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1. Characterization of the acrosome reaction-inducing substance in Xenopus (ARISX) secreted from the oviductal pars recta onto the vitelline envelope

Author

Yasushi Ueda, Hideo Kubo, and Yasuhiro Iwao

Subjects
Male, medicine.medical_specialty, Xenopus, Acrosome reaction, Vitelline membrane, Oviducts, Xenopus Proteins, Biology, Epitope, Mice, Xenopus laevis, Internal medicine, medicine, Animals, Acrosome, Molecular Biology, Glycoproteins, chemistry.chemical_classification, Tissue Extracts, urogenital system, Antibodies, Monoclonal, Oviduct, Cell Biology, biology.organism_classification, Spermatozoa, Molecular biology, Sperm, Endocrinology, chemistry, Fertilization, Oocytes, Female, Glycoprotein, Vitelline Membrane, Developmental Biology
Abstract

We previously demonstrated that Xenopus sperm undergo an acrosome reaction on the vitelline envelope (VE) in response to the materials secreted from the oviductal pars recta [Dev. Biol. 243 (2002), 55]. A monoclonal antibody against the acrosome reaction-inducing substance in Xenopus (ARISX) was obtained by immunizing mice with pars recta extract (PRE). The acrosome reaction by PRE or on the VE was effectively inhibited by the intact anti-ARISX antibody as well as its Fab fragment, indicating that the antibody recognizes the epitopes localized on the acrosome reaction-inducing substance. On Western blots, the anti-ARISX antibody recognized a molecule with an apparent molecular mass of 300 kDa in PRE and in the VE, but this molecule was not detected in the coelomic envelope. The amount of ARISX in PRE was increased by the treatment of females with pregnant mare serum gonadotropin. Periodate oxidation of PRE completely abolished the acrosome reaction-inducing activity, indicating the involvement of the carbohydrate moieties of ARISX in inducing the acrosome reaction. On immunofluorescence observation, ARISX was localized in the epithelial cells in the posterior region of the pars recta and on the VE as fibrous structures.

Published
2003
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2. Acrosome Reaction in Sperm of the Frog, Xenopus laevis: Its Detection and Induction by Oviductal Pars Recta Secretion

Author

Yasuhiro Iwao, Norio Yoshizaki, and Yasushi Ueda

Subjects
Male, Xenopus, Acrosome reaction, acrosome reaction, Oviducts, Biology, sperm, Xenopus laevis, pars recta, Extracellular, Animals, Secretion, Acrosome, Molecular Biology, Calcimycin, Microscopy, Confocal, Ionophores, urogenital system, Vesicle, Cell Biology, Anatomy, biology.organism_classification, Spermatozoa, Sperm, Cell biology, Oviduct, Calcium, Female, Indicators and Reagents, Developmental Biology
Abstract

Previous electron microscopic observations have shown that the acrosome of the sperm of the frog, Xenopus laevis, comprises a membrane-bounded vesicle covering the anterior-most position of the head. We obtained a sperm suspension from the testes and stained it with LysoSensor Green for observation under a confocal laser scanning microscope and found a bright fluorescence reflecting the presence of the acrosomes at the top of the sperm head in about 64% of the sperm, with no deterioration of their capacity to fertilize. About 40% of the sperm with an acrosome underwent an acrosome reaction in response to Ca2+ ionophore A23187, as evidenced by a loss of LysoSensor Green stainability, accompanied by breakdown of the acrosomal vesicle. About 53% of the sperm bound to isolated vitelline envelopes underwent an acrosome reaction, whereas both jelly water and solubilized vitelline envelopes weakly induced an acrosome reaction. When the sperm were treated with an oviductal extract obtained from the pars recta, but not the pars convoluta region, about 40% of the sperm with acrosomes underwent an acrosome reaction. The substance containing acrosome reaction-inducing activity in the pars recta extract seemed to be a heat-unstable substance with a molecular weight of greater than 10 kDa. The activity was not inhibited by protease inhibitors but required extracellular Ca2+ ions. These results indicate that the acrosome reaction occurs on the vitelline envelopes in response to the substance deposited from the pars recta during the passage of the oocytes through the oviduct.

Published
2002

3. Analysis of terminal sugar moieties and species-specificities of acrosome reaction-inducing substance in Xenopus (ARISX)

Author

Yasushi, Ueda, Chisato, Imaizumi, Hideo, Kubo, Ken-Ichi, Sato, Yasuo, Fukami, and Yasuhiro, Iwao

Subjects
Male, Xenopus laevis, Species Specificity, Acrosome Reaction, Carbohydrates, Animals, Fluorescent Antibody Technique, Indirect
Abstract

The acrosome reaction of Xenopus sperm is triggered by the acrosome reaction-inducing substance in Xenopus (ARISX), an oviductal pars recta-derived, sugar-rich substance decorated on the entire surface of the vitelline envelope (VE) during ovulation. Here we addressed the functional importance of the sugar moiety in ARISX. Among various lectins examined, soybean agglutinin and Dolichos biflorus agglutinin were shown to abolish the acrosome reaction-inducing activity of ARISX present in pars recta extract or on the VE, indicating the importance of the terminal alpha-N-acetylgalactosamine residue for the function of ARISX. Consistently, the acrosome reaction-inducing activity was not affected by proteinase K digestion, in spite of the simultaneous shift of ARISX to a smaller molecular weight. Indirect immunofluorescence microscopic examinations showed that ARISX was distributed as two types of structures on VE; thick fiber-like materials and thin filamentous materials, and that a new structure appeared on the fertilization envelope instead of the thin filamentous materials. Sperm from several amphibian species were subjected to an in vitro assay during induction of the acrosome reaction with ARISX. The resulting limited population of sperm from a non-Xenopus species underwent acrosome reaction, implying a weak species-specificity of ARISX.

