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Digital Humanities research often provides opportunities for collaboration – but it just as often requires collaboration. The demands placed on DH projects in terms of technical skills and know-how are such that collaboration and a reliance on adequate research infrastructures become a necessity.

Background: Cognitive aids (CAs) are clinical tools guiding clinical decision-making during critical events in the operating room. They may counteract the adverse effects of stress on the non-technical skills of the attending clinician(s). Although most clinicians acknowledge the importance of CAs, their uptake in clinical practice seems to be lagging behind. This situation has led us to investigate which features of CAs may enhance their uptake. Therefore, in this systematic review we explored the optimums regarding the 1) timing to consult the CA, 2) person consulting the CA, 3) location of the CA in the operating room, 4) CA design (paper vs. electronic), 5) CA lay-out, 6) reader of the CA and 7) if the use of CAs in the form of decision support tools lead to improved outcome. Methods: Seven PICO-questions guided our literature search in 4 biomedical databases (MEDLINE, Embase, Web of Science and Google Scholar). We selected English-language randomized controlled trials (RCTs), observational studies and expert opinions discussing the use of cognitive aids during life-threatening events in the operating theatre. Articles discussing non-urgent or non-operating room settings were excluded. The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: We found 7 RCTs, 14 observational studies and 6 expert opinions. All trials were conducted in a simulation environment. The person who should trigger the use of a cognitive aid and the optimal timing of its initiation, could not be defined by the current literature. The ideal location of the cognitive aids remains also unclear. A favorable lay-out of an aid should be well-structured, standardized and easily readable. In addition, several potentially beneficial design features are described. RCT’s could not demonstrate a possible superiority of either electronic or paper-based aids. Both have their advantages and disadvantages. Furthermore, electronic decision support tools are potentially associated with an enhanced performance of the clinician. Likewise, the presence of a reader was associated with an improved performance of key steps in the management of a critical event. However, it remains unclear who should fulfill this role. Conclusion: Several features of the design or utilization of CAs may play a role in enhancing the uptake of CAs in clinical practice during the management of a critical event in the operating room. However, robust evidence supporting the use of a certain feature over another is lacking.

INTRODUCTION: Older patients are at higher risk of chemotherapy-induced toxicity, raising interest in less toxic anti-HER2 regimens for older persons with HER2-positive (HER2+) metastatic breast cancer (MBC). PATIENTS AND METHODS: This phase II study randomized (1:1) patients with HER2+ MBC, aged 70+ or frail 60+, to first line chemotherapy with metronomic oral cyclophosphamide (M) + Trastuzumab (T) and Pertuzumab (P) or TP alone. T-DM1 was offered in case of progression. RESULTS: In total, 39 and 41 patients were randomized to TP and TPM arm respectively. Median follow-up is 54.0 months. 24-month PFS was 18.7% (95% CI 8.2-32.4) and 28.7% (95% CI 15.8-43.0), respectively. A total of 49 (61.3%) patients died of whom 37 (75.5%) from disease progression; number of deaths per arm was 27 (69.2%) for TP and 22 (53.7%) for TPM. There was no significant difference in OS between the two arms (median OS TP vs TPM: 32.1 vs 37.5 months, p 0.25). Among the 40 patients who have started T-DM1 after disease progression on TP/TPM, PFS rate at 6 months after start of T-DM1 was 43.6% (95% CI: 27.7-58.5) and grade 3 or higher AE occurred in 18 pts (45%). CONCLUSIONS: Metronomic chemotherapy-based dual blockade (TPM), followed by T-DM1 after progression, provides an active and relatively well tolerated treatment option in an older/frail HER2+ MBC population, with a median survival of over 3 years. Nevertheless, the majority of this older/frail population died from breast cancer, highlighting the need for well tolerated and efficacious treatments in these patients. ispartof: BREAST vol:64 pages:100-111 ispartof: location:Netherlands status: published

