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3-Aminopropyltriethoxysilane and -silatrane readily enter into the Michael aza reaction with various acrylates. Depending on the ratio of the reagents, Michael mono- or diadducts, containing functional groups (triethoxysilyl, carbonyl, nitrile, amino, etc.), are formed. These compounds have been characterized by IR and NMR spectroscopy, mass spectrometry, elemental and X-ray diffraction analyses. The siloxanes obtained from corresponding trialkoxysilanes form carbonyl and nitrile complexes with Ag, Cu, and Ni salts and comprise chemically and thermally stable promising sorbents (enterosorbents) of noble and heavy toxic metal ions. In silico calculations (Protos-II, PASS and Swiss ADMET programs) show that the synthesized silatranes are non-toxic and bioavailable compounds with a pronounced antitumor effect. The effect of silatranes on the growth of pathogenic bacteria (listeria, staphylococci, and plague bacilli) has been studied in vitro. It has been found that these silatranes in microconcentrations exhibit a significant stimulating effect and can be used as growth stimulators of bacterial biomass for rapid diagnosis of diseases caused by these and other pathogens. [ABSTRACT FROM AUTHOR]

Silatranes bearing the aryl(hetaryl)-substituted 1-azadienyl moiety ((Het)ArCH=C(YR) C(H)=N- (Y = O, S)) were synthesized by the reaction of 1-(3-aminopropyl)silatrane with 2-alkoxy- and 2-alkylthio-3-(het)arylpropenals. The structures and stereoisomeric compositions of the synthesized compounds were proved by elemental analysis, IR spectroscopy, 1D 1H, 13C, 15N, 29Si, and 2D NMR experiments, mass spectrometry, and DFT calculations. O-Containing compounds exist exclusively as the 1E,2Z isomers, while S-containing derivatives are the mixtures of the 1E,2Z and 1E,2E stereoisomers. Newly synthesized chalcogen-containing poly-functional compounds represent the promising building blocks for design and synthesis of advanced materials and pharmaceuticals. [ABSTRACT FROM AUTHOR]