Author: "Pros, A." / Topic: male - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Pros, A."' showing total 40 results

Start Over Author "Pros, A." Topic male

40 results on '"Pros, A."'

1. The waiting time for prostate cancer treatment in Italy: analysis from the PROS-IT CNR Study

Author: Gacci, M, Greco, I, Artibani, W, Bassi, P, Bertoni, F, Bracarda, S, Briganti, A, Carmignani, G, Carmignani, L, Conti, G, Corvò, R, DE Nunzio, C, Fusco, F, Graziotti, P, Maggi, S, Magrini, S, Mirone, V, Montironi, R, Muto, G, Noale, M, Pecoraro, S, Porreca, A, Ricardi, U, Russi, E, Salonia, A, Simonato, A, Serni, S, Tubaro, A, Zagonel, V, Crepaldi, G, Pros-IT CNR Study Group, D'Angelillo, R, Gacci, Mauro, Greco, Isabella, Artibani, Walter, Bassi, Pierfrancesco, Bertoni, Filippo, Bracarda, Sergio, Briganti, Alberto, Carmignani, Giorgio, Carmignani, Luca, Conti, Giario, Corvò, Renzo, De Nunzio, Cosimo, Fusco, Ferdinando, Graziotti, Pierpaolo, Maggi, Stefania, Magrini, Stefano M, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Noale, Marianna, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Russi, Elvio, Salonia, Andrea, Simonato, Alchiede, Serni, Sergio, Tubaro, Andrea, Zagonel, Vittorina, and Crepaldi, Gaetano
Subjects: Waiting time, Male, medicine.medical_specialty, Waiting Lists, Urology, Lymph node metastasis, Androgen deprivation therapy, Settore MED/06, Prostate cancer, Percutaneous Coronary Intervention, prostate cancer, radical prostatectomy, screening, Quality of life, Settore MED/36, Internal medicine, medicine, Humans, Waiting lists, Prostatic neoplasms, Prostatectomy, Radiotherapy, Androgens, Prostate, Quality of Life, Prostatic Neoplasms, Surgical approach, business.industry, screening, Cancer, prostate cancer, medicine.disease, radical prostatectomy, Nephrology, T-stage, Positive Surgical Margin, business
Abstract: Background Prostate cancer (PCa) is the second most common neoplasm in male patients. To date, there's no certain indication about the maximum waiting time (WT) acceptable for treatment beginning and the impact on oncological and functional outcomes has not been well established. Methods Data from the National Research Council PCa monitoring multicenter project in Italy (Pros-IT CNR) were prospectively collected and analyzed. WT was defined as the time from the bioptical diagnosis of PCa to the first treatment received. Patients were divided in two groups, using a time frame of 90 days. Quality of life was measured through the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and of the Short-Form Health Survey (SF-12). The occurrence of upgrading, upstaging, presence of lymph node metastasis and positive surgical margins at the final histopathological diagnosis, and PSA at 12 months follow-up were evaluated. Results The overall median WT was 93 days. The logistic multivariable model confirmed that age, being resident in Southern regions of Italy and T staging at diagnosis were significantly associated with a WT >90 days. At 6 months from diagnosis the mean SF-12 score for the emotionalpsychological component was significantly lower in WT ≥ 90 days group (p=0.0428). Among patients treated with surgical approach, no significant differences in oncological outcomes were found in the two groups. Conclusions In our study age, clinical T stage and provenance from Southern regions of Italy are associated with a WT > 90 days. WT might have no impact on functional and oncological outcome.
Published: 2022

2. Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

Author: Elisabet Aliagas, Alberto Villanueva, Alan G. Dawson, X. Sole, Maria Saigi, Jose Carlos Ruffinelli, M. Gausachs, Mar Varela, Dean A. Fennell, Montse Sanchez-Cespedes, Cristina Muñoz-Pinedo, Ignacio Escobar, Eduard Dorca, Susana Padrones, Ramon Palmero, Roger Llatjós, Sara Busacca, Miguel Hernández-Madrigal, Samantha Aso, Ernest Nadal, Ricard Ramos, Annabel J. Sharkley, María Martínez-Iniesta, August Vidal, Eva Pros, Ania Alay, and David Cordero
Subjects: Male, Mesothelioma, Cancer Research, Cell cycle checkpoint, Pyridines, medicine.medical_treatment, Cell, Immunoteràpia, Aminopyridines, Piperazines, Mice, 0302 clinical medicine, Cell proliferation, 0303 health sciences, Proliferació cel·lular, biology, Prognosis, preclinical models, 3. Good health, Up-Regulation, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, mesothelioma, Female, Pronòstic mèdic, Cell Survival, Palbociclib, Immunotheraphy, Article, 03 medical and health sciences, CDK4/6 inhibitors, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Protein Kinase Inhibitors, 030304 developmental biology, Aged, Cell Proliferation, Chemotherapy, business.industry, Cell growth, Mesothelioma, Malignant, Cyclin-Dependent Kinase 4, Immunotherapy, Cyclin-Dependent Kinase 6, Xenograft Model Antitumor Assays, Mesotelioma, Cancer research, biology.protein, Benzimidazoles, Cyclin-dependent kinase 6, business
Abstract: Background:There is no effective therapy for patients with malignant pleural mesothelioma (MPM) who progressed to platinum-based chemotherapy and immunotherapy. Methods:We aimed to investigate the antitumor activity of CDK4/6 inhibitors using in vitro and in vivo preclinical models of MPM. Results:Based on publicly available transcriptomic data of MPM, patients with CDK4 or CDK6 overexpression had shorter overall survival. Treatment with abemaciclib or palbociclib at 100 nM significantly decreased cell proliferation in all cell models evaluated. Both CDK4/6 inhibitors significantly induced G1 cell cycle arrest, thereby increasing cell senescence and increased the expression of interferon signalling pathway and tumour antigen presentation process in culture models of MPM. In vivo preclinical studies showed that palbociclib significantly reduced tumour growth and prolonged overall survival using distinct xenograft models of MPM implanted in athymic mice. Conclusions:Treatment of MPM with CDK4/6 inhibitors decreased cell proliferation, mainly by promoting cell cycle arrest at G1 and by induction of cell senescence. Our preclinical studies provide evidence for evaluating CDK4/6 inhibitors in the clinic for the treatment of MPM.
Published: 2021
Full Text: View/download PDF

3. An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME)

Author: Bhangu, Aneel, Minaya-Bravo, Ana María, Gallo, Gaetano, Glasbey, James C., Kamarajah, Sivesh, Pinkney, Thomas, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Frasson, Matteo, Glasbey, James, Morton, Dion, Negoi, Ionut, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Luis, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charles, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Ã., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Gallo, G., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Y. Y., Ng, Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å ., Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., Beltrán de Heredia, J. P., Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., Romero de Diego, A., Cordoba Diaz de Laspra, E., Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez- Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., W. -C., Su, Huang, C. -W., C. -J., Ma, Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S., European Society of Coloproctology (ESCP) Cohort Studie, Tonini V, Cervellera M, Vaccari S., Bhangu, A, Minaya-Bravo, A, Gallo, G, Glasbey, J, Kamarajah, S, Pinkney, T, El-Hussuna, A, Battersby, N, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Morton, D, Negoi, I, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckmann, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, El Nakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Korkolis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Toth, I, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, M, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Edden, Y, Halfteck, G, Reissman, P, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Ziggler, S, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, W, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flaaten Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Suleymanov, N, Tarasov, N, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Fernandez-Martinez, D, Otero, J, Solar-Garcia, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez- Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, L, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Gutierrez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, C, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Smolarek, S, Platt, E, Rossi, B, Tham, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, Surgery, Bhangu, Aneel, Minaya-Bravo, Ana María, Gallo, Gaetano, Glasbey, James C., Kamarajah, Sivesh, Pinkney, Thoma, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Frasson, Matteo, Glasbey, Jame, Morton, Dion, Negoi, Ionut, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Lui, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charle, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Ã ., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Gallo, G., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Ng, Y. Y., Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å&nbsp, Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., Beltrán de Heredia, J. P., Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., Romero de Diego, A., Cordoba Diaz de Laspra, E., Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez- Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã ., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã ., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., Su, W. -C., Huang, C. -W., Ma, C. -J., Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S., R. Tutino, G. salamone, L. Licari, G. Cocorullo, G. Gulotta, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, and CCA - Cancer Treatment and Quality of Life
Subjects: Male, Laparoscopic surgery, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Operative Time, Anastomosis, Malignancy, rectal cancer, laparoscopic surgery, TME, transanal TME, TaTME, robotic surgery, randomized clinical-trial, short-term outcomes, laparoscopic-assisted resection, pathological outcomes, anastomotic leakage, initial-experience, risk, NO, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Robotic Surgical Procedures, Humans, Medicine, Robotic surgery, Prospective Studies, Rectal cancer, Gastroenterology, Aged, Transanal Endoscopic Surgery, ta3126, Medical Audit, Univariate analysis, Proctectomy, Rectal Neoplasms, business.industry, Rectum, Margins of Excision, Middle Aged, medicine.disease, Total mesorectal excision, Surgery, Treatment Outcome, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Rectal cancer surgery, Female, Laparoscopy, 030211 gastroenterology & hepatology, business
Abstract: Introduction: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients undergoing elective total mesorectal excision (TME) for malignancy between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 2579 included patients, 76.2% (1966/2579) underwent TME with restorative anastomosis of which 19.9% (312/1966) had a minimally invasive approach (laparoscopic or robotic) which included a transanal component (TaTME). Overall, 9.0% (175/1951, 15 missing outcome data) of patients suffered an anastomotic leak. On univariate analysis both laparoscopic TaTME (OR 1.61, 1.02–2.48, P=0.04) and robotic TaTME (OR 3.05, 1.10–7.34, P=0.02) were associated with a higher risk of anastomotic leak than non-transanal laparoscopic TME. However this association was lost in the mixed-effects model controlling for patient and disease factors (OR 1.23, 0.77–1.97, P=0.39 and OR 2.11, 0.79–5.62, P=0.14 respectively), whilst low rectal anastomosis (OR 2.72, 1.55–4.77, P&nbsp
Published: 2018

4. Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi-centre, prospective audit

