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Your search keyword '"Darren F. MacLean"' showing total 3 results
Start Over Author "Darren F. MacLean" Topic medicinal chemistry
3 results on '"Darren F. MacLean"'

1. Synthesis and Reactivity of Platinum Group Metal Complexes Featuring the New Pincer-like Bis(phosphino)silyl Ligand [κ3-(2-Ph2PC6H4)2SiMe]− ([PSiP]): Application in the Ruthenium-Mediated Transfer Hydrogenation of Ketones

Author

Rylan J. Lundgren, Darren F. MacLean, Laura Turculet, Morgan C. MacInnis, and Robert McDonald

Subjects
Silylation, Chemistry, Ligand, Organic Chemistry, chemistry.chemical_element, Transfer hydrogenation, Medicinal chemistry, Catalysis, Pincer movement, Ruthenium, Inorganic Chemistry, Metal, visual_art, visual_art.visual_art_medium, Organic chemistry, Reactivity (chemistry), Physical and Theoretical Chemistry
Abstract

The synthesis of coordinatively unsaturated Ru, Rh, Pd, and Pt complexes supported by the new pincer-like bis(phosphino)silyl ligand [κ3-(2-Ph2PC6H4)2SiMe]− ([PSiP]) is described. In the first application of silyl pincer-type complexes in transfer hydrogenation catalysis, [PSiP]Ru species were shown to be effective in mediating the reduction of ketones employing basic iPrOH as the hydrogen source.

Published
2007
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2. Rhodium and iridium amido complexes supported by silyl pincer ligation: ammonia N-H bond activation by a [PSiP]Ir complex

Author

Laura Turculet, Robert McDonald, Darren F. MacLean, and Erin Morgan

Subjects
Magnetic Resonance Spectroscopy, Silylation, chemistry.chemical_element, Photochemistry, Crystallography, X-Ray, Iridium, Biochemistry, Medicinal chemistry, Catalysis, Reductive elimination, Rhodium, Ammonia, chemistry.chemical_compound, Colloid and Surface Chemistry, Organometallic Compounds, Organosilicon Compounds, Ammonia n, Aniline Compounds, Chemistry, Hydrogen bond, General Chemistry, Amides, Pincer movement
Abstract

Ir silyl pincer complexes insert into the N-H bonds of anilines and ammonia under mild conditions to form isolable [Cy-PSiP]Ir(H)(NHR) complexes that are resistant to N-H bond reductive elimination at room temperature, even in the presence of arenes, alkenes, and phosphines.

Published
2009

3. Room temperature benzene C–H activation by a new [PSiP]Ir pincer complex

Author

Michael J. Ferguson, Andrew J. Caddell, Darren F. MacLean, Laura Turculet, and Robert McDonald

Subjects
Silylation, Intermolecular force, Metals and Alloys, General Chemistry, Photochemistry, Medicinal chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Pincer movement, chemistry.chemical_compound, chemistry, Materials Chemistry, Ceramics and Composites, Reactivity (chemistry), Benzene, Pincer ligand
Abstract

The synthesis and reactivity of coordinatively unsaturated Rh and Ir complexes supported by the new bis(phosphino)silyl pincer ligand [kappa(3)-(2-Cy(2)PC(6)H(4))(2)SiMe](-) ([Cy-PSiP](-)) are reported, including the first example of facile, room temperature intermolecular arene C-H bond activation mediated by a silyl pincer complex.

Published
2008
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