1. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
- Author
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Small, Gary W, Siddarth, Prabha, Li, Zhaoping, Miller, Karen J, Ercoli, Linda, Emerson, Natacha D, Martinez, Jacqueline, Wong, Koon-Pong, Liu, Jie, Merrill, David A, Chen, Stephen T, Henning, Susanne M, Satyamurthy, Nagichettiar, Huang, Sung-Cheng, Heber, David, and Barrio, Jorge R
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Neurosciences ,Aging ,Complementary and Integrative Health ,Clinical Research ,Clinical Trials and Supportive Activities ,Behavioral and Social Science ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Neurological ,Aged ,Aged ,80 and over ,Anti-Inflammatory Agents ,Non-Steroidal ,Attention ,Brain ,Curcumin ,Double-Blind Method ,Female ,Humans ,Male ,Memory ,Middle Aged ,Placebos ,Plaque ,Amyloid ,Positron-Emission Tomography ,Treatment Outcome ,tau Proteins ,Bioavailable curcumin ,normal aging ,memory ,cognition ,positron emission tomography ,Clinical Sciences ,Public Health and Health Services ,Cognitive Sciences ,Geriatrics ,Clinical sciences ,Health services and systems ,Clinical and health psychology - Abstract
ObjectiveBecause curcumin's anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored its impact on brain amyloid and tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography (FDDNP-PET).MethodsForty subjects (age 51-84 years) were randomized to a bioavailable form of curcumin (Theracurmin® containing 90 mg of curcumin twice daily [N = 21]) or placebo (N = 19) for 18 months. Primary outcomes were verbal (Buschke Selective Reminding Test [SRT]) and visual (Brief Visual Memory Test-Revised [BVMT-R]) memory, and attention (Trail Making A) was a secondary outcome. FDDNP-PET signals (15 curcumin, 15 placebo) were determined in amygdala, hypothalamus, medial and lateral temporal, posterior cingulate, parietal, frontal, and motor (reference) regions. Mixed effects general linear models controlling for age and education, and effect sizes (ES; Cohen's d) were estimated.ResultsSRT Consistent Long-Term Retrieval improved with curcumin (ES = 0.63, p = 0.002) but not with placebo (ES = 0.06, p = 0.8; between-group: ES = 0.68, p = 0.05). Curcumin also improved SRT Total (ES = 0.53, p = 0.002), visual memory (BVMT-R Recall: ES = 0.50, p = 0.01; BVMT-R Delay: ES = 0.51, p = 0.006), and attention (ES = 0.96, p
- Published
- 2018