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Managing a massive crowd at a large event is a challenging task for the crowd managers. To deal with different levels of the Crowd, the decision-making authorities need a good understanding of sound knowledge and hands-on practice of crowd handling scenarios under different situations. The objective of this paper is to build an interactive evaluation framework for decision-makers or stakeholders to evaluate their level of decision-making skills dealing with intensive crowd scenarios in different environments. The proposed tool will facilitate crowd managers to gain mindset, skillset, and toolset for the flow of knowledge by experiencing different crowd scenario patterns, which will help them to take on spot better faster, and accurate decisions in real-life crowd scenarios. This research develops a conceptual evaluation tool that hypothesizes a positive and significant relationship between knowledge capture and knowledge implementation, which in turn contributes to the enhanced performance of decision-makers to handle any level of the mass crowd gathering events like political rallies, sports, or any religious gatherings across the globe.

Studies have consistently shown that childhood maltreatment is a significant risk factor for the development of drug addiction across human lifespan. Yet, little is known about the prevalence of childhood maltreatment history among drug addicts in Malaysia. The dataset presented in this article provides demographic information on 200 drug addicts recruited from two rehabilitation centres in Malaysia, the prevalence of different types of childhood maltreatment history and the correlation between all types of maltreatments. Analyses of the data can provide insights into the prevalence of maltreatment history and development of drug addiction, therefore indispensable for mental health professionals designing appropriate interventions for the drug addicts. The data can also provide baseline data for comparative studies in terms of childhood maltreatment history and drug addiction across different countries.

The current outbreak of coronavirus disease 2019 (COVID-19) caused by the novel coronavirus named SARS-CoV-2 represents a major global public health problem threatening many countries and territories. Mathematical modelling is one of the non-pharmaceutical public health measures that has the potential to play a crucial role for mitigating the risk and impact of the pandemic. A group of researchers and epidemiologists have developed a machine learning-powered inherent risk of contagion (IRC) analytical framework that, through the geo-referencing of COVID-19 cases in a particular region, is able to provide support to operational platforms from which response and mitigation activities can be planned and executed. This framework dataset provides a coherent picture to track and predict the COVID-19 epidemic post lockdown by piecing together preliminary data on publicly available health statistic metrics alongside the area of reported cases, drivers, vulnerable population, and number of premises that are suspected to become a transmission area between drivers and vulnerable population. The main aim of this new analytical framework is to measure the IRC and provide georeferenced data to protect the health system, aid contact tracing, and prioritise the vulnerable.

Objectives This systematic review aimed to investigate the effects if probiotics can inhibit oral carcinogenesis. Design PubMed, Web of Science, Scopus, and PLOS databases were searched up to February 2020 to identify randomised controlled trials that fulfilled the eligibility criteria. Joanna Briggs Institute (JBI) Critical Appraisal Tool was used for quality assessment of articles. This review was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA-P) 2015 protocol guidelines. Result The initial search retrieved 774 articles. Of these, only five articles were included in the qualitative synthesis. Two out of the five papers were further analysed for quantitative synthesis in meta-analysis. The majority of the included studies were found to be of “moderate quality”. The qualitative synthesis found four probiotics that exhibited potential therapeutic effects in oral carcinogenesis, includingAcetobacter syzygii, AJ2, Lactobacillus plantarum, and Lactobacillus salivarius REN. Among them, the application of L. salivarius REN resulted in a 95 % lower risk for developing oral cancer (p Conclusion It is known that probiotics have the potential to inhibit oral carcinogenesis, thus supporting the hypothesis of the study. The ability of L. salivarius REN to inhibit the development of oral cancer suggested that this bacterium can be a potential inhibitory agent against oral carcinogenesis.

Objective: Emergence of mutation in the BCR-ABL kinase domain (KD) impairs imatinib mesylate (IM) binding capacity, thus contribute to IM resistance. Identification of these mutations is important for treatment decision and precision medicine in CML patients. Our study aims to determine the genomic landscape of BCR ABL KD mutations in CML patients with IM resistance. Result: BCR-ABL KD mutations were observed in 23 patients (26.7%). Fifteen different types of mutations have been identified; Y253H, E255K, T267A, K285I, A287T, M290R, F311I, T315I, F317L, F359V, F359I, F359C, K357T, A399T and E459K. We also discovered three novel mutations; M290R, K285I and K357T and two silent mutations at codon 389 and 401. Mutational analysis is recommended to identify patients at risk of disease progression. Therefore, early detection of such mutations may allow timely treatment intervention to prevent or overcome resistance. Keywords: Chronic Myeloid Leukaemia; BCR-ABL kinase domain; imatinib resistance mutation.

Introduction: The prevalence of oral cancer has been reported annually along with high mortality rate. Probiotics have been suggested to possess anti-cancer properties, however the role of these microorganisms on oral cancer is remain unclear. The objective of the present study is to identify the mechanisms exerted by probiotics on oral carcinogenesis by using systematic review and meta analysis with the hypothesis that probiotics inhibit oral carcinogenesis. Materials and method: Comprehensive literature search was conducted on PubMed, Scopus and Web of Science electronic database from January 2019 until April 2019. Main keywords that were used are “probiotic” AND “oral cancer”. Articles that were published in English language were included in this review. Articles were selected independently by three authors and inspected independently by another researcher. The titles and abstracts of the studies were screened to identify studies that meet the inclusion criteria. Full text articles of the remaining studies were assessed to determine the availability to be included in the review. Meta-analysis was conducted by using RevMan 5 software, and the result was graphically plotted on the forest plot. This review was done according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA-P) 2015 guidelines. Results: After thorough screening of the full text articles, seven papers were eligible to be included in the systematic review. The included articles were mainly discussed on the association of probiotics and oral cancer. Two from the seven papers were selected to be analyse for quantitative synthesis (meta-analysis). The present study also showed that, Lactobacillus salivarius REN produces protective effect from developing neoplastic tongue lesions with odd ratio < 1. Conclusion: Probiotics were found to confer positive effect as an inhibitory agent against the oral carcinogenesis thus supported the hypothesis of the present study that probiotics can inhibit oral carcinogenesis.

