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The European Society of Medical Oncology took place in Paris Convention Centre, Paris, France on 9th −13th September 2022 and was attended by more than 28,000 delegates, 23,000 of which were in person and 5000 online. This was the first on-site ESMO congress after the COVID-19 pandemic. This report focuses on a selection of talks delivered at the conference. There was a vast collection of interesting talks, nevertheless, I attended talks that focused on rare cancers. [ABSTRACT FROM AUTHOR]