1. Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma
- Author
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Jun-Jie Zhou, Zhi-Jun Sun, De-Run Chen, Wen-Feng Zhang, Wei-Wei Deng, Cong-Cong Wu, Hao Li, Yao Xiao, and Lei Chen
- Subjects
Male ,Lymphatic metastasis ,Slug ,Malic enzyme ,Disease-Free Survival ,SOX2 ,Malate Dehydrogenase ,Biomarkers, Tumor ,Humans ,Medicine ,Basal cell ,Clinical significance ,Papillomaviridae ,Pathological ,·prognosis ,Proportional Hazards Models ,malic enzyme 2 ,tissue microarrays ,Tissue microarray ,biology ,Squamous Cell Carcinoma of Head and Neck ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,biology.organism_classification ,oral squamous cell carcinoma ,Gene Expression Regulation, Neoplastic ,stomatognathic diseases ,Tissue Array Analysis ,Lymphatic Metastasis ,Cancer research ,Female ,business ,Research Paper - Abstract
Our study investigated the expression of malic enzyme 2 (ME2) in human oral squamous cell carcinoma (OSCC) and associated pathological and clinical pattern. We demonstrated that human OSCC tissues expressed a high level of ME2, and the overexpression of ME2 is closely connected to a high pathological grade, lymphatic metastasis, large tumor size and human papillomavirus (HPV) (P < 0.001). Similarly, high levels of ME2 expression in OSCC tissue were shown to be correlated with poor prognosis (P < 0.05). The expression of ME2 was correlated with Slug, SOX2, and aldehyde dehydrogenase-1 (ALDH1) immunoreactivity.ME2 was shown to be overexpressed in OSCC tissue and indicated a poor prognosis for OSCC. ME2 may be correlated with several immune markers.
- Published
- 2020