Peningkatan berat badan intradialitik akibat ketidakpatuhan asupan cairan pasien yang menjalani hemodialisa berdampak pada terjadinya penumpukan cairan secara kronis dan berisiko terhadap gangguan pada kardiovaskuler dan hipertensi, serta meningkatkan mortalitas dan morbiditas pada pasien dengan gagal ginjal kronik. Dukungan sosial menjadi salah satu faktor yang mendukung kepatuhan pasien dalam menjalankan terapi. Penelitian ini menggunakan rancangan mixed methods dengan desain sequential explanatory. Populasi dalam penelitian ini adalah seluruh pasien gagal ginjal kronik yang menjalani hemodialisa di RSU Kabupaten Tangerang. Jumlah sampel kuantitatif dipilih menggunakan tehnik total sampling sebanyak 76 orang dan jumlah sampel kualitatif diambil secara purposive sampling sebanyak 6 orang. Pengumpulan data dilakukan dengan Chronic Kidney Disease Self-Efficacy Instrument dan Multidimentional Scale Perceived Social Support, serta wawancara. Analisis data kuantitatif dengan analisis deskriptif dan korelasi pearson. Analisis data kualitatif menggunakan teknik analisis model Miles dan Huberman. Hasil Uji korelasi Pearson, ada hubungan antara efikasi dan dukungan sosial dengan kepatuhan pembatasan cairan (r=0.476 p= 0.001) dan (r=0.308 p= 0.007). Berdasarkan hasil wawancara mendalam didapatkan bahwa rasa haus menjadi penyebab ketidakpatuhan menjalankan program pembatasan asupan cairan. Diharapkan rumah sakit memberikan ruang khusus kepada keluarga pasien dan perawat memberi motivasi yang tinggi kepada pasien dalam menjalankan regimen terapinya.

Introduction: The Radial Shock Wave Therapy (RSWT) expected could improve spasticity and hand function in chronic stroke patients. This study aimed to find out the improvement of hand function after RSWT as an additional therapy in chronic stroke patients. Methods: Design study was a randomized controlled trial. The patients were assigned randomly to the experimental group (Infrared, Stretching, and RSWT) and control group (Infrared and Stretching) for six weeks. Hand motor function was measured using Fugl-Meyer Motor Assesment (FMA) before and after intervention. Conclusion: There were improvement of wrist and hand FMA scores in the experimental as well as control group Results: Median of wrist FMA scores in the experimental and control group before intervention were 2 and 3 respectively whereas median of wrist FMA scores in the experimental and control group after intervention were 5 and 4 respectively. Median of hand FMA scores in the experimental and control group before intervention were 4 and 4 respectively whereas median of hand FMA scores in the control and experimental group after intervention were 6 and 5 respectively. The scores of wrist- hand FMA in the control and experimental group after intervention were increased P = 0.001P < 0.001 (wrist) and P = 0.001 P < 0.001 (hand) respectively. However, difference increased of wrist and hand FMA scores in the experimental group after intervention were more significant. Keywords: Spasticity, Hand Function, Stroke, Radial Shock Therapy, Fugl-Meyer Motor Assesment

The aims of this study were to analyze the Effect of Healthy Living Community Behavior (PHBS), Quality of Health Service against Overcoming Diarrhea Disease in Sub-division Karang Jaya Palembang. The type of research used in this study was analytical research. This research was conducted in Palembang City selected area of Karang Jaya Sub-district Gandus District. The study was conducted in May 2016 to June 2017. The samples of research were people affected by diarrhea in 2017 as many as 95 people. Method’s of data analysis using logistic regression. Result showed that the PHBS coefficient with odds ratio-0.760 (1.561-0.370) with significance of 0.045 less than the 0.05 significance level (α). This means that hypothesis one (H1) was accepted if the variable quality of health service, constant then every increase PHBS effect on the occurrence of diarrhea. The better PHBS will decrease the incidences of diarrhea. Coefficient of health service quality with odds ratio 1.598 (3.217-0.74) with significant equal to 0.009 less than level of significant (α) 0.05. This means that hypothesis two (H2) is accepted if the variable PHBS, constant then the quality of health services affect the occurrence of diarrhea. The better quality of health care will reduce the incidence of diarrhea Keywords: PHBS, quality of service, health, diarrhea

Objective: Chronic Myeloid Leukemia (CML) is caused by a reciprocal translocation between chromosomes 9 and 22, t(9;22) (q34;q11) which encodes for the BCR-ABL fusion protein. Discovery of Imatinib Mesylate (IM) as first line therapy has brought tremendous improvement in the management of CML. However, emergence of point mutations within the BCR-ABL gene particularly T315I mutation, affects a common BCR-ABL kinase contact residue which impairs drug binding thus contribute to treatment resistance. This study aims to investigate the BCR-ABL T315I mutation in Malaysian patients with CML. Methods: A total of 285 patients diagnosed with CML were included in this study. Mutation detection was performed using qualitative real-time PCR (qPCR). Results: Fifteen out of 285 samples (5.26%) were positive for T315I mutations after amplification with real-time PCR assay. From the total number of positive samples, six patients were in accelerated phase (AP), four in chronic phase (CP) and five in blast crisis (BC). Conclusion: Mutation testing is recommended for choosing various tyrosine kinase inhibitors (TKIs) to optimize outcomes for both cases of treatment failure or suboptimal response to imatinib. Therefore, detection of T315I mutation in CML patients are clinically useful in the selection of appropriate treatment strategies to prevent disease progression.

Psychological influence is a never-ending aspect that can not be separated from language teaching and learning, and Foreign Language Teaching Anxiety is one of those psychological hindrances. This study was aimed to find out the causes of foreign language teaching anxiety (FLTA) of teachers in bilingual school, the effects, how the teachers deal with their anxieties, and school support in helping the teachers. This research employed qualitative research, and using a close-ended questionnaire, interview, and observations as sources of the data. The participants were all teachers of Lazuardi Ibnu Sina Elementary School which consists of 10 teachers (6 Homeroom Teacher and 4 Subject Teachers). The results indicated that the majority of teachers fear negative evaluations from the students and supervising teachers. It also showed that the teachers used professional, personal, and social strategies to manage their anxieties. As for the effects, most of the teachers think that teacher anxiety will affect their image in front of students and students will not get enough exposure to English. In light of these findings, it also showed that bilingual school should provide more English Classes and English Day for their teachers and school in order to improve their English skills and manage their teaching anxieties.