Author: The 2017 European Society of Coloproctology (ESCP) collaborating group, Blanco-Colino, Kelly, Singh, Bhangu, Pinkney, Poskus, El-Hussuna, Battersby, N. J., Buchs, N. C., Buskens, Chaudri, Frasson, Gallo, Minaya-Bravo, A. M., Morton, Negoi, Nepogodiev, Pata, Sánchez-Guillén, Zmora, Perry, Magill, Altomare, Bemelman, Brown, Denost, Knowles, Laurberg, Lefevre, J. H., Möeslein, Vaizey, Bilali, Salomon, Cillo, Estefania, Patron, Uriburu, Ruiz, Farina, Carballo, Guckenheimer, Proud, Brouwer, Bui, Nguyen, Smart, Warwick, Theodore, J. E., Herbst, Birsan, Dauser, Ghaffari, Hartig, Stift, Argeny, Unger, Strouhal, Heuberger, Varabei, Lahodzich, Makhmudov, Selniahina, Feryn, Leupe, Maes, Reynvoet, Van, Langenhove, Nachtergaele, Monami, Francart, Jehaes, Markiewicz, Weerts, Van, Belle, Bomans, Cavenaile, Nijs, Vertruyen, Pletinckx, Claeys, Defoort, Muysoms, Van, Cleven, Lange, Vindevoghel, Wolthuis, Todorovic, Dabic, Kenjic, Lovric, Vidovic, Delibegovic, Mehmedovic, Christiano, Lombardi, Marchiori, J, R., Tercioti, Dardanov, Petkov, Simonova, Yonkov, Zhivkov, Maslyankov, Pavlov, Sokolov, Todorov, Stoyanov, Batashki, Iarumov, Lozev, Moshev, Slavchev, Atanasov, Belev, Krstev, Penkov, Šantak, Ćosić, Previšić, Vukušić, Zukanović, Zelić, Kršul, Lekić, Vitlov, Mendrila, Orhalmi, Dusek, Maly, Paral, Sotona, Skrovina, Bencurik, Machackova, Kala, Farkašová, Grolich, Procházka, Hoch, Kocian, Martinek, Antos, Pruchova, Ceccotti, Madsbøll, Straarup, Uth, Ovesen, Christensen, Bondeven, Edling, Elfeki, Alexandrovich, Gameza, Michelsen, Bach, Zheltiakova, Krarup, P. M., Krogh, Rolff, H. -C., Lykke, Juvik, A. F., Lóven, H. H. K., Marckmann, Osterkamp, J. T. F., Madsen, A. H., Worsøe, Ugianskis, Kjær, M. D., Youn Cho Lee, Khalid, Kristensen, M. H., Sorogy, El, Elgeidie, Elhemaly, Nakeeb, El, Elrefai, Shalaby, Emile, Omar, Sakr, Thabet, Awny, Metwally, Refky, Shams, Zuhdy, Lepistö, Keränen, Kivelä, Lehtonen, Siironen, Rautio, Ahonen-Siirtola, Klintrup, Paarnio, Takala, Hyöty, Haukijärvi, Kotaluoto, S. -M., Lehto, Tomminen, Huhtinen, Carpelan, Karvonen, Rantala, Varpe, Cotte, Francois, Glehen, Passot, D'Alessandro, Chouillard, Etienne, J. C., Ghilles, Vinson-Bonnet, Germain, Ayav, Bresler, Chevalier, Didailler, Rullier, Tiret, Chafai, Parc, Sielezneff, Mege, Lakkis, Barussaud, Krones, Bock, Webler, Baral, Lang, Münch, Pullig, Schön, Hinz, Becker, Möller, Richter, Schafmayer, Hardt, Kienle, Crescenti, Ahmad, Soleiman, Papaconstantinou, Gklavas, Nastos, Theodosopoulos, Vezakis, Stamou, Saridaki, Xynos, Paraskakis, Zervakis, Skroubis, Amanatidis, Germanos, Maroulis, Papadopoulos, Dimitriou, Alexandrou, Felekouras, Griniatsos, Karavokyros, Chouliaras, Ioannidis, Katsounis, Kefalou, Katsoulis, I. E., Balalis, Korkolis, D. P., Manatakis, Tzovaras, Baloyiannis, Mamaloudis, Lázár, Ábraham, Paszt, Simonka, Tóth, Zaránd, Baranyai, Ferreira, Harsányi, Ónody, Banky, Burány, Lakatos, Marton, Solymosi, Besznyák, Bursics, Papp, Saftics, Svastics, Valsdottir, Atladottir, Jonsson, Moller, Sigurdsson, Gupta, S. K., Kaul, Mohan, Sharma, Wani, Chowdri, Khan, Mehraj, Parray, F. Q., Coveney, Burke, Deasy, El-Masry, Mcnamara, Cahill, Faul, Mulsow, Shields, Bass, Martin, S. T., O'Connell, Ryan, Connelly, Bukhari, Cooke, Gold, Deutch, Haim, Lavy, Moscovici, Shussman, Gefen, Marom, Pikarsky, Weiss, Avital, Hermann, Raguan, Slavin, White, Wasserberg, Arieli, Gurevich, Freund, M. R., Dorot, Edden, Halfteck, Reissman, Pery, Tulchinsky, Weizman, Agresta, Curinga, Finotti, Savino, Verza, L. A., Asteria, C. R., Boccia, Pascariello, Tamini, Bugatti, Gianotti, Totis, Vincenti, Andriola, Giannini, Travaglio, Balestri, Buccianti, Roffi, Rossi, Urbani, Mellano, Cinquegrana, Lauretta, Belluco, Mistrangelo, Allaix, M. E., Arolfo, Morino, Testa, Delrio, Pace, Rega, Scala, Clerico, Cornaglia, Realis, Luc, Trompetto, Ugolini, Antonacci, Fabbri, Montroni, Zattoni, D'Urbano, Cornelli, Viti, Inama, Bacchion, Casaril, Impellizzeri, Moretto, Spinelli, Carvello, David, Candido, Di, Sacchi, Frontali, Ceriani, Molteni, Rosati, Aleotti, Elmore, Lemma, Vignali, Scabini, Casoni, Pattacini, Luzzi, Romairone, Marino, Lorusso, Pezzolla, Colombo, Baldi, Foschi, Sampietro, Sorrentino, Saverio, Di, Birindelli, Segalini, Spacca, Romano, G. M., Belli, Bianco, Franciscis, De, Falato, Muratore, Marsanic, Grimaldi, Castaldo, Ciolli, M. G., Picarella, Porfidia, Tugnoli, Bondurri, Cavallo, Maffioli, Pertusati, Pulighe, Balestra, Nisco, De, Podda, Opocher, Longhi, Mariani, N. M., Maroni, Pisani, Ceretti, Galleano, Aonzo, Curletti, Reggiani, Marconi, Del, Prete, Oldani, Pappalardo, Zaccone, L, Scatizzi, Baraghini, Cantafio, Feroci, Giani, Tutino, Cocorullo, Gulotta, Licari, Salamone, Sileri, Saraceno, Torre, La, Chirletti, Coletta, Toma, De, Mingoli, Papandrea, Luca, De, Sacco, Sammarco, Vescio, Tonini, Bianchini, Cervellera, Vaccari, Cracco, Barugola, Bertocchi, Rossini, Ruffo, Sartori, Clemente, Scaffidi, Lorenzon, Balducci, Bocchetti, Ferri, Mercantini, Bauce, Benevento, Bottini, Crapa, P. R., Rubbini, Michele, Anania, Gabriele, Carcoforo, Paolo, Cavallesco, Narciso Giorgio, Feo, Carlo, Yamamoto, Sivins, Ancans, Gerkis, Lunis, Pcolkins, Venskutonis, Bradulskis, Dainius, Subocius, Vencius, Zeromskas, Eismontas, Nutautiene, Simcikas, Tamosiunas, Svagzdys, Latkauskas, Lizdenis, Saladzinskas, Tamelis, Dulskas, Kuliavas, Samalavicius, N. E., Jotautas, Mikalauskas, Strupas, Zakaria, A. D., Lah, N. N., Wong, Zain, W. Z., Mazlan, Mohd, Azman, Z. A., Sagap, Psaila, Andrejevic, Cini, Ellul, Ahallat, Hamid, Hrora, Majbar, M. A., Raiss, Westerduin, Tanis, van der Sluis, P. C., Davids, P. H., Pronk, Schiphorst, A. H. W., Smakman, Zimmerman, Koeter, Stijns, Van, Loon, Y. -T., Vermaas, Graaf, De, Doornebosch, Van, Hagen, Van, Ruler, Toorenvliet, Nonner, van den Berg, Van, Steensel, Vles, Melenhorst, Orsini, Visschers, Hoff, Blom, Marsman, Mulder, Cense, Castro, De, Demirkiran, Hunfeld, Van, Geloven, Groof, De, Hendriks, Leeuwenburg, Van, Oorschot, Wit, Rupert, Veldman, Keijzers, Konsten, Den, Boer, Corver, Boerma, E. G., Koolen, Martens, Van, Wijck, Ignjatovic, Breuer, Gurpreet, Oresland, Tetens, Moe, Nesbakken, Flaaten, Backe, Wik, T. -A., Radiya, Dehli, Gjessing, Norderval, Woll, Anwer, Qureshi, M. S., A. U., Billah, Jawad, M. Y., Raza, Urooj, Wang, Jajtner, Gasinski, Kabiesz, Walega, Romaniszyn, Zawadzki, Czarnecki, Obuszko, Rzaca, Sitarska, Silva, Duarte, Gonçalves, Morais, Rama, Nobre, Sales, Costa, Pereira, Costa, Insua, Romero, Figueiredo, Cunha, Domingos, Vieira, Americano, Amorim, Rachadell, Carvas, J. M., Armas, Fernandes, Pires, Reis, Martins, Dos, Santos, Henriques, Oliveira, Miranda, Vilela, Corte, Real, Carlos, Frois, Borges, Moniz, Pereira, Simões, Silva-vaz, Bettencourt, Gouveia, Perez, Rainho, Bintintan, Ciuce, Dindelegan, Scurtu, Seicean, Cristian, Burcos, Grama, Mandi, D. M., Richiteanu, Miron, Calu, Enciu, Nadragea, Parvuletu, Mogoanta, S. S., Crafciuc, Paitici, Beuran, Ciubotaru, Prodan, Vartic, Tomulescu, Copaescu, Yanishev, Abelevich, Kokobelyan, Lebedeva, Luzan, Pozdnyakov, Cherdancev, Mahotin, Nesytykh, Samsonyuk, Pravosudov, Ivlev, Karachun, Lebedev, Samsonov, Aiupov, Feoktistov, Garipov, Suleymanov, Tarasov, Rasulov, Dzhumabaev, Mamedli, Bedzhanyan, Popov, Sednev, Klimenko, Semenov, Vasilyev, Khazov, Khanevich, Khrykov, Katorkin, Andreev, Chernov, Davidova, Zhuravlev, Achkasov, Shakhmatov, Shelygin, Sushkov, Vardanyan, Ilkanich, Barbashinov, Darvin, Onishchenko, Voronin, Krivokapić, Barišić, Dimitrijević, Marković, Sekulić, Stanojevic, Brankovic, Nestorovic, Pecic, Petrovic, Kostic, Aleksic, Maric, Perunicic, Radovanovic, Djuric, Lukic, Cuk, Juloski, Kenic, Krdzic, Ngu, Y. Y., Teo, Korcek, Lazorisak, Rems, Ramovš, Trampuš, Tomazic, Grosek, Kosir, Norcic, Vigorita, Caceres, Casal, Ruano, Trostchansky, Golda, Galvez, Saldaña, Kreisler, Moreno, Lopez, Dominguez, Vila, Tura, Labarga, Galvez, Maderuelo, Suero, Bargallo, Cayetano, Lamas, M. C., Bernal-Sprekelsen, Gómez, Jareño, Ríos, Vercher, García-González, J. -M., Cervera-Aldama, Ramos-Prada, Santamaría-Olabarrieta, Borda, Enrriquez-Navascués, Saralegui, Calero-Lillo, Aznar-Puig, López-Lara, Muñoz-Collado, Valverde-Sintas, Menendez, Leon, Truan, Baldonedo, Fernández-Martínez, Otero, Solar-García, Turrado-Rodriguez, de Lacy Oliver, Lacy, Fortuny, Martin, Perez, Otero, Piñeiro, Paredes, Fernandez, Ladra, M. J., Paulos, Prieto, Beltrán de Heredia, J. P., Blanco, Antona, de Andrés Asenjo, Ferreras, García, Romero de Diego, Cordoba Diaz de Laspra, Echazarreta, Gallego, Elia, Guedea, Escola, Martinez, Primo, Romaguera, Parreño, Pastor, Rosell, Lozoya, Trujillo, Alós, Company, Ruiz, Carmona, Solana, Bueno, Salvans, Ruiz, Alonso, Gonçalves, Jiménez-Toscano, Pascual, Damieta, Pera, Roman, Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, Soria-Aledo, Valero-Navarro, Vicente-Ruiz, Garcia-Zamora, Gonzalez-Gil, Montoya-Tabares, Paredes-Quiles, Die, Trill, Abadia, Moreno, Pina, J. D., Ramos, Rubio, Escartin, Blas, J. L., Fernando, Ferrer, Garcia, Egea, Pros, Rius, Socías, Sabia, Castellvi, Valls, Gonzalez, Santin, Mompart, Garcia, Viso, Pons, Julià, Codina-Cazador, Farrés, Planellas, Cuadrado, Camps, Rufas, Escoll, Fermiñán, Muriel, Sierra, Alvarez-Laso, Lora, Padin, Garcia-Septiem, Bustamante, Jimenez, Jimenez-Miramon, Ramos, Gallardo, A. B., Benito, Colao, Galindo, Garcia, Forero-Torres, Alonso, Poza, Dieguez, Fernandez, Gilsanz, Martin, Hernandez, Garcia, Rojo, López, Gil, López, González, Zunzárren, Martínez, Alegre, Zorrilla, Matilla, L. P., Navarro-Sánchez, Alcalá, Serrano, F. J., López-Fernández, Montesdeoca, Cabrera, Alvarez-Gallego, Guevara, Pascual, Miguelañez, Rubio-Perez, Gomez, Ruiz, Alonso, Martín, Cagigas, Fernández, Castillo, Diego, Pando, Maristany, Muñoz-Duyos, Rada-Palomino, Vargas-Pierola, Peña, Ros, Benavides, Buleje, Muñoz, Camarena, Parra, Baños, P. A., Ramirez, Faraco, Arenal, J. J., Citores, Marcos, Sánchez, Tinoco, García, Flórez, L. J., Arias, Pacheco, R. D., Mínguez, Ruiz, Gutiérrez, Corral, Rodríguez, Infante, Carrillo, López, Carrasco, Prats, M. M., Lage, Laredo, Martínez, Manzano, Rodríguez, García, Segura-Sampedro, Alonso-Hernández, Fernandez, Isart, Gamundi, Cuesta, Ochogavia, Segui, Ibañez, Abrisqueta, Lujan, Gómez, Pérez, Corrales, Valero, Monje, Salazar, Sanchiz, Cardenas, Soler, Humanes, Jimenez-Rodriguez, R. M., De la Portilla, Diaz, Pavon, Garcia, Cabrera, Reyes, Diaz, M. L., Espin, Marinello, Martí, Sanchez, Vallribera, Orts, Mico, Ortin, Navarro, Perez, Climent, Serra, Diaz, Millan, Caro, Escuder, Espina, Feliu, Climent, Aira, Estévez, Diz, Moreno, Asencio, M. T., Varela, Mato, Vázquez, Bouzán, Diez-Alonso, Villeta-Plaza, Guadalajara, Alías, García, Olmo, Valverde, Sanchez, Romero, Gardea, Gil, Santos, Nimmersgern, Serrano, Paz, Romero-Simó, Blasco-Segura, Caravaca-García, Costa-Navarro, Zarco-Pleguezuelos, Flor-Lorente, García-Granero, Arencibia, Alonso, Febles, Nogués, Roque, Segelman, Nygren, Nestler, Abraham-Nordling, Egenvall, Myrelid, Jung, Loftås, Lydrup, M. -L., Azahr, Buchwald, Mangell, Syk, Nikberg, Carlander, Chabok, Smedh, Tiselius, Haapaniemi, Benckert, Adamina, Freil-Lanter, Gingert, Müller, Schäfli, Regusci, Brenna, Fasolini, Misteli, Kirchhoff, Oertli, Hahnloser, Clerc, Hübner, Ris, Chevallay, Morel, Schiltz, J. Y., W. -C., Huang, C. -W., C. -J., Tsai, H. -L., Bugra, Agalar, Baloglu, Basoglu, Okkabaz, Binboga, Biricik, Celik, Yavuz, Canda, A. E., Fuzun, Sokmen, Terzi, Isik, Karip, Bilgili, A. C., Leventoğlu, Aytac, Küçükdiler, Yıldız, Yuksel, Sinan, Hancerliogullari, Kaymak, Kozak, Ozer, Sarici, I. S., Akca, Kalayci, M. U., Kara, Agcaoglu, Balik, Bayram, Özbalcı, G. S., Özkan, B. B., Karabacak, Sungurtekin, Ozgen, Demirbas, Öztürk, Yilmazlar, Colak, Karagul, Kinas, Fearnhead, Lord, Stewart, Zammit, Arnold, Broadhurst, Moran, Seretis, Shabbir, Jones, Kynaston, Vimalachandran, Blower, Mcfaul, Mcwhirter, Pilkington, Wilson, Chowdhary, Stubbs, Abdalkoddus, Lai, Thavanesan, Yao, Agarwal, Dindyal, Hill, R. M. C., Reade, Slesser, Paterson, Balfour, Boland, Geraghty, O'Kelly, Patel, Tezas, Yahia, Jadhav, Marimuthu, Narayanan, Piramanayagam, Bradley, Buchanan, Paul, Thomson, Korsgen, Bedford, Lee, Leong, Mcarthur, Malik, Mohamed, Pilavas, Reddy, Ahmed, Voll, Velchuru, Lal, Mirshekar-Syahkal, Kassai, Aleem, Keogh-Bootland, Sarmah, Keegan, Kelkar, Sen, Oliveira-Cunha, Chaudhri, Fares, Thomas, W. M., Aslam, M. I., Boyle, Hemingway, Miller, Norwood, Gurjar, Al-Saeedi, Anandan, Sudlow, Zampitis, Bogdan, Iqbal, Bailey, Lawes, Tamhane, Evans, Ather, Lim, Nageswaran, Taylor, Hunt, Nicholls, Shaikh, Muscara, O'Brien, Photi, Stearns, Meylemans, Cunningham, Hompes, Tennakoon, Kumarasinghe, Rao, Upanishad, Shweejawee, Stefan, Daniels, Gregoir, Longstaff, Mcdermott, Varcada, Drami, Gala, Moggia, Ratnatunga, Harries, Hayes, Williams, Raymond, Bronder, Davies, Hawkin, Ryska, Ayral, Beveridge, Bhowmik, Gill, Simpson, Schofield, Mcardle, Parmar, Williamson, Burton, Courtney, Grant, Saracino, Newton, Epstein, Branagan, Bignell, Symankewicz, Zaman, Mankotia, Siddiqui, Torrance, Artioukh, Eggleston, Gokul, Selwyn, Warusavitarne, Chandrasinghe, Grainger, Leo, C. A., Harris, Levy, Skull, Thaha, Garg, Ramsanahie, Mondragon-Pritchard, Cuinas, Leon, Shukla, Brewer, Fitzgerald, Kho, Torkington, Tate, Wheat, Smolarek, Platt, Tham, Knight, Richardson, Tzivanakis, Gregori, Ashraf, Atif, Santos, Saffaf, Canning, Chandratreya, Bowen, Graham, Hamad, Kaubrys, Chaudhry, Z. U., Bhan, Mukhtar, Oshowo, Gouvas, Nicol, Pandey, Zilvetti, Fatayer, Mothe, Rahman, Curtis, Allison, Dalton, Francis, Ockrim, Psaras, Dudarovaska, Marharint, Mostovoy, Voloshin, Kolesnik, Altinel, Tan, Surgery, European Society of Coloproctology (ESCP) Cohort Study, Tonini V, Cervellera M, Vaccari S., Tutino R., Salamone G., Licari L., G. Cocorullo, G. Gulotta, Glasbey, J, Blanco-Colino, R, Kelly, M, Singh, B, Bhangu, A, Pinkney, T, Poskus, T, El-Hussuna, A, Battersby, N, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Gallo, G, Minaya-Bravo, A, Morton, D, Negoi, I, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckmann, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, El Nakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Korkolis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Toth, I, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Edden, Y, Halfteck, G, Reissman, P, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, W, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flaaten Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Suleymanov, N, Tarasov, N, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Fernandez-Martinez, D, Otero, J, Solar-Garcia, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez-Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, L, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Gutierrez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, C, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Smolarek, S, Platt, E, Rossi, B, Tham, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, Glasbey, James C., Blanco-Colino, Ruth, Kelly, Michael, Singh, Baljit, Bhangu, Aneel, Pinkney, Thoma, Poskus, Toma, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Frasson, Matteo, Gallo, Gaetano, Minaya-Bravo, Ana María, Morton, Dion, Negoi, Ionut, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Lui, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charle, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., El-Hussuna, A., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Ã ., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Gallo, G., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Ng, Y. Y., Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å&nbsp, Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., Beltrán de Heredia, J. P., Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., Romero de Diego, A., Cordoba Diaz de Laspra, E., Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez-Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã ., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã ., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., Su, W. -C., Huang, C. -W., Ma, C. -J., Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., and Tan, S.
Subjects: Laparoscopic surgery, Male, Leak, medicine.medical_specialty, Cathartics/administration & dosage, medicine.drug_class, medicine.medical_treatment, Antibiotics, anastomotic leak, bowel preparation, colonic cancer, Colorectal surgery, laparoscopic surgery, Gastroenterology, 030230 surgery, Anastomosis, Preoperative Care/methods, NO, 03 medical and health sciences, 0302 clinical medicine, Anti-Bacterial Agents/administration & dosage, Preoperative Care, Medicine, Humans, risk factors, Prospective Studies, Multi centre, Prospective cohort study, Colectomy, Aged, ta3126, Medical Audit, business.industry, Cathartics, digestive, oral, and skin physiology, Middle Aged, digestive system diseases, Surgery, Anti-Bacterial Agents, 030220 oncology & carcinogenesis, Bowel preparation, Drug Therapy, Combination, Female, Colectomy/adverse effects, business, Anastomotic Leak/etiology
Abstract: INTRODUCTION: The optimal bowel preparation strategy to minimise the risk of anastomotic leak is yet to be determined. This study aimed to determine whether oral antibiotics combined with mechanical bowel preparation (MBP+Abx) was associated with a reduced risk of anastomotic leak when compared to mechanical bowel preparation alone (MBP) or no bowel preparation (NBP).METHODS: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 Left Sided Colorectal Resection audit was performed. Patients undergoing elective left sided colonic or rectal resection with primary anastomosis between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak.RESULTS: Of 3676 patients across 343 centres in 47 countries, 618 (16.8%) received MBP+ABx, 1945 MBP (52.9%) and 1099 patients NBP (29.9%). Patients undergoing MBP+ABx had the lowest overall rate of anastomotic leak (6.1%, 9.2%, 8.7% respectively) in unadjusted analysis. After case-mix adjustment using a mixed-effects multivariable regression model, MBP+Abx was associated with a lower risk of anastomotic leak (OR 0.52, 0.30-0.92, P = 0.02) but MBP was not (OR 0.92, 0.63-1.36, P = 0.69) compared to NBP.CONCLUSION: This non-randomised study adds 'real-world', contemporaneous, and prospective evidence of the beneficial effects of combined mechanical bowel preparation and oral antibiotics in the prevention of anastomotic leak following left sided colorectal resection across diverse settings. We have also demonstrated limited uptake of this strategy in current international colorectal practice.
Published: 2018

5. Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery

Author: Battersby, Nick, Glasbey, James C., Neary, Peter, Negoi, Ionut, Kamarajah, Sivesh, Sgro, Alessandro, Bhangu, Aneel, Pinkney, Thomas, Frasson, Matteo, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Gallo, Gaetano, Glasbey, James, Minaya-Bravo, Ana María, Morton, Dion, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Luis, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charles, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., El-Hussuna, A., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Ã., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Clerke, C., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Y. Y., Ng, Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å ., Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., Beltrán de Heredia, J. P., Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., Romero de Diego, A., Cordoba Diaz de Laspra, E., Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez- Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., W. -C., Su, Huang, C. -W., C. -J., Ma, Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S., European Society of Coloproctology (ESCP) Cohort Studies, Tonini V, Cervellera M, Vaccari S, Battersby, Nick, Glasbey, James C., Neary, Peter, Negoi, Ionut, Kamarajah, Sivesh, Sgro, Alessandro, Bhangu, Aneel, Pinkney, Thoma, Frasson, Matteo, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Gallo, Gaetano, Glasbey, Jame, Minaya-Bravo, Ana María, Morton, Dion, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Lui, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charle, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., El-Hussuna, A., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Ã ., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Gallo, G., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Ng, Y. Y., Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å&nbsp, Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., Beltrán de Heredia, J. P., Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., Romero de Diego, A., Cordoba Diaz de Laspra, E., Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez- Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã ., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã ., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., Su, W. -C., Huang, C. -W., Ma, C. -J., Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S., Surgery, Battersby, N, Glasbey, J, Neary, P, Negoi, I, Kamarajah, S, Sgro, A, Bhangu, A, Pinkney, T, Frasson, M, El-Hussuna, A, Buchs, N, Buskens, C, Chaudri, S, Gallo, G, Minaya-Bravo, A, Morton, D, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckmann, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, El Nakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Korkolis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Toth, I, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, M, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Edden, Y, Halfteck, G, Reissman, P, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Clerke, C, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, W, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flaaten Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Suleymanov, N, Tarasov, N, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Fernandez-Martinez, D, Otero, J, Solar-Garcia, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez- Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, L, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Gutierrez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, C, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Smolarek, S, Platt, E, Rossi, B, Tham, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, R. Tutino, G. Salamone, L. Licari, G. Cocorullo, and G. Gulotta
Subjects: Male, Colorectal cancer, deferral of surgery, neoadjuvant therapy, pathology, radiology, rectal cancer, Rectal surgery, surgical oncology, Gastroenterology, 0302 clinical medicine, Prospective Studies, Prospective cohort study, Complete response, Medical Audit, integumentary system, Incidence (epidemiology), Incidence, Remission Induction, Middle Aged, Magnetic Resonance Imaging, Europe, Treatment Outcome, Response Evaluation Criteria in Solid Tumors, 030220 oncology & carcinogenesis, Preoperative Period, 030211 gastroenterology & hepatology, Female, Adult, medicine.medical_specialty, NO, 03 medical and health sciences, medicine, Humans, Intensive care medicine, Deferral, Pathological, Aged, Neoplasm Staging, ta3126, business.industry, Rectal Neoplasms, Reproducibility of Results, Chemoradiotherapy, Adjuvant, medicine.disease, Rectal Neoplasms/diagnostic imaging, Neoplasm Staging/methods, business
Abstract: INTRODUCTION: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.METHODS: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging.RESULTS: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as 'fair' only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively).CONCLUSION: The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials.
Published: 2018

6. A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease

Author: González-Serna, David, Ochoa, Eguzkine, López-Isac, Elena, Julià, Antonio, Degenhardt, Frauke, Ortego-Centeno, Norberto, Radstake, Timothy R.D.J., Franke, Andre, Marsal, Sara, Mayes, Maureen D., Martín, Javier, Márquez, Ana, Assassi, Shervin, Zhou, Xiaodong, Tan, Filemon K., Arnett, Frank C., Reveille, John D., Gorlova, Olga, Chen, Wei V., Ying, Jun, Gregersen, Peter K., Lee, Annette T., Voskuyl, Alexandre E., de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Broen, Jasper, Koeleman, Bobby P.C., Simeón, Carmen P., Fonollosa, Vicente, Guillén, Alfredo, Carreira, Patricia, Castellví, Iván, González-Gay, Miguel A., Ríos, Raquel, Callejas-Rubio, Jose Luis, Vargas-Hitos, José A., García-Portales, Rosa, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., García-Hernández, Francisco José, Castillo, Ma Jesús, Aguirre, Ma Ángeles, Gómez-Gracia, Inmaculada, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, de la Peña, Paloma García, Vicente, Esther, Andreu, José Luis, Fernández de Castro, Mónica, López-Longo, Francisco Javier, Martínez, Lina, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Rodríguez-Carballeira, Mónica, Narváez, Francisco Javier, Rubio-Rivas, Manel, Ortiz-Santamaría, Vera, Madroñero, Ana Belén, Díaz, Bernardino, Trapiella, Luis, Sousa, Adrián, Egurbide, María Victoria, Fanlo-Mateo, Patricia, Sáez-Comet, Luis, Díaz-González, Federico, Hernández, Vanesa, Beltrán, Emma, Román-Ivorra, José Andrés, Grau, Elena, Alegre-Sancho, Juan José, Blanco-García, Francisco J., Oreiro, Natividad, Freire, Mayka, Balsa, Alejandro, Ortiz, Ana M., Hunzelmann, Nicolas, Riemekasten, Gabriela, Distler, Jörg H.W., Witte, Torsten, Airó, Paolo, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Universidad de Salamanca, Junta de Andalucía, Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad (España), Ministerio de Economía y Competitividad (España), Rheumatology, AII - Inflammatory diseases, Julià, Antonio [0000-0001-6064-3620], Franke, Andre [0000-0003-1530-5811], Mayes, Maureen D [0000-0001-5070-2535], Apollo - University of Cambridge Repository, Mayes, Maureen D. [0000-0001-5070-2535], and Universidad de Cantabria
Subjects: 0301 basic medicine, Male, Settore MED/09 - Medicina Interna, 692/699/249/2510, 45/43, Gene Expression, lcsh:Medicine, Genome-wide association study, Single-nucleotide polymorphism, Locus (genetics), Disease, Inflammatory diseases, SLC22A5, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, medicine, Humans, Genetic Predisposition to Disease, Allele, lcsh:Science, Genetic association, 030203 arthritis & rheumatology, Genetics, Crohn's disease, Multidisciplinary, Scleroderma, Systemic, 45, biology, lcsh:R, article, medicine.disease, digestive system diseases, 3. Good health, Settore MED/16 - Reumatologia, 030104 developmental biology, Risk factors, Genetic Loci, Case-Control Studies, biology.protein, Female, lcsh:Q, 692/499, Genome-Wide Association Study
Abstract: We thank Sofia Vargas and Gema Robledo for her excellent technical assistance and all the patients and control donors for their essential collaboration. We thank WTCCC (Welcome Trust Case Control Consortium) for the access to GWAS data of Crohn’s disease patients and healthy controls, Banco Nacional de ADN (University of Salamanca, Spain) who supplied part of the control DNA samples, and dbGap for granting access to the IBD Genetics Consortium (IBDGC) Crohn’s Disease GWAS data (phs000130.v1.p1). The IBDGC Crohn’s Disease Genome-Wide Association Study was conducted by the IBDGC Investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This manuscript was not prepared in collaboration with Investigators of the IBDGC Crohn’s Disease Genome-Wide Association Study and does not necessarily reflect the opinions or views of the IBDGC Crohn’s Disease Genome-Wide Association Study, the NIDDK Central Repositories, or the NIDDK., Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases and all of them showed a significant effect on gene expression. In addition, an enrichment in the IL-12 family and type I interferon signaling pathways was observed among the set of SSc-CD common genetic risk loci. In conclusion, through the first cross-disease meta-analysis of SSc and CD, we identified genetic variants with pleiotropic effects on two clinically distinct immune-mediated disorders. The fact that all these pleiotropic SNPs have opposite allelic effects in SSc and CD reveals the complexity of the molecular mechanisms by which polymorphisms affect diseases., This work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2015-66761-P; IPT-010000-2010-36, cofunded by the European Regional Development Fund), Consejería de Innovación, Ciencia y Tecnología, Junta de Andalucía (Spain) (P12-BIO-1395) and the Cooperative Research Thematic Network (RETICS) programme (RD16/0012/0013) (RIER) from Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Economy, Industry and Competitiveness). AM is recipient of a Miguel Servet fellowship (CP17/00008) from ISCIII (Spanish Ministry of Economy, Industry and Competitiveness). DGS was supported by the Spanish Ministry of Economy and Competitiveness through the FPI programme (SAF2015-66761-P). This work is part of the Doctoral Thesis “Bases Genéticas de la Esclerosis Sistémica: Integrando Genómica y Transcriptómica”.
Published: 2020

7. The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit

Author: van der Pool, Anne, Rawlings, Alexandra, Sánchez-Guillén, Luis, Kuiper, Sara, Negoi, Ionut, Buchs, Nicolas, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Frasson, Matteo, Gallo, Gaetano, Minaya-Bravo, Ana María, Morton, Dion, Nepogodiev, Dmitri, Pata, Francesco, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Christianne Buskens Quentin, Knowles, Charles, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., El-Hussuna, A., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Ã., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Gallo, G., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Y. Y., Ng, Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å ., Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., de Heredia, J. P. Beltrán, Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., de Diego, A. Romero, de Laspra, E. Cordoba Diaz, Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez- Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., W. -C., Su, Huang, C. -W., C. -J., Ma, Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S., European Society of Coloproctology (ESCP) Cohort Studie, Tonini V, Cervellera M, Vaccari S, van der Pool, A, Rawlings, A, Sanchez-Guillen, L, Kuiper, S, Negoi, I, Buchs, N, El-Hussuna, A, Battersby, N, Buskens, C, Chaudri, S, Frasson, M, Gallo, G, Minaya-Bravo, A, Morton, D, Nepogodiev, D, Pata, F, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, C, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Pinkney, T, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckmann, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, El Nakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Denost, Q, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Korkolis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Toth, I, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, M, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Edden, Y, Halfteck, G, Reissman, P, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, W, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flaaten Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Suleymanov, N, Tarasov, N, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Fernandez-Martinez, D, Otero, J, Solar-Garcia, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, de Diego, A, de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez- Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, L, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Gutierrez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, C, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Smolarek, S, Platt, E, Rossi, B, Tham, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, R. Tutino, G. Salamone, L. Licari, G. Cocorullo, G. Gulotta, AGEM - Digestive immunity, Surgery, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, RS: NUTRIM - R2 - Liver and digestive health, and 2017 and 2015 European Society of Coloproctology (ESCP) collaborating, Group
Subjects: Laparoscopic surgery, Male, Colorectal cancer, medicine.medical_treatment, surgery, 0302 clinical medicine, Postoperative Complications, Medicine, Major complication, Prospective Studies, Laparoscopy, SHORT-TERM OUTCOMES, Colectomy, Medical Audit, medicine.diagnostic_test, Prospective audit, Gastroenterology, Middle Aged, laparoscopic surgery, Conversion to Open Surgery, Colon cancer, Treatment Outcome, Elective Surgical Procedures, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, Colonic surgery, Adult, medicine.medical_specialty, CLINICAL-TRIAL, NO, OPEN COLECTOMY, 03 medical and health sciences, COLORECTAL SURGERY, Case mix index, gastrointestinal surgery, Humans, rectal cancer, RECTAL-CANCER, Aged, ta3126, business.industry, Elective resection, medicine.disease, RANDOMIZED-TRIAL, OPEN RESECTION, Surgery, business
Abstract: BACKGROUND: Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer outcomes than both laparoscopic completed or planned open surgery. The primary aim of this study was to determine whether laparoscopic conversion was associated with a higher major complication rate than planned open surgery in contemporary, international practice.METHODS: Combined analysis of the European Society of Coloproctology 2017 and 2015 audits. Patients were included if they underwent elective resection of a colonic segment from the caecum to the rectosigmoid junction with primary anastomosis. The primary outcome measure was the 30-day major complication rate, defined as Clavien-Dindo grade III-V.RESULTS: Of 3980 patients, 64% (2561/3980) underwent laparoscopic surgery and a laparoscopic conversion rate of 14% (359/2561). The major complication rate was highest after open surgery (laparoscopic 7.4%, converted 9.7%, open 11.6%, P < 0.001). After case mix adjustment in a multilevel model, only planned open (and not laparoscopic converted) surgery was associated with increased major complications in comparison to laparoscopic surgery (OR 1.64, 1.27-2.11, P < 0.001).CONCLUSIONS: Appropriate laparoscopic conversion should not be considered a treatment failure in modern practice. Conversion does not appear to place patients at increased risk of complications vs planned open surgery, supporting broadening of selection criteria for attempted laparoscopy in elective colonic resection.
Published: 2018

8. Safety of primary anastomosis following emergency left sided colorectal resection: an international, multi-centre prospective audit