Publisher Copyright: © 2022 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology. Background: Paediatric atopic dermatitis (AD) can be burdensome, affecting mental health and impairing quality of life for children and caregivers. Comprehensive guidelines exist for managing paediatric AD, but practical guidance on using systemic therapy is limited, particularly for new therapies including biologics and Janus kinase (JAK) inhibitors, recently approved for various ages in this indication. Objectives: This expert consensus aimed to provide practical recommendations within this advancing field to enhance clinical decision-making on the use of these and other systemics for children and adolescents aged ≥2 years with moderate-to-severe AD. Methods: Nineteen physicians from Northern Europe were selected for their expertise in managing childhood AD. Using a two-round Delphi process, they reached full or partial consensus on 37 statements. Results: Systemic therapy is recommended for children aged ≥2 years with a clear clinical diagnosis of severe AD and persistent disease uncontrolled after optimizing non-systemic therapy. Systemic therapy should achieve long-term disease control and reduce short-term interventions. Recommended are cyclosporine A for short-term use (all ages) and dupilumab or methotrexate for long-term use (ages ≥6 years). Consensus was not reached on the best long-term systemics for children aged 2–6 years, although new systemic therapies will likely become favourable: New biologics and JAK inhibitors will soon be approved for this age group, and more trial and real-world data will become available. Conclusions: This article makes practical recommendations on the use of systemic AD treatments for children and adolescents, to supplement international and regional guidelines. It considers the systemic medication that was available for children and adolescents with moderate-to-severe AD at the time this consensus project was done: azathioprine, cyclosporine A, dupilumab, methotrexate, mycophenolate mofetil and oral glucocorticosteroids. We focus on the geographically similar Northern European countries, whose healthcare systems, local preferences for AD management and reimbursement structures nonetheless differ significantly.

The concept of "deep mapping," has been increasingly reflected in recent years in the theory and practice of digital humanities. In this short paper we want to present the Polish experience in this matter, including the "Atlas of Holocaust Literature - Warsaw Ghetto," project prepared by our team in 2019.

The Digital Linguistic Atlas of Scotland is a digitization and reanalysis of the lexical section of the Linguistic Atlas of Scotland. The tool offers dynamic and costumizeable maps and aims to showcase the opportunities of the digitization of analogue linguistic research data.

This paper will discuss how interdisciplinarity, collaboration and participation have been re-imagined in large-scale digital cultural heritage projects, taking the Congruence Engine project as a case study, by highlighting how the interplay between the collaborative nature of DH, and systematic action research can bring together the human and computational.

The main aim of the presentation is to present a methodology for the digital elaboration of the maps of voivodeships and the parish sketches by Karol Perthées to create a map of pre-partition Poland in the last years of its existence.

Researchers from Temple University and Emory University will present the results of an ongoing collaboration using topic modeling and word2vec to explore the eco-poetics and eco-politics of a digitized 20th century speculative fiction corpus

In 2023, Digital Humanities Research Institute at Siberian Federal University starts a working prototype of a research digital infrastructure for the aggregation, preservation, dissemination of Siberian historical and cultural heritage for historical, literary, ethnographic, art history and other kinds of research at the intersection of the humanities and computer sciences — Siberiana.online. The aim of the project is to launch a long-term initiative for digitization, analysis, and curation of the different collections of historical, cultural, and natural heritage of the Central Siberia (so-called Angara-Yenisei macro-region). The project is designed for research and education needs of the digital humanists at Siberian Federal University and world over, because Siberian artifacts and collections evoke a steady interest in the current literature.

Establishing and operating research infrastructures designed for long-term use is a challenge. This holds especially true in small to medium scale institutes carrying out short-term projects. In our presentation, we would like to describe our approach to building an infrastructure for collecting and linking local cultural heritage data in Saxony.

This poster showcases three deployments of virtual reality kits and 360º video design for undergraduate classrooms. It features three examples. The first utilizes a browser-based application that allows users to upload media and view them in a 360º environment. The other examples showcase VR storytelling techniques with consumer-grade 360º cameras.