Background: Although aberrant expression of cytokines and small molecules (analytes) is well documented in acute myeloid leukaemia (AML), their co-expression patterns are not yet identified. In addition, plasma baselines for some analytes that are biomarkers for other cancers have not been previously reported in AML. Methods: We used multiplex array technology to simultaneously detect and quantify 32 plasma analyte (22 reported analytes and 10 novel analytes) levels in 38 patients. Results: In our study, 16 analytes are found to be significantly deregulated (13 higher, 3 lower, Mann–Whitney U-test, P-value

Obsessive-Compulsive Disorder (OCD) is a severe and debilitating anxiety disorder which causes severely impaired quality of life. The objective of the study was to assess the quality of life of the patients suffering from OCD. It was a cross-sectional study conducted from January 2011 to June 2011 among 46 patients who attended the out-patient department of the National Institute of Mental Health Sher-E-Bangla Nagar, Dhaka, Bangladesh and Holy Family Red Crescent Medical College and Hospital, Dhaka, Bangladesh by using purposive sampling technique. A Semi-structured questionnaire, Dhaka University Obsessive Compulsive Scale (DUOCS), World Health Organization Quality of Life-Scale Brief Version (WHOQOL-BREF), Diagnostic and Statistical Manual for Mental Disorder, 4th edition (DSM-IV) were used in each case for this assessment. Results showed that mean age of the patients was (29.07±6.11) years, majority of the respondents (71.7%) were male, 63.0% were unmarried and 34.8% were students. Patients were least satisfied with social domain and patients having only obsession had lower mean score (23.54±1.80) in environmental domain than in patients having both obsession and compulsion (25.15±3.70). OCD patients having major conflict (52.2%) were least satisfied with environmental health domain and patients suffering from OCD for more than ten years (78.3%) had low score than those suffering for less than ten years (21.7%) in overall quality of life domain. Patients having strained family relationship (34.8%) were less satisfied to psychological health domain and patients getting medication (91.3%) had better quality of life in all domains than those getting no medication (8.7%).Bang J Psychiatry June 2015; 29(1): 18-22

Despite being among the common primary intracranial tumors, intraosseous craniofacial meningioma is the least common subtype of meningioma accounting for only 1-2% of intracranial meningiomas. Interestingly, it can display clinical and radiologic features that can be confused for fibrous dysplasia. Scan imaging and biopsy are crucial for the diagnosis as well as for further proper treatment. We report a case of unilateral eye proptosis and optic neuropathy which was initially thought for fibrous dysplasia. Later the histopathology revealed meningioma grade 1. As the clinical presentations are almost undifferentiated, diagnosis and further prompt treatment are challenging.

Introduction: The increasing rate of breast cancer (BC) incidence in Malaysia hints a lack of awareness among Malaysians. One (1) woman out of nineteen (19) is at risk with BC and almost up to fifty percent (50%) of women diagnosed with BC were reported to be under the age of fifty (50). Our main concern is to study the level of awareness among the women on risk factors, clinical manifestations, diagnosis, preventions and treatments. Method: A cross-sectional study was conducted exclusively among women in the public with total sample of three hundred and forty six (346), questionnaires were distributed using a simple random technique. Data was collected and analyzed by student T test in SPPS version 20. Results: Our study reveals insufficient awareness on BC. Overall, awareness on risk factors is inadequate, but good knowledge on the importance of family history and diet as risk factors are discovered. Awareness on the cause and clinical manifestations of BC is required for improvement. As for treatment, alternatives especially surgery and chemotherapy are unclear to public, public is remotely unwitting on cessation of smoking to prevent BC at the early stage. Conclusion: Malaysian has spaces for improvement on awareness of BC in terms of risk factors, clinical manifestations, diagnosis, treatment and prevention. Early detection can be achieved with good awareness because it leads to better prognosis and lower mortality.

Optic perineuritis (OPN) involvement in demyelinating disease is rarely encountered. To our knowledge, this is the first reported case of bilateral OPN associated with neuromyelitis optica spectrum disorder (NMOSD). We present a case of a healthy young gentleman who presented with OPN, initially presumed to have a young stroke but later diagnosed to be NMOSD. Early neuroimaging is essential to help distinguish optic neuritis (ON), and prolonged treatment of systemic immunosuppression is the mainstay of treatment.

Mucus is an endogenous viscoelastic biopolymer barrier that limits the entry of foreign pathogens and therapeutic carriers to the underlying mucosal cells. This could be overcome with a hydrophilic and nonpositively charged carrier surface that minimizes interactions with the mucin glycoprotein fibers. Although PEGylation remains an attractive surface strategy to enhance mucopenetration, cell uptake of PEGylated nanoparticles (NPs) often remains poor. Here, we demonstrated polydopamine (PDA) coating to enhance both mucopenetration and cell uptake of NPs. PDA was polymerized on carboxylated polystyrene (PS) NPs to form a PDA coating, and the resulting PS-PDA achieved a similar level of mucopenetration as our PEGylated PS (PS-PEG) positive control in three separate studies: NP-mucin interaction test, transwell assay, and multiple particle tracking. Compared to water, the diffusions of PS-PDA and PS-PEG in reconstituted mucus solution were only 3.5 and 2.4 times slower, respectively, whereas the diffusion of bare PS was slowed by up to 250 times. However, the uptake of PS-PDA (61.2 ± 6.1%) was almost three times higher than PS-PEG (24.6 ± 5.4%) in T24 cells, which were used as a model for underlying mucosal cells. Our results showed a novel unreported functionality of PDA coating in enhancing both mucopenetration and cell uptake of NPs for mucosal drug delivery applications, not possible with conventional PEGylation strategies.

SUMMARYWe aimed to reparameterize and validate an existing dengue model, comprising an entomological component (CIMSiM) and a disease component (DENSiM) for application in Malaysia. With the model we aimed to measure the effect of importation rate on dengue incidence, and to determine the potential impact of moderate climate change (a 1 °C temperature increase) on dengue activity. Dengue models (comprising CIMSiM and DENSiM) were reparameterized for a simulated Malaysian village of 10 000 people, and validated against monthly dengue case data from the district of Petaling Jaya in the state of Selangor. Simulations were also performed for 2008-2012 for variable virus importation rates (ranging from 1 to 25 per week) and dengue incidence determined. Dengue incidence in the period 2010–2012 was modelled, twice, with observed daily weather and with a 1 °C increase, the latter to simulate moderate climate change. Strong concordance between simulated and observed monthly dengue cases was observed (up to r = 0·72). There was a linear relationship between importation and incidence. However, a doubling of dengue importation did not equate to a doubling of dengue activity. The largest individual dengue outbreak was observed with the lowest dengue importation rate. Moderate climate change resulted in an overall decrease in dengue activity over a 3-year period, linked to high human seroprevalence early on in the simulation. Our results suggest that moderate reductions in importation with control programmes may not reduce the frequency of large outbreaks. Moderate increases in temperature do not necessarily lead to greater dengue incidence.

