25 results on '"Schneider, Matthias"'
Search Results
2. An open presurgery MRI dataset of people with epilepsy and focal cortical dysplasia type II.
- Author
-
Schuch, Fabiane, Walger, Lennart, Schmitz, Matthias, David, Bastian, Bauer, Tobias, Harms, Antonia, Fischbach, Laura, Schulte, Freya, Schidlowski, Martin, Reiter, Johannes, Bitzer, Felix, von Wrede, Randi, Rácz, Atilla, Baumgartner, Tobias, Borger, Valeri, Schneider, Matthias, Flender, Achim, Becker, Albert, Vatter, Hartmut, and Weber, Bernd
- Subjects
FOCAL cortical dysplasia ,DYSPLASIA ,PEOPLE with epilepsy ,PARTIAL epilepsy ,ELECTRONOGRAPHY ,MAGNETIC resonance imaging ,COMPUTER-assisted image analysis (Medicine) - Abstract
Automated detection of lesions using artificial intelligence creates new standards in medical imaging. For people with epilepsy, automated detection of focal cortical dysplasias (FCDs) is widely used because subtle FCDs often escape conventional neuroradiological diagnosis. Accurate recognition of FCDs, however, is of outstanding importance for affected people, as surgical resection of the dysplastic cortex is associated with a high chance of postsurgical seizure freedom. Here, we make publicly available a dataset of 85 people affected by epilepsy due to FCD type II and 85 healthy control persons. We publish 3D-T1 and 3D-FLAIR, manually labeled regions of interest, and carefully selected clinical features. The open presurgery MRI dataset may be used to validate existing automated algorithms of FCD detection as well as to create new approaches. Most importantly, it will enable comparability of already existing approaches and support a more widespread use of automated lesion detection tools. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Proof-of-Concept Double-Blind Placebo-Controlled Trial Measuring Cartilage Composition in Early Rheumatoid Arthritis under TNF-α-Inhibitor Therapy.
- Author
-
Frenken, Miriam, Ostendorf, Benedikt, Brinks, Ralph, Schleich, Christoph, Wilms, Lena M., Vordenbäumen, Stefan, Müller-Lutz, Anja, Richter, Jutta G., Sander, Oliver, Antoch, Gerald, Schneider, Matthias, Baraliakos, Xenofon, Abrar, Daniel B., and Sewerin, Philipp
- Subjects
ADALIMUMAB ,CARTILAGE ,ANTIRHEUMATIC agents ,METACARPOPHALANGEAL joint ,MAGNETIC resonance imaging ,DISEASE duration - Abstract
Low levels of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) values are indicative of cartilage degeneration. Patients with early rheumatoid arthritis are known to have low dGEMRIC values due to inflammatory activity. The additional effect of biological disease-modifying antirheumatic drug (bDMARD) and conventional synthetic disease-modifying antirheumatic drug (csDMARD) treatment on cartilage status is still unclear. In this prospective, double-blinded, randomized proof-of-concept clinical trial, patients with early rheumatoid arthritis (disease duration less than 12 months from symptoms onset) were treated with methotrexate + adalimumab (10 patients: 6/4 (f/m)). A control group with methotrexate alone (four patients: 2/2 (f/m)) was used. Cartilage integrity in the metacarpophalangeal joints was compared using dGEMRIC at baseline, 12, and 24 weeks after treatment initiation. A statistically significant increase in dGEMRIC levels was found in the adalimumab group considering the results after 12 and 24 weeks of therapy (p < 0.05) but not in the control group (p: non-significant). After 24 weeks, a tendency towards increased dGEMRIC values under combination therapy was observed, whereas methotrexate alone showed a slight decrease without meeting the criteria of significance (dGEMRIC mean change: +85.8 ms [−156.2–+346.5 ms] vs. 30.75 ms [−273.0–+131.0 ms]; p: non-significant). After 24 weeks of treatment with a combination of methotrexate and adalimumab, a trend indicating improvement in cartilage composition is seen in patients with early rheumatoid arthritis. However, treatment with methotrexate alone showed no change in cartilage composition, as observed in dGEMRIC sequences of metacarpophalangeal joints. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. DGEMRIC in the Assessment of Pre-Morphological Cartilage Degeneration in Rheumatic Disease: Rheumatoid Arthritis vs. Psoriatic Arthritis
- Author
-
Abrar, Daniel B., Schleich, Christoph, Frenken, Miriam, Vordenbäumen, Stefan, Richter, Jutta, Schneider, Matthias, Ostendorf, Benedikt, Nebelung, Sven, and Sewerin, Philipp
- Subjects
musculoskeletal diseases ,psoriatic arthritis ,rheumatoid arthritis ,dGEMRIC ,lcsh:R5-920 ,magnetic resonance imaging ,cartilage ,lcsh:Medicine (General) ,Article ,compositional imaging - Abstract
Background: Even though cartilage loss is a known feature of psoriatic (PsA) and rheumatoid arthritis (RA), research is sparse on its role in the pathogenesis of PsA, its potential use for disease monitoring and for differentiation from RA. We therefore assessed the use of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to evaluate biochemical cartilage changes in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in PsA patients and compared these to RA patients. Materials and Methods: A total of 17 patients with active PsA and 20 patients with active RA were evaluated by high-resolution 3 Tesla dGEMRIC using a dedicated 16-channel hand coil. Images were analyzed by two independent raters for dGEMRIC indices and joint space width (JSW) at MCP and PIP joint levels. Results: No significant differences of dGEMRIC values could be found between both study populations (PsA 472.25 ms, RA 461.11 ms; p = 0.763). In all RA and most PsA patients, PIP joints showed significantly lower dGEMRIC indices than MCP joints (RA: D2: p = 0.009, D3: p = 0.008, D4: p = 0.002, D5: p = 0.002; PsA: D3: p = 0.001, D4: p = 0.004). Most joint spaces had similar widths in both disease entities and no significant differences were found. Conclusions: As evaluated by dGEMRIC, the molecular composition of the MCP and PIP joint cartilage of PsA patients is similar to that of RA patients, demonstrating the scientific and clinical feasibility of compositional magnetic resonance (MR) imaging in these disease entities. Patterns and severity of compositional cartilage degradation of the finger joints may therefore be assessed beyond mere morphology in PsA and RA patients.