The project develops an open-source machine learning platform for East Asian Studies, the first one in the United States.Our platform will be so versatile that humanists will not have to devote time to learning various digital tools. With our sample codes and tutorials, researchers can conduct computer-aided research.

This project builds upon the work by German libraries to convert all 65,658 pages of the 536 Messkataloge (the printed "book catalogs" created for the Frankfurt and Leipzig book fairs from 1594 to 1860) from images to machine-readable plaintext, resulting in the first digital database of the Messkataloge.

The poster presents the results of a workshop to be held during the annual DHd conference in March 2023. The workshop addresses the question how to strengthen the role of software and research software engineers in DH and how openness and collaboration can lead to more professionalization.

This paper explores the practices and experiences we have learned from developing an Open Science Infrastructure in the Asia Pacific. The paper purposes a unique three-pillar model; Advanced Technology to improve internet connectivity, a Knowledge Base on internet engineering, and Community Building across universities.

In Digital Humanities "Distant Listening" scholarship with sound, the expectation is that the data set will be clean and audible and that its metadata will be descriptive and informative.[1] In contrast to this notion, this talk demonstrates the importance of distortions in approximately seventy-five brief "tracks" or recorded songs, stories, and explanations from a folklore recording trip Zora Neale Hurston took in 1935 to Florida and Georgia with Alan Lomax and Mary Elizabeth Barnicle for the Library of Congress. Close listening to her 1935 recordings reveals that social and technical distortions are in line with how Hurston expresses the complexities of authority, authenticity, and subjectivity in her writings, which amplifying black epistemologies of self-making and creating resonant possibilities for imagining new transgressive formulations of cultural identity. This talk will consider how distortions play an important in large-scale digital projects with sound in the humanities.

SnECB is an online bibliographical resource on the whole of scholarly sources concerning the old Icelandic Snorra Edda (1220). The database is created through a crowdsourced Zotero public library; data and metadata are exported in a customized TEI file, which is displayed and searched through a front-ent TEI publisher application.

This panel examine four different approaches to creating digital visualizations: database-driven networks, encoded TEI network analysis using IIIF, a material culture digital archive, and spatial analysis using GIS. Presentations will outline the details of each project and the collaborations necessary for each methodological appraoch to creating visualizations.

Using the original, manually applied labels, this poster presents whether early modern legal texts can be automatically labelled through AI. Using Annif (by the National Library of Finland) the applicability of the tool to early modern handwritten texts is and its various backends (e.g. TF-IDF; Omikujji, and fastText) are tested.

Mapping Color in HIstory compiles pigment analysis data from existing and on-going research on scientific analysis of pigments for historical research. As a digital humanities project at the intersection of art and science, multidisciplinary collaboration is at its heart. The paper will introduce the project and discuss methods and contributions.

This paper presents the results of a study evaluating the feasibility of automatic acquisition of small-scale diachronic Latin corpora for linguistic research. The study was conducted on a collection of Neo-Latin works composed by Polish authors, using tools for automatic segmentation (Kraken) and text recognition (Calamari OCR).

This presentation describes the development and analysis of a corpus of the early Irish-language novel: one that strengthens existing resources for the comparative computational analysis of Europe's multilingual literary history and clears a path for dedicated computational analysis of the early novel tradition in Irish.

In this panel we offer a multifaceted and interdisciplinary perspective on the development of the Sloane Lab. We contextualise it both within a wider, nationally-funded drive to make the UK's cultural heritage, and information about it, computationally tractable and the more internationally-positioned work of 'Collections as Data'.

This paper contributes to the assessment of various – possibly impacting – factors during the collection of ground truth data for training HTR-systems. By scrutinising different parameters (e.g. scribal hands, handwriting styles, spelling profiles, textual genres, etc.) we will report on the impact of various train-target combinations.

This contribution illustrates the preliminary results of the project concerning Giorgio Bassani's personal library. The project provides both a printed traditional edition of the notes he wrote on his books and the development of a digital environment to browse and analyze them.

