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Purpose This research aims to discuss the key civil rights problems in mental well-being and the solutions to those challenges in standard-setting and institutional practice, as well as proposes an integrated approach to adapting the emerging principles of practice to divisive mental health concerns. Design/methodology/approach This study is based on review of literature focused on mental health and human rights with special reference to international standards and clinical practices. Recent articles related to mental health and human rights and mechanisms suggested by United nations were included to draw conclusion. Findings Review of literature suggested to switch from reactive to a constructive and pragmatic approach, which is community-based, emphasizing alliance, rather than action, when the client is still too damaged to agree. Treatment should go hand in hand with mental health and civil rights education in the neighbourhood, as well as opportunities for engagement in shared interests in the group and interaction of other individuals with living experience. Originality/value While consent to care is a vital issue for human rights, the view of individuals with psychiatric illnesses as dangerous and “out of reach” is perpetuated by a disproportionate emphasis on it. Treatment should go hand in hand with mental health and civil rights education in the neighbourhood, as well as opportunities for engagement in shared interests in the group and interaction of other individuals with living experience.

Purpose This paper aims to investigate impact of coronavirus COVID-19 on children’s mental health specifically emotional and behavioral disorders. It aims at identifying the main disorders faced by children during epidemics and suggests recommendations to nurture resilience among children and involving them in various positive activities. Design/methodology/approach This study is based on review of literature focused on COVID-19. Recent articles related to coronavirus or COVID-19 and psychological distress among children were included to draw conclusion and impact of COVID-19 on mental health of children. Due to the limited availability of studies on CONID-19 impact on mental health of children, studies focused on recent pandemic were focused. Findings The identified literature reports a negative impact of COVID-19 on individual’s mental health. Relatives’ health, poor appetite, fear of asking questions about epidemics, agitation, clinginess, physical discomfort, nightmares and poor sleep, inattention and separation issues were among the major psychological conditions analyzed. Personal attributes such as resilience, should be nurtured so that children will be empowered to manage difficult situations such as traumas and disappointments. Several measures were suggested by pediatricians in China to family members and parents such as playing games with children to reduce feeling of loneliness, increased communication to address their concerns and fears, promoting and encouraging physical activities and involving in musical activities to reduce fear, worry and stress among children. Originality/value Coronavirus is new pandemic and growing rapidly. most of the research studies are focused on physical health of individuals, but mental health concept has bene overlooked. This study helps to broaden the scope of research on children's mental health by examining the impact of COVID-19.

Purpose The purpose of this paper is to investigate key milestones in development of standards of human rights to health care in particular context of addressing palliative care, relevant efforts of advocacy in past decade and future area of growth. Design/methodology/approach In this study, analysis of human rights and its standards in context of palliative care has been provided through the lens of freedom from ill treatment and torture, right to health care and older persons’ and children’s rights. Findings Findings of this study highlighted significant developments in this area which include following: first treaty of human rights which explained right to palliative care; first resolution on palliative care by World Health Assembly; special rapporteur’s report focussed on denial of pain; and addressing issue of controlled medicine availability in special session of UN General Assembly. Originality/value Human rights standards and their development in context of palliative care have been most significant in relation to freedom from ill treatment and torture, right to health care and older persons’ rights. Further work is required in context of children’s rights and treaty bodies of human rights need to consistently address state obligations towards palliative care.

Cytochrome P450 (P450) is a super-family of drug metabolizing enzymes. P450 enzymes have dual function; they can metabolize drugs to pharmacologically inactive metabolites facilitating their excretion or biotransform them to pharmacologically active metabolites which may have longer half-life than the parent drug. The variable pharmacological response to psychoactive drugs typically seen in population groups is often not accountable by considering dissimilarities in hepatic metabolism. Metabolism in brain specific nuclei may play a role in pharmacological modulation of drugs acting on the CNS and help explain some of the diverse response to these drugs seen in patient population. P450 enzymes are also present in brain where drug metabolism can take place and modify therapeutic action of drugs at the site of action. We have earlier demonstrated an intrinsic difference in the biotransformation of alprazolam (ALP) in brain and liver, relatively more alpha-hydroxy alprazolam (alpha-OHALP) is formed in brain as compared to liver. In the present study we show that recombinant CYP3A43 metabolizes ALP to both alpha-OHALP and 4-hydroxy alprazolam (4-OHALP) while CYP3A4 metabolizes ALP predominantly to its inactive metabolite, 4-OHALP. The expression of CYP3A43 mRNA in human brain samples correlates with formation of relatively higher levels of alpha-OH ALP indicating that individuals who express higher levels of CYP3A43 in the brain would generate larger amounts of alpha-OHALP. Further, the expression of CYP3A43 was relatively higher in brain as compared to liver across different ethnic populations. Since CYP3A enzymes play a prominent role in the metabolism of drugs, the higher expression of CYP3A43 would generate metabolite profile of drugs differentially in human brain and thus impact the pharmacodynamics of psychoactive drugs at the site of action.

Online shopping is a new way in the world of retailing and future of ecommerce world definitely. A report by Avendus Capital in “India goes Digital” Indian ecommerce market was estimated at 28,500 Crore in 2011. According to Forrester, ecommerce market in India will grow fastest within Asia-Pacific region at a CAGR of 57% between years 2012-2016. Both single branded and multi branded companies are selling their products and services online. This increasing growth has generated the idea to conduct this study. In this context, research paper explores three factors that influence consumer intentions to purchase products online: safety oriented, convenience oriented and price oriented. The study analyzes the perception of 150 online shoppers in Bangalore regarding convenience, safety and price and their intention and attitude towards online shopping. A structured close ended questionnaire was administered to online shoppers. The collected data were analyzed in two stages. In the first stage correlation was performed to analyze between online shopping features and consumer purchase intention. In the second stage factor analysis was carried out to find the critical factors responsible for making consumer purchase intentions towards online shopping. The findings of this research shows that ‘safety’ produces trust, ‘convenience’ originates user friendliness and ‘price’ provides economy, all three influenced directly the attitude towards purchase intentions of consumers to shop online. This paper provides useful insight for the researchers to understand the consumer’s attitude towards online shopping intention.