The escalating trend of murder victim concealment worldwide appears worrying, and literature does not reveal any specific study focusing on victim concealment amongst convicted male Malaysian murderers. Therefore, this study was aimed at investigating the psychological traits that may underlie the act of murder concealment in Malaysia via mixed method approaches. Male murderers (n = 71) from 11 prisons were selected via purposive sampling technique. In the quantitative analysis, a cross-sectional study design using the validated questionnaire was used. The questionnaire contained murder concealment variables and four Malay validated psychometric instruments measuring: personality traits, self-control, aggression, and cognitive distortion. The independent sample t-tests revealed the significantly higher level of anger in murderers who did not commit concealment acts (8.55 ± 2.85, p &lt, 0.05) when compared with those who did so (6.40 ± 2.64). Meanwhile, the Kruskal–Wallis H test revealed that anger and the personality trait of aggressiveness-hostility significantly varied across the different groups of murder concealment acts (p &lt, 0.05). The qualitative data obtained via the in-depth interviews revealed two important themes for the murderers to commit murder concealment acts: (1) fear of discovery and punishment and (2) blaming others. These findings discussed from the perspectives of the murderers within the context of criminology and psychology may provide the first ever insight into the murder concealment acts in Malaysia that can benefit the relevant authorities for crime prevention and investigation efforts.

Objective: This study aims to evaluate the knowledge of postnatal care among confinement ladies in Malaysia and assess the effectiveness of an intervention workshop.Methods: A quasi-experimental study was conducted among 65 confinement ladies residing in East Coast Malaysia. Among them, 36 ladies were purposely selected to participate in a workshop, while 29 ladies were selected using a snowball sampling method to be in the control group. A validated Malay translation of Knowledge on Postnatal Care for Mothers and Care of the Newborn Questionnaire was used. Data were analysed using IBM SPSS Statistics (Version 25). Multiple logistic regression was employed to determine factors associated with baseline knowledge. Repeated measure ANCOVA was used to measure the effectiveness of the intervention workshop.Results: Overall, the mean (SD) age of the respondents was 46.23 (8.49) with mean (SD) number of children of 4.0 (2.0) and working experience as confinement ladies of 36.0 months (20.24). Majority (77.1%) were married, from B40 group (91.4%) and received at least secondary education (77.1%). Confinement ladies who received secondary and tertiary education were found to have higher knowledge scores compared to those with primary education (p=0.026 and p=0.049 respectively). There was a significant increase in knowledge of postnatal care scores in those attending the postnatal care workshop (p

Background Tumor cell migration and diffuse infiltration into brain parenchyma are known causes of recurrence after treatment in glioblastoma (GBM), mediated in part by the interaction of glioma cells with the extracellular matrix, followed by degradation of matrix by tumor cell derived proteases, particularly the matrix metalloproteinases (MMP). Sevoflurane and thiopental are anesthetics commonly used in cancer surgery. However, their effect on the progression of glioma cells remains unclear. The aim of this study was to explore the role of these anesthetics on the migration and activity of MMP-2 in glioma cells. Methodology Cultured U87MG cells were pretreated with sevoflurane or thiopental and in vitro wound healing scratch assay was carried out to analyze their effect on migration of these cells. Gelatin zymography was carried out to examine the effect of these anesthetics on tumor cell MMP-2 activity using the conditioned media 24 h after pretreatment. Cell viability was analyzed using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Results U87MG cells exposed to 2.5% sevoflurane or different concentrations of thiopental significantly decreased migration and activity of MMP-2 compared to control. No effect was seen on the viability of these cells after pretreatment with sevoflurane or thiopental. Conclusion/significance These results suggest that both sevoflurane and thiopental have inhibitory effect on the migration and MMP-2 activity in glioma cells. Thus, it is important that the choice of anesthetics to be used during glioma surgery takes into account their inhibitory properties against the tumor cells.

Determining the cause of death is an important factor in the forensic investigation process.”Some aspects of death will be difficult to find if the condition of the body has suffered severe damage when found. “Corpses due to drug abuse found in hidden places are often difficult to know with certainty the cause of death. Insects that eat the corpse tissue, then xenobiotics such as drugs and other toxic substances will be transferred to the larval body’s metabolic system so that it is easily detected with sophisticated equipment.”Techniques such as “immunoassays, High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) have been used routinely to detect xenobiotics from the body, larvae, and insects.”The study of “insects as alternative toxicological samples is known as forensic entomotoxicologyInternational Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 185-190

Procedures for the preparation of the nucleophilic diphosphine ligands (R)-(4,4',6,6'-tetramethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine) ((R)-Ph-Garphos, 2a) and (S)-(4,4',6,6'-tetramethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine) ((S)-Ph-Garphos, 2b) were described. The ligands were used to prepare the ruthenium(II) Ph-Garphos complexes, chloro(p-cymene)(R)-(4,4',6,6'-tetraamethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine)ruthenium(II) chloride ([RuCl(p-cymene)(R)-Ph-Garphos]Cl (3)) and chloro(p-cymene)(S)-(4,4',6,6'-tetraamethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine)ruthenium(II) chloride ([RuCl(p-cymene)(S)-Ph-Garphos]Cl (4)). In the presence of the chiral diamine co-ligands (1R,2R)-1,2-diphenylethane-1,2-diamine (R,R-DPEN) and (1S,2S)-1,2-diphenylethane-1,2-diamine (S,S-DPEN), complexes 3 and 4 were found to be active catalyst precursors for the enantioselective reduction of aryl ketones under mild conditions (room temperature and 3-4 atm of H2). The chiral alcohols were isolated in moderate to good yields and with enantioselectivities of up to 93%. The ruthenium complexes, chloro(p-cymene)(R)-(4,4',6,6'-tetramethoxybiphenyl-2,2'-diyl)bis(bis(3,5-dimethylphenyl)-phosphine)ruthenium(II) chloride ([RuCl(p-cymene)(R)-Xyl-Garphos]Cl (5)) and chloro(p-cymene)(S)-(4,4',6,6'-tetramethoxybiphenyl-2,2'-diyl)bis(bis(3,5-dimethylphenyl)-phosphine)ruthenium(II) chloride ([RuCl(p-cymene)(S)-Xyl-Garphos]Cl (6)), were also prepared and used as catalyst precursors for the hydrogenation of aryl ketones in the presence of (R,R)-DPEN and (S,S)-DPEN. Significant improvements in the enantioselectivities of the alcohols (up to 98% ee.) were afforded. A combination of 6 and (S,S)-DPEN afforded (R)-1-(3-methoxyphenyl)ethanol in 89% yield and with 95% ee which was shown to be a suitable precursor for the preparation of (S)-rivastigmine.

