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As the number of COVID-19 cases worldwide rises exponentially, clinicians and healthcare systems are faced with a difficult dilemma. Should they focus on supportive care and wait for the results of clinical trials or join other clinicians who are already prescribing specific antimicrobials which may be active against the virus? Eighty per cent of patients with COVID-19 have mild infection, 15% develop severe illness and 5% require critical care admissions for organ support.1 Mortality is currently estimated to be 1%–3%.1 Older patients (>80 years old) and patients with comorbidity such as respiratory disease, diabetes, stroke, cardiac disease and cancer are more likely to die from the illness.2 Mortality for a patient admitted to critical care is estimated to be about 50%; however, this may be dependent on access to and quality of critical care services. So far, no vaccine or drug has been approved to treat human coronaviruses including COVID-19. In addition, there is no validated clinical tool or test to predict patients who are likely to develop complications. There are currently multiple …

e19016 Background: Approximately 9,050 Americans gets diagnosed annually with Hodgkin's Lymphoma HL and approximately 1,150 dies each year from HL(1).Nodular Lymphocyte-predominant LP (NLPHL) represents 5% of HL (2). Mafraq Hospital is a tertiary hospital in Abu Dhabi, UAE, We suspected that we are seeing more than expected cases of NLPHL.Therefore, we carried a retrospective study to review all cases of HL seen at our oncology unit for the period from 01/01/2016 till 30/06/ 2018. Methods: We developed Excel data collection tool. After Ethics approval, Electronic Medical Records of all cases seen with the diagnosis of HL between 01/2016 and 06/2018 at Mafraq Hospital were reviewed. Results: Total of 47 case were collected. 8 cases (17%) were found to have NLPHL, The rest of cohort were 39 cases, 22 (57%) of them had nodular sclerosis HL, 4 cases (10%) mixed cellularity HL, 2 (5%) lymphocyte rich HL, no cases of lymphocyte depleted HL. 9 (23%) of cases were classical HL with no type as diagnosis was made from core biopsies. 2 cases (5%) unlisted type.The stage for the 42 case were as follows Stage I: 1 case = 2.3%, Stage II: 24 case = 57.1%Stage III: 11 case = 26.1%Stage IV: 6 cases = 14.2%. Conclusions: We saw 23 (49%) females and 24 (51%) males. Our hypothesis that NLPHL is more frequently seen in UAE seems to be correct as 17% of all HL cases seen were from this subtype. Mean age at diagnosis of all HL cases is 33 years. In the NLPHL there were 2 (25%) females and 6 (75%) males. Mean age at diagnosis for NLPHL is 31.8 years. Most HL patients received ABVD as first line regimen. This is documented in 38 out of 47 case. Mean overall survival registered at the closure of the study is 45 months. It is important that this overall survival is premature as no patient has relapsed or died.

Detailed, country‐specific epidemiological data are needed to characterize the burden of chronic hepatitis C virus (HCV) infection around the world. With new treatment options available, policy makers and public health officials must reconsider national strategies for infection control. In this study of 15 countries, published and unpublished data on HCV prevalence, viraemia, genotype, age and gender distribution, liver transplants and diagnosis and treatment rates were gathered from the literature and validated by expert consensus in each country. Viraemic prevalence in this study ranged from 0.2% in Iran and Lebanon to 4.2% in Pakistan. The largest viraemic populations were in Pakistan (7001000 cases) and Indonesia (3187000 cases). Injection drug use (IDU) and a historically unsafe blood supply were major risk factors in most countries. Diagnosis, treatment and liver transplant rates varied widely between countries. However, comparison across countries was difficult as the number of cases changes over time. Access to reliable data on measures such as these is critical for the development of future strategies to manage the disease burden.

The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 15 countries in Europe, the Middle East and Asia, and the relative impact of two scenarios was considered: increased treatment efficacy while holding the annual number of treated patients constant and increased treatment efficacy and an increased annual number of treated patients. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, were critical for achieving substantial reductions in disease burden. A 90% reduction in total HCV infections within 15 years is feasible in most countries studied, but it required a coordinated effort to introduce harm reduction programmes to reduce new infections, screening to identify those already infected and treatment with high cure rate therapies. This suggests that increased capacity for screening and treatment will be critical in many countries. Birth cohort screening is a helpful tool for maximizing resources. Among European countries, the majority of patients were born between 1940 and 1985. A wider range of birth cohorts was seen in the Middle East and Asia (between 1925 and 1995).

Gilead Sciences The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. in addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing. 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