1. A Superfluorinated Molecular Probe for Highly Sensitive in Vivo 19F-MRI.
- Author
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Tirotta, Daria, Mastropietro, Alfonso, Cordiglieri, Chiara, Gazzera, Lara, Baggi, Fulvio, Baselli, Giuseppe, Bruzzone, Maria Grazia, Zucca, Deana, Cavallo, Gabriella, Terraneo, Giancarlo, Bombelli, Francesca Baldelli, Metrangolo, Pierangelo, and Resnati, Giuseppe
- Subjects
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MOLECULAR probes , *FLUORINATION , *MOLECULAR biology techniques , *FLUORESCENT probes , *MAGNETIC resonance imaging , *DIAGNOSTIC imaging , *CONTRAST media - Abstract
19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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