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4 results on '"Saladino V"'

1. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P

Subjects
Simeprevir, Male, medicine.medical_specialty, Cirrhosis, SVR, Sofosbuvir, Sustained Virologic Response, liver cirrhosis, antiviral treatment, Hepacivirus, Antiviral Agents, law.invention, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Humans, chronic hepatitis C, Prospective cohort study, DAA, Retrospective Studies, Hepatology, liver cirrhosi, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Discontinuation, Regimen, Infectious Diseases, Treatment Outcome, business, medicine.drug
Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for

Published
2021

2. Cardiac risk stratification in elective non-cardiac surgery: Role of NT-proBNP

Author

Novo, G., Egle Corrado, Tortorici, E., Novo, A., Agrusa, A., Saladino, V., Marturana, I., Lentini, R., Ferrandes, M., Visconti, C., Massenti, F., D Arienzo, M., Vitale, F., Gulotta, G., Novo, S., Novo, G, Corrado, E, Tortorici, E, Novo, A, Agrusa, A, Saladino, V, Marturana, I, Lentini, R, Ferrandes, M, Visconti, C, Massenti, F, D'Arienzo, M, Vitale, F, Gulotta, G, and Novo, S

Subjects
Male, Chi-Square Distribution, Time Factors, Middle Aged, Risk Assessment, Peptide Fragments, Up-Regulation, Logistic Models, Treatment Outcome, Italy, NT-proBNP, Cardiovascular Diseases, Elective Surgical Procedures, Predictive Value of Tests, Risk Factors, Surgical Procedures, Operative, Natriuretic Peptide, Brain, Preoperative Period, Odds Ratio, Humans, Female, Biomarkers, Aged
Abstract

AIM: The aim of the study was to investigate the utility of NT-proBNP measurement for the stratification of presurgical cardiac risk. METHODS: Cardiac risk before elective non-cardiac surgery was evaluated in 82 consecutive patients. From each patient a venous blood sample was drawn to determinate NT-proBNP levels. Patients were followed up over three months in order to detect the occurrence of cardiac adverse events. RESULTS: NT-proBNP was positively correlated (P

3. Open mini-invasive cholecystectomy in high risk elderly. A review of 121 consecutive procedures

Author

Amato, G., Giuseppe SALAMONE, Romano, G., Agrusa, A., Saladino, V., Gulotta, G., Amato, G, Salamone, G, Romano, G, Agrusa, A, Saladino, V, and Gulotta, G

Subjects
Aged, 80 and over, Male, Laparotomy, Time Factors, Cost-Benefit Analysis, Frail Elderly, Length of Stay, Middle Aged, Risk Assessment, Radiography, Settore MED/18 - Chirurgia Generale, Treatment Outcome, Cholecystectomy, Laparoscopic, Cholelithiasis, Risk Factors, Humans, Minimally Invasive Surgical Procedures, Cholecystectomy, Female, open mini-invasive cholecystectomy, Aged, Retrospective Studies
Abstract

INTRODUCTION: the report describes the features of a low cost, open mini-invasive procedure for cholecystectomy in a sample of 121 consecutive high risk elderly (ASA score 3 to 5). PATIENTS AND METHODS: the surgery is performed through a 3 - 4 cm right subcostal skin incision. An optimal exposition of the operating field was achieved thanks to an innovative three valve retractor. RESULTS: a mean hospital stay of 3,02 days, low complication rate and 2,4% mortality are the results of the described procedure. CONCLUSIONS: in high risk elderly the results are extremely encouraging, particularly in comparison with both laparoscopic and traditional open cholecystectomy. The open minisurgical cholecystectomy could be considered a cost-effective alternative to laparoscopy, with excellent results in this subset of patients. The described mini-surgical procedure can also integrate the laparoscopic in case of conversion.

4. The Italian Registry of Therapeutic Apheresis: granulocyte-monocyte apheresis in the treatment of inflammatory bowel disease. A multicentric study

Author

Giampaolo Bresci, Annalisa Aratari, A. Santini, Alessandro Armuzzi, Renata D'Incà, Pietro Manuel Ferraro, Valeria D'Ovidio, Francesca Calella, Francesco Costa, Marco Astegiano, Stefano Passalacqua, Vincenza Di Leo, V. Saladino, Elisabetta Colombo, R. Testa, P. Lecis, M. Silla, Maria Luisa Guidi, D. Valpiani, G. Repaci, Marino Marco, Flaminia Cavallaro, Gabriele Riegler, R. Sablich, Mariabeatrice Principi, Chiara Ricci, Passalacqua, S, Ferraro, Pm, Bresci, G, D'Ovidio, V, Astegiano, M, Principi, M, Testa, R, D'Incà, R, Valpiani, D, Armuzzi, A, Sablich, R, Cavallaro, F, Costa, F, Di Leo, V, Colombo, E, Santini, A, Aratari, A, Lecis, P, Saladino, V, Riegler, Gabriele, Marco, M, Calella, F, Ricci, C, Guidi, Ml, Repaci, G, and Silla, M.

Subjects
Adult, Male, medicine.medical_specialty, Medication history, Adolescent, Settore MED/12 - GASTROENTEROLOGIA, Ulcerative, Disease, Extracorporeal treatments, Granulocyte-monocyte apheresis, Gastroenterology, Inflammatory bowel disease, Monocytes, Pathogenesis, Young Adult, Crohn Disease, Internal medicine, Medicine, Settore MED/14 - NEFROLOGIA, Humans, Leukapheresis, Registries, Adverse effect, Aged, medicine.diagnostic_test, business.industry, Remission Induction, General Medicine, Hematology, Colitis, Ulcerative, Female, Follow-Up Studies, Granulocytes, Inflammatory Bowel Diseases, Italy, Middle Aged, Treatment Outcome, medicine.disease, Colitis, Ulcerative colitis, Surgery, Apheresis, Erythrocyte sedimentation rate, business, extracorporeal treatments, granulocytemonocyte apheresis, inflammatory bowel disease
Abstract

Leukocytes are thought to play an important role in the pathogenesis of inflammatory bowel diseases; granulocyte monocyte adsorptive (GMA) apheresis, an extracorporeal technique aimed at removing activated circulating leukocytes from the blood, may represent a safe and effective therapeutic tool in these patients. The Italian Registry of Therapeutic Apheresis performed an observational, multicentric study involving 24 Gastroenterology Units. In this study, laboratory data and clinical outcomes of 230 patients (148 males, mean age 43.5 years) affected with ulcerative colitis (UC, n 5 194) or Crohn’s disease (CD, n 5 36) who underwent one or more cycles of GMA were analyzed. Each cycle consisted of five GMA treatments. The patients were followed up for a mean of 8.7 (min. 3 to max. 12) months. At 3 months, positive outcome was achieved in 77.7% of UC patients (72.0% remission, 5.7% clinical response) and 61.3% of CD patients (54.8% remission, 6.5% clinical response). The cumulative proportion of positive outcome at 12 months was 87.1% for UC patients (83.7% remission, 3.4% clinical response) and 77.4% for CD patients (74.2% remission, 3.2% clinical response). No single clinical or laboratory parameter among those analyzed (age, sex, disease characteristics, history of smoking, medication history, baseline values of clinical activity index (CAI)/Crohn’s disease activity index (CDAI), hemoglobin, white blood cells count, and erythrocyte sedimentation rate) was independently associated with clinical outcome. The procedure was well tolerated with no significant adverse effects registered. J. Clin. Apheresis 26:332–337, 2011.

Published
2011

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