- Published
- 2021
5. Cartilage Degradation in Psoriatic Arthritis Is Associated With Increased Synovial Perfusion as Detected by Magnetic Resonance Imaging
- Author
-
Abrar, Daniel B., Schleich, Christoph, Müller-Lutz, Anja, Frenken, Miriam, Radke, K. Ludger, Vordenbäumen, Stefan, Schneider, Matthias, Ostendorf, Benedikt, and Sewerin, Philipp
- Subjects
psoriatic arthritis ,dGEMRIC ,lcsh:R5-920 ,Medicine ,magnetic resonance imaging ,General Medicine ,cartilage ,lcsh:Medicine (General) ,compositional imaging ,Original Research - Abstract
Objective: Even though cartilage loss is a known feature of psoriatic arthritis (PsA), research is sparse on its role in the pathogenesis of PsA and its potential use for disease detection and monitoring. Using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and dynamic contrast-enhanced MRI (DCE MRI), research has shown that early cartilage loss is strongly associated with synovial inflammation in rheumatoid arthritis (RA). The aim of this study was to determine if acute inflammation is associated with early cartilage loss in small finger joints of patients with PsA. Methods: Metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints of 17 patients with active PsA were evaluated by high-resolution 3 Tesla dGEMRIC and DCE MRI using a dedicated 16-channel hand coil. Semi-quantitative and quantitative perfusion parameters were calculated. Images were analyzed by two independent raters for dGEMRIC indices, PsA MRI scores (PsAMRIS), total cartilage thickness (TCT), and joint space width (JSW). Results: We found significant negative correlations between perfusion parameters (except Kep) and dGEMRIC indices, with the highest value at the MCP joints (KTrans: τ = −0.54, p = 0.01; Kep: τ = −0.02, p = 0.90; IAUC: τ = −0.51, p = 0.015; Initial Slope: τ = −0.54, p = 0.01; Peak: τ = −0.67, p = 0.002). Heterogeneous correlations were detected between perfusion parameters and both, total PsAMRIS and PsAMRIS synovitis sub-scores. No significant correlation was seen between any perfusion parameter and JSW and/or TCT. Conclusion: As examined by DCE MRI and dGEMRIC, there is a potential association between early cartilage loss and acute synovial inflammation in small finger joints of PsA patients.
- Published
- 2020
6. Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging.
- Author
-
Sewerin, Philipp, Schleich, Christoph, Brinks, Ralph, Müller-Lutz, Anja, Fichter, Florian, Eichner, Markus, Schneider, Matthias, Ostendorf, Benedikt, and Vordenbäumen, Stefan
- Subjects
CARTILAGE ,RESEARCH ,SYNOVITIS ,SYNOVIAL membranes ,METACARPOPHALANGEAL joint ,RESEARCH methodology ,HEALTH outcome assessment ,MAGNETIC resonance imaging ,CONTRAST media ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,RHEUMATOID arthritis ,DISEASE remission ,LONGITUDINAL method - Abstract
Objective: To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).Methods: Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.Results: Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).Conclusion: Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
7. Diagnostic assessment and procedural imaging for transcatheter edge-to-edge tricuspid valve repair: a step-by-step guide.