Author: Sánchez-Guillén, L, Nepogodiev, D, Sivrikoz, E, van Elst, T, Minaya, A, Pata, F, Glasbey, J, Pinkney, T, Bhangu, A, El-Hussuna, A, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Gallo, G, Morton, D, Negoi, I, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefèvre, J, Möeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M Jr, Tercioti, V Jr, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Šantak, G, Ćosić, J, Previšić, A, Vukušić, L, Zukanović, G, Zelić, M, Kršul, D, Lekić Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkašová, M, Grolich, T, Procházka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsbøll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, Pm, Krogh, A, Rolff, Hc, Lykke, J, Juvik, Af, Lóven, Hhk, Marckman, M, Osterkamp, Jtf, Madsen, Ah, Worsøe, J, Ugianskis, A, Kjaer, Md, Youn Cho Lee, B, Khalid, A, Kristensen, Mh, El Sorogy, M, Elgeidie, A, Elhemaly, M, Elnakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepistö, A, Keränen, I, Kivelä, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyöty, M, Haukijärvi, E, Kotaluoto, Sm, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, Jc, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Lefevre, J, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Münch, S, Pullig, F, Schön, M, Hinz, S, Becker, T, Möller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lázár, G, Ábraham, S, Paszt, A, Simonka, Z, Zaránd, A, Baranyai, Z, Ferreira, G, Harsányi, L, Ónody, P, Banky, B, Burány, Á, Lakatos, M, Marton, J, Solymosi, A, Besznyák, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, Sk, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Khan, Mf, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, Me, Bass, G, Martin, St, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, Mr, Dorot, S, Halfteck, G, Reissman, P, Yair, E, Eden, Y, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, La, Asteria, Cr, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, Me, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, Gm, Belli, A, Bianco, F, De Franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, Mg, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, Nm, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, L S, Zaccone, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, Pr, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismiontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, Ne, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, Nn, Wong, M, Zain, Z, Zakaria, Z, Mazlan, L, Mohd Azman ZA, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, Ma, Raiss, M, Westerduin, E, Tanis, P, van der Sluis PC, Davids, Ph, Pronk, A, Schiphorst, Ahw, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon YT, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, Ej, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flateh Backe, I, Wik, Ta, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, Ms, Qureshi, Au, Billah, M, Jawad, My, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Gonçalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simões, J, Silva-Vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, Dm, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, Ss, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Nail, S, Tarasov, N, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapić, Z, Barišić, G, Dimitrijević, I, Marković, V, Sekulić, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, Jc, Ng, Yy, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovš Trampuš, Š, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldaña, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, Mc, Bernal-Sprekelsen, Jc, Gómez, R, Jareño, S, Ríos, A, Vercher, D, García-González, Jm, Cervera-Aldama, J, Ramos-Prada, J, Santamaría-Olabarrieta, M, Borda, N, Enrriquez-Navascués, Jm, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, López-Lara, Ma, Muñoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Martínez, D, Otero, J, Solar, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny AM, Martin Perez, B, Otero Piñeiro AM, Paredes, J, Fernandez, F, Ladra, Mj, Paulos, A, Prieto, D, Beltrán de Heredia JP, Blanco Antona, F, de Andrés Asenjo, B, Ferreras García, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreño, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alós Company, R, Ruiz Carmona MD, Solana Bueno, A, Salvans Ruiz, S, Alonso Gonçalves, S, Jiménez-Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, Em, Garcia-Marin, Ja, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, Mj, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, Jd, Ramos Rubio, D, Escartin, J, Blas, Jl, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socías, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julià, D, Codina-Cazador, A, Farrés, R, Gómez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Fermiñán, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, Jl, Gallardo, Ab, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo López JA, Gil López JM, González Zunzárren, M, Martínez Alegre, J, Zorrilla Matilla JP, Navarro-Sánchez, A, Alcalá Serrano FJ, López-Fernández, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelañez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martín, J, Cagigas Fernández, C, Castillo Diego, J, Pando, Ja, Maristany, C, Muñoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Peña Ros, E, Benavides Buleje JA, Muñoz Camarena JM, Parra Baños PA, Ramirez Faraco, M, Arenal, Jj, Citores, Ma, Marcos, Jl, Sánchez, J, Tinoco, C, García Flórez LJ, Arias Pacheco RD, Mínguez Ruiz, G, Rodríguez Corral, N, Rodríguez Infante, A, Carrillo López MJ, Carrasco Prats MM, Lage Laredo, A, Martínez Manzano, Á, Rodríguez García, P, Segura-Sampedro, Jj, Alonso-Hernández, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibañez, N, Abrisqueta, J, Lujan, J, Gómez Pérez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, Rm, De la Portilla, F, Diaz Pavon JM, Garcia Cabrera AM, Reyes Diaz ML, Espin, E, Marinello, F, Martí, M, Sanchez, Jl, Vallribera, F, Orts Mico FJ, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estévez Diz, A, Moreno Asencio MT, Varela Mato, A, Vázquez Bouzán, R, Minaya-Bravo, Am, Diez-Alonso, Mm, Villeta-Plaza, R, Guadalajara, H, Alías, D, García Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simó, M, Blasco-Segura, T, Caravaca-García, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, García-Granero, Á, García-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogués, Em, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftås, P, Lydrup, Ml, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Müller, P, Schäfli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hübner, M, Ris, F, Buchs, Nc, Chevallay, M, Morel, P, Schiltz, B, Wang, Jy, Su, Wc, Huang, Cw, Ma, Cj, Tsai, Hl, Özbalcı, Gs, Özkan, Bb, Karabacak, U, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, Ae, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, Ac, Leventoglu, S, Aytac, B, Yıldız, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, Mt, Sarici, Is, Akca, O, Kalayci, Mu, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Sungurtekin, U, Ozgen, U, Demirbas, S, Öztürk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Battersby, N, Broadhurst, J, Mehta, A, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, Rmc, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, Wm, Aslam, Mi, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, Mr, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Smolarek, S, Platt, E, Rossi, B, Tham, Jc, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, Ca, Vaizey, Cj, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, Ma, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Zu, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S., 2017 European Society of Coloproctology (ESCP) collaborating, Group, Rosati, R, Sileri, P, Sanchez-Guillen, L, Nepogodiev, D, Sivrikoz, E, van Elst, T, Minaya, A, Pata, F, Glasbey, J, Pinkney, T, Bhangu, A, El-Hussuna, A, Buchs, N, Buskens, C, Chaudri, S, Frasson, M, Gallo, G, Morton, D, Negoi, I, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckman, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, Elnakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, M, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Halfteck, G, Reissman, P, Yair, E, Eden, Y, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Donald, Z, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Jackson, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismiontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, Z, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flateh Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Nail, S, Tarasov, N, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Martinez, D, Otero, J, Solar, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez-Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, J, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Rodriguez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Minaya-Bravo, A, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Ozbalci, G, Ozkan, B, Karabacak, U, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Battersby, N, Broadhurst, J, Mehta, A, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Smolarek, S, Platt, E, Rossi, B, Tham, J, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, C, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, Surgery, R. Tutino, G. Salamone, L. Licari, G. Cocorullo, G. Gulotta, European Society of Coloproctology (ESCP) Cohort Studie, and Tonini V, Cervellera M, Vaccari S
Subjects: Male, Medical audit, Treatment outcome, anastomotic leak, 030230 surgery, 0302 clinical medicine, Postoperative Complications, Prospective Studies, Multi centre, emergency surgery, Prospective cohort study, Colectomy, Medical Audit, Proctectomy, Proctectomy/adverse effects, Prospective audit, Primary anastomosis, Anastomosis, Surgical, Gastroenterology, Middle Aged, surgical complications, Europe, Treatment Outcome, colon cancer, gastrointestinal surgery, rectal cancer, Surgery, surgical outcomes, 030220 oncology & carcinogenesis, Postoperative Complications/etiology, Female, Colectomy/adverse effects, Emergency Treatment/adverse effects, Adult, medicine.medical_specialty, Adolescent, surgical outcome, Left sided, NO, 03 medical and health sciences, Young Adult, surgical complication, medicine, Humans, Emergency Treatment, Colorectal resection, Aged, ta3126, Anastomosis, Surgical/methods, business.industry, General surgery, Surgical Stomas, Surgical Stomas/statistics & numerical data, Settore MED/18 - Chirurgia Generale, Multivariate Analysis, business
Abstract: Introduction: Some evidence suggests that primary anastomosis following left sided colorectal resection in the emergency setting may be safe in selected patients, and confer favourable outcomes to permanent enterostomy. The aim of this study was to compare the major postoperative complication rate in patients undergoing end stoma vs primary anastomosis following emergency left sided colorectal resection. Methods: A pre-planned analysis of the European Society of Coloproctology 2017 audit. Adult patients (>16years) who underwent emergency (unplanned, within 24h of hospital admission) left sided colonic or rectal resection were included. The primary endpoint was the 30-day major complication rate (Clavien-Dindo grade 3 to 5). Results: From 591 patients, 455 (77%) received an end stoma, 103 a primary anastomosis (17%) and 33 primary anastomosis with defunctioning stoma (6%). In multivariable models, anastomosis was associated with a similar major complication rate to end stoma (adjusted odds ratio for end stoma 1.52, 95%CI 0.83–2.79, P=0.173). Although a defunctioning stoma was not associated with reduced anastomotic leak (12% defunctioned [4/33] vs 13% not defunctioned [13/97], adjusted odds ratio 2.19, 95%CI 0.43–11.02, P=0.343), it was associated with less severe complications (75% [3/4] with defunctioning stoma, 86.7% anastomosis only [13/15]), a lower mortality rate (0% [0/4] vs 20% [3/15]), and fewer reoperations (50% [2/4] vs 73% [11/15]) when a leak did occur. Conclusions: Primary anastomosis in selected patients appears safe after left sided emergency colorectal resection. A defunctioning stoma might mitigate against risk of subsequent complications.
Published: 2018

9. Genetic screening and molecular characterization of MET alterations in non-small cell lung cancer

Author: M. Sanchez-Cespedes, Elisabeth Brambilla, Eva Pros, Ernest Nadal, A. McLeer-Florin, and Maria Saigi
Subjects: Adult, Male, 0301 basic medicine, Cancer Research, Lung Neoplasms, Receptor, ErbB-2, Adenocarcinoma, 03 medical and health sciences, Exon, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Gene duplication, Biomarkers, Tumor, medicine, Carcinoma, Humans, Genetic Testing, Lung cancer, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Gene Amplification, Exons, General Medicine, Middle Aged, Proto-Oncogene Proteins c-met, Prognosis, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Mutation, Carcinoma, Squamous Cell, Cancer research, Carcinoma, Large Cell, Immunohistochemistry, Female, business, Immunostaining, Follow-Up Studies, Fluorescence in situ hybridization
Abstract: Aberrant activation of MET as a result of exon 14-skipping (METex14) mutations or gene amplification is an oncogenic mechanism in non-small cell lung carcinoma (NSCLC) and a potential therapeutic target. The purpose of this study was to characterize MET alterations in a cohort of NSCLC patients treated with surgery. 157 NSCLCs of various histopathologies, including pulmonary sarcomatoid carcinomas (PSC), were tested for MET alterations. METex14 mutations, MET copy number alterations and the levels of MET protein were determined by Sanger sequencing, fluorescence in situ hybridization and immunohistochemistry, respectively. Concurrent alterations of other important cancer genes and immunostaining of the downstream effector, phopho-S6, were also determined. METex14 mutations and MET amplification were detected in seven tumors. MET genetic alterations were found predominantly in the lung adenocarcinoma (ADC) and PSC histopathologies. High levels of MET protein were found in most MET-amplified tumors, but not in all METex14-mutated tumors. Strong phopho-S6 staining was observed in about half of the MET-activated tumors. One tumor with METex14 exhibited concurrent ERBB2 amplification. MET activation, by either METex14 mutations or amplification, is characteristic of a subset of early stage NSCLCs and may coexist with ERBB2 amplification. This may have potential therapeutic implications. The presence of METex14 mutations was associated with low levels of MET protein, which may limit the use of total MET immunostaining as a marker for preselecting patients for MET-targeted therapies.
Published: 2017

10. Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate after Transanal Total Mesorectal Excision in 2653 Patients with Rectal Cancer

Author: S X, Roodbeen, F B, Lacy, S, Dieren, M, Penna, F, Ris, B, Moran, P, Tekkis, W A, Bemelman, R, Hompes, Adamina, Michel, Aigner, Felix, Al Furajii, Hazar, Albers, Benjamin, S Allison, Andrew, Arezzo, Alberto, J Arnold, Steven, Aryal, Kamal, Atallah, Sam, Austin, Ralph, Khurrum Baig, Mirza, Baloyiannis, Ioannis, Bandyopadhyay, Dibyendu, Banerjee, Saswata, Banky, Balazs, Baral, Joerg, Belgers, Eric, Bell, Stephen, Berti, Stefano, Biebl, Matthias, Bloemendaal, Bobby, Boni, Luigi, Bordeianou, Liliana, Borreca, Dario, I Bosker, Robbert J., Box, Benjamin, Boyce, Stephen, Bravo, Raquel, Den Broeck, Sylvie, Brown, Carl, Bruegger, Lukas, Brunner, Walter, Buchli, Christian, C Buchs, Nicolas, Buia, Alexander, Burt, Caroline, Cahill, Ronan, Pablo Campana, Juan, Campbell, Kenneth, Di Candido, Francesca, T Capolupo, Gabriella, Caricato, Marco, Caro-Tarrago, Aleidis, Cassinotti, Elisa, Caycedo, Antonio, Chandrasinghe, Pramodh, Chaudhri, Sanjay, Chernyshov, Stanislav, Chitsabesan, Praminthra, Christoforidis, Dimitri, A Clark, David, Coget, Julien, D Courtney, Edward, Cunningham, Chris, D’hooge, Pieter, D’hoore, Andre, Dagbert, Francois, J Dalton, Stephen, Dapri, Giovanni, Dawson, Robin, Dayal, Sanjeev, Delgado, Salvadora, Delrio, Paolo, Doerner, Johannes, Doornebosch, Pascal, Duff, Sarah, Erkinovich Dzhumabaev, Khasan, Edwards, Tom, Egenvall, Monika, Ravn Eriksen, Jens, Espin, Eloy, Estevez-Schwarz, Lope, Faes, Seraina, Fearden, Arne, Feleppa, Cosimo, Forgan, Tim, Forsmo, Havard, K Francis, Nader, Frontali, Alice, Fu, Cherylin, Gamage, Bawantha, Ignacio Rodriguez Garcia, Jose, Geissmann, Daniel, Geluwe, Bart, Gill, Kathryn, Glockler, Markus, Gloor, Severin, Javier Gomez, Carlos, Graaf, Eelco, Grolich, Tomas, Guido, Jutten, Hahnloser, Dieter, Hance, Julian, Harikrishnan, Athur, Haunold, Ingrid, Hayes, Julian, Hendrickx, Tom, Heriot, Alexander, Hoffmann, Theo-Julian, Hongwei, Yao, Huang, Joe, James, Horwood, Ial, Roshan, Ito, Masaaki, Janssens, Marc, Joy, Howard, Pagin Sao Juliao, Guilherme, Karimuddin, Ahmer, Katory, Mark, Killeen, Shane, Werner Kneist, Knol, Joep, Komen, Niels, Kukreja, Neil, Kusters, Miranda, Lacy, Antonio, Lakatos, Lorand, Lambrechts, Anton, Alvarez Laso, Carlos, Leao, Pedro, Lezoche, Emanuele, A Liberman, Sender, Lidder, Paul, Andrade Lima, Meylina, Lorenzon, Laura, Mackey, Paul, Maggiori, Leon, Zaur Mamedli, Zaman, Mansfield, Steve, Marcoen, Steven, Marcy, Tobias, Maroon, Tohmeh, Marta Pascual, Damieta, Marti, Lukas, Maslekar, Sushil, Mccallum, Iain, Mccarthy, Kathryn, Ramon Silveira Mendes, Carlos, Merrie, Arend, Michalopoulos, Antonios, Mikalauskas, Saulius, F Miles, Anthony W., C Mills, Sarah, Miroshnychenko, Yevgen, Mittermair, Christof, Molloy, Richard, Montroni, Isacco, Moore, Etienne, Moore, Tim, Mooslechner, Barbara, Morino, Mario, Moslein, Gabriela, Muratore, Andrea, Metodiev Mutafchiyski, Ventsislav, Myers, Alistair, Nicol, Deborah, Nieuwenhove, Yves, Nishizaki, Daisuke, John Nolan, Gregory, Ochsner, Alex, Hwan Oh, Jae, Collera Ormazabal, Pablo, Otero, Ana, Ouro, Susana, Panis, Yves, Papavramidis, Theodosios, Papen, Michael, Paraoan, Marius, Pastor, Carlos, Pastor, Enrique, Penchev, Dimitar, Pera, Miguel, Karim Perdawood, Sharaf, Oliva Perez, Rodrigo, Persiani, Roberto, Pfeffer, Frank, Terry Phang, P., Pichetto, Andrea, Pirenne, Yves, Pockney, Peter, Pooter, Karl, Poskus, Eligijus, Pros, Imma, Rajendran, Nirooshun, J Raval, Manoj, Rega, Daniela, Ricciardi, Rocco, Riel, Wouter, Ris, Frederic, Riss, Stefan, Alexander Rockall, Timothy, Romagnolo, Luis, Manuel Romero-Marcos, Juan, Roquete, Paulo, Rossi, Gustavo, Gomez Ruiz, Marcos, Rybakov, Evgeny, Sakai, Yoshiharu, Scala, Andrea, Millan Scheiding, Monica, Monica Millan, Gerald, Seva-Pereira, Gustavo, Sguinzi, Raffaella, A Shaikh, Irshad, Shalaby, Mostafa, Sharma, Abhiram, Sietses, Colin, Sileri, Pierpaolo, Simo, Vicente, Singh, Baljit, Slesser, Alistair, Kyung Sohn, Dae, Sosef, Meindert, Soravia, Claudio, Speakman, Christopher, Spinelli, Antonino, Sprundel, Frank, Steenkiste, Franky, L Stevenson, Andrew R., Stift, Anton, Storms, P., Studer, Peter, Konraad Talsma, Aaldert, J Tanis, Pieter, Tejedor, Patricia, La Terra, Antonio, Torkington, Jared, Jimenez Toscano, Marta, Tschann, Peter, Tuech, Jean-Jacques, Tuynman, Jurriaan, Tzovaras, George, Ugolini, Giampaolo, Vallribera, Francesc, Vanrykel, Filip, Vorburger, Stephan, Warner, Michael, J Warren, Oliver, Warrier, Satish, Warusavitarne, Janindra, Wegstapel, Henk, Weiss, Helmut, Witzig, Jacques-Alain, Wolff, Torsten, Wolthuis, Albert, Wu, Linus, Wynn, Greg, Zhongtao, Zhang, Zingg, Urs, Ziyaie, Dorin, Graduate School, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Surgery, APH - Methodology, and International TaTME Registry Collaborative
Subjects: Male, Colorectal cancer, registry, circumferential resection margin, rectal cancer, risk factors, transanal total mesorectal excision, Adenocarcinoma, Aged, Cohort Studies, Disease-Free Survival, Endoscopic Mucosal Resection, Female, Follow-Up Studies, Humans, Length of Stay, Logistic Models, Middle Aged, Multivariate Analysis, Operative Time, Predictive Value of Tests, Proctectomy, Prognosis, Prospective Studies, Rectal Neoplasms, Registries, Risk Assessment, Survival Analysis, Transanal Endoscopic Surgery, Treatment Outcome, Margins of Excision, 0302 clinical medicine, Prospective cohort study, ddc:617, integumentary system, Incidence (epidemiology), food and beverages, Total mesorectal excision, 030220 oncology & carcinogenesis, Predictive value of tests, embryonic structures, 030211 gastroenterology & hepatology, Risk assessment, Cohort study, medicine.medical_specialty, animal structures, 03 medical and health sciences, medicine, Survival analysis, business.industry, fungi, medicine.disease, Surgery, Human medicine, business
Abstract: Objective: The aim of this study was to determine the incidence of, and preoperative risk factors for, positive circumferential resection margin (CRM) after transanal total mesorectal excision (TaTME). Background: TaTME has the potential to further reduce the rate of positive CRM for patients with low rectal cancer, thereby improving oncological outcome. Methods: A prospective registry-based study including all cases recorded on the international TaTME registry between July 2014 and January 2018 was performed. Endpoints were the incidence of, and predictive factors for, positive CRM. Univariate and multivariate logistic regressions were performed, and factors for positive CRM were then assessed by formulating a predictive model. Results: In total, 2653 patients undergoing TaTME for rectal cancer were included. The incidence of positive CRM was 107 (4.0%). In multivariate logistic regression analysis, a positive CRM after TaTME was significantly associated with tumors located up to 1 cm from the anorectal junction, anterior tumors, cT4 tumors, extra-mural venous invasion (EMVI), and threatened or involved CRM on baseline MRI (odds ratios 2.09, 1.66, 1.93, 1.94, and 1.72, respectively). The predictive model showed adequate discrimination (area under the receiver-operating characteristic curve >0.70), and predicted a 28% risk of positive CRM if all risk factors were present. Conclusion: Five preoperative tumor-related characteristics had an adverse effect on CRM involvement after TaTME. The predicted risk of positive CRM after TaTME for a specific patient can be calculated preoperatively with the proposed model and may help guide patient selection for optimal treatment and enhance a tailored treatment approach to further optimize oncological outcomes.
Published: 2019

