1. A Mathematical Lens on the Zoonotic Transmission of Lassa Virus Infections Leading to Disabilities in Severe Cases
- Author
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Yasir Ramzan, Hanadi Alzubadi, Aziz Ullah Awan, Kamel Guedri, Mohammed Alharthi, and Bandar M. Fadhl
- Subjects
mathematical application ,Lassa virus ,disabilities ,empirical data ,sensitivity analysis ,optimal control ,Applied mathematics. Quantitative methods ,T57-57.97 ,Mathematics ,QA1-939 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
This study aims to analyze the dynamics of Lassa fever transmission and its impact on the brain and spinal cord then devise and analyze preventive actions. The stability of the infection-free equilibrium point is evaluated; the model’s precision is examined using empirical data; and all parameters are estimated and fitted. Subsequently, the basic reproductive number is determined, and subpopulation trends are observed over time. Sensitivity analysis is conducted to identify critical drivers influencing transmission dynamics. Two-dimensional plots visualize the impact of crucial parameters on the reproductive number. Through a comprehensive literature review and case analysis, an association between Lassa fever and various disabilities is established, including conditions such as encephalitis, hearing loss, ataxia, neuropsychiatric manifestations, meningitis, seizures, and coma. Solutions are devised and analyzed to enhance early detection, treatment, and mitigation of disease.
- Published
- 2024
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