1. Aspidoptoids A-D: Four New Diterpenoids from Aspidopterys obcordata Vine.
- Author
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Sun P, Cao DH, Xiao YD, Zhang ZY, Wang JN, Shi XC, Xiao CF, Hu HB, and Xu YK
- Subjects
- Animals, Cell Line, Tumor, Diterpenes pharmacology, Humans, Magnetic Resonance Spectroscopy, Mice, Models, Molecular, Molecular Structure, Nitric Oxide metabolism, Plant Extracts pharmacology, RAW 264.7 Cells, Diterpenes chemistry, Malpighiaceae chemistry, Plant Extracts chemistry
- Abstract
Four new diterpenoids, named aspidoptoids A-D ( 1 - 4 ), together with two known analogues ( 5 - 6 ) were isolated from Aspidopterys obcordata vine. Aspidoptoids A-B ( 1 - 2 ) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B ( 2 ) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production., Competing Interests: The authors declare no conflict of interest.
- Published
- 2020
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