Published
2007

4. Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization

Author

Keiichi Sakakibara, A. K. M. Mahbub Hasan, Yasushi Ueda, Kazuyoshi Yonezawa, Yasuo Fukami, Ken-ichi Sato, Ken-ichi Yoshino, Noriko Oshiro, Shino Hirahara, Yasuhiro Iwao, and Tetsushi Iwasaki

Subjects
Male, Cytoplasm, Xenopus, Biochemistry, Mass Spectrometry, CSK Tyrosine-Protein Kinase, chemistry.chemical_compound, Protein structure, Tetraspanin, Tissue Distribution, Tyrosine, Cloning, Molecular, Phosphorylation, Fluorescent Antibody Technique, Indirect, Glutathione Transferase, Expressed Sequence Tags, Uroplakin III, Membrane Glycoproteins, Protein-Tyrosine Kinases, Immunohistochemistry, Transmembrane protein, src-Family Kinases, embryonic structures, Electrophoresis, Polyacrylamide Gel, Female, Protein Binding, DNA, Complementary, Immunoprecipitation, Recombinant Fusion Proteins, Immunoblotting, Molecular Sequence Data, Biology, Tetraspanin 29, Cell Line, Membrane Microdomains, Antigens, CD, Centrifugation, Density Gradient, Animals, Humans, Biotinylation, Amino Acid Sequence, Molecular Biology, Uroplakin Ib, Sperm-Ovum Interactions, Sequence Homology, Amino Acid, Cell Membrane, Tyrosine phosphorylation, Cell Biology, Hydrogen Peroxide, Sequence Analysis, DNA, biology.organism_classification, Lipid Metabolism, Protein Structure, Tertiary, chemistry, Fertilization
Abstract

Here we describe mass spectrometric identification, molecular cloning, and biochemical characterization of a lipid/membrane raft-associated protein that is tyrosine-phosphorylated upon Xenopus egg fertilization. This protein is homologous to mammalian uroplakin III, a member of the uroplakin family proteins (UPs) that constitute asymmetric unit membranes in the mammalian urothelial tissues, thus termed Xenopus uroplakin III (xUPIII). xUPIII contains N-linked sugars and is highly expressed in Xenopus eggs, ovary, urinary tract, and kidney. In unfertilized eggs, xUPIII is predominantly localized to the lipid/membrane rafts and exposed on the cell surface, as judged by surface biotinylation experiments and indirect immunofluorescent studies. After fertilization or hydrogen peroxide-induced egg activation, xUPIII becomes rapidly phosphorylated on tyrosine residue-249, which locates in the carboxyl-terminal cytoplasmic tail of the molecule. Raft localization and tyrosine phosphorylation of xUPIII can be reconstituted in HEK293 cells by coexpression of xUPIII, and Xenopus c-Src, a tyrosine kinase whose fertilization-induced activation in egg rafts is required for initiation of development. In mammals, UPIII is forming a complex with a tetraspanin molecule uroplakin Ib. As another tetraspanin, CD9, is known to be a critical component for sperm-egg fusion in the mouse, we have assumed that xUPIII is involved in sperm-egg interaction. An antibody against the extracellular domain of xUPIII blocks sperm-egg interaction, as judged by the occurrence of egg activation and first cell cleavage. Thus, xUPIII represents an egg raft-associated protein that is likely involved in sperm-egg interaction as well as subsequent Src-dependent intracellular events of egg activation in Xenopus.

Published
2005

5. [Biological effects of exposure to high frequency electromagnetics on rabbits and guinea pigs]

Author

Motohiko Kurita, Hidenori Ohashi, Kazuyoshi Maejima, Yoshiko Aoyama, Chikao Torigata, and Yasushi Ueda

Subjects
Male, Pathology, medicine.medical_specialty, Skin surface temperature, Guinea Pigs, Food consumption, General Biochemistry, Genetics and Molecular Biology, Microcirculation, Guinea pig, medicine, Animals, Laser doppler flowmeter, Skin, Hematologic Tests, General Veterinary, Chemistry, General Medicine, Blood flow, Environmental Exposure, Organ Size, medicine.anatomical_structure, Regional Blood Flow, Animal Science and Zoology, Female, Rabbits, Skin Temperature, Electromagnetic Phenomena, Blood vessel
Abstract

To investigate the biological effects of exposure to feeble high frequency electromagnetism, skin surface temperature, blood vessel (arterioles and venules) diameter were examined, using infrared thermography, a laser doppler flowmeter, and a video microscope, respectively, in the ear of rabbits. After exposing the ear of rabbits to high frequency electromagnetism value of 9 MHz for 15 minutes, continued rising of local temperature was demonstrated. Though dilatation of arterioles was not seen. In addition, venules tended to dilate and blood flow also to increase, and microcirculation was accelerated at the site where electromagnetism was exposed. Hazardous effects of long term exposures of high frequency electromagnetism (9 MHz for 30 days, 8 hours/day) on guinea pigs were not observed in their behavior, food consumption, body and organ weights, hematological and biochemical values, macroscopic and microscopic findings on autopsy.

