1. Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination
- Author
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Fuqiang Cui, Fuzhen Wang, Xiaohong Gong, Hui Zheng, Shengli Bi, Zhiyuan Jia, Jianhua Liu, Shuigao Jin, Huiming Luo, Gang Cui, Feng Wang, Yu Wang, Longde Wang, Liang Li, Yong Zhang, Weizhong Yang, Xiaofeng Liang, Jing-Chen Ma, Yuansheng Chen, Stephen C. Hadler, Jing Guo, and Huaqing Wang
- Subjects
Adult ,Male ,China ,HBsAg ,Pediatrics ,medicine.medical_specialty ,Adolescent ,medicine.disease_cause ,Young Adult ,Age Distribution ,Orthohepadnavirus ,Seroepidemiologic Studies ,Prevalence ,medicine ,Humans ,Hepatitis B Vaccines ,Child ,Hepatitis B in China ,Hepatitis B virus ,Hepatitis B Surface Antigens ,General Veterinary ,General Immunology and Microbiology ,biology ,Immunization Programs ,business.industry ,Public Health, Environmental and Occupational Health ,Infant ,virus diseases ,Middle Aged ,Hepatitis B ,biology.organism_classification ,medicine.disease ,Hepatitis B Core Antigens ,Virology ,digestive system diseases ,Vaccination ,Logistic Models ,Infectious Diseases ,Hepadnaviridae ,Child, Preschool ,Multivariate Analysis ,Molecular Medicine ,Female ,Viral hepatitis ,business - Abstract
To determine the prevalence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core anti-body (anti-HBc) in a representative population in China 14 years after introduction of hepatitis B vaccination of infants.National serosurvey, with participants selected by multi-stage random sampling. Demographics and hepatitis B vaccination history collected by questionnaire and review of vaccination records, and serum tested for HBsAg, antibody to anti-HBc and anti-HBs by ELISA.The weighted prevalences of HBsAg, anti-HBs and anti-HBc for Chinese population aged 1-59 years were 7.2%, 50.1%, 34.1%, respectively. HBsAg prevalence was greatly diminished among those age15 years compared to that found in the 1992 national serosurvey, and among children age5 years was only 1.0% (90% reduction). Reduced HBsAg prevalence was strongly associated with vaccination among all age groups. HBsAg risk in adults was associated with male sex, Western region, and certain ethnic groups and occupations while risk in children included birth at home or smaller hospitals, older age, and certain ethnic groups (Zhuang and other).China has already reached the national goal of reducing HBsAg prevalence to less than 1% among children under 5 years and has prevented an estimated 16-20 million HBV carriers through hepatitis B vaccination of infants. Immunization program should be further strengthened to reach those remaining at highest risk.
- Published
- 2009