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Chemical and electrochemical techniques were used to evaluate the effect of expired paracetamil–Zn+2 systems (PC–Zn+2) as potential nontoxic inhibitor for the dissolution process of iron in 2.0 M s...

Synthesis for new pyrazolin derivatives, which oriented for coordination with Cr(III) ion then all new synthesizes were characterized with reliable techniques. Octahedral geometry was the only form suggested from bi-negative tetra-dentate mode of bonding within bi-nuclear complexes. Such offering is based on analytical and spectral tools (IR, UV–Vis and MS). TGA confirms and discriminates water molecules profiles with relative to coordination sphere. Practical and computational XRD patterns appeared having high extent of similarity attributing to nano-crystalline particulate sizes. Hirshfeld surface properties and the efficiency of molecular-contact in crystal-packing, were obtained upon Crystal explorer 3.1 software beside VESTA package. Some physical indices were estimated based on frontier energy gaps over optimized structures upon Gauss-view software. Computational simulation approach was implemented to monitor changes on cancer cell proteins after treatment by new Cr(III) complexes, for assessment. Promising antitumor activity might be expected for Cr(III)-L4, Cr(III)-L3 and Cr(III)-L2 complexes, based on exported interaction parameters. It is worthy to note that, in-vitro assay reflects an excellent cytotoxicity recorded for such three complexes, in excellent harmony with simulation suggestions.

Herein, a novel carbon paste electrode incorporated with reduced graphene oxide (rGO) was electrochemically characterized for sensitive adsorptive voltammetric determination of oxfendazole (OXF) in veterinary formulations and spiked milk samples. On the electrode surface, oxfendazole showed a reversible electrooxidation behavior through a mixed adsorption-diffusion with the involvement of one-electron on the electroanalytical measurements and molecular orbital studies. Linear calibration curves were constructed within OXF concentration ranged from 1.75 to 1890.9 ng ml−1 with LOD value of 0.85 ng ml−1. Compared with the reported OXF sensor, the rGO based sensors showed improved sensitivity with measurement reproducibility and long operational lifetime and shelf lifetime. The fabricated sensors were applied for the quantification of oxfendazole in the local veterinary formulations and spiked milk samples with high accuracy and precision compared with the traditional spectrophotometric techniques.