11. Estimating Suicide Rates in Developing Nations

Author: Rattanakorn Ratanashevorn, Choloe Britts, Keith M. Harris, Megan L. Perry, Joanne Thandrayen, Boontriga Lewchalermwongse, Chien Samphoas, and Pros Se
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Developing country, Poison control, 01 natural sciences, Suicide prevention, Occupational safety and health, Newspaper, Mark and recapture, Young Adult, 010104 statistics & probability, 03 medical and health sciences, 0302 clinical medicine, Environmental health, medicine, Humans, 030212 general & internal medicine, 0101 mathematics, Developing Countries, Aged, Government, business.industry, Public health, Public Health, Environmental and Occupational Health, Newspapers as Topic, Reproducibility of Results, Middle Aged, Suicide, Costs and Cost Analysis, Female, Cambodia, business
Abstract: This study tested a low-cost method for estimating suicide rates in developing nations that lack adequate statistics. Data comprised reported suicides from Cambodia’s 2 largest newspapers. Capture-recapture modeling estimated a suicide rate of 3.8/100 000 (95% CI = 2.5-6.7) for 2012. That compares to World Health Organization estimates of 1.3 to 9.4/100 000 and a Cambodian government estimate of 3.5/100 000. Suicide rates of males were twice that of females, and rates of those
Published: 2016

12. Isolated DLco/VA reduction in systemic sclerosis patients: a new patient subset?

Author: Juana Martinez-Llorens, Eva Balcells, Anna Pros, Luis Molina, P. Corzo, and Stephanie Ling
Subjects: Male, medicine.medical_specialty, Hypertension, Pulmonary, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, DLCO, Diffusing capacity, Internal medicine, Medicine, Humans, In patient, Pulmonary pathology, skin and connective tissue diseases, Lung, Aged, Retrospective Studies, Skin, 030203 arthritis & rheumatology, Carbon Monoxide, Scleroderma, Systemic, integumentary system, business.industry, General Medicine, respiratory system, Middle Aged, medicine.disease, Prognosis, Respiratory Function Tests, Echocardiography, Case-Control Studies, Cohort, Cardiology, Pulmonary Diffusing Capacity, Female, business
Abstract: Introduction Diffusing capacity for carbon monoxide (DLco) reduction is the first detectable pulmonary functional test (PFT) change in systemic sclerosis (SSc)–related pulmonary complications. reduction in patients without cardiopulmonary alterations has also been observed; a good characterisation of these patients is lacking. The objective of this study is to describe the characteristics of SSc patients with isolated DLco reduction and compare these patients to SSc patients with DLco reduction with a known cause. Methods SSc patients with DLco < 80%predicted were included and classified into cases (isolated DLco reduction) and controls (DLco reduction in the presence of known pulmonary pathology). SSc clinico-serological data, PFT and echocardiography features were collected and analysed. Results Froma total SSc cohort of 115 patients, 75 patients were included: 20 cases (26.7%) and 55 controls (73.3%). Cases were predominantly limited skin subset (90% vs 60%, p < 0.001), were anti-centromere antibody (ACA)-positive (95% vs 40%, p < 0.001) and had an infrequent oesophageal involvement (45% vs 74%; p = 0.016). The mean DLco reduction of cases was mild (65.60%± 10.56). Only 1 out of 20 patients had normal DLco/VAvalues, and tricuspid regurgitation was more frequent (85% vs 53.8%, p = 0.014). Conclusion There is a subgroup of SSc patients with mild isolated DLco and DLco/VA reduction, predominantly limited SSc with ACA seropositivity, which could identify a particular SSc subset.We hypothesise that isolated DLco/VA reduction could indicate a pulmonary vascular involvement. Nevertheless, a close follow-up is mandatory, as a pre-PAH situation cannot be excluded.
Published: 2018

13. Peer counselling versus role-playing: Two training methods of therapeutic skills in clinical psychology

Author: José, Ruiz Rodríguez, Arturo, Bados López, Adela, Fusté Escolano, Eugeni, García-Grau, Carmina, Saldaña García, Gemma, Balaguer Fort, Teresa, Lluch, and Mar, Arcos Pros
Subjects: Adult, Male, Self Disclosure, Communication Barriers, Psychology, Clinical, Professional-Patient Relations, Self Concept, Life Change Events, Young Adult, Surveys and Questionnaires, Humans, Female, Clinical Competence, Education, Graduate, Peer Influence, Empathy, Role Playing
Abstract: Training programmes for clinical psychologists should include evidence-based teaching methods that enable trainees to learn therapeutic skills. Here we compared the perceived utility of role-playing vs. peer counselling. In peer counselling, one student recounts a personal experience to the other, who thus has the opportunity to act as the therapist in relation to a real situation. Given that sharing such personal experiences may provoke discomfort in students, we also examined this aspect.Trainees (n=202) were given both role-play and peer counselling activities as a way of practising empathy and active listening. After completing the skills training programme they completed a questionnaire to assess the extent to which each method had helped them to develop their self-awareness and to acquire these therapeutic skills.In general, peer counselling was considered more useful than role-playing for enhancing self-awareness and personal growth, as well as for learning these professional skills. Regarding the discomfort experienced by students, our data suggest that any initial reluctance to share personal experiences is outweighed by the personal and professional benefits obtained.Our results indicate that experiential learning involving emotionally charged situations is an effective way of teaching therapeutic skills to clinical and health psychology trainees.
Published: 2018

14. Perioperative transfusion management in gastric cancer surgery: Analysis of the Spanish subset of the EURECCA oesophago-gastric cancer registry

Author: Dulce Momblan, Javier Osorio, Inmaculada Pros, Josep Feliu, Gonzalo Galofré, Xabier García-Albéniz, Joaquín Rodríguez-Santiago, Aurora Aldeano, Carles Olona, David Ruiz, Miguel Lozano, Manuel Pera, Alexis Luna, Eva Artigau, Carlos Jericó, C Miranda, Mónica Miró, Maite Santamaría, Sandra Castro, and Elisenda Garsot
Subjects: Male, medicine.medical_specialty, Blood transfusion, Multivariate analysis, medicine.medical_treatment, Intravenous iron, 030230 surgery, Adenocarcinoma, Bloodless Medical and Surgical Procedures, Perioperative Care, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Stomach Neoplasms, Internal medicine, Medicine, Humans, Registries, Aged, Retrospective Studies, business.industry, General Engineering, Cancer, Retrospective cohort study, Perioperative, medicine.disease, Cancer registry, Spain, 030220 oncology & carcinogenesis, Female, business, Erythrocyte Transfusion, Cancer surgery
Abstract: Introduction This study evaluated allogenic packed red blood cell (aPRBC) transfusion rates in patients undergoing resection for gastric cancer and the implementation of blood-saving protocols (BSP). Methods Retrospective study of all gastric cancer patients operated on with curative intent in Catalonia and Navarra (2011–2013) and included in the Spanish subset of the EURECCA Oesophago-Gastric Cancer Registry. Hospitals with BSP were defined as those with a preoperative haemoglobin (Hb) optimization circuit associated with restrictive transfusion strategies. Predictors of aPRBC transfusion were identified by multinomial logistic regression analysis. Results A total of 652 patients were included, 274 (42.0%) of which received aPRBC transfusion. Six of the 19 participating hospitals had BSP and treated 145 (22.2%) patients. Low Hb level at diagnosis (10 vs 12.4 g/dL), ASA score III/IV, pT3-4, open surgery, associated visceral resection, and having being operated on in a hospital without BSP were predictors of aPRBC transfusion, while low Hb level, associated visceral resection, and non-BSP hospital remained predictors in the multivariate analysis. In case of comparable risk factors for aPRBC transfusion, there was a higher use of preoperative intravenous iron treatment (26.2% vs 13.2%) and a lower percentage of transfusions (31.7% vs 45%) in hospitals with BSP. Conclusions The perioperative transfusion rate in gastric cancer was 42%. Hospitals with BSP showed a significant reduction of blood transfusions but treated only 22% of patients. Main predictors of aPRBC were low Hb level, associated visceral resection, and undergoing surgery at a hospital without BSP.
Published: 2017

15. Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition

Author: Pereira C, Gimenez-Xavier P, Pros E, Pajares MJ, Moro M, Gomez A, Navarro A, Condom E, Moran S, Gomez-Lopez G, Graña O, Rubio-Camarillo M, Martinez-Martí A, Yokota J, Carretero J, Galbis JM, Nadal E, Pisano D, Sozzi G, Felip E, Montuenga LM, Roz L, Villanueva A, and Sanchez-Cespedes M
Subjects: transporter associated with antigen processing 1, genetic association, HLA antigen class 1, CD274 protein, human, immunosurveillance, PDCD1 protein, human, genetic analysis, cytotoxic T lymphocyte, B2M gene, whole exome sequencing, middle aged, somatic mutation, cancer survival, clinical article, beta 2 microglobulin, adult, CD8 antigen, CALR gene, alpha interferon, antigen recognition, aged, female, priority journal, gene inactivation, gene expression microarray, gamma interferon, pembrolizumab, genomic profiling, down regulation, atezolizumab, mutational analysis, animal experiment, RNA sequence, Article, high throughput sequencing, lymphocytic infiltration, male, ani, controlled study, human, gene, mouse, gene identification, nivolumab, cancer immunotherapy, nonhuman, animal model, TAP1 gene, programmed death 1 receptor, human tissue, predictor variable, programmed death 1 ligand 1, lung cancer, PDIA3 gene, microarray analysis, upregulation
Abstract: Purpose: We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs). Experimental Design: We undertook an integrated RNA and whole-exome sequencing of 14 PDXs. We focused on the genetic and functional analysis of beta 2-microglobulin (B2M), a component of the HLA class-I complex. Results: We identified alterations in genes involved in various functions, such as B2M involved in immunosurveillance. We extended the mutational analysis of B2M to about 230 lung cancers. Five percent of the lung cancers carried somatic mutations, most of which impaired the correct formation of the HLA-I complex. We also report that genes such as CALR, PDIA3, and TAP1, which are involved in the maturation of the HLA-I complex, are altered in lung cancer. By gene expression microarrays, we observed that restitution of B2M in lung cancer cells upregulated targets of IFN alpha/IFN gamma. Furthermore, one third of the lung cancers lacked the HLA-I complex, which was associated with lower cytotoxic CD8(+) lymphocyte infiltration. The levels of B2M and HLA-I proteins correlated with those of PD-L1. Finally, a deficiency in HLA-I complex and CD8(+) infiltration tended to correlate with reduced survival of patients with lung cancer treated with anti-PD-1/anti-PD-L1. Conclusions: Here, we report recurrent inactivation of B2M in lung cancer. These observations, coupled with the mutations found at CALR, PDIA3, and TAP1, and the downregulation of the HLA-I complex, indicate that an abnormal immunosurveillance axis contributes to lung cancer development. Finally, our observations suggest that an impaired HLA-I complex affects the response to anti-PD-1/anti-PD-L1 therapies. (C) 2016 AACR.
Published: 2017

16. Anomalous intraosseous venous drainage: Bone perforators?

Author: Carlos D′Alotto, J.-L. Gillet, Guillermo Buero, Didier Rastel, Alfred Obermayer, Erika Mendoza, Anne Grenot-Mercier, Kenedy Pacheco, Albert-Adrien Ramelet, Jean-Michel Monsallier, Vincent Crebassa, Stefan Küpfer, Dominique Soulié, and Nicolas Pros
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, Varicose Veins, 03 medical and health sciences, 0302 clinical medicine, Varicose veins, Sclerotherapy, Medicine, Humans, Tibia, Lipodermatosclerosis, Aged, Aged, 80 and over, business.industry, Advanced stage, Venous drainage, General Medicine, Middle Aged, Surgery, medicine.vein, Venous reflux, Female, Posterior tibial vein, medicine.symptom, Bone Diseases, Cardiology and Cardiovascular Medicine, business
Abstract: Objectives Anomalous intraosseous venous drainage is a rare and almost unknown entity; only 14 cases have been reported in the literature and 4 mentioned in textbooks. We report the characteristics of 35 further cases observed in 32 patients. Method After the presentation of two cases at the congress of the French Society of Phlebology in Paris (2013), 12 colleagues joined to present a large series of so-called bone perforators observed in their practice, all identified with at least a duplex investigation. Results Thirty-two patients suffering from varicose veins and/or skin changes (C2−C6) associated with a bone perforator of the tibia (with bilateral anomalies in three) are reported: 19 females and 13 males, average age 56.9. The majority of the affected legs were symptomatic (30/35). Bone perforator was an isolated finding in 27/35 legs. In three cases, the investigations revealed that the venous reflux in the bone originated from an incompetent posterior tibial vein. Conclusions We suggest the name of “bone perforators” for an anomalous tibial intraosseous venous drainage, feeding varicose veins, and in more advanced stages lipodermatosclerosis and leg ulcers. Most of them were successfully treated with surgery or sclerotherapy.
Published: 2016

