Search

From 1999 to 2015, there were 6 186 cases of leukemia deaths in tianjin residents, the males accounted for 58.28% (3 605) and 52.31% (3 236) deaths lived in urban areas; the crude mortality rate of Leukemia increased from 3.47/100 000 to 4.28/100 000 [1999—2015年天津市居民白血病死亡病例共6 186例，男性占58.28%（3605），城市地区病例占52.31%（3236）；天津市白血病死亡粗率为3.47/10万~4.28/10万，呈上升趋势[

To apply amide proton transfer magnetic resonance imaging (APT-MRI) technique to acute ischemic stroke, and to discuss clinical values of the APT-MRI main parameter - MTRasym(3.5 ppm).A total of 18 emergency admitted patients, with acute ischemic stroke from Beijing Hospital, were recruited from March to November 2015. Eventually, 18 patients (male 14, female 4, average age 72 years old, age ranged from 52 to 92 years, symptom onset ≤24 hours, 2 patients≤ 6 hours) were included in this study. All patients underwent MR scanning on the brain at 3.0 Tesla. Besides the conventional scans for stroke, the APT sequence (saturation time 0.8 s, saturation power 2 μT) was performed. APT weighted (APTW) images were calculated using magnetization transfer ratio asymmetry at 3.5 ppm with respect to water. MRI signals in APTW, diffusion weighted images (DWI) and fluid attenuated iversion recovery (FLAIR) were visually evaluated. Shapiro-Wilk tests were performed to find out the distribution of MTRasym(3.5 ppm) in the whole sample, infarction regions, and normal appearing white matter (NAWMs), respectively. Detrended normal P-P plots were also used to evaluate its normality. Paired-t test and two-sample t test were applied to compare the mean MTRasym(3.5 ppm) of infarction regions with that of contra lateral NAWMs.(1) High signal intensity was observed in DWI and FLAIR in all 18 patients. However, signal intensity was somewhat different in APTW. 13 patients were found decreased APT effect, and 5 patients were with equal APT effect in infarction regions. In NAWMs, 14 patients were found equal APT effect, and 4 patients were with decreased APT effect. (2) MTRasym(3.5 ppm)s were proven, with Shapiro-Wilk test, to distribute normally within the whole sample (W=0.964, P=0.288), infarction regions (W=0.962, P=0.645), and NAWMs(W=0.929, P=0.187). However, its normality was not so satisfactory due to greater deviations (absolute value0.06) of some cases in detrended normal P-P plots. (3) Paired-t test analysis showed that MTRasym(3.5 ppm) in infarction regions (-0.035%±1.020%) was significantly lower than that in NAWMs (0.386%±0.790%) (t=-2.273, P=0.036). However, there was no statistically significant difference between infarction regions and NAWMs when two sample t-test was performed (t=-1.386, P=0.175).MTRasym(3.5 ppm) can be used to evaluate acute ischemic stroke with a broad future scope in clinical.

DALY (Disability Adjusted Life Years) was recommended as a new indicator to measure burden of disease (BOD). Although BOD combines information from both morbidity and mortality, it only reflects the burden from the patients themselves because of their illness or death. As a common indicator, BOD should not only include the burden from the patients, but also the burden to the society around the patients, such as the input and support from the society to the ill person, and the losses from the related events. The aim of this study is to explore the scope and the magnitude of the burden to the society using stroke as an example. Results show that the burden due to time lost for caring for patients in hospitals accounts for 2.4% of total BOD (in a narrow sense), which indicates that BOD may be underestimated if the burden to the society is ignored.

Among 108 cases of severely burned patients, 11 were complicated with septicemia in early stage. This analysis showed that pathogenic bacteria might mainly come from the intestinal tract, and shock played a critical role in the occurrence of septicemia, and at the same time septicemia aggravated shock and also induced complications of internal organs. Attention should be paid to severely burned patients who were hospitalized late or with severe shock, and early administration of broad-spectrum antibiotic against intestinal flora might improve the therapeutic effect.