Published
1992

6. Comparative Study of Cefuzonam (CZON) with Cefotiam in Bacterial Pneumonia and Pulmonary Suppuration

Author

Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayasu KAWANISHI, Masatoshi WATANABE, Jiro HINO, Yoshihisa NAKAGAWA, Shigenobu UMEKI, Masaru SUMI, Toshio KISHIMOTO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Shinya YASUDA, Tetsuji KORAKU, Hiromichi HORIKAWA, Akio HIRAYAMA, Soichiro UEHARA, Masashi TAMURA, Takashi ITO, Fumitoshi YAMAUCHI, Hitoshi KOBAYASHI, Kazumichi MIYA, Yoshikatsu NEMOTO, Tamotsu TAKISHIMA, Shiro IDA, Makoto TAKAHASHI, Tadao ISE, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Kikuo ONUMA, Yuji NAKAI, Kosaku NAGAI, Kenji BABA, Masayuki ITO, Fumio ARIJI, Teruo HASUIKE, Yoichi FUKUDA, Izumi HAYASHI, Tsuguji ITO, Masaaki ARAKAWA, Koichi WADA, Masanaga TAKATO, Morito IWANAGA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Takashi YOKOSE, Yasushi UEDA, Tadashi MIYAHARA, Atsushi SAITO, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kota KONO, Hiroaki TAKEDA, Keimei MASHIMO, Tadahiro KURASAWA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Hiroko SUGI, Junzaburo KABE, Yasuyuki SANO, Koichiro KUDO, Tetsuzo WATANABE, Mitsuo YAMAGISHI, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Shinichi OKA, Akio AOYAGI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Hideo TAKAHASHI, Tomiji MIURA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Fumio MATSUMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Ryujiro SUZUKI, Shigeki YOKOYAMA, Hitoshi IWATA, Motohide SASAMOTO, Tomoyasu SASAKI, Masatoshi IMAI, Masao TANO, Masahito KATO, Toshihiko TAKEUCHI, Teiichi KATO, Yoshimitsu HAYASHI, Hidekazu HANAKI, Yoji USAMI, Hideaki KUROKI, Fumiyuki KUZE, Takako MURAYAMA, Hideki NISHIYAMA, Motokazu KATO, Hiroshi OKUBO, Yoshihiro UEDA, Tadanao TAKEDA, Naotsugu KURIHARA, Kazuhiko TERAKAWA, Yuriko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Kojiro YASUNAGA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenzo SHIODA, Keiji KOBAYASHI, Yoshio YAMADA, Kiyomichi YOSHIMARU, Eiro TSUBURA, Koichi FUKUYAMA, Masaru NAKAGAWA, Eiji CHIKATA, Yasuhiro HASEGAWA, Einosuke UEDA, Hideki NISHIKAWA, Yukio NISHIMOTO, Michiro YAMAKIDO, Akimitsu KAMITSUNA, Yoshinao IHARA, Kazuo ITASAKA, Osamu KURIMURA, Hirofumi FUKUHARA, Hideo SASAKI, Masakazu TAMURA, Yoshiro SAWAE, Yukio KUMAGAI, Jun NAGANO, Hiroshi NAKANO, Chiharu KUBO, Hiroko KAWAMURA, Atsushi SHINODA, Masahiro TAKAMOTO, Tsuneo ISHIBASHI, Masashi KAWAHARA, Yasuko HARADA, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Takakazu KIYA, Kyoko YAMASHITA, Kazuo SASAYAMA, Toshiaki HAYASHI, Hiroshi TOMITA, Kinichi IZUMIKAWA, Kazunori SHIMOGUCHI, Tsunetoshi KOTEDA, Koichi WATANABE, Kazuhiro OKUNO, Keizo MATSUMOTO, Fumishige SONODA, Toshiaki YOSHIDA, Akira SAKAMOTO, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Yasuko OJIRO, Minoru NISHIMIYA, Toshinori KAWASAKI, Syukuro ARAKI, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Hidetsugu KAMIYAMA, Kazuko YOSHIDA, Fujio TANAKA, Kazumine KOBORI, and Masao NAKATOMI

Subjects
Adult, Aged, 80 and over, Lung Diseases, Male, Suppuration, Cefotiam, business.industry, Ceftizoxime, Bacterial pneumonia, Bacterial Infections, Cefotaxime, Pneumonia, General Medicine, Middle Aged, medicine.disease, Cefuzonam, Cephalosporins, Microbiology, Humans, Medicine, Female, business, Aged, medicine.drug
Published
1986

