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To summarize the clinical experience of sandwich-shaped resection and cheiloplasty in the treatment of macrocheilia secondary to arteriovenous malformation, and to observe its clinical efficacy and complications. The clinical data of 27 patients with macrocheilia secondary to arteriovenous malformation who received surgical treatment from January 2018 to October 2020 in Linyi Cancer Hospital were retrospectively analyzed. There were 14 males and 13 females. The median age was 4.5 years (ranged from 2 to 57 years). There were 18 cases of upper lip and 9 cases of lower lip. All patients had received interventional embolization sclerotherapy for 5 to 10 times before surgery with unsatisfied effect. There was no obvious improvement in the appearance,whereas 3 cases progressed presenting as abnormal enlargement. Sandwich-shaped resection and cheiloplasty was performed in all the patients. Histopathological examinations confirmed arteriovenous malformations in all 27 cases. Twenty-six patients received one course of operation and one received two courses. Partial mucosal necrosis occurred in 1 case and healed after dressing change, while the rest healed by first intention. Local recurrence occurred in 2 cases within 6 months after operation. A four-level standard was used for long-term evaluation, and 24 cases got grade Ⅲ (good), three cases got grade Ⅱ (moderate) after 1 to 3 years of follow-up. Sandwich-shaped resection and cheiloplasty can achieve good long-term efficacy with excellent appearance and function. Due to its advantages of hidden incision and three-dimensional resection and reservation, it is worthy of further clinical promotion.总结“三明治”式唇病变切除成形术治疗动静脉畸形巨唇症的临床经验，观察其临床疗效和并发症。回顾性分析2018年1月至2020年10月在临沂市肿瘤医院接受手术治疗的27例动静脉畸形巨唇症患者的临床资料，其中男14例，女13例；中位年龄4.5岁（2~57岁）；上唇18例，下唇9例。所有患者在手术前均接受过（外院或本院）5~10次的介入栓塞硬化治疗，巨唇外形改善均不明显，3例病变进展增大。本组病例均采用“三明治”式唇病变切除成形术治疗。共行“三明治”式唇病变切除成形术28例次（1例2次手术）。27例次患者一期切口愈合，1例部分黏膜坏死，后经换药后愈合。有2例分别于术后半年内局部复发。随访1~3年，远期疗效评价Ⅲ级（好）24例，Ⅱ级（中）3例，Ⅰ级（差）0例。“三明治”式唇病变切除成形术切口隐蔽，立体式切除病变彻底，能最大限度保留三维结构，术后外形和功能良好，远期疗效好，建议临床推广该手术方式。.

The nasal type, extranodal natural killer or T(NK/T)-cell lymphoma is usually associated with latent Epstein–Barr virus (EBV) infection. In order to elucidate the EBV gene expression patterns in vivo, we examined eight patients with cutaneous EBV-related NK/T-cell lymphomas, including six patients with a NK-cell phenotype and two patients with a T-cell phenotype. The implication of EBV in the skin lesions was determined by the presence of EBV-DNA, EBV-encoded nuclear RNA (EBER) and a clonality of EBV-DNA fragments containing the terminal repeats. Transcripts of EBV-encoded genes were screened by reverse transcription- polymerase chain reaction (RT-PCR), and confirmed by Southern blot hybridization. The expression of EBV-related antigens was examined by immunostaining using paraffin-embedded tissue sections and cell pellets of EBV-positive cell lines. Our study demonstrated that all samples from the patients contained EBV nuclear antigen (EBNA)-1 mRNA which was transcribed using the Q promoter, whereas both the Q promoter and another upstream promoter (Cp/Wp) were used in EBV-positive cell lines, B95.8, Raji and Jiyoye. Latent membrane protein-1 (LMP-1) mRNA was detected in seven of eight patients and all cell lines, whereas EBNA-2 transcripts were found only in the cell lines. Immunostaining showed no LMP-1, EBNA-2 or ZEBRA antigens in the paraffin-embedded tissue sections, although they were positive in the cell line cells. Latent BHRF1 transcripts encoding bcl-2 homologue and BCRF1 transcripts encoding viral interleukin (vIL)-10 were detected in one and two of eight patients, respectively. A patient with NK-cell lymphoma expressing both transcripts died of rapid progression of the illness. Our results indicate that the restricted expression of the latency-associated EBV genes and the production of vIL-10 and bcl-2 homologue may favour tumour growth, evading the host immune surveillance. © 2001 Cancer Research Campaign http://www.bjcancer.com

