1. Angiopoietin-2 predicts morbidity in adults with Fontan physiology
- Author
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Shirali, Aditya S, Lluri, Gentian, Guihard, Pierre J, Conrad, Miles B, Kim, Helen, Pawlikowska, Ludmila, Boström, Kristina I, Iruela-Arispe, M Luisa, and Aboulhosn, Jamil A
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Cardiovascular ,Heart Disease ,Aetiology ,Detection ,screening and diagnosis ,2.1 Biological and endogenous factors ,4.2 Evaluation of markers and technologies ,Adult ,Angiopoietin-2 ,Arrhythmias ,Cardiac ,Arteriovenous Fistula ,Arteriovenous Malformations ,Biomarkers ,Blood Proteins ,Cardiac Catheterization ,Edema ,Endothelial Cells ,Female ,Fontan Procedure ,Heart Septal Defects ,Atrial ,Humans ,Male ,Neovascularization ,Physiologic ,Pulmonary Artery ,Pulmonary Veins - Abstract
Morbidity in patients with single-ventricle Fontan circulation is common and includes arrhythmias, edema, and pulmonary arteriovenous malformations (PAVM) among others. We sought to identify biomarkers that may predict such complications. Twenty-five patients with Fontan physiology and 12 control patients with atrial septal defects (ASD) that underwent cardiac catheterization were included. Plasma was collected from the hepatic vein and superior vena cava and underwent protein profiling for a panel of 20 analytes involved in angiogenesis and endothelial dysfunction. Ten (40%) of Fontan patients had evidence of PAVM, eighteen (72%) had a history of arrhythmia, and five (20%) were actively in arrhythmia or had a recent arrhythmia. Angiopoietin-2 (Ang-2) was higher in Fontan patients (8,875.4 ± 3,336.9 pg/mL) versus the ASD group (1,663.6 ± 587.3 pg/mL, p
- Published
- 2019