- Author
-
Dannenberg, Varius, Schneider, Matthias, Bartko, Philipp, Koschutnik, Matthias, Donà, Carolina, Nitsche, Christian, Kammerlander, Andreas A, Aschauer, Stefan, Goliasch, Georg, Hengstenberg, Christian, and Mascherbauer, Julia
- Subjects
HEART radiography ,TRICUSPID valve surgery ,CARDIAC catheterization ,ECHOCARDIOGRAPHY ,FLUOROSCOPY ,CARDIAC surgery ,MAGNETIC resonance imaging ,POSTOPERATIVE care ,PREOPERATIVE care ,TRANSESOPHAGEAL echocardiography ,TRICUSPID valve diseases - Published
- 2021
- Full Text
- View/download PDF
8. Silent progression in patients with rheumatoid arthritis: is DAS28 remission an insufficient goal in RA? Results from the German Remission-plus cohort.
- Author
-
Sewerin, Philipp, Vordenbaeumen, Stefan, Hoyer, Annika, Brinks, Ralph, Buchbender, Christian, Miese, Falk, Schleich, Christoph, Klein, Sabine, Schneider, Matthias, and Ostendorf, Benedikt
- Subjects
RHEUMATOID arthritis ,DISEASE progression ,MAGNETIC resonance imaging ,DISEASE remission ,HEALTH outcome assessment ,PATIENTS ,ANTIRHEUMATIC agents ,COMPARATIVE studies ,GOAL (Psychology) ,HAND ,JOINTS (Anatomy) ,RESEARCH methodology ,MEDICAL cooperation ,PROGNOSIS ,RESEARCH ,WRIST ,EVALUATION research ,TREATMENT effectiveness ,RETROSPECTIVE studies ,SEVERITY of illness index - Abstract
Background: Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). Even in those patients, the number and scope of erosions can increase. We, therefore, investigated the value of MRI for the detection of radiological progression in patients with DAS28 improvement and/or clinical remission of the German Remission-plus cohort.Methods: Data-sets of 80 RA patients (according to 2010 ACR/EULAR criteria) from the Remission-plus study cohort, who fulfilled the following criteria, were retrospectively analysed: availability of two consecutive MRI scans (low-field MRI, follow-up interval 1 year) of the clinically dominant hand and wrist, and the presence of DAS28 (CRP) scores at both time points, which was used to assess disease activity.Results: Seventy-one of the 80 investigated patients presented a numerical improvement of the DAS28 (CRP) after 12 months (DAS28(CRP) T0 average (Ø) 4.96, SD 1.2; DAS28 T4 (12 month) Ø 2.6, SD 1.0), 73% of them also improved in the RAMRIS-Score, while 24% demonstrated an increase despite DAS28 improvement and 3% showed equal values. 48% of patients who improved in the DAS28 reached EULAR remission. 41% of these patients had an increase in the RAMRIS Erosion-subscore after 12 months. When considering EULAR response criteria (non-response (n = 7), moderate response (n = 19), good response (n = 45)), an increase of erosions was found in 71.4% of non-responders, 52.6% of moderate responders, and 31.1% of good responders after 12 months, all compared to baseline.Conclusion: Up to 40% of patients in this study demonstrated a progressive erosive disease detected by MRI despite DAS28 improvement or EULAR remission. Future studies are needed to determine the prognostic clinical impact of disease progression in MRI despite clinical remission, and to investigate if DAS28 remission may be an insufficient therapeutic goal and should be accompanied by MRI remission criteria. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
9. Advantages of a combined rheumatoid arthritis magnetic resonance imaging score (RAMRIS) for hand and feet: does the RAMRIS of the hand alone underestimate disease activity and progression?
- Author
-
Sewerin, Philipp, Buchbender, Christian, Vordenbäumen, Stefan, Scherer, Axel, Miese, Falk, Brinks, Ralph, Wittsack, Hans-Joerg, Klein, Sabine, Schneider, Matthias, Antoch, Gerald, and Ostendorf, Benedikt
- Abstract
Background: To evaluate a combined rheumatoid arthritis magnetic resonance imaging score (RAMRIS) for hand and foot (HaF-score) in rheumatoid arthritis (RA). Methods: Magnetic resonance imaging (MRI, 0.2 Tesla) of the dominant hand and foot of 26 ACPA positive RA patients before and 6 months after initiation of methotrexate was obtained. RAMRIS of the hand was complemented by corresponding scoring of the foot (MTP I-V; HaF-score). Disease Activity Score 28 (DAS28) and a tender and swollen joint count (JC) of the joints scored in MRI were recorded. Changes in these scores (Δ) were assessed. Results: ΔHaF-score correlated significantly with ΔDAS28 (r = 0.820, 95%-CI 0.633-0.916). Correlations to ΔDAS28 were best for changes in the synovitis subscore (0.648) and bone marrow edema (0.703). Correlations to ΔDAS28 were significantly better for of the ΔHaF-score than ΔRAMRIS (0.499, 0.139-0.743, p = 0.0368). All patients with at least moderate response (EULAR criteria, n = 11) had continuing disease activity on MRI, including five cases with new erosions, three of them at the feet. Improvements of the hand JC or foot JC were seen in 16 and 15 cases, respectively. However, MRI of the hand or feet improved in only 10 and 9 cases, respectively. No patient fulfilled SDAI remission criteria. Conclusions: The HaF-score identifies patients with continuing disease activity despite clinical response that would have been missed by consideration of the traditional RAMRIS or the DAS28 alone. Response as opposed to remission may be an insufficient goal in RA as all patients showed continuing disease activity, especially at the feet. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
