1. Hyperpolarized 13 C urea myocardial first-pass perfusion imaging using velocity-selective excitation.
- Author
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Fuetterer M, Busch J, Peereboom SM, von Deuster C, Wissmann L, Lipiski M, Fleischmann T, Cesarovic N, Stoeck CT, and Kozerke S
- Subjects
- Animals, Blood Flow Velocity, Disease Models, Animal, Feasibility Studies, Female, Myocardial Infarction physiopathology, Myocardial Perfusion Imaging instrumentation, Phantoms, Imaging, Predictive Value of Tests, Reproducibility of Results, Sus scrofa, Carbon Isotopes administration & dosage, Contrast Media administration & dosage, Coronary Circulation, Magnetic Resonance Imaging instrumentation, Myocardial Infarction diagnostic imaging, Myocardial Perfusion Imaging methods, Urea administration & dosage
- Abstract
Background: A velocity-selective binomial excitation scheme for myocardial first-pass perfusion measurements with hyperpolarized
13 C substrates, which preserves bolus magnetization inside the blood pool, is presented. The proposed method is evaluated against gadolinium-enhanced1 H measurements in-vivo., Methods: The proposed excitation with an echo-planar imaging readout was implemented on a clinical CMR system. Dynamic myocardial stress perfusion images were acquired in six healthy pigs after bolus injection of hyperpolarized13 C urea with the velocity-selective vs. conventional excitation, as well as standard1 H gadolinium-enhanced images. Signal-to-noise, contrast-to-noise (CNR) and homogeneity of semi-quantitative perfusion measures were compared between methods based on first-pass signal-intensity time curves extracted from a mid-ventricular slice. Diagnostic feasibility is demonstrated in a case of septal infarction., Results: Velocity-selective excitation provides over three-fold reduction in blood pool signal with a two-fold increase in myocardial CNR. Extracted first-pass perfusion curves reveal a significantly reduced variability of semi-quantitative first-pass perfusion measures (12-20%) for velocity-selective excitation compared to conventional excitation (28-93%), comparable to that of reference1 H gadolinium data (9-15%). Overall image quality appears comparable between the velocity-selective hyperpolarized and gadolinium-enhanced imaging., Conclusion: The feasibility of hyperpolarized13 C first-pass perfusion CMR has been demonstrated in swine. Comparison with reference1 H gadolinium data revealed sufficient data quality and indicates the potential of hyperpolarized perfusion imaging for human applications.- Published
- 2017
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