7. A comparative Study Between Aztreonam and Cefoperazone in Respiratory Tract Infections

Author

Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Yasushi UEDA, Tsugio TERAI, Shosaku ABE, Etsuro YAMAGUCHI, Nozomu OKAZAKI, Yoshikazu KAWAKAMI, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Kiyofumi ISHIKAWA, Akira SUZUKI, Mitsunari NAKAMURA, Hiroshi NATORI, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Sokichi ONODERA, Nobuhiro SASAKI, Fumio NAGAHAMA, Rensuke KURODA, Yuji IKEDA, Kazuo TAKEBE, Shiro KOSAKA, Ken-ichi KIMURA, Masafumi KITAOKA, Shuichiro YOSHIDA, Katsuhiro OKAMOTO, Teruo NAKAMURA, Osamu UEHARA, Shigetoshi YANAGIYA, Toyokazu TAMURA, Hitoshi YASHIRO, Takahiko KAWAGISHI, Masao TAMURA, Takashi ITO, Takehisa MURAKAMI, Kohtaroh ITAKURA, Hiroshi KURAMITSU, Katsura MORIYA, Kazutoshi GOMI, Tamotsu TAKISHIMA, Shiro IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Reiko SASAKI, Izumi HAYASHI, Koichi WADA, Hajimu TAKEDA, Masaaki ARAKAWA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OHYAMA, Kuninori SUZUKI, Hisashi TAKIZUKA, Masato NAKANO, Hajime YAMAGATA, Yumiko MURAYAMA, Kazumichi TSURUMACHI, Hiroichi TANIMOTO, Tatsuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Katsunori UENO, Tetsuro UKAI, Kazuaki HANAOKA, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Fukuo IIJIMA, Kentaro WATANABE, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kihachiro SHIMIZU, Fumio MATSUMOTO, Kazufuto FUKAYA, Shigeki ODAGIRI, Masanori MATSUMURA, Kaneo SUZUKI, Kou MUROHASHI, Keinosuke NOZE, Shin-ichiro WATANABE, Hisako SUZUKI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Kenzo TAKAGI, Ken-ichi YAMAKI, Shigeki YOKOYAMA, Masao TANO, Hitoshi IWATA, Motohide SASAMOTO, Tatsuo SATAKE, Nobuo MAEKAWA, Fumiyuki KUZE, Michiyasu NAKANISHI, Hideki NISHIYAMA, Hiroyuki TSUJINO, Nobuo INABA, Yoshiro ODA, Akira KAGIOKA, Takekuni IWATA, Kazukiyo OIDA, Hitoshi NAKAI, Hiroko SAKAMOTO, Nobuyuki KATAGAMI, Eiichi MATSUYAMA, Shin-ichi USHIDA, Sadao IKEDA, Kohei AOKI, Kenzo SHIOTA, Yoshio YAMADA, Keiji KOBAYASHI, Kojiro YASUNAGA, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Yoshihiro UEDA, Akira OOKUBO, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Tetsuro MURATA, Shin-ichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenji TAKAMATSU, Kazuya HIGASHINO, Toshikazu HADA, Kenji NABESHIMA, Akitaka HIROSAKI, Takashi NAKANO, Rinzo SOEJIMA, Yoshihito NIKI, Yukio NISHIMOTO, Michio YAMAKIDO, Akimitsu KAMITSUNA, Kenji HASEGAWA, Osamu KURIMURA, Yoshihiko ARATANI, Eiro TSUBURA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Nobuaki SHIGEMATSU, Norichika MATSUMOTO, Reiko KISHIKAWA, Takeo YOKOTA, Hitoshi NAGANO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Kazuhiro OKUNO, Koichi WATANABE, Tsunetoshi KOTEDA, Kenji MORI, Keizo MATSUMOTO, Yoshio UZUKA, Naoto RIKITOMI, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Takashi ITOGA, Masayuki ANDO, Mineharu SUGIMOTO, Moritake SUGA, Akira MIYAZAKI, Shukuro ARAKI, Kazumine KOBARI, Masao NAKATOMI, Yuei IRABU, Tatsuo OHGIMI, and Yutoku KINJO

Subjects
Adult, Male, Adolescent, Respiratory tract infections, business.industry, Cefoperazone, Pneumonia, General Medicine, Aztreonam, Middle Aged, Haemophilus influenzae, Microbiology, chemistry.chemical_compound, chemistry, Humans, Medicine, Female, business, Respiratory Tract Infections, Aged, medicine.drug
Published
1985

8. A STUDY OF RENAL GLYCOSURIA

Author

Teruo Takasu, Kanpachiro Yamamoto, Fusanosuke Kobayashi, and Yasushi Ueda

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, business.industry, Urology, General Medicine, Glycosuria, Renal, Middle Aged, medicine.disease, Pedigree, medicine, Renal glycosuria, Humans, Female, business, Aged
Abstract