Patients with hydroa vacciniforme (HV)-like eruptions and malignant potential have been reported from Asia and Mexico, and those patients frequently had an associated latent Epstein-Barr virus (EBV) infection. In order to elucidate the association of latent EBV infection with HV, we studied six children with typical manifestations of HV by detection of EBV genes and EBV-related RNAs in biopsy specimens from cutaneous lesions. Cutaneous lesions of all six children with typical HV contained EBV-encoded small nuclear RNA (EBER)+ cells in 3-10% of the dermal infiltrates, whereas no Bam HI-H, l-fragment (BHLF) mRNA, or transcripts encoding EA-D antigen, were detected. No EBER + cells were detected in other inflammatory or benign lymphoproliferative skin disorders tested. Polymerase chain reaction amplification confirmed the presence of EBV DNA sequences in five of six biopsy specimens from the patients. Latent EBV infection is associated with the development of cutaneous lesions of HV.

The results of management of neck nodes in 295 cases with supraglottic laryngeal carcinoma were reviewed. Different approaches had been adopted. For N1-N3 cases RND was instituted routinely; for N0 cases, RND, which has been advocated by many authors, seems to be an overtreatment. We prefer upper jugular node dissection for pathologic evaluation. Out of 86 N0 cases, only 6 were proved to be positive for metastases. The 3 and 5 year survival rates for this series were 89.5% and 75.3% respectively which were comparable with those reported to have RND.

In recent ten years, physicians and surgeons in Beijing Tong Ren Hospital cooperated well in the treatment of acute hemorrhagic necrotic pancreatitis. Twenty four cases were chosen to determine whether medical conservative or surgical operative treatment should be given. In the surgical operation group there were fourteen cases. Twelve cases survived and the remaining two died. In the medical conservative group only one of the ten cases died. The overall mortality of the twenty four cases of acute hemorrhagic pancreatitis was 12.5%. In our study, the indications for operation were as follows: (1) Presence of more than five positive diagnostic criteria. (2) Accompaniment of gall stone. (3) Inability to differentiate with other acute surgical abdominal emergencies such as intestinal obstruction.

Hybridization experiments were conducted by forced mating between Anopheles minimus from Guangxi (G) and Yunnan (Y). F1 hybrid females were all fertile with normally developed ovaries. (Y female x G male) F1 males were all sterile, with abnormally enlarged testes. (G female x Y male) F1 males, though fertile, showed somewhat atrophic testes, and when they were back crossed with parental females, the latter produced eggs with very low hatching rate. Ovarian nurse cell polytene chromosomes from F1 hybrid females showed partial asynapsis in X chromosome as well as in autosonles, asynapsis at 38 zone in 3L being the most constant. It was obvious that there was definite, though partial, reproductive isolation between An minimus from Guangxi and that from Yunnan. Whether they are sibling species remains to be further investigated (Figs. 1-8).

Sixteen patients with far advanced recurrent malignancies (later than Stage IV) of the head and neck were treated with radical salvage surgery combined with radiotherapy, chemotherapy, immunotherapy, laser and/or traditional Chinese medicine. The 2- and 3- year survival rates were 56.3% (9/16) and 37.5% (6/16), which were superior to 6.3% (1/16) and 6.3% (1/16) of similar patients who refused treatment. The authors are of the opinion that aggressive treatment should be attempted for patients with far advanced recurrent cancers of the head and neck.

Thirty-seven domestic rabbits, 4 dogs, and 2 freshly amputated human limbs were divided into three groups as three different models of fasciosteal flaps that were taken from the distal radii or the tibiae. Through the methods of histology, fluorochrome bone labeling, and perfusing stain, it was confirmed that viability of the bone graft can be maintained by blood flow by means of the fascial route. This technique was used for treating eight patients with nonunion of such different fractured sites as the scaphoid, the talus, and so forth or with osteomyelitic tibial defects or both skin and tibial defects. With 8 to 15 months of follow-up, the osteomyelitis cleared uneventfully and the fracture healed. Patients recovered their normal function. We think that there are at least three routes for the blood supply from deep fascia to bone: direct blood supply, blood supply by means of bone membrane, and blood supply by means of the intermuscular septum. We feel that the fasciosteal flap is an ideal random-pattern vascularized bone graft.