1. The Effect of Angiotensin-Converting Enzyme Inhibitors of Left Atrial Pressure in Dogs with Mitral Valve Regurgitation
- Author
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Ryuji Fukushima, Y. Iino, Ryou Tanaka, Taisuke Ishikawa, Yuka Miyaishi, Yoshihisa Yamane, Shuji Suzuki, and H. Akagi
- Subjects
Male ,medicine.medical_specialty ,Captopril ,Thiazepines ,Alacepril ,Angiotensin-Converting Enzyme Inhibitors ,Blood Pressure ,Temocapril ,Dogs ,Enalapril ,Internal medicine ,medicine ,Animals ,Dog Diseases ,General Veterinary ,biology ,business.industry ,Mitral Valve Insufficiency ,Angiotensin-converting enzyme ,medicine.disease ,Circadian Rhythm ,Blood pressure ,ACE inhibitor ,Cardiology ,biology.protein ,Atrial Function, Left ,Female ,business ,Mitral valve regurgitation ,medicine.drug - Abstract
Background: Despite many epidemiological reports concerning the efficacy of angiotensin-converting enzyme (ACE) inhibitors in dogs with mitral regurgitation (MR), the hemodynamic effects of ACE inhibitor administration have not been fully evaluated. Objectives: To document left atrial pressure (LAP) in dogs with MR administered ACE inhibitors, in order to obtain interesting information about daily LAP changes with administration of ACE inhibitors. Animals: Five healthy Beagle dogs weighing 9.8 to 14.2 kg (2 males and 3 females; aged 2 years). Methods: Experimental, crossover, and interventional study. Chordae tendineae rupture was induced, and a radiotelemetry transmitter catheter was inserted into the left atrium. LAP was recorded for 72 consecutive hours during which each of 3 ACE inhibitors—enalapril (0.5 mg/kg/d), temocapril (0.1 mg/kg/d), and alacepril (3.0 mg/kg/d)—were administered in a crossover study. Results: Averaged diurnal LAP was significantly, but slightly reduced by alacepril (P= .03, 19.03 ± 3.01–18.24 ± 3.07 mmHg). The nightly drops in LAP caused by alacepril and enalapril were significantly higher than the daily drops (P= .03, −0.98 ± 0.19 to −0.07 ± 0.25 mmHg, and P= .03, −0.54 ± 0.21–0.02 ± 0.17 mmHg, respectively), despite the fact that the oral administrations were given in the morning. Systolic blood pressure (122.7 ± 14.4–117.4 ± 13.1 mmHg, P= .04) and systemic vascular resistance (5800 ± 2685–5144 ± 2077 dyne × s/cm5, P= .03) were decreased by ACE inhibitors. Conclusions and Clinical Importance: ACE inhibitors decrease LAP minimally, despite reductions in left ventricular afterload. ACE inhibitors should not be used to decrease LAP.
- Published
- 2010
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