Marbleのcriteriaに一致した6家系,計28人の腎性糖尿患者について病態生理,遺伝関係など種々な観点から分析した.尿糖は常時存在し, 1日尿糖量は中等度である.空腹時血糖値は正常ないし低値を示し,耐糖能に異常はなく,糖負荷時の血清電解質ならびにNEFAの変動も正常であつた.糖質摂取量を変えても,またインスリンを投与しても1日尿糖量の変化はほとんどなかつた. glucose titrationによりえた結果は, (1) relative glomerular activityの増大は著明であつた. (2) TG/CFとPG CFとの関係ではPG CF値が高くなるとTG/CFが正常値をとる群と異常高値をとる群とに分けられた. (3) titration curveでsplayは著明に拡大していた.すなわち本症例が示す糠尿は個々のnephronのheterogeneityにより出現することが示唆される.遺伝関係では常染色体優性遺伝型で浸透は完全であつた. 10カ月から2年3カ月間では1例も真性糖尿病へ移行していない。

Published
1967

9. [Comparative study of cefuzonam (CZON) with cefmenoxime in chronic respiratory tract infections by the double-blind method]

Author

Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayasu KAWANISHI, Masatoshi WATANABE, Jiro HINO, Yoshihisa NAKAGAWA, Shigenobu UMEKI, Masaru SUMI, Toshio KISHIMOTO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Shinya YASUDA, Tetsuji KORAKU, Hiromichi HORIKAWA, Akio HIRAYAMA, Soichiro UEHARA, Masashi TAMURA, Takashi ITO, Fumitoshi YAMAUCHI, Hitoshi KOBAYASHI, Kazumichi MIYA, Yoshikatsu NEMOTO, Tamotsu TAKISHIMA, Shiro IDA, Makoto TAKAHASHI, Tadao ISE, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Kikuo ONUMA, Yuji NAKAI, Kosaku NAGAI, Kenji BABA, Masayuki ITO, Fumio ARIJI, Teruo HASUIKE, Yoichi FUKUDA, Izumi HAYASHI, Tsuguji ITO, Masaaki ARAKAWA, Koichi WADA, Masanaga TAKATO, Morito IWANAGA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Takashi YOKOSE, Yasushi UEDA, Tadashi MIYAHARA, Atsushi SAITO, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kota KONO, Hiroaki TAKEDA, Keimei MASHIMO, Tadahiro KURASAWA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Hiroko SUGI, Junzaburo KABE, Yasuyuki SANO, Koichiro KUDO, Tetsuzo WATANABE, Mitsuo YAMAGISHI, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Shinichi OKA, Akio AOYAGI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Hideo TAKAHASHI, Tomiji MIURA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Fumio MATSUMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Ryujiro SUZUKI, Shigeki YOKOYAMA, Hitoshi IWATA, Motohide SASAMOTO, Tomoyasu SASAKI, Masatoshi IMAI, Masao TANO, Masahito KATO, Toshihiko TAKEUCHI, Teiichi KATO, Yoshimitsu HAYASHI, Hidekazu HANAKI, Yoji USAMI, Hideaki KUROKI, Fumiyuki KUZE, Takako MURAYAMA, Hideki NISHIYAMA, Motokazu KATO, Hiroshi OKUBO, Yoshihiro UEDA, Tadanao TAKEDA, Naotsugu KURIHARA, Kazuhiko TERAKAWA, Yuriko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Kojiro YASUNAGA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenzo SHIODA, Keiji KOBAYASHI, Yoshio YAMADA, Kiyomichi YOSHIMARU, Eiro TSUBURA, Koichi FUKUYAMA, Masaru NAKAGAWA, Eiji CHIKATA, Yasuhiro HASEGAWA, Einosuke UEDA, Hideki NISHIKAWA, Yukio NISHIMOTO, Michiro YAMAKIDO, Akimitsu KAMITSUNA, Yoshinao IHARA, Kazuo ITASAKA, Osamu KURIMURA, Hirofumi FUKUHARA, Hideo SASAKI, Masakazu TAMURA, Yoshiro SAWAE, Yukio KUMAGAI, Jun NAGANO, Hiroshi NAKANO, Chiharu KUBO, Hiroko KAWAMURA, Atsushi SHINODA, Masahiro TAKAMOTO, Tsuneo ISHIBASHI, Masashi KAWAHARA, Yasuko HARADA, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Takakazu KIYA, Kyoko YAMASHITA, Kazuo SASAYAMA, Toshiaki HAYASHI, Hiroshi TOMITA, Kinichi IZUMIKAWA, Kazunori SHIMOGUCHI, Tsunetoshi KOTEDA, Koichi WATANABE, Kazuhiro OKUNO, Keizo MATSUMOTO, Fumishige SONODA, Toshiaki YOSHIDA, Akira SAKAMOTO, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Yasuko OJIRO, Minoru NISHIMIYA, Toshinori KAWASAKI, Syukuro ARAKI, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Hidetsugu KAMIYAMA, Kazuko YOSHIDA, Fujio TANAKA, Kazumine KOBORI, and Masao NAKATOMI

Subjects
Adult, Male, Clinical Trials as Topic, Computer science, business.industry, Ceftizoxime, General Medicine, Cefotaxime, Middle Aged, computer.software_genre, Cefuzonam, Cephalosporins, Cefmenoxime, Text mining, Double-Blind Method, Chronic Disease, Humans, Female, Artificial intelligence, business, computer, Respiratory Tract Infections, Natural language processing, Aged
Published
1986