The main objective of CrowdHistory project is to identify, analyse, test and standardise methodological practices of citizen participation in Spanish R&D projects from the perspective of Digital Humanities, both within and outside the academic field.

Our goal is to collect the sounds of Hebrew and to make them accessible for linguistic studies and cultural heritage preservation. Our presentation is focused on the pipeline we have developed and on two main tools that we have developed for it: 1. A Hebrew sound parser and 2. The database platform.

At present there is no way to search the corpus of Greek papyri for lemmas, or to search for specific grammatical forms of a word. Much less is there a way to search for examples of a grammatical category. Polyphemus comes to solve these shortcomings, and some more. For this purpose we have processed all the papyrus texts from PapyInfo (). This processing is done at the same time as the processing that results in the Callimachus database, which we also present at this DH Congress Congress. I summarize below the procedure by which we obtain our database Polyphemus. A) First we analyze each line of papyrus and differentiate the actual full words from the gaps or non-textual elements. B) Then we identify the complete words and separate them from the fragments. This can sometimes be done because of the editorial criteria used in the original edition, before digitizing. Other times it is necessary to check if the text meets some of the external qualities that define a word in ancient Greek (presence of accentuation, etc.). C) We then proceed to lemmatize each of the words, and determine to which part of speech it corresponds, and what is its morphological analysis. All this is done with the help of the Madrid list, which I will discuss below. For text fragments (incomplete words), we try to see if they can be ascribed to a root. We also separate proper nouns from common nouns. D) Lemma assignment and POS-tagging is performed in two phases. In a first pass we tag the forms with the highest frequency of occurrence. We calculate this from the frequency with which lexical forms were tagged in several manually annotated treebanks (over 700,000 words). We then go on to label all the remaining forms using the Madrid Wordlist. The Madrid Wordlist incorporates information about the dialect in which a form appears, so in case of multiple possible analyses we prefer those belonging to Koine (the Greek form of Papyri Greek) or Attic Greek. Naturally this procedure has the consequence that we reduce the number of multiple analyses for the same form (thus drastically reducing the number of false positives) in exchange for losing the correct POS- tagging for low-frequency forms that coincide with high-frequency ones. E) All this information is transferred to a SQL database, and put in relation with the data on the papyri that we have obtained when creating the Callimachus database. In this way, for each lexical form we obtain a lemma, a non-disambiguated morphological analysis, and a translation or gloss. Each of these parameters can be searched in combination with the more than fifty categories available to us thanks to Callimachus, such as date, origin, category, extension, subject, etc. To date, we have been able to analyze 97% of the complete words, including proper names, which are very numerous. 4. The Madrid Ancient Greek Word List The lemmatization and analysis in Parts Of Speech (POS tagging) is performed by comparing each record in our database with the records of a word list that we have created over the last 3 years, which we have called the Madrid Ancient Greek Wordlist. Most of the Ancient Greek wordlists are evolutions, simplifications, or improvements from the Morpheus list developed by Gregory Crane between 1984 and 1990 (Crane 1991; Celano et al. 2016). Our list also starts with Morpheus, but has been enriched with our own treebank (Aristarchus Treebank, 200,000 words; cf. Riaño 2006), and almost 100,000 proper names from The Lexicon of Greek Personal Names and the Trismegistos repository of papyrological and epigraphic resources. All these data were processed to obtain morphological information. I have manually entered several hundred (mostly irregular) pronominal forms in this list. To complete this list I have processed the digital version of the Greek-English Lexicon of Liddell-Scott-Jones, and extracted all the nominal lemmas; then I have determined the declension of each one of them, and I have proceeded to decline each lemma in its Attic and Ionic form by means of a program we have developed. Then we search for each of these forms in the papyri. The program thus produces over 600,000 lexical forms (many of them already in the Morpheus list). The lemmas are then assigned a translation, or rather a gloss

Institutionalized DH units are primed to transform their superordinate humanities organizations as their core skills and values map requirements of organizational development. The concepts of "organizational ambidexterity" and "embeddedness" empowers DH units to evolve their organizations integratively while remaining true to their own mission and practices.

