1. Quantitative peripheral computed tomography to measure muscle area and assess lean soft tissue mass in children
- Author
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Paloma Flores-Barrantes, Iris Iglesia, Alejandro Gómez-Bruton, José A. Casajús, Diana Paola Córdoba-Rodríguez, Luis A. Moreno, María L Miguel-Berges, and Gerardo Rodríguez
- Subjects
Male ,0301 basic medicine ,Aging ,Physiology ,Epidemiology ,Measure (physics) ,Computed tomography ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Genetics ,medicine ,Humans ,Soft tissue mass ,030216 legal & forensic medicine ,Child ,Muscle, Skeletal ,Dual-energy X-ray absorptiometry ,Leg ,medicine.diagnostic_test ,business.industry ,Public Health, Environmental and Occupational Health ,Skeletal muscle ,Peripheral ,030104 developmental biology ,medicine.anatomical_structure ,Female ,Tomography, X-Ray Computed ,business ,Biomedical engineering - Abstract
Skeletal muscle is one of the main components of lean soft tissue mass (LSTM). Low levels in children affect locomotion, posture, and increase the risk of metabolic syndrome.(1) To evaluate the association between muscle cross-sectional area (MCSA) of the lower left leg measured by peripheral quantitative computed tomography (pQCT) and total LSTM; namely, total left leg and left lower leg LSTM assessed by dual-energy X-ray absorptiometry (DXA) in a group of children, (2) to examine if MCSA is a predictor of LSTM, (3) to determine the ability of pQCT to identify children with low LSTM.Lower left leg MCSA and LSTM were measured using pQCT and DXA, respectively, in 396 children.Statistically significant positive correlations were found between the lower leg MCSA - total LSTM (Our results showed that lower left leg MCSA, measured using pQCT, could be a tool to predict low LSTM in children.
- Published
- 2021
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