10. Left atrial diverticulum—An unexpected finding in routine transesophageal echocardiography.
- Author
-
Schneider, Matthias, Morris, Daniel A., Pieske‐Kraigher, Elisabeth, Walter‐Rittel, Thula, Parwani, Abdul S., Pieske, Burkert, and Boldt, Leif‐Hendrik
- Subjects
- *
ATRIAL fibrillation , *MAGNETIC resonance imaging , *TRANSESOPHAGEAL echocardiography , *DIVERTICULUM , *LEFT heart atrium - Abstract
We report a 55‐year‐old male patient with lone paroxysmal atrial fibrillation who underwent routine transesophageal echocardiography (TOE) at our institution. In a mid‐esophageal 125° three‐chamber angulation, a distinct thinning of the left atrial (LA) wall was observed, forming a 7 × 4 mm canal with only a small membrane separating the LA from the pericardial space. Cardiac magnetic resonance imaging diagnosed a small LA diverticulum. To the best of our knowledge, this is the first manuscript describing detection of a small LA diverticulum via TOE. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
11. Patterns of magnetic resonance imaging of the foot in rheumatoid arthritis: which joints are most frequently involved?
- Author
-
Buchbender, Christian, Scherer, Axel, Miese, Falk, Sewerin, Philipp, Haferkamp, Alexandra, Brinks, Ralph, Wittsack, Hans-Joerg, Antoch, Gerald, Schneider, Matthias, and Ostendorf, Benedikt
- Subjects
RHEUMATOID arthritis treatment ,RHEUMATOID arthritis diagnosis ,MAGNETIC resonance imaging ,INFLAMMATION ,FOLLOW-up studies (Medicine) ,MEDICAL statistics - Abstract
To investigate patterns of inflammatory MRI pathologies of the fore- and midfoot in rheumatoid arthritis (RA) and early RA (ERA) and their changes under therapy. In this prospective study, MRI data of the foot of 39 RA patients (29 female, 10 male; age: 54 ± 13 years; disease duration: 35 ± 37 months; baseline DAS28: 3.0 ± 2.0; medication: 29 DMARD, 1 biological, 9 symptomatic or non-specific treatment) were evaluated for synovitis in 314 joints, bone marrow edema and erosions according to RAMRIS criteria in a total of 585 joints. The change in joint pathology intensity was evaluated on follow-up MRI (time of follow-up: 8 ± 4 months) in 25 patients. Inflammation was generally more frequent in the metatarsophalangeal (MTP) joints (221/292; 76 %) than in the proximal metatarsal (47/292; 16 %) and tarsal bones (24/292; 8 %). The overall most frequently involved joints of the foot were MTP 5 (51/292; 18 %) and 1 (49/292; 17 %). Change under therapy was most frequently seen in the MTP 1 joint. Progress of inflammation in the MTP 1 was more frequently found in ERA patients than in patients with established RA (disease duration >12 months) ( p = 0.002). In RA, the MTP joints, primarily MTP 5 and 1, are the predominant sites of inflammatory MRI pathologies of the foot. A change of inflammatory activity under therapy can be most frequently noted in the MTP 1 joint. This information might be helpful to improve effectiveness of MRI-controlled therapy approaches and clinical trials. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
12. PET/MRI in head and neck cancer: initial experience.
- Author
-
Platzek, Ivan, Beuthien-Baumann, Bettina, Schneider, Matthias, Gudziol, Volker, Langner, Jens, Schramm, Georg, Laniado, Michael, Kotzerke, Jörg, and Hoff, Jörg
- Subjects
MAGNETIC resonance imaging ,POSITRON emission ,CANCER patients ,LYMPHATICS ,LYMPH nodes - Abstract
Purpose: To evaluate the feasibility of PET/MRI (positron emission tomography/magnetic resonance imaging) with FDG (F-fluorodeoxyglucose) for initial staging of head and neck cancer. Methods: The study group comprised 20 patients (16 men, 4 women) aged between 52 and 81 years (median 64 years) with histologically proven squamous cell carcinoma of the head and neck region. The patients underwent a PET scan on a conventional scanner and a subsequent PET/MRI examination on a whole-body hybrid system. FDG was administered intravenously prior to the conventional PET scan (267-395 MBq FDG, 348 MBq on average). The maximum standardized uptake values (SUV) of the tumour and of both cerebellar hemispheres were determined for both PET datasets. The numbers of lymph nodes with increased FDG uptake were compared between the two PET datasets. Results: No MRI-induced artefacts where observed in the PET images. The tumour was detected by PET/MRI in 17 of the 20 patients, by PET in 16 and by MRI in 14. The PET/MRI examination yielded significantly higher SUV than the conventional PET scanner for both the tumour ( p < 0.0001) and the cerebellum ( p = 0.0009). The number of lymph nodes with increased FDG uptake detected using the PET dataset from the PET/MRI system was significantly higher the number detected by the stand-alone PET system (64 vs. 39, p = 0.001). Conclusion: The current study demonstrated that PET/MRI of the whole head and neck region is feasible with a whole-body PET/MRI system without impairment of PET or MR image quality. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
13. Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging.