10. [Comparative test of the effectiveness of Netilmicin and Sisomicin on respiratory tract infection by double blind method]

Author

Atsushi SAITO, Jingoro SHIMADA, Masahisa OOMORI, Kooya SHIBA, Takehisa YAMAJI, Hironobu IHARA, Toshio HOJO, Masanobu KAJI, Mikio SAEGUSA, Tadashi MIYAHARA, Yasushi UEDA, Kazuo TAKEBE, Kenichi IMAMURA, Yoshihiro KUMASAKA, Yuzuru FUJIOKA, Aiichiro KURIHARA, Hisashi NAKAHATA, Hiroyuki KOBAYASHI, Mituko TAKAMURA, Michiro NAKASHIMA, Keishi HASHIMOTO, Takashi TANIGUCHI, Takehiko SAKURAMI, Kazumi NOZU, Fumio NAGAHAMA, Shinya YASUDA, Takehito NAKABAYASHI, Tetsushi KOROKU, Takahisa SAITO, Hiroshi KON, Norimichi KONNO, Akira NAKAZATO, Yomei HIRAGA, Kohki KIKUCHI, Katuo SUZUKI, Akihiko KUSE, Osamu MITSUHASHI, Tokio WAKAMATSU, Rensuke KURODA, Nobuichi OHSHIMA, Michiyasu HONDA, Yoshiro ISHII, Kiyoshi KONDO, Masayoshi NISHIDA, Yuichiro FUKASAWA, Sanpachi SAKUMA, Choei ITOH, Keisuke TAKEUCHI, Kazuhiko TANABE, Hiromitsu KONDO, Hagime INOOKA, Yaeko HANEDA, Norimasa NARITA, Naoyoshi MASAKI, Toyokazu TAMURA, Kazumi AOYAGI, Yasuhisa ABE, Mikihiko KUDOU, Shiro KOSAKA, Kenichi KIMURA, Koumei YOSHIOKA, Yoshihiro TUTUI, Katsuhiro OKAMOTO, Tadanao OMI, Shuichiro YOSHIDA, Hiroyasu KAWABE, Masatoku OTA, Masao TAMURA, Takashi ITOH, Mikio MATSUI, Nobuhisa SATO, Izumi HAYASHI, Setsuo KOBAYASHI, Ryuzo FUEKI, Hideo OZEKI, Toru NAGASAWA, Motoichi TANAKA, Kaoru SHIMADA, Takashi INAMATSU, Tadashi TAKIGAMI, Toshio FUKUI, Hiroshi NAKAMURA, Kaoru OHYAMA, Kuninori SUZUKI, Hiromi KATO, Hidehiko SUZUKI, Masakatsu SUGIMORI, Naohiro YAMASHITA, Saburo YANO, Nobuo OHYA, Mitsuru HAYASE, Hirofumi KATO, Kikuo SUGIMOTO, Chiyoo SUMIYA, Toshio OKUNO, Kazuhiko KOSUGA, Yasuo HOSOMI, Yoshio TAKAHASHI, Hidekazu HATA, Sinobu KINEHARA, Sinji HIRANO, Takeshi IKEGUCHI, Hiroto HIMURO, Isao IYODA, Shinichi SOTOMATSU, Yoshiko ASHIDA, Naoki FUJIMURA, Ituo IKEZOE, Yoshimi KISHIMOTO, Shogo YAMAMOTO, Kazuo OCHI, Tadashi TAKEYAMA, Saburo TAKEUCHI, Tsunemichi YAMADA, Kisao SATAKE, Kazue SHIMADA, Yoichi SERIU, Toshio NISIMURA, Masao SUZUKI, Syogo OKI, Hisayuki INOUE, Seiichi MATSUNOBE, Yoshimitsu TAKASHIMA, Akira YAMANAKA, Seiichi TONOMURA, Katsuhiko FUJIMORI, Hiromi KIZU, Yoshimi UESHIMA, Sadao IKEDA, Satoshi KOSABA, Kazuyuki YAGI, Masayoshi KUWABARA, Masataka SASADA, Yoshiro DOI, Hidehiro NANBA, Hiromasa YANO, Yutaka NAKANO, Hitoshi MUROMOTO, Masanori FUJITA, Hiroyuki TSUJINO, Tadashi NISHIKAWA, Haruaki HOSHIZAKI, Shigenori NAKAJIMA, Ohmi TAKAGI, Yuki MITSUFUJI, Ryoji WATANABE, Masayasu AIDA, Tsuneto HAYAMA, Shoji TANAKA, Susumu YODOSAWA, Jiro INUI, Yoshiaki IWAHASHI, Reiko NAGAO, Wataru OHTA, Shun YAMAMOTO, Masakaze URAGAMI, Harumi USHIO, Masatomo WATANABE, Toshio KAWAI, Toshifumi KONDO, Hideo FUKUSHIMA, and Morio OSHIRO

