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Background and objectives: To perform comparative investigation of intra-operative Fentanyl dose administered between the study group and the control group of the population selected for study. To distinguish the intra-operative dose requirement of Fentanyl administered between the study group and the control group. Evaluation of the degree of post operative pain in the study and the control group. Estimation of the rescue analgesic required in Post Operative Care Unit in the study group and the control group. To report the peri operative adverse events in the study and the control group. To approximate the time required for extubation in the study group and the control group. Methods: A Prospective comparative randomized study was conducted after obtaining Institutional Ethical Committee approval with no EC/NIMS/2736/2021 and Informed Consent of the patients was conducted in Department of Anaesthesia at Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India from December 2020 - November 2021 which included females of 18-60 years age undergoing mastectomy Surgery under General Anaesthesia. Results:The study statistically evaluated impression of intra operative fentanyl dose guided by hemodynamic and SPI parameters. Correlation of different fentanyl doses to the parameters like age, BMI, cardiological health, Spectral entropy, intraoperative and post operative events and symptoms, mean extubation time was estimated during mastectomy. Conclusion: The study derives inference from mastectomy performed under general anaesthesia that SPI guided group will distinguish by better hemodynamic stability which will probably result into lower intraoperative fentanyl requirement. Also, apositive postoperative analgesic property andlesser chance of postoperative nausea and vomiting reported when compared with study conducted using conventional hemodynamic guidance. [ABSTRACT FROM AUTHOR]