- Author
-
Buchbender, Christian, Scherer, Axel, Kröpil, Patric, Körbl, Birthe, Quentin, Michael, Reichelt, Dorothea, Lanzman, Rotem, Mathys, Christian, Blondin, Dirk, Bittersohl, Bernd, Zilkens, Christoph, Hofer, Matthias, Wittsack, Hans-Jörg, Schneider, Matthias, Antoch, Gerald, Ostendorf, Benedikt, and Miese, Falk
- Subjects
CARTILAGE ,RHEUMATOID arthritis ,JOINT diseases ,MAGNETIC resonance imaging ,CELL differentiation - Abstract
Purpose: To prospectively evaluate four non-invasive markers of cartilage quality-T2* mapping, native T1 mapping, dGEMRIC and ΔR1-in healthy volunteers and rheumatoid arthritis (RA) patients. Materials and methods: Cartilage of metacarpophalangeal (MCP) joints II were imaged in 28 consecutive subjects: 12 healthy volunteers [9 women, mean (SD) age 52.67 (9.75) years, range 30-66] and 16 RA patients with MCP II involvement [12 women, mean (SD) age 58.06 (12.88) years, range 35-76]. Sagittal T2* mapping was performed with a multi-echo gradient-echo on a 3 T MRI scanner. For T1 mapping the dual flip angle method was applied prior to native T1 mapping and 40 min after gadolinium application (delayed gadolinium-enhanced MRI of cartilage, dGEMRIC, T1). The difference in the longitudinal relaxation rate induced by gadolinium (ΔR1) was calculated. The area under the receiver operating characteristic curve (AROC) was used to test for differentiation of RA patients from healthy volunteers. Results: dGEMRIC (AUC 0.81) and ΔR1 (AUC 0.75) significantly differentiated RA patients from controls. T2* mapping (AUC 0.66) and native T1 mapping (AUC 0.66) were not significantly different in RA patients compared to controls. Conclusions: The data support the use of dGEMRIC for the assessment of MCP joint cartilage quality in RA. T2* and native T1 mapping are of low diagnostic value. Pre-contrast T1 mapping for the calculation of ΔR1 does not increase the diagnostic value of dGEMRIC. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
14. Molecular imaging of cartilage damage of finger joints in early rheumatoid arthritis with delayed gadolinium-enhanced magnetic resonance imaging.
- Author
-
Miese, Falk, Buchbender, Christian, Scherer, Axel, Wittsack, Hans-Jörg, Specker, Christof, Schneider, Matthias, Antoch, Gerald, and Ostendorf, Benedikt
- Subjects
CARTILAGE injuries ,MAGNETIC resonance imaging ,FINGERS ,LONGITUDINAL method ,RESEARCH funding ,RHEUMATOID arthritis ,STATISTICS ,T-test (Statistics) ,EQUIPMENT & supplies ,INTER-observer reliability ,CASE-control method ,DATA analysis software - Abstract
Objective To assess cartilage glycosaminoglycan content and cartilage thickness in the metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis (RA) and healthy volunteers. Methods After review board approval and informed consent were obtained, 22 subjects were prospectively enrolled (9 patients with early RA [7 women and 2 men with a mean ± SD age of 49 ± 13 years; range 25-68 years] and 13 healthy volunteers [10 women and 3 men with a mean ± SD age of 51 ± 12 years; range 25-66 years). In a total of 44 MCP joints of the index and middle fingers, measurements of cartilage thickness and delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) index (T1 [msec]) were obtained using the variable flip-angle method and a 3T MR scanner. MRIs were evaluated for bone edema, erosions, and synovitis (using the RA MRI Scoring criteria). Student's t-test was used to test the significance of differences between groups. Results The mean ± SD dGEMRIC index was 497 ± 86 msec in healthy volunteers and was significantly lower in the early RA group (421 ± 76 msec) ( P = 0.042). There was no joint space narrowing seen on standard radiographs. No significant difference was found between cartilage thickness in patients with early RA and that in controls (index finger mean ± SD 1.27 ± 0.23 mm in RA patients versus 1.46 ± 0.34 mm in controls [ P = 0.16] and middle finger 1.26 ± 0.23 mm in RA patients versus 0.97 ± 0.47 mm in controls [ P = 0.10]). No significant correlation was noted between cartilage thickness and dGEMRIC index (R = 0.36, P = 0.88 in RA patients; R = 0.156, P = 0.445 in controls). Conclusion Our findings indicate that cartilage damage is present in the MCP joints of patients with early RA despite the absence of joint space narrowing on standard radiographs and MRI. Cartilage damage in RA can be imaged with dGEMRIC. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
15. Hybrid F-FDG PET-MRI of the hand in rheumatoid arthritis: initial results.
- Author
-
Miese, Falk, Scherer, Axel, Ostendorf, Benedikt, Heinzel, Alexander, Lanzman, Rotem, Kröpil, Patric, Blondin, Dirk, Hautzel, Hubertus, Wittsack, Hans-Jörg, Schneider, Matthias, Antoch, Gerald, Herzog, Hans, and Shah, N.