Background Indonesia’s national health information systems collect data on maternal deaths but the completeness of reporting is questionable, making it difficult to design appropriate interventions. This study examines the completeness of maternal death reporting by the district health office (DHO) system in Banten Province. Method We used a nested-control study design to compare data on maternal deaths in 2016 from the DHO reporting system and the MADE-IN/MADE-FOR method in two districts and one municipality in Banten Province, with the aim of identifying and characterizing missed deaths in the DHO reporting system. The capture-recapture method was used to assess the magnitude of underreporting of maternal deaths by both systems. Results A total of 169 maternal deaths were reported in the MADE-IN/MADE-FOR study for calendar year 2016 in the three study areas. The DHO system reported 105 maternal deaths for the same period, of which 90 cases were found in both data sources. Capture-recapture analyses suggest that the MADE-IN/MADE-FOR approach identified 92% (95% CI: 87%–95%) of all maternal deaths, while the DHO system captured 57% (95% CI: 50%–64%) of all maternal deaths. Deaths of women who resided in urban areas had four times higher odds (OR 4.3, 95% CI: 1.52–12.3) of being missed by the DHO system compared to deaths among women who lived in rural or remote areas after adjusting for other covariates. Conclusion The DHO reporting system missed approximately half of the maternal deaths in the 3 study areas, suggesting that the DHO system is likely to grossly underestimate the maternal mortality ratio. The DHO reporting system needs to be improved to capture and characterize all maternal deaths.

Glutathione (GSH) transferase deficiency due to paracetamol exposure causes further oxidative stress to liver necrosis. To reduce oxidative stress that can cause damage to the liver of the body requires antioxidants. One plant to treat liver disease is the kelor leaf (because it has an active flavonoid material also has antioxidant activity). This study was conducted to determine the difference of glutathione hepar levels of male white rat induced paracetamol toxic dose by giving kelor leaf extract. The type of research is experimental laboratory in vivo with rancagan randomized post test only control group design. With the stages as follows 1.Leaf Extract Kelor with Ethanol 96%, 2.Perpeteration of experimental animals, 3.Treatment of experimental animals by giving extract of 3-dose of kelor leaf that is KP I 250 mg / 200 gr BB rat, KP II 500 mg / 200 gr BB rat, KP III 1000 mg / 200 gr BB rat for 14 days combined with paracetamol dose 2 gr / 200 gr BB rat compared with the negative control group (group given only paracetamol dose 2 gr / 200 gr BB rat) and control group positif only fed regular feed for 14 days). The result showed that there was a significant difference mean of GSH levels between all treatment groups obtained p = 0,000 (p

Objective: The most frequent acquired molecular abnormalities and important prognostic indicators in patients with Acute Myeloid Leukaemia (AML) are fms-like tyrosine kinase-3 gene (FLT3) and nucleophosmin-1 (NPM1) mutations. Our study aims to develop a cost effective and comprehensive in-house conventional PCR method for detection of FLT3-ITD, FLT3-D835 and NPM1 mutations and to evaluate the frequency of these mutations in patients with cytogenetically normal (CN) AML in our population. Methods: A total of 199 samples from AML patients (95 women, 104 men) were included in the study. Mutation analyses were performed using polymerase chain reaction (PCR) and gene sequencing. Result: Sixty-eight patients were positive for the mutations. FLT3-ITD mutations were detected in 32 patients (16.1%), followed by FLT3-D835 in 5 (2.5%) and NPM1 in 54 (27.1%). Double mutations of NPM1 and FLT3-ITD were detected in 23 cases (11.6%). Assays validation were performed using Sanger sequencing and showed 100% concordance with in house method. Conclusion: The optimized in-house PCR assays for the detection of FLT3-ITD, FLT3-D835 and NPM1 mutations in AML patients were robust, less labour intensive and cost effective. These assays can be used as diagnostic tools for mutation detection in AML patients since identification of these mutations are important for prognostication and optimization of patient care.

Introduction: Acute myeloid leukemia (AML) is a disparate hematopoietic malignancy, with many subtypes and variable responsiveness to therapy. Identification of a targetable biomarker can be used to improve survival outcome of this disease. High mobility group box 1 (HMGB1), contributes to the progression of AML by inducing various cytokines production and angiogenic vascular endothelial growth factor (VEGF). Receptor for advanced glycation end products (RAGE) exists as both a membrane and soluble receptor (sRAGE). HMGB1 is a ligand for RAGE, with sRAGE serving as a natural antagonist of RAGE signaling. Accumulating evidence suggests that HMGB1/sRAGE axis is critically involved in many cancers.Objective: The aim of this study was to investigate whether there is a difference in the plasma levels of HMGB1/sRAGE between AML patients with good and poor prognosis and those who go into relapse.Methods: A total of 97 plasma samples from peripheral blood were analysed for the study (47 AML, 50 healthy subjects). HMGB1 and sRAGE levels were measured using ELISA and analysed using GraphPad Prism 5.0.Results: HMGB1 levels were found to be significantly higher in relapsed AML cases as compared to newly diagnosed cases (49.81 ± 25.25 (N=11) vs 9.461 ± 4.770 (N=36), pg/ml, p = 0.0161). HMGB1 was also significantly higher among new AML cases classified as having poor prognosis as compared to good prognosis (26.11 ± 13.31 (N=12) vs 1.135 ± 0.7147 (N=24), pg/ml, p = 0.0114). Although sRAGE levels were also high where HMBG1 levels were high, the differences were not significant.Conclusion: HMGB1 may be used as a prognostic biomarker, as it appears to promote AML progression with higher levels seen in more malignant forms. Unravelling the mechanisms of HMGB1 in the pathogenesis of AML could provide means to regulate its expression and activities and serve as an effective treatment for more aggressive subtypes.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 59

