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We determined anti-rubella and anti-measles immunoglobulin G (IgG) in 7- to 19-year-old children and adolescents with vaccine only-induced immunity of Córdoba, Argentina, during a 6-month period over 2021-2022. Of the 180 individuals studied, 92.2% and 88.3% were positive for anti-measles and anti-rubella IgG, respectively. No significant differences were found comparing anti-rubella IgG concentrations ( p  = 0.144) and anti-measles IgG concentrations ( p  = 0.105) of individuals classified by age, but anti-measles IgG and anti-rubella IgG levels were significantly higher among female individuals compared with males ( p  = 0.031 and p  = 0.036, respectively). Female subjects in the younger age group had higher concentrations of anti-rubella IgG as well ( p  = 0.020), even when anti-measles IgG concentrations did not differ among female age-subgroups ( p  = 0.187). In contrast, age subgroups of male individuals did not have significantly different IgG concentrations for rubella ( p  = 0.745) or measles ( p  = 0.124). Among samples with discordant results (22/180, 12.6%), 9.1% were negative for rubella but positive for measles; 13.6% were equivocal for rubella and positive for measles; 22.7% were equivocal for rubella and negative for measles, while 54.5% were positive for rubella but negative for measles. The findings indicate a seroprevalence below recommended for preventing measles in the population studied, while they evidence the need for standardization of serological tests for rubella IgG.