17. Functional variants of Fc gamma receptor (FCGR2A) and FCGR3A are not associated with susceptibility to systemic sclerosis in a large European Study (EUSTAR)

Author: Behrooz Z, Alizadeh, Jasper, Broen, Blanca, Rueda, Roger, Hesselstrand, Dirk, Wuttge, Carmen, Simeon, Norberto, Ortego-Centeno, Miguel A, Gonzalez-Gay, Miguel, Gonzalez-Gay, Anna, Pros, Ariane, Herrick, Jane, Worthington, Christopher, Denton, Carmen, Fonseca, Gabriela, Riemekasten, Madelon C, Vonk, Frank, van den Hoogen, Serena, Guiducci, Marco, Matucci-Cerinic, Rafaella, Scorza, Lorenzo, Beretta, Paolo, Airó, Marieke, Coenen, Javier, Martin, Bobby P C, Koeleman, and Timothy R D J, Radstake
Subjects: Male, Genotype, Immunology, FCGR2A, Polymorphism, Single Nucleotide, Auto-immunity, transplantation and immunotherapy [N4i 4], Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], Gene Frequency, Rheumatology, Scleroderma, Limited, Genetic predisposition, Humans, Immunology and Allergy, Medicine, Genetic Predisposition to Disease, skin and connective tissue diseases, Allele frequency, Genotyping, Autoantibodies, integumentary system, business.industry, Receptors, IgG, Autoantibody, FCGR3A, Middle Aged, Allelic discrimination, Europe, Scleroderma, Diffuse, Female, business, Infection and autoimmunity [NCMLS 1]
Abstract: Objective.To investigate the possible role ofFCGR2A519A>G andFCGR3A559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype.Methods.A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of theFCGR2A519A>G andFCGR3A559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5′ allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3.Results.NeitherFCGR2A519A>G norFCGR3A559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement.Conclusion.Our study strongly suggests the lack of a role for theFCGR2A519A>G andFCGR3A559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts.
Published: 2010

18. Assessment of nailfold capillaroscopy by נ30 digital epiluminescence (dermoscopy) in patients with Raynaud phenomenon

Author: A. Toll, A. Pros, R.M. Pujol, J. Carbonell, and E. Beltrán
Subjects: Male, Pathology, medicine.medical_specialty, Systemic disease, Dermoscopy, Dermatology, Sensitivity and Specificity, Scleroderma, Microscopic Angioscopy, Mixed connective tissue disease, Humans, Medicine, Prospective Studies, Dermatoscopy, medicine.diagnostic_test, business.industry, Reproducibility of Results, Raynaud Disease, Sclerodactyly, Overlap syndrome, Middle Aged, medicine.disease, Connective tissue disease, Capillaries, Nails, Spain, Case-Control Studies, Rheumatoid arthritis, Female, medicine.symptom, business
Abstract: Summary Background Dermoscopy is a useful tool for dermatologists to study melanocytic lesions. Its possible usefulness in the assessment of capillary nailfold morphological changes (capillaroscopy) has recently been advocated. Objectives To assess the practical utility of digital epiluminescence microscopy as a capillaroscopic instrument in patients with Raynaud phenomenon (RP). To compare the sensitivity and specificity rates obtained by epiluminescence microscopy with those previously reported with conventional capillaroscopic devices. Methods Fifty-six consecutive patients with primary RP (PRP; n = 5) or secondary RP (SRP; n = 51) (11 men and 45 women in total) were included in the study. A control group of 10 healthy subjects was also evaluated. Twenty-six patients (46%) had systemic sclerosis (SS), 12 (21%) presystemic sclerosis (pre-SS), one (2%) dermatopolymyositis–SS, one (2%) mixed connective tissue disease, two (4%) Sjogren syndrome, two (4%) an overlap syndrome, one (2%) rheumatoid arthritis and six (11%) other connective tissue diseases. Capillary nailfold changes were studied using a nonportable digital epiluminescence device (magnification × 30). Following a systematized protocol, capillary nailfold morphology, density and distribution were evaluated. Several capillaroscopic patterns were identified (normal, sclerodermic, nonspecific, nondiagnostic) as previously defined. A possible relationship between capillary nailfold changes and the intensity of RP or the presence of associated autoimmune diseases was assessed. Results The sclerodermic pattern showed a sensitivity of 76·9% and a specificity of 90·9% in SS. A typical capillaroscopic SS pattern was observed in 73% of cases of limited SS and in 82% of cases of diffuse SS. Patients with Sjogren syndrome and dermatopolymyositis–SS showed a nonspecific capillaroscopic pattern. All patients with PRP presented a normal capillaroscopic pattern. A normal capillaroscopic pattern was also observed in 11 of 12 patients with pre-SS. In one of two patients presenting severe sclerodactyly and in all patients showing hand oedema (three of 56), capillaroscopic changes could not be evaluated. Avascular areas correlated significantly with severe RP (P
Published: 2007

19. [Satisfaction, health and work-related stress of the university professorship according to their contractual status]

Author: Ramón, Cladellas-Pros, Antoni, Castelló-Tarrida, and Eva, Parrado-Romero
Subjects: Adult, Employment, Male, Occupational Stress, Spain, Humans, Female, Middle Aged, Faculty, Job Satisfaction, Occupational Health, Aged
Abstract: There's a lot of literature about teachers' work conditions and the effects of such conditions on them. The goal of this research focuses on the analysis of the effects derived from the type of labour relationship with the University on the psycho-social dimensions of satisfaction, stress and perceived health.Quasi-experimental study on a sample of 145 university professors from the seven public universities from Catalonia (Spain). The data was obtained in April 2014, by means of ISTAS21 questionnaire, intermediate version, in Spanish. From the 21 subscales in the instrument, only seven were used for data-gathering since they encompassed the dimensions of interest. A series of ANOVA analyses were performed, taking the three psycho-social dimensions as dependent variables and work stability and dedication (e.g. full- vs. partial-time) as independent variables.Professors with full-time work and unstable contracts showed worse health (both physical and mental) despite being the youngest, as well as larger symptoms of stress and lower job-satisfaction, compared with full-time professors with stable contracts and even compared part-time-jobs professors.Job-stability seems to be a central variable in work-quality and health for the professors whose labour situation is unstable, something that influences both their teaching and research quality.Analizar los efectos de la estabilidad contractual de los profesores universitarios en las dimensiones psicosociales de satisfacción, salud y estrés.Estudio descriptivo cuasi-experimental, tomando como muestra a 145 profesores de siete universidades públicas catalanas. El estudio se realizó durante el mes de abril de 2014. Se utilizó como base el cuestionario ISTAS21, versión media, en lengua castellana, del Cuestionario Psicosocial de Copenhaguen. De las 21 escalas incluidas, sólo se han tenido en cuenta las siete escalas relacionadas con los factores evaluados. Se realizaron una serie de análisis de varianza (ANOVA) considerando las puntuaciones obtenidas en las tres dimensiones psicosociales evaluadas como variables dependientes y la estabilidad laboral (permanencia y dedicación laboral) como variable independiente.Los profesores de tiempo completo con contratos laborales temporales muestran una peor salud física y mental -a pesar de ser el grupo más joven-, mayores síntomas de estrés y una menor satisfacción laboral, en comparación con profesores a tiempo completo y contrato estable; o profesores de tiempo parcial.La estabilidad laboral tiene repercusiones en la salud y calidad de vida laboral de los profesores que se encuentran en situación de inestabilidad, teniendo ello además repercusiones en la docencia y la investigación.
Published: 2015

20. Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

Author: Maureen D. Mayes, Lara Bossini-Castillo, Olga Gorlova, José Ezequiel Martin, Xiaodong Zhou, Wei V. Chen, Shervin Assassi, Jun Ying, Filemon K. Tan, Frank C. Arnett, John D. Reveille, Sandra Guerra, María Teruel, Francisco David Carmona, Peter K. Gregersen, Annette T. Lee, Elena López-Isac, Eguzkine Ochoa, Patricia Carreira, Carmen Pilar Simeón, Iván Castellví, Miguel Ángel González-Gay, Alexandra Zhernakova, Leonid Padyukov, Marta Alarcón-Riquelme, Cisca Wijmenga, Matthew Brown, Lorenzo Beretta, Gabriela Riemekasten, Torsten Witte, Nicolas Hunzelmann, Alexander Kreuter, Jörg H.W. Distler, Alexandre E. Voskuyl, Annemie J. Schuerwegh, Roger Hesselstrand, Annika Nordin, Paolo Airó, Claudio Lunardi, Paul Shiels, Jacob M. van Laar, Ariane Herrick, Jane Worthington, Christopher Denton, Fredrick M. Wigley, Laura K. Hummers, John Varga, Monique E. Hinchcliff, Murray Baron, Marie Hudson, Janet E. Pope, Daniel E. Furst, Dinesh Khanna, Kristin Phillips, Elena Schiopu, Barbara M. Segal, Jerry A. Molitor, Richard M. Silver, Virginia D. Steen, Robert W. Simms, Robert A. Lafyatis, Barri J. Fessler, Tracy M. Frech, Firas AlKassab, Peter Docherty, Elzbieta Kaminska, Nader Khalidi, Henry Niall Jones, Janet Markland, David Robinson, Jasper Broen, Timothy R.D.J. Radstake, Carmen Fonseca, Bobby P. Koeleman, Javier Martin, Norberto Ortego-Centeno, Raquel Ríos, José Luis Callejas, Nuria Navarrete, Rosa García Portales, María Teresa Camps, Antonio Fernández-Nebro, María F. González-Escribano, Julio Sánchez-Román, Francisco José García-Hernández, María Jesús Castillo, María Ángeles Aguirre, Inmaculada Gómez-Gracia, Benjamín Fernández-Gutiérrez, Luis Rodríguez-Rodríguez, Esther Vicente, José Luis Andreu, Mónica Fernández de Castro, Paloma García de la Peña, Francisco Javier López-Longo, Lina Martínez, Vicente Fonollosa, Gerard Espinosa, Carlos Tolosa, Anna Pros, Mónica Rodríguez Carballeira, Francisco Javier Narváez, Manel Rubio Rivas, Vera Ortiz Santamaría, Bernardino Díaz, Luis Trapiella, María del Carmen Freire, Adrián Sousa, María Victoria Egurbide, Patricia Fanlo Mateo, Luis Sáez-Comet, Federico Díaz, Vanesa Hernández, Emma Beltrán, José Andrés Román-Ivorra, Elena Grau, Juan José Alegre Sancho, Francisco J. Blanco García, Natividad Oreiro, Luis Fernández Sueiro, Rheumatology, CCA - Disease profiling, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Translational Immunology Groningen (TRIGR)
Subjects: Male, Linkage disequilibrium, systemic sclerosis, Genome-wide association study, immunochip array, DNASE-GAMMA, Linkage Disequilibrium, DISEASE, Autophagy-Related Protein 5, DEAD-box RNA Helicases, FUNCTIONAL POLYMORPHISM, 0302 clinical medicine, HLA Antigens, Risk Factors, Genetics(clinical), Genetics (clinical), Genetics, 0303 health sciences, HLA, Female, Chromosomes, Human, Pair 3, Microtubule-Associated Proteins, SNPs, GENETIC RISK-FACTOR, Genotype, Single-nucleotide polymorphism, Locus (genetics), Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, Article, Interleukin-12 Subunit p35, White People, 03 medical and health sciences, Proto-Oncogene Proteins, Microchip Analytical Procedures, LUPUS-ERYTHEMATOSUS, Humans, Genetic Predisposition to Disease, JAPANESE POPULATION, Allele, GENOME-WIDE ASSOCIATION, Alleles, 030304 developmental biology, Genetic association, 030203 arthritis & rheumatology, PRIMARY BILIARY-CIRRHOSIS, Endodeoxyribonucleases, Scleroderma, Systemic, Chromosomes, Human, Pair 11, Haplotype, DNASE1L3, RHEUMATOID-ARTHRITIS, Logistic Models, Genetic Loci, Case-Control Studies, Carrier Proteins, FOLLOW-UP, Genome-Wide Association Study
Abstract: In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses resulted in a model composed of six polymorphic amino acid positions and seven SNPs that explained the observed significant associations in the region. In addition, a replication step comprising 4,017 SSc cases and 5,935 controls was carried out for several selected non-HLA variants, reaching a total of 5,850 cases and 9,401 controls of European ancestry. Following this strategy, we identified and validated three SSc risk loci, including DNASE1L3 at 3p14, the SCHIP1-IL12A locus at 3q25, and ATG5 at 6q21, as well as a suggested association of the TREH-DDX6 locus at 11q23. The associations of several previously reported SSc risk loci were validated and further refined, and the observed peak of association in PXK was related to DNASE1L3. Our study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
Published: 2014

21. A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype

Author: F.H.J. van den Hoogen, C.P. Simeon, Julio Sánchez-Román, M. A. González-Gay, Bo R. Rueda, Roger Hesselstrand, Madelon C. Vonk, A. Pros, V. Fonollosa, Ariane L. Herrick, M F González-Escribano, Trdj Radstake, M. T. Camps, Nathalie C. Lambert, M. A. Aguirre-Zamorano, J. L. Nelson, Javier Martin, Marieke J H Coenen, Jane Worthington, Norberto Ortego-Centeno, G. Riemekasten, and Rosa Garcia-Portales
Subjects: Male, Genotype, Immunology, Auto-immunity, transplantation and immunotherapy [N4i 4], Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], Rheumatology, Gene Frequency, Polymorphism (computer science), Immunology and Allergy, Medicine, Humans, Genetic Predisposition to Disease, Allele, Promoter Regions, Genetic, skin and connective tissue diseases, Allele frequency, Scleroderma, Systemic, integumentary system, business.industry, Case-control study, Connective Tissue Growth Factor, Phenotype, CTGF, Case-Control Studies, Population study, Female, business, Infection and autoimmunity [NCMLS 1]
Abstract: Contains fulltext : 81261.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To conduct a replication study to investigate whether the -945 CTGF genetic variant is associated with systemic sclerosis (SSc) susceptibility or specific SSc phenotype. METHODS: The study population comprised 1180 patients with SSc and 1784 healthy controls from seven independent case-control sets of European ancestry (Spanish, French, Dutch, German, British, Swedish and North American). The -945 CTGF genetic variant was genotyped using a Taqman 5' allelic discrimination assay. RESULTS: An independent association study showed in all the case-control cohorts no association of the CTGF -945 polymorphism with SSc susceptibility. These findings were confirmed by a meta-analysis giving a pooled OR = 1.12 (95% CI 0.99 to 1.25), p = 0.06. Investigation of the possible contribution of the -945 CTGF genetic variant to SSc phenotype showed that stratification according to SSc subtypes (limited or diffuse), selective autoantibodies (anti-topoisomerase I or anticentromere) or pulmonary involvement reached no statistically significant skewing. CONCLUSION: The results do not confirm previous findings and suggest that the CTGF -945 promoter polymorphism does not play a major role in SSc susceptibility or clinical phenotype.
Published: 2009

22. Randomised trial of endoscopic sphincterotomy with gallbladder left in situ versus open surgery for common bileduct calculi in high-risk patients