Following the declaration of eradication of wild poliovirus (WPV) type 2 in September 2015, trivalent oral poliovirus vaccine (tOPV) was withdrawn globally to reduce the risk for type 2 vaccine-derived poliovirus (VDPV2) transmission; all countries implemented a synchronized switch to bivalent OPV (type 1 and 3) in April 2016 (1,2). Any isolation of VDPV2 after the switch is to be treated as a potential public health emergency and might indicate the need for supplementary immunization activities (3,4). On August 9, 2016, VDPV2 was isolated from a sewage sample taken from an environmental surveillance site in Hyderabad, Sindh province, Pakistan. Possible vaccination activities in response to VDPV2 isolation include the use of injectable inactivated polio vaccine (IPV), which poses no risk for vaccine-derived poliovirus transmission. Fractional-dose, intradermal IPV (fIPV), one fifth of the standard intramuscular dose, has been developed to more efficiently manage limited IPV supplies. fIPV has been shown in some studies to be noninferior to full-dose IPV (5,6) and was used successfully in response to a similar detection of a single VDPV2 isolate from sewage in India (7). Injectable fIPV was used for response activities in Hyderabad and three neighboring districts. This report describes the findings of an assessment of preparatory activities and subsequent implementation of the fIPV campaign. Despite achieving high coverage (>80%), several operational challenges were noted. The lessons learned from this campaign could help to guide the planning and implementation of future fIPV vaccination activities.

Medicinal plants are rich source of bioactive compounds which are important for human healthcare. The production of bioactive compounds such as artemisinin is limited in plants. Novel antimalarial drug artemisinin was obtained from leaves of Artemisia annua L. plants. The content of artemisinin in the natural plant is 0.01–1.1 % on dry weight basis. Due to its low content, the drug could not be commercialized in the global market to explore the artemisinin-based combined therapies in the world. The economic limitations of chemical synthesis is unfeasible due to its complexity and cost effectiveness. In this article, we have studied the effect of rate limiting enzymes/genes expression, HMG-Co A reductase and amorpha-4,11-diene synthase on physiochemical changes in terms of total biomass, chlorophyll, total protein, artemisinin content and yield in transgenic lines of A. annua L. plants. The shoot length (42.00 %), number of leaves (86.89 %), the number of root (39.82 %) root length (83.61 %), total biomass accumulation (100 %), total chlorophyll level (138.14 %), total protein level (73.36 %) in TR4 at in vitro level while artemisinin (93.54 %) and its yield (237.26 %) were maximum in TR5 at polyhouse conditions, followed by TR1, TR2, TR3, TR7 and TR9 as compared to non-transgenic Artemisia annua L. plants. A similar trend in leaf biomass, stem biomass and leaf:stem ratio was also recorded in polyhouse condition.

Acute myeloid leukemia (AML) is a heterogeneous disease with a complex interplay of genetic and/or cytogenetic alterations in hematopoietic progenitors, together with aberrant cytokines, chemokines, and small molecules (analytes) expression in the tumor microenvironment, contribute to AML pathogenesis. Although deregulated analytes are well documented in AML, their co-expression patterns are not yet identified. The baseline of circulating analytes in AML is found to be significantly variable between studies. Also, plasma baselines for some analytes that are biomarkers for other cancers have not been previously reported in AML. We hypothesized that comprehensive profiling of plasma analytes would provide greater insight of baselines variability and co-expression signature compared with individual analyses, potentially leading to the identification of novel diagnostic biomarkers and therapeutic targets in AML. Two sets of analytes were selected for this study: (i) 22 reported-analytes (baselines have been previously reported in AML) and (ii) 10 novel-analytes (baselines have not been previously reported in AML). We used multiplex array technology to simultaneously detect and quantify 32 plasma analytes levels in 38 patients (cases= 19, controls=19). We observed that baseline expression ranges are higher for three analytes (FGF2, MPO, and sFas) and lower for two analytes (SCF and sFasL) compared to previously published reports. In our study, 16 analytes are found to be significantly deregulated (13 higher, 3 lower, Mann-Whitney U-test, p-value Note: This abstract was not presented at the conference. Citation Format: Mirazul Islam, Elsa Haniffah Mohamed, Ezalia Esa, Nor Rizan Kamaluddin, Shamsul Mohd Zain, Yuslina Yusoff, Yassen Assenov, Zahurin Mohamed, Zubaidah Zakaria. Circulating cytokines, chemokines, and small molecules follow distinct expression patterns in acute myeloid leukemia [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2017 Oct 1-4; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2018;6(9 Suppl):Abstract nr B86.

Metabolic engineering is a modulation of metabolic pathway(s) of the host either to increase the concentration of existing compounds or to produce a novel compound. It began with the engineering of microorganisms, and the concept has been extrapolated to plants opening newer promising perspectives. The high-value secondary metabolites such as drugs (e.g. paclitaxel, artemisinin and vincristine), dye and pigments, flavour and fragrances and food additives are the main target. Cloning and expression of gene(s) in host plant allow partial/complete reconstitution of biosynthetic pathways.

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive distal axonopathy that precedes actual motor neuron death. Triggers for neuromuscular junction degeneration remain to be determined, but the axon repulsion factor semaphorin 3A (Sema3A), which is derived from terminal Schwann cells, is a plausible candidate. This study examines the hypothesis that Sema3A signaling through its motor neuron neuropilin-1 (NRP1) receptor triggers distal axonopathy and muscle denervation in the SOD1G93A mouse model of ALS. Neuropilin-1 was found to be expressed in axonal terminals at the mouse neuromuscular junction in vivo and in NSC-34 motor neuron–like cells in vitro. In differentiated NSC-34 cells, an anti-NRP1A antibody that selectively blocks Sema3A binding to NRP1 prevented Sema3A-induced growth cone collapse. Furthermore, intraperitoneal injections of anti-NRP1A antibody administered twice weekly from age 40 days significantly delayed and even temporarily reversed motor functional decline while prolonging the life span of SOD1G93A mice. Histologic evaluation at 90 and 125 days revealed that anti-NRP1A antibody reduced neuromuscular junction denervation and attenuated pathologic alterations in ventral roots at late-stage disease. These data suggest that peripheral NRP1A signaling is involved in the pathobiology of this ALS model and that antagonizing Sema3A/NRP1 binding or downstream signals could have implications for the treatment of ALS.

