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Introduction: The purpose of this study was to compare the thickness and length of the zygomatic process (ZP) of the maxilla, infrazygomatic crest area, and mandibular buccal shelf by sex and age., Methods: Cone-beam computed tomography images of 128 subjects were divided into 3 groups: (1) 22 female and 19 male subjects aged 9-13 years, (2) 27 female and 20 male subjects aged 14-23 years, and (3) 20 female and 20 male subjects aged 24-50 years. A previously calibrated operator was used to take all measurements of the zygomatic process vertical bone thickness, zygomatic process horizontal bone length, zygomatic process/cementoenamel length (ZP/CEJL), infrazygomatic crest region bone thickness (IZCBT), infrazygomatic crest region bone length (IZCL), and mandibular buccal shelf bone thickness. Analysis of variance and Kruskal-Wallis tests were used for statistical analyses. Two-way analysis of variance was used for variables with significant differences by sex (P <0.002 as determined by Bonferroni correction for multiple comparisons)., Results: Differences by sex were only found for IZCL in the maxillary second premolar and first molar (U5-U6) and the maxillary first molar (U6). Significant differences were observed among age groups for ZP/CEJL, IZCBT in U5-U6 and U6, and IZCL in U6-distal., Conclusions: The results suggest that ZP/CEJL and IZCL are larger in adults than in younger subjects, whereas IZCBT is smaller in adults than in younger subjects., (Copyright © 2021 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)