Subjects
Adult, Male, medicine.medical_specialty, Double blind, Double-Blind Method, Internal medicine, medicine, Humans, Netilmicin, Bronchitis, Respiratory Tract Infections, Aged, Clinical Trials as Topic, Comparative test, business.industry, General Medicine, Pneumonia, Middle Aged, medicine.anatomical_structure, Sisomicin, Female, Gentamicins, business, medicine.drug, Respiratory tract
Published
1983

11. [Comparative clinical study of ceftazidime and cefotiam for respiratory tract infections by a double-blind method]

Author

Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Toshiro ODA, Kazuhiro OKUNO, Hiromaru IWASAKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Shinya YASUDA, Takehito NAKABAYASHI, Tetsuji KOROKU, Takahisa SAITO, Hiromichi HORIKAWA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Mitsunari NAKAMURA, Mitsuo ASAKAWA, Akira SUZUKI, Yoshiro ISHII, Kazuo TAKEBE, Morio SAGARA, Shuichiro YOSHIDA, Toyokazu TAMURA, Hideya MURABAYASHI, Naoki TAMAZAWA, Tomio ONUMA, Osamu UEHARA, Gen ENOOKA, Katsuhiro OKAMOTO, Naoyoshi MASAKI, Shigetoshi YANAGIYA, Hiroshi TAKAHASHI, Mitsunobu HONMA, Tomohiro KANAZAWA, Keiji TAKAHASHI, Hideki SASAKI, Shoji YASUI, Shiro IDA, Kiyo NISHIOKA, Tamotsu TAKISHIMA, Seiichi AONUMA, Kikuo ONUMA, Akira WATANABE, Masako SASAKI, Kotaro OIZUMI, Kiyoshi KONNO, Izumi HAYASHI, Tatsuya ABE, Shigeru TAMAKI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Fuyuhiko HIGASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keimei MASHIMO, Tetsuro UKAI, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroichi TANIMOTO, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Yasushi UEDA, Jingoro SHIMADA, Kohya SHIBA, Takehisa YAMAJI, Hironobu IHARA, Tadashi MIYAHARA, Keiichi NAKAGAWA, Masaru KOYAMA, KOUJIN KIN, Fukuo IIJIMA, Ryuji AKIYOSHI, Hiroyuki KAWAHARA, Takashi YAMAMOTO, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kohta KOHNO, Seiji MITA, Yoshio KOBAYASHI, Ippei FUJIMORI, Akira ITO, Kunihiko SHINDO, Jun CHIBA, Shohei NAGAOKA, Kokichi FUKUSHIMA, Hideyuki HASEGAWA, Makio KURIHARA, Shigeki ODAGIRI, Hirotada IKEDA, Kohu MUROHASHI, Kaneo SUZUKI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Yasuko YUASA, Isao NITTA, Kyoko WATANABE, Kaoru OYAMA, Ryusaku SHIMIZU, Kuninori SUZUKI, Fumio MIKI, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Muneto YOSHIOKA, Kojiro YASUNAGA, Yoshihiro UEDA, Hiroshi OKUBO, Rinzo SOEJIMA, Yoshihito NIKI, Osamu KURIHARA, Hideo SASAKI, Masao MIKITANI, Yoshihiko ARATANI, Eiji KANETO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuyuki HIROSE, Nobuaki SHIGEMATSU, Hitoshi NAGANO, Hiromi KIHARA, Masaro KAJI, Yoichiro ICHIKAWA, Fumio TANAKA, Syunji HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Keizo MATSUMOTO, Tomoyuki HARADA, Takeshi ISHIZAKI, Taketsune MATSUMOTO, Tsunetoshi KOTEDA, Shigeru KOHNO, Masaru NASU, Jun GOTO, Takashi ITOGA, Tsutomu YAMAZAKI, Kunio NOMURA, Shigetake MIYAZAKI, Junichi SUETSUNA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yoshio AOKI, and Kenji MARUMO

Subjects
Adult, Male, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, Cefotiam, business.industry, Ceftazidime, General Medicine, Cefotaxime, Middle Aged, Double blind, Clinical study, Double-Blind Method, medicine, Humans, Female, Intensive care medicine, business, Respiratory Tract Infections, medicine.drug, Aged
Published
1984

12. [Comparative study of MK-0787/MK-0791 and piperacillin in respiratory tract infections]

