1. Etomidate improves seizure adequacy during electroconvulsive therapy
- Author
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Òscar Alcoverro-Fortuny, Gemma Molist Señé, Ferran Viñas Usan, Maitane Oscoz-Irurozqui, David Suárez Ruíz, and Belén García Alarcón
- Subjects
Adult ,Male ,medicine.medical_treatment ,Electroencephalography ,03 medical and health sciences ,0302 clinical medicine ,Electroconvulsive therapy ,Seizures ,Etomidate ,medicine ,Humans ,Hypnotics and Sedatives ,Electroconvulsive Therapy ,Propofol ,Biological Psychiatry ,Retrospective Studies ,medicine.diagnostic_test ,Drug Substitution ,business.industry ,Repeated measures design ,Retrospective cohort study ,Middle Aged ,030227 psychiatry ,Psychiatry and Mental health ,Anesthesia ,Female ,business ,Anesthetics, Intravenous ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The purpose of this study was to assess whether switching propofol to etomidate during an electroconvulsive therapy course improves seizure quality in convulsion-resistant patients. A retrospective study of paired cases included thirty-three patients. Seizure variables for each agent were assessed. A generalized linear mixed model (GLMM) for repeated measures was used for the analysis. Anesthesia with etomidate leads to greater seizure duration, improved seizure quality in the EEG register, and prevents further need for restimulation; although did not differ from propofol in the amount of energy delivered or in other automated parameters. These results suggest that this procedure appears to be an adequate strategy to improve seizure quality.
- Published
- 2019
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