Background: Cervical cancer is the third commonest type of cancer among women in Malaysia. Our aim was to determine the distribution of human papilloma virus (HPV) genotypes in cervical cancer in our multi-ethnic population. Materials and Methods: This was a multicentre study with a total of 280 cases of cervical cancer from 4 referral centres in Malaysia, studied using real-time polymerase chain reaction (qPCR) detection of 12 high risk-HPV genotypes. Results: Overall HPV was detected in 92.5% of cases, in 95.9% of squamous cell carcinomas and 84.3%of adenocarcinomas. The five most prevalent high-risk HPV genotypes were HPV 16 (68.2%), 18 (40%), 58 (10.7%), 33 (10.4%) and 52 (10.4%). Multiple HPV infections were more prevalent (55.7%) than single HPV infections (36.8%). The percentage of HPV positive cases in Chinese, Malays and Indians were 95.5%, 91.9% and 80.0%, respectively. HPV 16 and 18 genotypes were the commonest in all ethnic groups. We found that the percentage of HPV 16 infection was significantly higher in Chinese (75.9%) compared to Malays (63.7%) and Indians (52.0%) (p

Artemisinin, a natural product isolated from aerial parts of Artemisia annua L. plant, is a potent antimalarial drug against drug-resistant malaria. In recent times, the demand (101–119 MT) for artemisinin is exponentially increasing with the increased incidence of drug-resistant malaria throughout the world, especially African and Asian continents. However, the commercial production of artemisinin-based combination therapies has limitation because of the presence of low concentration of artemisinin in plants. Therefore, transgenic lines of A. annua L. plants over-expressing both HMG-Co A reductase (hmgr) and amorpha-4, 11-diene synthase (ads) genes were developed to enhance the content of artemisinin. The selected transgenic lines (TR4, TR5, and TR7) were found to accumulate higher artemisinin (0.97–1.2%) as compared to the non-transgenic plants (0.63%). The secondary metabolite profiles of these lines were also investigated employing gas chromatography mass spectrometry, which revealed a clear differenc...

A photovoltaic (PV) mechanism consists of three important steps, i.e., (i) electron excitation upon absorption of photon with energy higher than the bandgap of fluorophore, (ii) excited-state electron injection from the fluorophore to the photoelectrode, and (iii) electron regeneration from the electrolyte to the fluorophore. An efficient electron regeneration could be achieved upon fulfillment of the requirements of energy alignment, i.e., lowest unoccupied molecular orbital of fluorophore (LUMOfluorophore) > redox potential of electrolyte > highest occupied molecular orbital of fluorophore (HOMOfluorophore). This study investigated the electron regeneration efficiency of excitonic solar cells fabricated using three polymer-based electrolytes, i.e., (i) 60% carboxymethyl cellulose (CMC) blended with 40% polyvinyl alcohol (PVA), (ii) alginate, and (iii) xanthan. The redox potentials of the electrolytes (Eo ) were calculated using quantum chemical calculations under the framework of density functional theory. The compatibility of fluorophore and electrolyte was analyzed in terms of the energy level alignment. The cells fabricated using the three polymer-based electrolytes were analyzed, with the CMC/PVA-based cell yielding the highest efficiency, η, of 1.39% under the illumination of the sun. The low η of the cells can be attributed to the incompatible Eo of the electrolytes, which exhibited a higher energy level than the LUMOfluorophore . The alginate- and xanthan-based cells exhibited inferior PV properties (i.e., open circuit voltage, short circuit current, fill factor, and η) to that of the CMC/PVA-based cell. This finding can be attributed to the increment of energy offset between Eo and HOMO

The study seeks to establish the requirement for the Information and Communication Technology (ICT) competency among counselors in the effort to assist clients that is in need of guidance and counseling. A total of twenty students from the Department of Educational Psychology and Counseling, Faculty of Education, University of Malaya that is currently undergoing professional training in various organizations have been selected as respondents in this study. The study establishes whether or not the knowledge in ICT benefits the trainers in their professional training and facilitates their counseling activities at the respective organizations. Data collected through a combination of interactive observation, documentary analysis and recording sessions of structured interviews are analyzed utilizing a qualitative data analysis approach. Initial findings show that the knowledge and skills in ICT assist the trainers in assessing the needs requirements of the clients based on four areas identified as problematic to the client namely; (1) personal (2) social (3) education and (4) career. The findings also hoped to be able to further assist trainee counselors at institutions of higher educations to augment their skills in counseling and ICT in the pursuit to become competent counselors of the future.

Patients presenting with stage-IV breast cancer are usually offered systemic chemotherapy to control metastatic tumor burden and palliative radiation therapy to manage the symptomatic primary tumor. The aim of this study was to assess the result of local therapy on the overall outcome of patients with metastatic breast cancer. We reviewed medical records of all patients with metastatic breast cancer that presented to our institution between 2000 and 2009. Based on the treatment received, the patients were grouped as follows: group 1 included patients who underwent surgery and also received radiotherapy and chemotherapy/hormonal therapy, group 2 included patients who received radiotherapy and chemotherapy/hormonal therapy only, and group 3 included patients who received chemotherapy/hormonal therapy alone. Of the 37 patients included in the study, 10 patients were placed in group 1, 17 patients in group 2, and 10 patients in group 3. About 38% had high to anaplastic tumor grade, and 48% had ≥2 metastatic sites in the body. Overall, the average survival time was 3.13 years (range: 0-17 years). A significant difference in survival estimates was noted between groups 1, 2, and 3 with mean survival times of 8.83, 4.9, and 2.26 years, respectively (log rank χ = 10.44, P = 0.005). In age-adjusted multivariate Cox regression model (χ = 21.729, P= 0.001), high/anaplastic tumor grade (P = 0.036), African American race (P = 0.009), central nervous system metastasis (P = 0.003), group 2 (P = 0.006), and group 3 (P = 0.002) were associated with poor survival. Survival was not associated with estrogen and progesterone receptor and visceral or bone metastases. We conclude that aggressive local control of primary tumor in patients presenting with stage-IV breast cancer is associated with improved survival.

