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Your search keyword '"Potalivo, G"' showing total 6 results
Start Over Author "Potalivo, G" Topic mast cells
6 results on '"Potalivo, G"'

1. Vascular endothelial growth factor (VEGF), mast cells and inflammation.

Author

Shaik-Dasthagirisaheb YB, Varvara G, Murmura G, Saggini A, Potalivo G, Caraffa A, Antinolfi P, Tete' S, Tripodi D, Conti F, Cianchetti E, Toniato E, Rosati M, Conti P, Speranza L, Pantalone A, Saggini R, Theoharides TC, and Pandolfi F

Subjects
Animals, Cytokines metabolism, Humans, Inflammation immunology, Inflammation physiopathology, Inflammation Mediators metabolism, Mast Cells immunology, Neovascularization, Pathologic, Neovascularization, Physiologic, Signal Transduction, Inflammation metabolism, Mast Cells metabolism, Vascular Endothelial Growth Factor A metabolism
Abstract

Vascular endothelial growth factor (VEGF) is one of the most important inducers of angiogenesis, therefore blocking angiogenesis has led to great promise in the treatment of various cancers and inflammatory diseases. VEGF, expressed in response to soluble mediators such as cytokines and growth factors, is important in the physiological development of blood vessels as well as development of vessels in tumors. In cancer patients VEGF levels are increased, and the expression of VEGF is associated with poor prognosis in diseases. VEGF is a mediator of angiogenesis and inflammation which are closely integrated processes in a number of physiological and pathological conditions including obesity, psoriasis, autoimmune diseases and tumor. Mast cells can be activated by anti-IgE to release potent mediators of inflammation and can also respond to bacterial or viral antigens, cytokines, growth factors and hormones, leading to differential release of distinct mediators without degranulation. Substance P strongly induces VEGF in mast cells, and IL-33 contributes to the stimulation and release of VEGF in human mast cells in a dose-dependent manner and acts synergistically in combination with Substance P. Here we report a strong link between VEGF and mast cells and we depict their role in inflammation and immunity.

Published
2013
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2. Impact of IL -9 and IL-33 in mast cells.

Author

Sabatino G, Nicoletti M, Neri G, Saggini A, Rosati M, Conti F, Cianchetti E, Toniato E, Fulcheri M, Caraffa A, Antinolfi P, Frydas S, Pandolfi F, Potalivo G, Galzio R, Conti P, and Theoharides TC

Subjects
Humans, Inflammation etiology, Interleukin-33, Interleukin-9 physiology, Interleukins physiology, Mast Cells physiology
Abstract

Cytokines serve as chemical communicators from one cell to another and most of them have pro-inflammatory activity. Mast cells have been recognised as important mediators of the pathogenesis of allergy and inflammation, suggesting a role for IL-33-mediated mast cell activation. IL-33 was recently identified as a ligand for the orphan IL-1 family receptor T1/ST2 and is mainly expressed by mast cells, fibroblasts, epithelial cells, and endothelial cells, particularly in high endothelial venules. IL-33 is a potent inducer of pro-inflammatory cytokines such as IL-1, IL-6, IL-13 and TNF, and chemokines (MCP-1), by mast cells. Substance P is capable to induce VEGF from mast cells, and IL-33, the newest pro-inflammatory member of the IL-1 cytokine family, augments the effect of SP in VEGF transcription and translation protein. IL-9 is a pleiotropic and is expressed by multiple T helper (TH) cell subsets. IL-9 promotes the expression of mast cell pro-inflammatory cytokines in vitro and is involved in Th2 responses. This article focuses on recent developments of mast cells, IL-9 and IL-33, and recent literature and investigations were reviewed.

Published
2012

3. Interleukin-9 and mast cells.

Author

Tete S, Saggini A, Maccauro G, Rosati M, Conti F, Cianchetti E, Tripodi D, Toniato E, Fulcheri M, Salini V, Caraffa A, Antinolfi P, Frydas S, Pandolfi F, Conti P, Potalivo G, Nicoletti M, and Theoharides TC

Subjects
Animals, Cytokines immunology, Gene Expression Regulation immunology, Humans, Mast Cells pathology, Respiratory Hypersensitivity pathology, Adaptive Immunity, Autoimmunity, Immunity, Innate, Interleukin-9 immunology, Mast Cells immunology, Respiratory Hypersensitivity immunology
Abstract

Mast cells are granulated hematopoietic cells derived from stem cells that reside in nearly all tissues and are involved in protection of a host from bacterial infection with a protective and pathogenic activity. Mast cells are important for both innate and adaptive immunity in tissues which are in close contact with the environment. These cells express proinflammatory cytokines such as IL-1, IL-6, IL-8 and tumor necrosis factor which are necessary for innate immunity. Mast cells also produce interleukin-9 and enhance mast cell expression of several cytokines including IL-1beta, IL-5, IL-6, IL-9 and IL-13. In addition, IL-9 can induce mast cell production of TGF-beta which can have proinflammatory downstream effects. IL-9 can function as either a positive or a negative regulator of immune responses and can have a detrimental role in allergy and autoimmunity. Furthermore, IL-9 contributes to disease by promoting mast cell expansion and production of IL-13 which in turn contributes to airway hyperresponsiveness. Here, in this editorial we review the interrelationship between IL-9 and mast cells.