- Subjects
RHEUMATOID arthritis ,GLUCOSE ,INFLAMMATION ,MAGNETIC resonance imaging ,SYNOVITIS ,METACARPOPHALANGEAL joint ,MEDICAL care - Abstract
18F-fluorodeoxyglucose PET (18F-FDG PET) is highly sensitive to inflammatory changes within the synovial tissue in rheumatoid arthritis (RA). However, the highest spatial resolution for soft tissue can be achieved with MRI. Here, we report on the first true hybrid PET-MRI examination of the hand in early RA exploiting the advantages of both modalities. PET-MRI was performed with a prototype of an APD-based magneto-insensitive BrainPET detector (Siemens Healthcare, Erlangen, Germany) operated within a standard 3T MR scanner (MAGNETOM Trio, Siemens). PET images were normalized, random, attenuation and scatter-corrected, iteratively reconstructed and calibrated to yield standardized uptake values (SUV) of 18F-FDG uptake. T1-weighted TSE in coronal as well as sagittal orientation prior to and following Gadolinium administration were acquired. Increased 18F-FDG uptake was present in synovitis and tenovaginitis as identified on contrast-enhanced MRI. The tracer distribution was surrounding the metacarpophalangeal joints II and III. Maximum SUV of 3.1 was noted. In RA, true hybrid 18F-FDG PET-MRI of the hand is technically feasible and bears the potential to directly visualize inflammation. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
16. The New ACR/EULAR Classification Criteria for Rheumatoid Arthritis: Will They Change Our Trials and Clinical Management?
- Author
-
Schneider, Matthias, Blumenroth, Martina, and Fischer-Betz, Rebecca
- Subjects
- *
RHEUMATOID arthritis diagnosis , *SYNOVITIS , *MAGNETIC resonance imaging , *CLINICAL trials , *METHOTREXATE - Abstract
In rheumatoid arthritis (RA), early diagnosis leading to early intervention is a successful strategy for reducing and even fully preventing the consequences of this chronic inflammatory disorder. In 2010, the American College of Rheumatology/European League Against Rheumatism developed classification criteria for identification of the subset of new patients with undifferentiated synovitis who are at high risk of chronicity and erosive damage, and also for use as a basis for initiating disease-modifying therapy. These criteria are primarily classification criteria for clinical trials; however, their use in daily practice will likely completely change the picture of RA. The aim of this article is to reflect on and discuss the possible consequences of implementing the new criteria in the clinic, especially in terms of the transfer from primary into specialized care. [ABSTRACT FROM AUTHOR]
- Published
- 2011
17. Introduction of a Simplified Psoriatic Arthritis Magnetic Resonance Imaging Score (sPsAMRIS): A Potential Tool for Treatment Monitoring in Peripheral Psoriatic Arthritis.
- Author
-
Abrar, Daniel B., Schleich, Christoph, Brinks, Ralph, Goertz, Christine, Frenken, Miriam, Schneider, Matthias, Nebelung, Sven, and Sewerin, Philipp
- Subjects
PSORIATIC arthritis ,MAGNETIC resonance imaging - Abstract
Background: To evaluate whether a simplified (s) version of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS), sPsAMRIS, is a potential tool for therapy monitoring in psoriatic arthritis (PsA). Methods: Seventeen patients with active psoriatic arthritis (PsA) underwent magnetic resonance imaging (MRI) at 3 T of the clinically dominant hand at baseline and after 6 months. Scoring was performed by two musculoskeletal radiologists in terms of the PsAMRIS and sPsAMRIS, which is a simplified version with reduced item numbers based on prior evaluation of responsiveness to change by standardized response means (SRMs). Both scores were compared by calculation of overall and each sub-score's SRMs and relative efficacy (RE) after bootstrapping. Results: PsAMRIS sub-scores of MCP joints 3 and 4, and proximal interphalangeal (PIP) joint 4 had the highest SRM (−0.07 each), indicating highest responsiveness to change, and were, therefore, included in sPsAMRIS. Compared to PsAMRIS, sPsAMRIS was characterized by higher SRMs (sPsAMRIS: −0.13 vs. PsAMRIS: −0.02) and higher RE (29.46). sPsAMRIS and PsAMRIS were highly correlated at baseline (r = 0.75, p < 0.01 (Pearson's correlation)) and at 6-month follow-up (r = 0.64, p = 0.01). Mean time burden for completion of scoring per MRI study was significantly reduced when using PsAMRIS (469 ± 87.03 s) as compared to sPsAMRIS (140.1 ± 21.25 s) (p < 0.001). Conclusion: Due to its similar responsiveness to change compared to standard PsAMRIS, and time efficiency, sPsAMRIS might be a potential diagnostic tool to quantitatively assess and monitor therapy in PsA. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
