anders Ivarsen
Subjects: PENETRATING KERATOPLASTY, medicine.medical_specialty, Cornea/surgery, Lamellar keratoplasty, keratoplasty, Logistic regression, Donor age, Cornea, Corneal Transplantation, 03 medical and health sciences, AGE, 0302 clinical medicine, Primary outcome, Ophthalmology, SUITABILITY, medicine, Humans, Donor cornea, business.industry, Endothelium, Corneal, Organ Preservation, General Medicine, Eye banking, Tissue Donors, medicine.anatomical_structure, ORGAN-CULTURE, ENDOTHELIUM, LONGER, 030221 ophthalmology & optometry, corneal organ culture, eye banking, business, Keratoplasty, Penetrating, 030217 neurology & neurosurgery, corneal storage
Abstract: PURPOSE: The aim of this study is to examine whether donor age, death-to-retrieval time (DRT) and death-to-preservation time (DPT) as well as total preservation time affect donor cornea suitability for endothelial keratoplasty (EK) or penetrating keratoplasty (PK).METHODS: A registry-based study was performed identifying 3248 corneas donated between 2011 and 2017. Data regarding donated corneas were extracted from The Danish Cornea Bank and donor medical records and evaluated for missing information. The primary outcome was whether ECD at preservation (ECD-P) or at release (ECD-R) was >2000 cells/mm2 .RESULTS: Logistic regression for ECD-P showed a significant negative effect of increasing age (OR: 1.07, 95%CI: 1.05;1.08, p < 0.001) on donor suitability. Higher ECD-P had a significant positive effect on graft eligibility (OR: 1.007 95%CI: 1.003;1.010, p < 0.001). No significant effect of donor sex (p = 0.547), DRT (p = 0.289) or DPT (p = 0.102) on donor suitability for EK or PK (Chi-squared test).CONCLUSION: High donor age and low ECD-P negatively affect the suitability of donor corneas for EK/PK whereas DRT and DPT did not affect graft suitability.
Published: 2021
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50. Patient‐important outcomes other than mortality in recent ICU trials: Protocol for a scoping review

Author: Praleene Sivapalan, Carl Thomas Anthon, Thomas Strøm, Benjamin Skov Kaas-Hansen, Morten Hylander Møller, Aksel Karl Georg Jensen, Anders Perner, Anders Granholm, Ole Mathiesen, Olav L. Schjørring, Maj-Brit Nørregaard Kjaer, and Lars W. Andersen
Subjects: Adult, medicine.medical_specialty, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Intensive care, Outcome Assessment, Health Care, medicine, Humans, Patient Reported Outcome Measures, 030212 general & internal medicine, Intensive care medicine, Protocol (science), business.industry, 030208 emergency & critical care medicine, General Medicine, Missing data, Clinical trial, Intensive Care Units, Anesthesiology and Pain Medicine, Systematic review, Research Design, Life support, Quality of Life, business, Systematic Reviews as Topic
Abstract: BACKGROUND: Randomised clinical trials (RCTs) conducted in intensive care units (ICUs) frequently focus on all-cause mortality, but other patient-important outcomes are increasingly used and recommended. Their use, however, is not straightforward: choices and definitions, operationalisation of death, handling of missing data, choice of effect measures, and statistical analyses for these outcomes vary greatly.METHODS: We will conduct a scoping review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. We will search 10 selected general and speciality journals for RCTs conducted in adult ICU patients from 2018 and onwards reporting at least one patient-important outcome other than mortality (including days alive without life support/days alive and out of hospital-type outcomes, health-related quality of life, functional/cognitive/neurological outcomes and other general patient-important outcomes). We will summarise data on outcome measures and definitions, assessment time points, proportions and handling of death, proportions and handling of missing data, and effect measures and statistical methods used for analysis.DISCUSSION: The outlined scoping review will provide an overview of choices, definitions and handling of patient-important outcomes other than mortality in contemporary RCTs conducted in adult ICU patients. This may guide discussions with patients and relatives, the design of future RCTs, and research on optimal outcome choices and handling.
Published: 2021
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