1. Effect of zinc pyrithione shampoo treatment on skin commensal Malassezia.
- Author
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Leong C, Wang J, Toi MJ, Lam YI, Goh JP, Lee SM, and Dawson TL
- Subjects
- Adult, Aged, Cohort Studies, Humans, Longitudinal Studies, Malassezia classification, Malassezia genetics, Microbial Sensitivity Tests, Middle Aged, Pilot Projects, Scalp microbiology, Skin microbiology, Soaps chemistry, Soaps pharmacology, Surveys and Questionnaires, Young Adult, Antifungal Agents pharmacology, Malassezia drug effects, Malassezia growth & development, Organometallic Compounds pharmacology, Pyridines pharmacology, Scalp drug effects, Skin drug effects, Symbiosis drug effects
- Abstract
Malassezia restricta and Malassezia globosa are lipid dependent commensal yeasts associated with dandruff. Antifungal actives such as zinc pyrithione are commonly used in antidandruff shampoos, although their efficacy is not clearly demonstrated. In this study, we assessed the efficacy of antifungal treatments on scalp Malassezia via a combination of culturomic and genomic detection methods. Zinc pyrithione inhibited Malassezia growth at low minimum inhibitory concentrations (MICs). In a longitudinal pilot study, quantitative polymerase chain reaction (qPCR) analysis showed a decrease in M. restricta on the scalp after zinc pyrithione treatment. These findings validate the antifungal efficacy of zinc pyrithione as a dandruff treatment., Lay Abstract: Malassezia yeasts are associated with dandruff and seborrheic dermatitis. Zinc pyrithione is effective against Malassezia growth in vitro and when tested on human skin as a shampoo. These findings will be useful for investigating the role of Malassezia in skin microbiome intervention studies., (© The Author(s) 2020. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
- Published
- 2021
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