1. Lesions of lateral habenula attenuate win-stay but not lose-shift responses in a competitive choice task
- Author
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Aaron J. Gruber, Robert J. Sutherland, Clifford H. Donovan, Rajat Thapa, and Scott A. Wong
- Subjects
Male ,0301 basic medicine ,endocrine system ,Nucleus accumbens ,Choice Behavior ,Task (project management) ,03 medical and health sciences ,0302 clinical medicine ,Reward ,Dopamine ,Animals ,Medicine ,Neural system ,Rats, Long-Evans ,Reinforcement ,Amphetamine ,Lateral habenula ,Habenula ,business.industry ,General Neuroscience ,030104 developmental biology ,Systemic administration ,business ,Neuroscience ,hormones, hormone substitutes, and hormone antagonists ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Multiple neural systems contribute to choice adaptation following reinforcement. Recent evidence suggests that the lateral habenula (LHb) plays a key role in such adaptations, particularly when reinforcements are worse than expected. Here, we investigated the effects of bilateral LHb lesions on responding in a binary choice task with no discriminatory cues. LHb lesions in rats decreased win-stay responses but surprisingly left lose-shift responses intact. This same dissociated effect was also observed after systemic administration of d-amphetamine in a separate cohort of animals. These results suggest that at least some behavioural responses triggered by reward omission do not depend on an intact LHb.
- Published
- 2019