Author: E. M. Targarona, Josep Terés, M. Trias, Josep M. Bordas, R.M.P Ayuso, Emilio Ros, Joaquín Martínez, and Pros I
Subjects: Male, Risk, medicine.medical_specialty, Biliary Tract Diseases, medicine.medical_treatment, Gallstones, Patient Readmission, law.invention, Sphincterotomy, Endoscopic, Postoperative Complications, Randomized controlled trial, Recurrence, law, medicine, Humans, Cholecystectomy, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, Cholangiopancreatography, Endoscopic Retrograde, medicine.diagnostic_test, business.industry, Gallbladder, Open surgery, General surgery, General Medicine, Odds ratio, Surgery, Endoscopy, Clinical trial, medicine.anatomical_structure, Multivariate Analysis, Female, business, Follow-Up Studies
Abstract: Summary Background Morbidity and mortality after surgical treatment of bileduct stones increase with age and associated diseases. A proposed alternative therapy is endoscopic sphincterotomy (ES) with the gallbladder left in situ, and we elected to compare this option with standard open surgery in high-risk patients. Methods 98 patients (mean age 80 years) with symptoms likely to be due to bileduct stones or a recent episode of biliary pancreatitis were randomised to be treated either by open cholecystectomy with operative cholangiography and (if necessary) bileduct exploration (n=48) or by endoscopic sphincterotomy alone (n=50). Findings The procedure was accomplished successfully in 94% of the surgery group and 88% of the ES group, and there were no significant differences in immediate morbidity (23% vs 16%) or mortality (4% vs 6%). During mean follow-up of 17 months biliary symptoms recurred in three surgical patients, none of whom underwent repeat surgery, and in 10 ES patients, seven of whom had biliary surgery. By multivariate regression analysis endoscopic sphincterotomy was an independent predictor of recurrent biliary symptoms (odds ratio 6·9; 95% Cl 1·46 to 32·54). Interpretation In elderly or high-risk patients, surgery is preferable to endoscopic sphincterotomy with the gallbladder left in situ as a definitive treatment for bileduct stones or non-severe biliary pancreatitis.
Published: 1996

23. The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype

Author: V. Fonollosa, Marieke J H Coenen, F.H.J. van den Hoogen, M. T. Camps, Javier Martin, Bo R. Rueda, C.P. Simeon, M M V A P Schrijvenaars, Norberto Ortego-Centeno, M. A. González-Gay, Jasper C A Broen, Julio Sánchez-Román, Trdj Radstake, Orlando Jorge Martins Torres, Rosa Garcia-Portales, M. A. Aguirre-Zamorano, Madelon C. Vonk, and A. Pros
Subjects: Interleukin-23 receptor, Adult, Male, Systemic disease, Genotype, Immunology, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Auto-immunity, transplantation and immunotherapy [N4i 4], General Biochemistry, Genetics and Molecular Biology, Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], Rheumatology, Gene Frequency, Immunology and Allergy, SNP, Medicine, Humans, Genetic Predisposition to Disease, Allele, skin and connective tissue diseases, Aged, Scleroderma, Systemic, integumentary system, business.industry, Receptors, Interleukin, Middle Aged, medicine.disease, Connective tissue disease, Phenotype, Case-Control Studies, Cohort, Female, business, Infection and autoimmunity [NCMLS 1]
Abstract: Objectives:Multiple studies indicate the role of the interleukin (IL)-17/IL-23 axis in autoimmune diseases, including systemic sclerosis (SSc). The aim of the current study was to investigate the possible implication of the IL23R gene in SSc susceptibility and/or clinical phenotype.Methods:An initial case–control study in 143 Dutch patients with SSc and geographically matched healthy individuals (n = 246) was carried out and followed by a replication study in a cohort of 365 Spanish patients with SSc and 515 healthy individuals. Seven single nucleotide polymorphisms (SNPs) spanning the IL23R gene were selected and genotyped using a Taqman assay.Results:Using a Dutch cohort of patients with SSc and controls we observed an association between two (rs11209032, rs1495965) of the seven tested SNPs and disease susceptibility (allelic p values: p = 0.02 and p = 0.01 respectively). However, a replication study in an independent Spanish cohort did not confirm these findings and reveal no association of any of the IL23R-tested SNP with disease susceptibility or clinical phenotype. Similarly, a meta-analysis considering both populations did not reveal any significant association. In addition, no association was observed between IL23R genetic variants and SSc clinical phenotypes.Conclusions:Our results suggest that the IL23R gene is not associated with SSc susceptibility or clinical phenotype.
Published: 2009

24. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype

Author: H. Suarez, Roger Hesselstrand, P. Airo, R. Scorza, J. L. Nelson, M. T. Camps, Julio Sánchez-Román, Gabriela Riemekasten, Madelon C. Vonk, C. P. Simeon, J. C. A. Broen, M. A. Aguirre-Zamorano, A. Pros, L. Beretta, Blanca Rueda, V. Fonollosa, María Francisca González-Escribano, Javier Martin, F.H.J. van den Hoogen, M. A. Gonzalez-Gay, M. J. H. Coenen, Norberto Ortego-Centeno, J.M. van Laar, Rosa Garcia-Portales, B. Diaz, and Trdj Radstake
Subjects: Male, Oncology, medicine.medical_specialty, Genotype, Biology, Polymorphism, Single Nucleotide, Auto-immunity, transplantation and immunotherapy [N4i 4], White People, Cohort Studies, Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], Polymorphism (computer science), Internal medicine, Genetics, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, Allele, Molecular Biology, STAT4, Genetics (clinical), Scleroderma, Systemic, Case-control study, General Medicine, Odds ratio, STAT4 Transcription Factor, Phenotype, Genetic marker, Case-Control Studies, Immunology, Female, Infection and autoimmunity [NCMLS 1]
Abstract: Contains fulltext : 81363.pdf (Publisher’s version ) (Closed access) The aim of this study was to investigate the possible role of STAT4 gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility or clinical phenotype. A total of 1317 SSc patients [896 with limited cutaneous SSc (lcSSc) and 421 with diffuse cutaneous SSc (dcSSc)] and 3113 healthy controls, from an initial case-control set of Spanish Caucasian ancestry and five independent cohorts of European ancestry (The Netherlands, Germany, Sweden, Italy and USA), were included in the study. The rs7574865 polymorphism was selected as STAT4 genetic marker. We observed that the rs7574865 T allele was significantly associated with susceptibility to lcSSc in the Spanish population [P = 1.9 x 10(-5) odds ratio (OR) 1.61 95% confidence intervals (CI) 1.29-1.99], but not with dcSSc (P = 0.41 OR 0.84 95% CI 0.59-1.21). Additionally, a dosage effect was observed showing individuals with rs7574865 TT genotype higher risk for lcSSc (OR 3.34, P = 1.02 x 10(-7) 95% CI 2.11-5.31). The association of the rs7574865 T allele with lcSSc was confirmed in all the replication cohorts with different effect sizes (OR ranging between 1.15 and 1.86), as well as the lack of association of STAT4 with dcSSc. A meta-analysis to test the overall effect of the rs7574865 polymorphism showed a strong risk effect of the T allele for lcSSc susceptibility (pooled OR 1.54 95% CI 1.36-1.74; P < 0.0001). Our data show a strong and reproducible association of the STAT4 gene with the genetic predisposition to lcSSc suggesting that this gene seems to be one of the genetic markers influencing SSc phenotype.
Published: 2009

25. A comparative study of conventional and energy-storing prosthetic feet in high-functioning transfemoral amputees

Author: Ben Heller, Dip Pros, D. Datta, Lorraine Graham, and J. Howitt
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Artificial Limbs, Walking, Prosthesis Design, Prosthesis, Gait (human), Amputees, medicine, Humans, Gait, Prosthetic feet, Rehabilitation, Cross-Over Studies, business.industry, Foot, Middle Aged, medicine.anatomical_structure, Lower Extremity, Gait analysis, Orthopedic surgery, Physical therapy, Ankle, business, Foot (unit)
Abstract: To compare the results of gait analysis, timed walking tests, and socket comfort for transfemoral amputees wearing initially a Multiflex conventional prosthetic foot and then a Vari-Flex energy-storing prosthetic foot.Experimental crossover trial.A regional prosthetic and amputee rehabilitation tertiary referral center in a teaching hospital.Six established unilateral transfemoral prosthetic users.Not applicable.Gait analysis, a timed walking test, and a Prosthetic Socket Fit Comfort Score for each amputee wearing the Multiflex foot and then repeated wearing the Vari-Flex foot.Wearing the Vari-Flex foot, our subjects walked faster in the gait lab (1.38 +/- 0.13 m/s, P.001) and took more equal step lengths at fast speed (1.063 +/- 0.05, P.05). They also had greater peak ankle dorsiflexion at push-off on the prosthetic side (18.3 degrees +/-4.73 degrees, P.001) and 3 times as much power from the prosthetic ankle at push-off (1.13 +/- 0.22 W/kg, P.001). There were no significant changes in temporal symmetry or loading of the prosthetic limb, in the timed walking test with each foot, or in the comfort score.A transfemoral amputee who wears an energy-storing foot can have a more symmetric gait with regard to some measures of spatial symmetry, kinetics, and kinematics than one who wears a conventional foot. However, in this study important aspects such as more symmetric loading and comfort did not differ significantly between the 2 foot types.
Published: 2007

26. [Analysis of experience in an integrated program of hospital rheumatological service and primary care]

Author: A, Pros, P, Benito, V, Grenzner, M, Pacheco, J, Blanch, M A, Campillo, and N, Martí
Subjects: Adult, Male, Adolescent, Primary Health Care, Middle Aged, Rheumatology, Spain, Data Interpretation, Statistical, Rheumatic Diseases, Outpatients, Humans, Female, Aged, Follow-Up Studies
Abstract: In order to improve the health quality at the Primary care level, the Catalonian Health Authority (Servei Catala de la Salut) has begun a reform of the medical and surgical specialties. In this reform process the Hospital del Mar, Barcelona, Spain, has taken part in the incorporation of several medical and surgical hospital specialists to primary care within its influence area. In this study, we describe the results of the collaboration between Hospital health care and Primary care on rheumatic complaints during one year.We carried out a descriptive study of some clinical and epidemiological variables of the population visited during one year (1995), at the Primary care level by the Rheumatologist. Our area has a population of 90,612 people, and its located in Barcelona City, Ciutat Vella Variables of study were collected during the period of time between January and December 1995. The following variables were recorded: age, gender, referral cause, rheumatologic diagnosis, intra-articular and peri-articular corticosteroid injections perform, techniques used for the diagnosis of rheumatic disease, follow-up level Data were statistically analyzed.Visits performed were 2,668 on 1,384 patients. Fifty-two percent were first visits, 48% were follow-up visits (Ratio first visits Nolfow-up visits: 0.57). Fifty-one percent of the patients were65 years old. Unspecific polyarthralgias, chronic low back pain, gonalgia and pathology of the shoulder were the most frequent complaints (50%). Osteoarthritis and soft-tissue diseases were the most frequent diagnosis with a percentage of 41% and 30.7%, respectively. Connective tissue diseases and spondyloarthropathies had account for 3.8% of global diagnosis. X-ray film has been the commonest technique used for the diagnosis of rheumatic diseases (80.5%). The waiting list for first visit initially has been 5 weeks, and at the end of study it has been 3 weeks. Ten percent of patients had been referred to the Hospital.Collaboration between Hospital care rheumatology and Primary care, improves the diagnostic quality, as well as it decreases the waiting list and allows the patients' control at the most appropriate care level.
Published: 1998

27. Prospective evaluation of a minimally invasive approach for treatment of bile-duct calculi in the high-risk patient

Author: Josep Terés, R. M. Perez Ayuso, Carmen Balagué, Emilio Ros, Josep M. Bordas, M. Trias, Pros I, and E. M. Targarona
Subjects: Laparoscopic surgery, Male, medicine.medical_specialty, medicine.medical_treatment, Gallstones, Sphincterotomy, Endoscopic, Postoperative Complications, Recurrence, Risk Factors, medicine, Humans, Prospective Studies, Aged, Aged, 80 and over, Cholangiopancreatography, Endoscopic Retrograde, medicine.diagnostic_test, business.industry, Bile duct, Gallbladder, Surgery, Endoscopy, Survival Rate, medicine.anatomical_structure, Treatment Outcome, Cholecystectomy, Laparoscopic, Biliary tract, Cholecystectomy, Female, business, Duct (anatomy), Abdominal surgery, Follow-Up Studies
Abstract: The best approach to bile duct stones in high-risk patients is controversial. We showed in a randomized trial that open surgery had a morbi-mortality similar to that of endoscopic sphincterotomy alone (ES) and less late biliary complications. The aim of this study was to evaluate a minimally invasive approach to duct stones in high-risk patients compared with open surgery or ES alone.Sixty high-risk patients (mean age 80 years) suspected of duct stones were treated by ES + laparoscopic cholecystectomy (LC). High-risk factors were: age70 years, Goldman cardiac index13, chronic pulmonary disease, liver cirrhosis, neurologic deficit, and severe obesity.ERCP success was 87%. Duct stones were found in 75%. LC succeeded in 92%. Post-LC stay was 4 days. Overall morbidity was 19% and mortality was 3%. Recurrent symptoms (mean follow-up: 9 months) was 3.6%. When compared with open surgery or ES alone, ES + LC had a similar morbi-mortality, but shorter postop stay (p0.001). Late symptoms appeared in 20% after ES alone vs 4% after open surgery or ES plus LC (p0.04).Combined ES + LC is an effective alternative to open surgery or ES alone for treatment of duct stones in high-risk patients.
Published: 1997

28. Changes in weight gain and anaemia attributable to malaria in Tanzanian children living under holoendemic conditions

Author: Peter J. Winch, Zul Premji, William Checkley, J.N. Minjas, Pros Lubega, and Clive Shiff
Subjects: Male, medicine.medical_specialty, Pediatrics, Mosquito Control, Anemia, Holoendemic, Weight Gain, Tanzania, Antimalarials, Age Distribution, Chloroquine, parasitic diseases, medicine, Humans, Longitudinal Studies, Malaria, Falciparum, biology, business.industry, Public Health, Environmental and Occupational Health, Infant, Plasmodium falciparum, General Medicine, medicine.disease, biology.organism_classification, Confidence interval, Surgery, Infectious Diseases, Hematocrit, Child, Preschool, Parasitology, Female, medicine.symptom, Underweight, business, Weight gain, Malaria, medicine.drug
Abstract: We investigated the effect of Plasmodium falciparum malaria on weight gain and haematocrit in Tanzanian children aged 6-40 months following a malaria control scheme which combined insecticide-impregnated bed nets with chloroquine chemotherapy on demand. Data from 7 villages (3 intervention and 4 control) were collected before, and one year after, the implementation of the programme. Initially, 82% of the children were parasitaemic, 78% were anaemic (i.e., packed cell volume
Published: 1996

29. Application of free radial forearm flap in reconstruction of the face and oral cavity

Author: M, Tvrdek, A, Nejedlý, J, Kletenský, and Z, Pros
Subjects: Male, Forearm, Mouth, Palatal Neoplasms, Carcinoma, Basal Cell, Cysts, Face, Nose Neoplasms, Humans, Facial Neoplasms, Middle Aged, Surgical Flaps
Abstract: The authors have shown the possibilities of application of the free radial forearm flap in clinical cases when reconstructing defects in the region of the face and of oral cavity. This flap is particularly useful in cases where it is necessary to duplicate the flap and to reconstruct two layers at the same time.
Published: 1994

30. Importance of an early tissue transfer in the treatment of complicated injuries of lower extremities

Author: A, Nejedlý, M, Tvrdek, J, Kletenský, and Z, Pros
Subjects: Adult, Male, Tibial Fractures, Fractures, Open, Adolescent, Fibula, Fracture Fixation, Accidents, Traffic, Humans, Surgical Flaps, Leg Injuries
Abstract: 3rd degree fractures with extensive defects of soft tissues represent a major therapeutical problem. The technique of free tissue transfer makes it possible to adopt an active access to primary treatment to this injuries. Radical necrectomies may be performed without respect to the extent of the defect that will arise. The authors present their experience regarding an early coverage of the defect of the lower extremity by means of a free flap. The time period between the accident and tissue transfer as well as a suitable flap type are taken in consideration.
Published: 1994

31. Ten years of replantation surgery at the Department of Plastic Surgery, Charles University Hospital, Prague

Author: J, Kletenský, A, Nejedlý, Z, Pros, S, Svoboda, and M, Tvrdek
Subjects: Adult, Male, Arm Injuries, Adolescent, Hand Injuries, Infant, Middle Aged, Czechoslovakia, Child, Preschool, Replantation, Humans, Female, Child, Vascular Surgical Procedures, Aged
Abstract: The authors present results of the ten years replantation surgery centre at the department of plastic surgery in Prague. The presented series of patients includes 393 persons operated on because of amputation or ischaemic injury to the region of the upper extremity. The number of replantations and revascularisations in the individual years is analysed, as well as the age of the patients, type of injury, mechanism of injury and operation results.
Published: 1994