18. Chronic rupture of the left ventricular wall with a giant pseudoaneurysm.
- Author
-
Riesenhuber, Martin, Schneider, Matthias, Maier, Andrea, Rohla, Miklos, and Gyöngyösi, Mariann
- Subjects
CHEST X rays ,CHEST pain ,COMPUTED tomography ,CORONARY artery bypass ,DYSPNEA ,ECHOCARDIOGRAPHY ,LEFT heart ventricle ,CARDIAC radionuclide imaging ,MAGNETIC resonance imaging ,MYOCARDIAL infarction ,MYOCARDIAL revascularization ,POSTOPERATIVE period ,THREE-dimensional imaging ,PATIENT refusal of treatment ,CONTRAST media ,DISEASE progression ,FALSE aneurysms ,PREOPERATIVE period ,CORONARY angiography ,DIAGNOSIS - Published
- 2019
- Full Text
- View/download PDF
19. Ex Vivo Fluorescence Confocal Microscopy of MRI-Guided Targeted Prostate Biopsies for Rapid Detection of Clinically Significant Carcinomas—A Feasibility Study.
- Author
-
Titze, Ulf, Titze, Barbara, Hansen, Torsten, Barth, Peter J., Ali, Furat Abd, Schneider, Fried, Benndorf, Matthias, and Sievert, Karl-Dietrich
- Subjects
BIOPSY ,RISK assessment ,PROSTATE-specific antigen ,EARLY detection of cancer ,PILOT projects ,ARTIFICIAL intelligence ,PROSTATE tumors ,MAGNETIC resonance imaging ,DESCRIPTIVE statistics ,PROSTATE ,PSYCHOLOGICAL stress ,COMPUTER-aided diagnosis ,MICROSCOPY ,COMPARATIVE studies ,SENSITIVITY & specificity (Statistics) - Abstract
Simple Summary: Ex vivo fluorescence confocal microscopy is a novel microscopic technique that allows lossless analysis of unfixed tissue. By examining MRI-guided biopsies from suspicious lesions of the prostate, the majority of prostate carcinomas requiring treatment can be diagnosed. The recorded digital images are a promising basis for future AI-supported diagnostic algorithms. The rapid feedback within a few hours of the biopsy collection can reduce the stress burden on patients and contribute to better patient care, as the necessary steps for the therapies can be organized promptly. It is also a promising diagnostic approach for future local therapies in which effective substances can be applied specifically to tumor foci. Background: MRI-guided prostate biopsies from visible tumor-specific lesions (TBx) can be used to diagnose clinically significant carcinomas (csPCa) requiring treatment more selectively than conventional systematic biopsies (SBx). Ex vivo fluorescence confocal microscopy (FCM) is a novel technique that can be used to examine TBx prior to conventional histologic workup. Methods: TBx from 150 patients were examined with FCM on the day of collection. Preliminary findings were reported within 2 h of collection. The results were statistically compared with the final histology. Results: 27/40 (68%) of the csPCa were already recognized in the intraday FCM in accordance with the results of conventional histology. Even non-significant carcinomas (cisPCa) of the intermediate and high-risk groups (serum prostate-specific antigen (PSA) > 10 or 20 ng/mL) according to conventional risk stratifications were reliably detectable. In contrast, small foci of cisPCa were often not detected or were difficult to distinguish from reactive changes. Conclusion: The rapid reporting of preliminary FCM findings helps to reduce the psychological stress on patients, and can improve the clinical management of csPCa. Additional SBx can be avoided in individual cases, leading to lower rates of complications and scarring in the future surgical area. Additional staging examinations can be arranged without losing time. FCM represents a promising basis for future AI-based diagnostic algorithms. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. The aureole sign: a rare echocardiographic artefact.