Author

Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Hiroshi KAWANE, Yoshihito NIKI, Masayoshi KAWANISHI, Chikara NAKAHAMA, Jiro HINO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Kazuo TAKEBE, Yoshihiro KUMASAKA, Teruo NAKAMURA, Tsukasa YOSHIDA, Masayuki YOSHIZAWA, Kazuo MIZUKOSHI, Shiroh IDA, Tamotus TAKISHIMA, Seiichi AONUMA, Akira WATANABE, Kotaro OIZUMI, Kiyoshi KONNO, Tsugushi ITOH, Izumi HAYASHI, Masaaki ARAKAWA, Koichi WADA, Ryohji YOSHIDA, Ariyoshi KONDOH, Akio HOSHINO, Koichi HIRONO, Yukio NOZAWA, Haruo TERADA, Ryozoh ASANO, Masanori NARITA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Shizuo HASEGAWA, Yasuyuki YOSHIZAWA, Yoshiaki KAMEYAMA, Yoshiyuki UCHIDA, Masataka KATSU, Toshio FUKUI, Hajime YAMAGATA, Mieko KAWAI, Reiko SAITO, Minoru SATO, Takashi YOKOSE, Takeshi KAWAI, Akio ONAKA, Atsushi AJISAWA, Takeshi KAMO, Fuyuhiko HIGASHI, Masahiko NAKAMURA, Kazumi ARIKAWA, Keiichi YAMAGAMI, Makoto TAKANO, Sozo NUMASA, Yuzo FUNATSU, Mitsuo KITAHARA, Yukinori TAKAHASHI, Yasushi UEDA, Atsushi SAITO, Masanobu KAJI, Tadashi MIYAHARA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Yoshitaka NAKAMORI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDOH, Toshinobu SATOH, Makoto DOI, Keimei MASHIMO, Tetsuro UKAI, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Motokazu TANAKA, Hajime MORINARI, Syuichi OKUBO, Kazuo FUJIEDA, Toshio ITOH, Kihachiro SHIMIZU, Teppei KUMADA, Satoshi OOI, Kyoichi TOTSUKA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Masahiko YOSHIDA, Ippei FUJIMORI, Yoshio KOBAYASHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITOH, Shigeki ODAGIRI, Hideyuki HASEGAWA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Hideo TAKAHASHI, Tomiji MIURA, Fumio MATSUMOTO, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Kunio NANJO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Naohiro YAMASHITA, Kiyoshi HOSHINO, Eiji SUGIYAMA, Yutaka MIZUSHIMA, Saburo YANO, Kaoru OYAMA, Hideki NISHIYAMA, Hitoshi NAKAI, Kazukiyo OIDA, Nobuaki IKEDA, Hiroyuki TSUJINO, Mitsuo HASE, Eiichi MATSUYAMA, Fumiyuki KUZE, Yuruko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiro UEDA, Hiroshi OKUBO, Fumio MIKI, Akihito MURATA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Michio YAMAKIDO, Masao KUWABARA, Toshiya NOMURA, Toyofumi MITSUYAMA, Horoyuki ARITA, Akimitsu KAMITSUNA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Yoshiyuki NIHO, Nobuaki SHIGEMATSU, Osamu KOHASHI, Kiyoshi NINOMIYA, Hitoshi NAGANO, Takahito HIROSE, Atsusi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Shigeru KOHNO, Yoshiteru SHIGENO, Toshiro ODA, Hirosuke OHTA, Takashige MIYAZAKI, Toshiyuki OYE, Keizo MATSUMOTO, Naoto RIKITOMI, Tsuyoshi NAGATAKE, Harumi SISIDO, Yoshio UZUKA, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Yoshinobu KURODA, Shukuro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yuei IRABU, Minoru HIGA, and Hiroaki NAKAMURA

Subjects
Adult, Cyclopropanes, Male, Piperacillin, Respiratory tract infections, business.industry, Cilastatin, Imipenem Drug Combination, General Medicine, Middle Aged, Drug Administration Schedule, Drug Combinations, Imipenem, Cilastatin, Immunology, Medicine, Humans, Female, Thienamycins, business, Infusions, Intravenous, Respiratory Tract Infections, medicine.drug, Aged
Published
1986

13. Moxalactam--absorption, excretion, distribution, and metabolism

Author

Yasushi Ueda and Jingoro Shimada

Subjects
Microbiology (medical), Adult, Male, medicine.medical_specialty, Adolescent, Cefazolin, Urology, Renal function, Intestinal absorption, Excretion, Bolus (medicine), Internal medicine, polycyclic compounds, Medicine, Bile, Humans, Tissue Distribution, Cephamycins, Moxalactam, business.industry, Probenecid, organic chemicals, biochemical phenomena, metabolism, and nutrition, Middle Aged, Body Fluids, Cephalosporins, Kinetics, Infectious Diseases, Endocrinology, Intestinal Absorption, bacteria, Female, Kidney Diseases, business, Intramuscular injection, medicine.drug
Abstract

Levels of moxalactam in serum of healthy volunteers after single intramuscular injection, slow bolus intravenous injection, or intravenous infusion were proportional to the dose given. After intravenous bolus injection of 1 g of moxalactam, the peak serum level was 201.0 micrograms/ml, the half-life (beta-phase) was 126 min, and the cumulative urinary excretion during a 10-hr period was 90.5% of the dose. The values for cefazolin in the same volunteers were similar to those for moxalactam. No accumulation of the drug in serum was found even after multiple intravenous injections of 1 g every 12 hr for five days. Probenecid administered orally did not significantly affect levels of moxalactam in serum or urinary recovery, an observation which suggests that renal excretion of moxalactam takes place mainly through glomerular filtration. The serum half-life (beta-phase) of moxalactam in subjects with a creatinine clearance rate of less than or equal to 10 ml/min was markedly prolonged. Concentrations of moxalactam in bile were higher than those of cefazolin in a crossover study. Concentrations in sputum were 1.84-2.11 micrograms/ml in individuals given 1 g by intravenous slow bolus injection. No active metabolite of moxalactam was detected in plasma or urine.

Published
1982

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