32. Scalp replantation--a case report

Author: Z, Pros and J, Vrtisková
Subjects: Adult, Male, Scalp, Replantation, Accidents, Occupational, Humans, Agriculture
Abstract: A case of successful scalp replantation is referred. Attention is paid to problems that may accompany this less frequent type of surgery.
Published: 1994

33. Use of free flaps in burn trauma

Author: M, Tvrdek, A, Nejedlý, J, Kletenský, Z, Pros, and L, Broz
Subjects: Adult, Male, Adolescent, Burns, Electric, Humans, Female, Burns, Surgical Flaps
Abstract: The present currently used method of treating and reconstructing injuries caused by electric current and deep thermal injuries is compared with the method of early reconstruction using free flaps. Brief summary of present experience substantiating this method is presented. The three presented clinical cases show subacute reconstruction in this type of injury by free flaps transfer.
Published: 1994

34. Upper digestive hemorrhage secondary to the rupture of the splenic artery as the first sign of a squamous gastric carcinoma

Author: Carlos Parada, Manuel Trias, Jaume Ordi, Carmen Balagué, Eduardo M. Targarona, and Inmaculada Pros
Subjects: Male, Pathology, medicine.medical_specialty, Rupture, Spontaneous, Vascular disease, business.industry, Stomach, Gastroenterology, Gastric carcinoma, Splenic artery, medicine.disease, medicine.anatomical_structure, Stomach Neoplasms, medicine.artery, medicine, Carcinoma, Squamous Cell, Humans, Complication, business, Gastrointestinal Hemorrhage, Splenic Artery, Sign (mathematics), Aged
Published: 1993

35. Sequelae of an injury from the Second World War treated by free flap transfer

Author: J, Kletenský, M, Tvrdek, A, Nejedlý, Z, Pros, V, Lebeda, J, Prokopová, and H, Stĕnhová
Subjects: Male, Warfare, Tibia, Cutaneous Fistula, Muscles, Chronic Disease, Humans, Osteomyelitis, Wounds, Penetrating, Skin Transplantation, Middle Aged, Surgical Flaps
Abstract: The authors present the case-history of patients with chronic osteomyelitis of the proximal third of the tibia-resulting from an injury during the Second World War. The defect of bone and soft tissues was treated by free transfer of a musculocutaneous flap. The behaviour of the flap in the osteomyelitic cavity is followed up and checked by repeated CT and NMR examinations.
Published: 1993

36. [Digestive manifestations and metabolic acidosis secondary to intravenous administration of cotrimoxazol]

Author: E, Ferrer, A, Pros, M, Farré, A, del Villar, P, Saballs, and L, Drobnic
Subjects: Adult, Male, Bicarbonates, Digestive System Diseases, Pneumonia, Pneumocystis, Injections, Intravenous, Trimethoprim, Sulfamethoxazole Drug Combination, Humans, Female, Prospective Studies, Acidosis, Retrospective Studies
Abstract: Digestive features and metabolic acidosis have been observed in patients with Pneumocystis carinii pneumonia treated with intravenous high dose co-trimoxazole.To evaluate this phenomenon, a retrospective study of 22 patients (group A) and a prospective study of 12 patients (group B) were carried out. Group B patients were investigated following a protocol lasting for the 21 days of treatment.Metabolic acidosis developed in 23 (67%) of the overall number of study patients, and it was associated with digestive features such as nausea, vomiting and epigastralgia in 12. One patient had digestive features without metabolic acidosis. Metabolic acidosis developed early, between the days 4 and 7 of administration of the drug. The mean value of bicarbonate at the onset of therapy was 24,55 mEq; the mean value in the patients with metabolic acidosis was 16,43 mEq. The overall mean value of base excess at the onset of therapy was -2,39, and it was -8,46 in the patients who developed metabolic acidosis.As in all patients other causes of metabolic acidosis were ruled out, it became obvious that intravenous co-trimoxazole was directly related to the development of digestive features and metabolic acidosis, which disappeared with bicarbonate administration or with cessation of therapy.
Published: 1991

37. The nonoperative management of pediatric hepatic trauma

Author: Gary A. Pros, Donald R. Cooney, Barry M. Newman, Theodore C. Jewett, and Melvyn P. Karp
Subjects: Male, medicine.medical_specialty, Adolescent, Computed tomography, Wounds, Nonpenetrating, Avulsion, Hepatic trauma, Blunt, Hematoma, medicine, Humans, Nonoperative management, Child, Liver injury, Surgical repair, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Surgery, Liver, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Radiology, business, Tomography, X-Ray Computed
Abstract: Although nonoperative therapy is well-accepted for renal and splenic injuries in children, this mode of treatment has not been widely advocated for children with blunt hepatic injury. Surgical repair or excision of the traumatized tissue has been the generally accepted standard of care. In the present series, 17 consecutive children between 2 and 13 years of age with liver trauma were managed by nonoperative means. Patients were carefully selected for treatment based on clinical criteria and initial computed tomography (CT) scan findings. The 17 patients with hepatic trauma identified by CT scan all responded to initial resuscitative measures. The children clinically remained stable and required only a limited number of transfusions. No immediate surgical intervention was necessary for isolated hepatic injuries. However, one patient required exploration due to an associated renal pedicle avulsion. One child required exploration on the fourth post-injury day because of a suspected infected hematoma. The remaining 15 injuries resolved without operation. Healing was documented on follow-up CT scans. The mean time required for resolution of the injury was 4 months. One child developed a late subhepatic hematoma which resolved without drainage. The progression of healing of hepatic parenchymal injuries was observed by serial CT scans. The liver injury progressed through stages of coalescence, resorption, and remodeling prior to final healing. Utilizing proper patient selection, many blunt liver injuries can be managed nonoperatively.
Published: 1983

38. [Subcutaneous venous reservoirs: comparative study of their efficacy in patients with AIDS versus oncology and hematology patients]

Author: Moral A, Eduardo m Targarona, Mallolas J, Martínez J, Pros I, Valverde M, Palombo H, and Trias M
Subjects: Adult, Male, Acquired Immunodeficiency Syndrome, Catheterization, Central Venous, Incidence, Pneumothorax, Prostheses and Implants, Middle Aged, Infections, Subclavian Vein, Hematologic Diseases, Catheters, Indwelling, Evaluation Studies as Topic, Neoplasms, Humans, Female, Prospective Studies, Aged
Abstract: Chronic venous access may constitute a serious problem in some patients and the subcutaneous venous reservoirs have demonstrated to be a useful alternative. AIDS patients require intense pharmacologic treatment, thus the use of subcutaneous venous reservoirs may be specially useful. However, the prevalence of septic type complications following placement of the subcutaneous venous reservoirs in these patients is particularly high.To know the efficacy of subcutaneous venous reservoirs in the AIDS population and compare the results in a non AIDS population.All the subcutaneous venous reservoirs placed between January 1990 and December 1992 were prospectively studied with two groups being established: Group I: patients with positive serology for HIV and who achieved criteria of AIDS requiring placement of a subcutaneous venous reservoirs. Group II: All the remaining patients in whom a subcutaneous venous reservoirs was placed during the same period of time.The incidence of infection was higher in group I (AIDS) with respect to group II (0.1 versus 0.014 infections/100 catheters/day, p0.01) and the non septic complications were higher in group II (3.6% versus 12.7%, p0.0004). The catheters were most frequently used in group I with respect to group II (12.7 +/- 7.1 versus 3.3 +/- 4.9 punctures/month) but the period was use longer in group II (13.7 +/- 9.2 versus 4.3 +/- 3.1 months, p0.0001).The population of AIDS patients may benefit greatly from the systematic use of subcutaneous venous reservoir due to their clinical and therapeutic characteristics. Nonetheless greater risk of infection may occur in these patients because of the greater need for punctures with respect to the other indications for placement of these catheters.

39. Juxta-anastomotic sacciform dilation: an unusual complication of colonic stapled suture

Author: Eduardo m Targarona, Pros I, Bagur C, Martinez J, Piulachs J, and Trias M
Subjects: Male, Laparotomy, Postoperative Complications, Surgical Staplers, Time Factors, Colon, Anastomosis, Surgical, Humans, Middle Aged, Colectomy, Dilatation, Pathologic
Abstract: The commonest complications of stapling closure in gastrointestinal surgery are dehiscence, bleeding at the site of anastomosis and stenosis. Juxta-anastomotic sacciform dilation following end-to-side circular stapling anastomosis of the left colon is reported as an unusual complication. The case highlights the need for careful technique in order to obtain all the advantages offered by staplers.

40. Pros-IT CNR: an Italian prostate cancer monitoring project

Author: Noale, Marianna, Maggi, Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvo', RENZO GIACINTO, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Corvò, Renzo, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Bruno, Giorgio, Brunocilla, Eugenio, Buffoli, Alberto, BUGLIONE DI MONALE E BASTIA, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devis, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D'Angelillo, Rolando, Da Pozzo, Luigi, D'Agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, Marianna Noale, Stefania Maggi, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Riccardo Maurizi Enrici, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Angelo Porreca, Umberto Ricardi, Andrea Tubaro, Vittorina Zagonel, Filiberto Zattoni, Gaetano Crepaldi, the Pros-IT CNR study group: [.., Marco Borghesi, Eugenio Brunocilla, Riccardo Schiavina, ], Noale, M, Maggi, S, Artibani, W, Bassi, P, Bertoni, F, Bracarda, S, Conti, G, Corvò, R, Gacci, M, Graziotti, P, Magrini, S, Maurizi Enrici, R, Mirone, V, Da Pozzo, L, and Pros-IT CNR study, G, Noale, Marianna, Maggi, Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Bruno, Giorgio, Brunocilla, Eugenio, Buffoli, Alberto, Buglione, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devi, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D’Angelillo, Rolando, Da Pozzo, Luigi, D’Agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, Noale, M., Maggi, S., Artibani, W., Bassi, P. F., Bertoni, F., Bracarda, S., Conti, G. N., Corvo, R., Gacci, M., Graziotti, P., Magrini, S. M., Maurizi Enrici, R., Mirone, V., Montironi, R., Muto, G., Pecoraro, S., Porreca, A., Ricardi, U., Tubaro, A., Zagonel, V., Zattoni, F., Crepaldi, G., Alitto, A. R., Ambrosi, E., Antonelli, A., Aristei, C., Barbieri, M., Bardari, F., Bardoscia, L., Barra, S., Bartoncini, S., Basso, U., Becherini, C., Bellavita, R., Bergamaschi, F., Berlingheri, S., Berruti, A., Borghesi, M., Bortolus, R., Borzillo, V., Bosetti, D., Bove, G., Bove, P., Brausi, M., Bruni, A., Bruno, G., Brunocilla, E., Buffoli, A., Buglione, M., Buttigliero, C., Cacciamani, G., Caldiroli, M., Cardo, G., Carmignani, G., Carrieri, G., Castelli, E., Castrezzati, E., Catalano, G., Cattarino, S., Catucci, F., Cavallini Francolini, D., Ceccarini, O., Celia, A., Chiancone, F., Chini, T., Cianci, C., Cisternino, A., Collura, D., Corbella, F., Corinti, M., Corsi, P., Cortese, F., Corti, L., de Nunzio, C., Cristiano, O., D'Angelillo, R., Da Pozzo, L., D'Agostino, D., D'Andrea, D., Dandrea, M., De Angelis, M., De Cobelli, O., De Concilio, B., De Lisa, A., De Luca, S., De Stefani, A., Deantoni, C. L., Degli Esposti, C., Destito, A., Detti, B., Di Muzio, N., Di Stasio, A., Di Stefano, C., Di Trapani, D., Difino, G., Falivene, S., Farullo, G., Fedelini, P., Ferrari, I., Ferrau, F., Ferro, M., Fodor, A., Fontana, F., Francesca, F., Giulio, F., Frata, P., Frezza, G., Gabriele, P., Galeandro, M., Garibaldi, E., Gennari, P., Gentilucci, A., Giacobbe, A., Giussani, L., Giusti, G., Gontero, P., Guarneri, A., Guida, C., Gurioli, A., Huqi, D., Imbimbo, C., Ingrosso, G., Iotti, C., Italia, C., La Mattina, P., Lamanna, E., Lastrucci, L., Lazzari, G., Liberale, F., Liguori, G., Lisi, R., Lohr, F., Lombardo, R., Lovisolo, J., Ludovico, G. M., Macchione, N., Maggio, F., Malizia, M., Manasse, G., Mandoliti, G., Mantini, G., Marafioti, L., Marciello, L., Marconi, A. M., Martillotta, A., Marzano, S., Masciullo, S., Maso, G., Massenzo, A., Mazzeo, E., Mearini, L., Medoro, S., Mole, R., Monesi, G., Montanari, E., Montefiore, F., Montesi, G., Morgia, G., Moro, G., Muscas, G., Musio, D., Muto, P., Muzzonigro, G., Napodano, G., Negro, C. L. A., Nidini, M., Ntreta, M., Orsatti, M., Palazzolo, C., Palumbo, I., Parisi, A., Parma, P., Pavan, N., Pericolini, M., Pinto, F., Pistone, A., Pizzuti, V., Platania, A., Polli, C., Pomara, G., Ponti, E., Porcaro, A. B., Porpiglia, F., Pugliese, D., Pycha, A., Raguso, G., Rampini, A., Randone, D. F., Roscigno, M., Ruggieri, M. P., Ruoppo, G., Sanseverino, R., Santacaterina, A., Santarsieri, M., Santoni, R., Scagliarini, S., Scagliotti, G. V., Scanzi, M., Scarcia, M., Schiavina, R., Sciarra, A., Sciorio, C., Scolaro, T., Scuzzarella, S., Selvaggio, O., Serao, A., Serni, S., Signor, M. A., Silvani, M., Silvano, G., Silvestris, F., Simeone, C., Simone, V., Spagnoletti, G., Spinelli, M. G., Squillace, L., Tombolini, V., Toninelli, M., Triggiani, L., Trinchieri, A., Trodella, L. E., Trodella, L., Trombetta, C., Tronnolone, L., Tucci, M., Urzi, D., Valdagni, R., Valeriani, M., Vanoli, M., Vitali, E., Zaramella, S., Zeccolini, G., and Zini, G.
Subjects: Italian UCLA Cancer Index, Prostate cancer, Prostate cancer treatments, Quality of life, SF-12 Scale, Adult, Aged, Biopsy, Disease Management, Health Status, Humans, Italy, Male, Middle Aged, Neoplasm Staging, Prospective Studies, Prostatic Neoplasms, Quality of Life, Aging, Geriatrics and Gerontology, medicine.medical_specialty, 03 medical and health sciences, 0302 clinical medicine, medicine, 030212 general & internal medicine, Risk factor, Disease management (health), Prospective cohort study, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Cancer staging, business.industry, medicine.disease, Clinical trial, Prostate cancer, Monitoring, Survival, Outcomes, Settore MED/24, Prostate cancer treatment, 030220 oncology & carcinogenesis, Family medicine, Physical therapy, Observational study, business
Abstract: Aims: The Pros-IT CNR project aims to monitor a sample of Italian males ≥18years of age who have been diagnosed in the participating centers with incident prostate cancer, by analyzing their clinical features, treatment protocols and outcome results in relation to quality of life. Methods: Pros-IT CNR is an observational, prospective, multicenter study. The National Research Council (CNR), Neuroscience Institute, Aging Branch (Padua) is the promoting center. Ninety-seven Italian centers located throughout Italy were involved. The field study began in September 1, 2014. Subjects eligible were diagnosed with biopsy-verified prostate cancer, naïve. A sample size of 1500 patients was contemplated. A baseline assessment including anamnestic data, clinical history, risk factors, the initial diagnosis, cancer staging information and quality of life (Italian UCLA Prostate Cancer Index; SF-12 Scale) was completed. Six months after the initial diagnosis, a second assessment evaluating the patient’s health status, the treatment carried out, and the quality of life will be made. A third assessment, evaluating the treatment follow-up and the quality of life, will be made 12months after the initial diagnosis. The 4th, 5th, 6th and 7th assessments, similar to the third, will be completed 24, 36, 48 and 60months after the initial diagnosis, respectively, and will include also a Food Frequency Questionnaire and the Physical Activity Scale for the Elderly. Discussion: The study will provide information on patients’ quality of life and its variations over time in relation to the treatments received for the prostate cancer.
Published: 2017

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

40 results on '"Pros, A."'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources