1. Cardiac transplantation after heparin‐induced thrombocytopenia: A systematic review
- Author
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Diana C. Jimenez, Eric D. Warner, Danial Ahmad, Jake L. Rosen, Nawar Al‐Rawas, Rohinton J. Morris, Rene Alvarez, J. Eduardo Rame, John W. Entwistle, H. Todd Massey, and Vakhtang Tchantchaleishvili
- Subjects
Male ,Transplantation ,Heparin ,Anticoagulants ,Heart Transplantation ,Humans ,Thrombosis ,Thrombocytopenia - Abstract
Heparin-induced thrombocytopenia (HIT) presents a unique challenge in patients requiring orthotopic heart transplantation (OHT). We sought to pool the existing evidence in a systematic review.Electronic search was performed to identify all relevant studies on OHT in patients with HIT. Patient-level data for 33 patients from 21 studies were extracted for statistical analysis.Median patient age was 51 [IQR 41, 55] years, with 75.8% (25/33) males. All patients had a clinical diagnosis of HIT, and anti-PF4/Heparin antibodies were positive in 87.9% (29/33). Median lowest reported platelet count was 46 × 10Heparin use during OHT may be associated with less adverse effects compared to use of other anticoagulants with no difference in 30-day mortality.
- Published
- 2022