Digital humanities is deeply collaborative and the importance of project planning in the field has grown due to work shifting to hybrid or remote environments. This paper aggregates project planning literature from the point of view of Centers for Digital Humanities (CDH) management to analyze key questions in project planning.

This paper presents a platform providing a digital census of copies of a limited number of printed editions and mapping their owners and readers' annotations represented in an RDF framework. Its ResearchSpace instance, magnetic-margins.com, provides interactive statistical analyses of the data that is encoded predominantly using CIDOC-CRM and FRBRoo.

The paper presents the implementation of various anthropological analyses such as sex, age at death, and body height estimations within the open source database application OpenAtlas and their usages as well as visualisations in thanatoarchaeological and Digital Humanities research projects.

The tutorial demonstrates a workflow that we developed for the text-based digital classification of an early modern advertisement newspaper which allows for subsequent and dynamic classification of the single ads according to the researcher's interest. It also shows how this approach could be applied to similar publications, using our R-package.

This paper reflects on three interdisciplinary undergraduate digital humanities courses that featured study abroad trips to Rome, Italy and collaborative approaches to student-focused digital projects. Faculty presenters are housed in Digital Humanities, New Media, and Religious Studies, and co-developed courses that prioritize methods for researching, documenting, and visualizing placed-based discourse.

The paper presents the work on the Telamon and the Tituli projects which aim at creating online databases respectively of Greek and Latin epigraphic heritage from Bulgaria. The AIAX front-end service for the indexing and visualisation of EpiDoc XML files is described, as well as collaborations with different Bulgarian museums.

Eulalie is an operational, open-source, and free information system dedicated to electroacoustic music to document and preserve works. It is based on the Doremus ontology. We propose adapting this ontology to the specific field of electroacoustic music and its implementation in a database (Heurist, in dialogue with Nakala to host the documents). The project was born in the context of Art Zoyd Studios, a center for musical creation. One of the missions is to preserve the repertoire of the XXth and XXIst century pieces involving electronics. The principles of interoperability and Open Data have guided the different choices made throughout the project. Thus, it is not only possible to make the Art Zoyd Studios information database's content interact with other music resources, but the system itself, Eulalie, can be used by other institutions facing problems similar to those of Art Zoyd Studios.

Living with Machines rethinks the impact of technology on the lives of ordinary people during the Industrial Revolution. The project queries metadata for large-scale newspaper collections. This poster describes the workflow of building a database infrastructure that facilitates quicker and easier humanities research on heterogeneous and complex newspaper data.

The contemporary focus on the 'data problem' in the humanities centers on the uniqueness of humanities data. We argue this is a mistake. Humanities data are not special because of what they are, but rather because of how they are used. The "problem" with Humanities data lies in the use-case.

Our workshop will continue conversations about building community around multilingual DH research in non-Latin alphabets and right-to-left script languages. Participants will think through the languages, skill sets, aspirations and challenges of digital researcher personas working in these languages and scripts through a guided discussion and community co-writing experience.

With this paper we would like to reflect on Proyecto Humboldt Digital's strategy for building digital capacities –that is, learning new skills and methodologies at an individual and organizational level– through collaboration. The international collaboration established in Proyecto Humboldt Digital (ProHD) has not been limited to carrying out a technical workflow but continuously organizes the exchange of research activities and experiences, and builds on a wide set of both internal (team oriented) and external (community oriented) training activities. Despite restrictions during the COVID-19 pandemic, short stays in both Havana and Berlin have taken place since 2019 as well as monthly meetings in virtual format; more recently, in 2022 an international DH conference and a workshop about digital scholarly editions took place in La Habana (Cuba) organized by the team members. During these encounters, we were able to define software requirements, present our main results, share the main issues and progress made in retrospect, and plan our following activities in order to publish online a collection of texts related to Alexander von Humboldt's trip to Cuba in the 19th century.