Delay in seeking treatment for breast cancer is a barrier to the early diagnosis and management of the disease, resulting in a poorer prognosis. We here estimated the prevalence of delayed presentation for breast cancer and identified possible influential sociodemographic factors in a cross-sectional study of 250 patients diagnosed with primary breast cancer at the Radiotherapy and Oncology Clinic in Kuala Lumpur Hospital. Data were collected by face-to-face interview using a structured questionnaire and from medical records. We examined associations between delayed presentation (presenting to a physician more than 3 months after self-discovery of a symptom) and sociodemographic characteristics, practice of breast self examination (BSE), history of benign breast disease, family history of breast cancer and type of symptom, symptom disclosure and advice from others to seek treatment using multiple logistic regression. Time from self-discovery of symptom to presentation ranged from tghe same day to 5 years. Prevalence of delayed presentation was 33.1% (95%CI: 27.4, 39.3). A significantly higher proportion of delayers presented with late stages (stage III/IV) (58.3% vs. 26.9%, p

Glomerular filtration rate (GFR) is the filtrate produced by the kidneys in each minute. Chronic kidney disease epidemiology (CKD-EPI) and standardized modification of diet in renal disease (MDRD) equations are the commonly used equations to estimate GFR. Evaluation of GFR prediction equations regarding body mass index is not available in Bangladeshi population. In this study we compared estimated GFR (eGFR) with GFR measured by creatinine clearance rate (CCR) in lean and obese Bangladeshi subjects. Measured GFR were 40±21 and 45±22 ml/min/1.73m2 in lean and obese groups, respectively. Compared to measured GFR, estimated GFRs were 7.5 (p0.05) ml/min/1.73 m2 higher for CKD-EPI and MDRD4 equations in obese group. The precision (r2) was 0.6461 for CKD-EPI, 0.6508 for MDRD4 equations in lean group and 0.6337 for CKD-EPI and 0.6021 for MDRD4 equations in obese group. The percentages of eGFR falling within 15% measured GFR were 37 for CKD-EPI, 52 for MDRD4 in lean group; 41 for CKD-EPI, 39 for MDRD4 in obese group. CKD-EPI equation overestimates GFR in both lean and obese, but MDRD4 equation overestimates GFR only in lean Bangladeshi subjects.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i1.8764 J. Sci. Res. 5 (1), 207-213 (2013)

Introduction: Despite general acknowledgement of the importance in assessing family needs in critical care patients, there is no psychometric instrument to measure the family needs within Malaysian settings. This study aimed to perform factorial validation and establish psychometric properties of Malay translated Critical Care Family Need Inventory (CCFNI-M) for Malaysians. Methods: This study consisted of four protocols: Forward-Backward translation, validity, internal reliability and inter domain correlations phases. The factorial validation of the CCFNI-M was based on its administration to 109 family members of critical care patients admitted to the Intensive Care Unit of Hospital Universiti Sains Malaysia, Kelantan, Malaysia. At validity phase, factorial validation was performed using Exploratory Factor Analysis using Principal Component Analysis with Varimax rotation. The internal consistency and inter domain correlations were calculated using Cronbach’s alpha and Pearson correlation coefficient respectively. Results: Preliminary analyses reported the suitability of data for factorial validation. With reference to the original CCFNI, five factors were extracted which explained 49.4% of the total variance. After removal of several items for different reasons, the final items in CCFNI-M were 42. The internal consistency values for five dimensions ranged from 0.72 to 0.87 with inter domain correlation values (r) among the dimensions ranged between 0.36 and 0.61. Conclusion: The high measures of factorial validity, internal consistency and inter domain correlations values of the CCFNI-M make it suitable measure for assessing the family needs of critical care patients.

The incidence of aplastic anemia is reported to be higher in Asia than elsewhere. We studied the frequency of human leukocyte antigen (HLA) DRB1 alleles in aplastic anemia patients from 2 genetically similar aboriginal groups, the Kadazan and the Dusun, and compared them with genetically matched community and hospital controls. HLA-DRB1*15 was significantly higher in the patients compared with controls (p = 0.005), confirming similar findings in Japanese and Caucasian studies. Further testing indicated a significantly higher frequency of HLA-DRB1*1501 in patients compared with controls (p = 0.0004) but no significant difference in the frequency of HLA-DRB1*1502. The high frequency of HLA-DRB1*15 in the Kadazan and Dusun population combined with the wide variety of environmental factors associated with aplastic anemia could be the reason for the elevated incidence of aplastic anemia in the Kadazan and Dusun in Sabah.

The adsorption of indole onto chromium, iron and iron/chromium mixed oxides has been studied using UV-vis spectrophotometry, FT-IR spectroscopy and scanning electron microscopy (SEM) with the aim of obtaining an in-depth understanding of the adsorption mechanism. The maximum extent of adsorption was observed in acidic medium (pH ~ 4.0), the corresponding data being fitted by the Langmuir adsorption isotherm. Chromium oxide showed a higher adsorption affinity than the other metal/mixed metal oxides studied. The adsorption of indole onto the various metal oxides was also studied by SEM methods. FT-IR studies of indole, the metal oxides and the indole-metal oxide adduct showed that interaction occurred through attraction between the positively charged surface of the metal oxides and the negatively charged indole moieties. Adominating factor in the adsorption mechanism could be the π-electron system of the indole molecule. The results of the present study suggest that metal oxides could play an important role...

Repeated dose of adrenaline in anaphylaxis is limited evidence in clinical setting. Hence, the usage is depending on physician best interest and knowledge. We reported a case of repeated doses of adrenalin was given through nebulizer and intravenous in anaphylaxis. We believed the unusual circumstances of this case was likely to be repeated on some readers' clinical practice and this mode of treatment is an adjunct to consider in such cases especially in Emergency Department (ED). DOI: http://dx.doi.org/10.3329/bjms.v13i2.16100 Bangladesh Journal of Medical Science Vol.13(2) 2014 p.209-211

In this study, the effects of thermal annealing temperature on the structural and optical properties of S-doped ZnO nanobelts were investigated. The XRD pattern shows that the crystallinity of S-doped ZnO nanobelts improves with increased annealing temperature. Room temperature photoluminescence spectroscopy of the as-grown S-doped ZnO nanobelts shows no detectable ultraviolet peak with the broad peaks in the visible emission region at 480, 505, and 518 nm. A weak peak in the ultraviolet region at 383 nm appears after annealing at 400 and 600 °C. Raman spectroscopy of the sample also shows a significant change with an increase in the annealing temperature.

This study aims to explore the profiles of Malaysian female prisoners. Using a qualitative method through face-to-face interviews, the study was conducted in two prisons among 21 female prisoners who committed various types of crimes. The interview protocol contains open-ended questions and data obtained was analysed using Interpretative Phenomenological Analysis. The crime profiles showed that the informants committed various types of criminal offenses for the first time with different criminal motives in selected closed locations. They used various objects as weapons and committed non-individual crimes. Theirpsycho-criminogenic profiles demonstrated that negative personality traits, high level of stress, aggression and cognitive distortion as psychological factors for committing crimes.