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Various spirofluorenyl oxindoles and spiroindeno[1,2- b ]indolyl oxindoles were synthesized in good yields in one-pot reaction by TiCl 4 -catalyzed sequential inter- and intramolecular Friedel–Crafts reactions of isatins with meta -arylphenols and 2-arylindoles in 1,2-dichloroethane.

Thermal cyclization of E,E,E-trienes prepared from isatines and Morita—Baylis—Hillman bromides results in highly diastereoselective 6π-electrocyclization to form spirocyclic oxindole derivatives (II) and (V).

The title reaction follows an oxidative Heck arylation, allylic palladium migration, aryl C—H bond functionalization/arylation sequence.

E-mail: kimjn@chonnam.ac.krReceived July 1, 2014, Accepted July 21, 2014Intramolecular Diels-Alder (IMDA) reaction of vinylarenes bearing a Z-alkenyl tether, prepared from Morita-Baylis-Hillman (MBH) adducts, afforded arene-fused isoindoline derivatives in good yields. Vinylfurans,vinylthiophenes, and vinylnaphthalenes could be used successfully as dienes, while vinylbenzene failed underthe same reaction conditions.Key Words : Intramolecular Diels-Alder reaction, Morita-Baylis-Hillman adducts, Vinylarenes, IsoindolinesIntroductionThe construction of a cyclohexene ring by using vinyl-arene (such as styrenyl) as a 1,3-diene moiety in both inter-and intramolecular Diels-Alder reactions has been welldocumented.

Various dihydrobenzo[c]azepines were synthesized in good yields via Pictet–Spengler cyclization protocol from tosylamide derivatives of Morita–Baylis–Hillman adducts and 1,3,5-trioxane. The synthesis was carried out in the presence of easily removable montmorillonite K-10 in short time in high yields.

Various spirofluorenyl oxindoles and spiroindeno[1,2- b ]indolyl oxindoles were synthesized in good yields in one-pot reaction by TiCl 4 -catalyzed sequential inter- and intramolecular Friedel–Crafts reactions of isatins with meta -arylphenols and 2-arylindoles in 1,2-dichloroethane.

Thermal cyclization of E,E,E-trienes prepared from isatines and Morita—Baylis—Hillman bromides results in highly diastereoselective 6π-electrocyclization to form spirocyclic oxindole derivatives (II) and (V).

The title reaction follows an oxidative Heck arylation, allylic palladium migration, aryl C—H bond functionalization/arylation sequence.

The introduced procedure involves a novel one-pot preparation of functionalized pyrazoles (III), (VI) from α,β-enones, a one-pot Cu-mediated intermolecular N-arylation, and the deprotection.