1. Cocrystal of Apixaban–Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs
- Author
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Haiguang Yang, Shiying Yang, Dezhi Yang, Junke Song, Li Zhang, Yang Lu, Jiao Lingtai, Hongjuan Wang, Guanhua Du, Dewen Kong, and Xiaoyue Zhao
- Subjects
Male ,Pharmaceutical Science ,Organic chemistry ,02 engineering and technology ,01 natural sciences ,Cocrystal ,Analytical Chemistry ,quercetin ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,QD241-441 ,X-Ray Diffraction ,Drug Discovery ,Solubility ,Dissolution ,Chromatography, High Pressure Liquid ,media_common ,Calorimetry, Differential Scanning ,Chemistry ,drug–drug cocrystal ,Temperature ,food and beverages ,021001 nanoscience & nanotechnology ,Solvent ,Drug Combinations ,Pharmaceutical Preparations ,Chemistry (miscellaneous) ,Thermogravimetry ,Molecular Medicine ,Powders ,Crystallization ,0210 nano-technology ,Quercetin ,Drug ,Pyridones ,media_common.quotation_subject ,apixaban ,Biological Availability ,010402 general chemistry ,Article ,Fibrinolytic Agents ,Animals ,Physical and Theoretical Chemistry ,solubility ,Hydrogen Bonding ,APX ,Combinatorial chemistry ,Rats ,0104 chemical sciences ,Bioavailability ,Solvents ,Pyrazoles ,bioavailability - Abstract
Drug combinations have been the hotspot of the pharmaceutical industry, but the promising applications are limited by the unmet solubility and low bioavailability. In this work, novel cocrystals, consisting of two antithrombotic drugs with poor solubility and low bioavailability in vivo, namely, apixaban (Apx) and quercetin (Que), were developed to discover a potential method to improve the poor solubility and internal absorption of the drug combination. Compared with Apx, the dissolution behavior of Apx–Que (1:1) and Apx–Que–2ACN (1:1:2) was enhanced significantly, while the physical mixture of the chemicals failed to exhibit the advantages. The dissolution improvements of Apx–Que–2ACN could be explained by the fact that the solid dispersion-like structure and column-shaped cage of Que accelerated the access of the solvent to the inner layer of Apx. The fracture of the hydrogen bonds of Apx, which was the joint of the adjacent Que chains, facilitated the break-up of the structures. Besides, the bioavailability of Apx–Que was increased compared with the physical mixture and Apx, and Apx–Que remained stable in high temperature and illumination conditions. Therefore, a drug–drug cocrystal of two antithrombotic agents with poor solubility was developed, which exhibited greatly improved solubility, bioavailability and superior stability, indicating a novel method to overcome the shortages of drug combination.
- Published
- 2021