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Study objective Systemic administration of s-agonist and anticholinergic drugs markedly impair normal autonomic heart rate control. The purpose of this study was to quantify and compare the effects of therapeutic doses of inhaled albuterol and ipratropium on autonomic control of the cardiovascular system. Design Randomized, double-blind, placebo-controlled, crossover design study. Setting Tertiary-care hospital. Subjects Twelve healthy male volunteers. Interventions Subjects self-administered four puffs through a spacer device from one of three identical inhalers containing albuterol (100 µg per puff), ipratropium (20 µg per puff), or placebo in three different testing sessions. Measurements ECG and noninvasive continuous BP traces were recorded at baseline and from 45 to 75 min after administration of the drug. Autonomic control of the cardiovascular system was quantified by analysis of spontaneous baroreflex sensitivity and power spectral analysis of heart rate variability. Results Neither albuterol nor ipratropium caused a significant alteration in baroreflex sensitivity, normalized low-power frequency, or normalized high-power frequency. No adverse effects were reported by subjects. Conclusions Inhalation of four puffs of albuterol (400 µg) or ipratropium (80 µg) does not alter the autonomic control of the cardiovascular system in young, healthy male subjects.

Smaller semirigid ureteroscopes with large working channels and excellent optics are widely available. Ureteroscopic treatment of upper-ureteral stones has become increasingly popular, although flexible ureteroscopy is more frequently the method of choice. Access to the upper ureter with a semirigid ureteroscope (SR-URS) can be challenging and hazardous, especially when negotiating the iliac vessels. We sought to determine whether lower-abdominal pressure (LAP) facilitated SR-URS access to the upper ureter for safe laser lithotripsy.Thirty-two consecutive patients who underwent ureteroscopic management of upper- ureteral stones were evaluated. Twenty-four (75%) were male; seventeen (53%) had a right-sided stone. The mean largest stone diameter was 10.2 +/- 4.6 mm. These 32 patients were compared with a matched cohort of patients who underwent SR-URS procedures without the use of LAP.Access to the upper ureter was possible in 30 patients (94%). The LAP was helpful in 18 patients (56%): it facilitated passage of the SR-URS in 16 patients (50%) and laser fiber placement in 11 cases (34%). Access to the upper ureter was possible in all women. The mean operative time was 54 minutes in the LAP group and 75 minutes in the matched cohort without LAP (P = 0.026). There were no significant deformities of the SR-URS and no complications.Contrary to popular practice, the upper ureter can be accessed safely and efficiently with a 7.5F SR-URS in nearly all patients. Lower-abdominal pressure can be helpful to negotiate passage of the endoscope over the iliac vessels or to place the laser fiber on stones.

Vaso-cutaneous fistulae occur rarely after vasectomy. We report three cases encountered in our hospital over the last 18 years and recommend technical considerations to avoid this complication.

Metabolic evaluation is indicated in stone formers to identify and subsequently modify risk factors for nephrolithiasis. Some believe that serum phosphate may be an important indicator of nephrolithiasis risk. We determined whether serum phosphate is an independent risk factor for recurrent calcium stone formation and whether it may be used as an early marker for occult disease, such as hyperparathyroidism.The charts of all patients with regular long-term stone clinic followup were reviewed. Initial serum phosphate levels were compared with stone recurrence, complications due to stones, initial visit urinary laboratory values and the medical diagnoses made during followup. Unpaired 2-sample t tests, and correlation and logistic regression analyses were performed with statistical significance at p0.05.Data were available on 51 men and 25 women 22 to 74 years old (mean age 52). Of the patients 50 were recurrent and 26 were single stone formers. Serum phosphate levels were lower in women than in men. No consistent associations existed between initial or future serum phosphate levels and stone recurrence, complications from stones, urinary values or other medical diagnoses made during followup.Serum phosphate does not appear to be an independent risk factor for urinary tract stone recurrence or complications, or a reliable early predictor of occult disease.