Published
2012

4. IMPACT OF IL-33 ON PGD2 GENERATION BY ACTIVATED HUMAN CORD BLOOD-DERIVED MAST CELL: LACK OF EFFECT ON TRYPTASE RELEASE.

Author

NICOLETTI, M., MACCAURO, G., TRIPODI, D., SAGGINI, A., POTALIVO, G., CASTELLANI, M. L., CONTI, F., ROSATI, M., TONIATO, E., CARAFFA, A., ANTINOLFI, P., CONTI, P., and THEOHARIDES, T. C.

Subjects
CORD blood, MAST cells, INFLAMMATION, PROSTAGLANDINS, ALLERGIES, CYTOKINES, CYCLOOXYGENASES, ARACHIDONIC acid
Abstract

Mast cells are important not only in allergic reactions, but also in inflammation and are involved in a variety of responses including the immediate release of potent inflammatory mediators after activation by cross-linking of FCERI molecules. Prostaglandin D2 (PGD2) is a major cyclooxygenase metabolite of arachidonic acid produced by mast cells and it is released following allergen challenge in allergic diseases. IL-33 is an iflammatory cytokine which is critically involved in the regulation of in vitro and in vivo cyclooxygenase production, providing a potential therapeutic target for inflammatory disorders. In this study, using human derived umbelical cord blood mast cells, we show that IL-33 (50 ng/ml), and calcium ionophore A 23187 (0.5 (xg/ml), compound 48/80 (10-5 M) or anti-IgE (10 μg/ml), enhaced the production of PGD2 and this effect was inhibited by indomethacin. However, IL-33 was unable to induce tryptase release in these cells. These effects confirm the inflammatory property of IL-33 by stimulating PGD2 but not tryptase in human mast cells. The inhibitory effect of this new cytokine may have a potential therapeutic response in allergic and inflammatory diseases. [ABSTRACT FROM AUTHOR]

Published
2012
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5. Interleukin-9 and mast cells

Author

Tetè, S., Nicoletti, M., Sagginp, A., Maccauro, G., Rosati, M., Conti, F., Cianchetti, E., Tripodi, D., Toniato, E., Mario Fulcheri, Salini, V., Caraffa, A., Antinolfi, P., Frydas, S., Pandolfi, F., Conti, P., Potalivo, G., and Theoharides, T. C.

Subjects
Interleukin-9, IL-9, mast cells, inflammation, cytokine, Autoimmunity, mast cells, Adaptive Immunity, IL-9, Immunity, Innate, Gene Expression Regulation, inflammation, Respiratory Hypersensitivity, cytokine, Animals, Cytokines, Humans
Abstract

Mast cells are granulated hematopoietic cells derived from stem cells that reside in nearly all tissues and are involved in protection of a host from bacterial infection with a protective and pathogenic activity. Mast cells are important for both innate and adaptive immunity in tissues which are in close contact with the environment. These cells express proinflammatory cytokines such as IL-1, IL-6, IL-8 and tumor necrosis factor which are necessary for innate immunity. Mast cells also produce interleukin-9 and enhance mast cell expression of several cytokines including IL-1beta, IL-5, IL-6, IL-9 and IL-13. In addition, IL-9 can induce mast cell production of TGF-beta which can have proinflammatory downstream effects. IL-9 can function as either a positive or a negative regulator of immune responses and can have a detrimental role in allergy and autoimmunity. Furthermore, IL-9 contributes to disease by promoting mast cell expansion and production of IL-13 which in turn contributes to airway hyperresponsiveness. Here, in this editorial we review the interrelationship between IL-9 and mast cells.

6. Impact of IL -9 and IL-33 in mast cells

Author

Sabatino, G., Nicoletti, M., Neri, G., Saggini, A., Rosati, M., Conti, F., Cianchetti, E., Toniato, E., Fulcheri, M., Caraffa, A., Pierluigi Antinolfi, Frydas, S., Pandolfi, F., Potalivo, G., Galzio, R., Conti, P., and Theoharides, T. C.

Subjects
Inflammation, Interleukins, Interleukin-9, IL-33, Humans, Mast Cells, Interleukin-33, IL-9, IL-33, IL-9, Inflammation, Mast cell, Mast cell
Abstract

Cytokines serve as chemical communicators from one cell to another and most of them have pro-inflammatory activity. Mast cells have been recognised as important mediators of the pathogenesis of allergy and inflammation, suggesting a role for IL-33-mediated mast cell activation. IL-33 was recently identified as a ligand for the orphan IL-1 family receptor T1/ST2 and is mainly expressed by mast cells, fibroblasts, epithelial cells, and endothelial cells, particularly in high endothelial venules. IL-33 is a potent inducer of pro-inflammatory cytokines such as IL-1, IL-6, IL-13 and TNF, and chemokines (MCP-1), by mast cells. Substance P is capable to induce VEGF from mast cells, and IL-33, the newest pro-inflammatory member of the IL-1 cytokine family, augments the effect of SP in VEGF transcription and translation protein. IL-9 is a pleiotropic and is expressed by multiple T helper (TH) cell subsets. IL-9 promotes the expression of mast cell pro-inflammatory cytokines in vitro and is involved in Th2 responses. This article focuses on recent developments of mast cells, IL-9 and IL-33, and recent literature and investigations were reviewed.

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