- Author
-
Schneider, Matthias, Binder, Thomas, Maurer, Gerald, Lang, Irene, and Goliasch, Georg
- Subjects
CORONARY heart disease surgery ,CHEST pain ,COMPUTED tomography ,CORONARY disease ,DOPPLER echocardiography ,DYSPNEA ,ECHOCARDIOGRAPHY ,FOREIGN bodies ,MAGNETIC resonance imaging ,SPLINTS (Surgery) ,MEDICAL artifacts ,RADIOGRAPHY - Published
- 2017
- Full Text
- View/download PDF
21. FDG PET/MR for lymph node staging in head and neck cancer.
- Author
-
Platzek, Ivan, Beuthien-Baumann, Bettina, Schneider, Matthias, Gudziol, Volker, Kitzler, Hagen H., Maus, Jens, Schramm, Georg, Popp, Manuel, Laniado, Michael, Kotzerke, Jörg, and van den Hoff, Jörg
- Subjects
- *
POSITRON emission tomography , *LYMPH node cancer , *COMPUTED tomography , *MAGNETIC resonance imaging , *SQUAMOUS cell carcinoma , *DIAGNOSTIC imaging - Abstract
Abstract: Objective: To assess the diagnostic value of PET/MR (positron emission tomography/magnetic resonance imaging) with FDG (18F-fluorodeoxyglucose) for lymph node staging in head and neck cancer. Materials and methods: This prospective study was approved by the local ethics committee; all patients signed informed consent. Thirty-eight patients with squamous cell carcinoma of the head and neck region underwent a PET scan on a conventional scanner and a subsequent PET/MR on a whole-body hybrid system after a single intravenous injection of FDG. The accuracy of PET, MR and PET/MR for lymph node metastases were compared using receiver operating characteristic (ROC) analysis. Histology served as the reference standard. Results: Metastatic disease was confirmed in 16 (42.1%) of 38 patients and 38 (9.7%) of 391 dissected lymph node levels. There were no significant differences between PET/MR, MR and PET and MR (p >0.05) regarding accuracy for cervical metastatic disease. Based on lymph node levels, sensitivity and specificity for metastatic involvement were 65.8% and 97.2% for MR, 86.8% and 97.0% for PET and 89.5% and 95.2% for PET/MR. Conclusions: In head and neck cancer, FDG PET/MR does not significantly improve accuracy for cervical lymph node metastases in comparison to MR or PET. [Copyright &y& Elsevier]
- Published
- 2014
- Full Text
- View/download PDF
22. Annual Meeting Abstracts of the German Society of Skeletal Radiology (DGMSR) 2021, April 23 - 24, Berlin/ Germany.
- Subjects
MENISCECTOMY ,MAGNETIC resonance imaging ,IDIOPATHIC femoral necrosis ,OSTEOCHONDRITIS ,POSTERIOR cruciate ligament ,ANNUAL meetings ,PROGNOSIS ,COMPUTED tomography - Abstract
B Materials and Methods: b 50 AS patients (mean age 50 ± 10.5 years) and 30 age-matched volunteers underwent 3-T magnetic resonance imaging (MRI) and conventional radiography (CR). In 2/46 patients, MRI revealed ligamentous injury; both patients showed LADI asymmetry >3 mm together with cervical tenderness and received treatment for ligamentous injury. I Munich, Germany i B Purpose: b To evaluate whether magnetic resonance (MR) imaging-based bone marrow Proton-Density Fat Fraction (PDFF) can differentiate between patients with and without acute osteoporotic/osteopenic vertebral fractures and whether PDFF values can differentiate between low-energy osteoporotic/osteopenic and high-energy traumatic vertebral fractures. Thereof, 46 patients (39±22y, 28 men; mean LADI asymmetry 2.54±1.33mm) underwent supplementary MRI with no other signs of CSI on initial CT. 10/46 patients showed cervical tenderness on clinical examination, while 34/46 patients were asymptomatic. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF
23. Reports Outline Investigative Radiology Findings from University of Freiburg (Accelerated Diffusion-weighted Imaging In 3 T Breast Mri Using a Deep Learning Reconstruction Algorithm With Superresolution Processing: a Prospective Comparative...).
- Subjects
MACHINE learning ,DIFFUSION magnetic resonance imaging ,DEEP learning ,INVESTIGATIVE reporting ,MAGNETIC resonance imaging ,DICOM (Computer network protocol) - Abstract
A study conducted at the University of Freiburg in Germany explored the use of deep learning reconstruction algorithms to improve the efficiency and image quality of diffusion-weighted imaging (DWI) in breast MRI. DWI is a technique that enhances specificity in breast MRI but is associated with longer acquisition times. The researchers evaluated the acquisition time and image quality of a deep learning-accelerated DWI sequence with superresolution processing and compared it to standard imaging. The study found that the deep learning reconstruction algorithm significantly shortened acquisition time and improved spatial resolution. The research concluded that this technique has the potential to enhance the efficiency and accuracy of breast MRI. [Extracted from the article]
- Published
- 2024
24. Utility of combined high-resolution bone SPECT and MRI for the identification of rheumatoid arthritis patients with high-risk for erosive progression
- Author
-
Buchbender, Christian, Sewerin, Philipp, Mattes-György, Katalin, Miese, Falk, Wittsack, Hans-Joerg, Specker, Christof, Antoch, Gerald, Müller, Hans-Wilhelm, Schneider, Matthias, Scherer, Axel, and Ostendorf, Benedikt
- Subjects
- *
HIGH resolution imaging , *SINGLE-photon emission computed tomography , *MAGNETIC resonance imaging , *RHEUMATOID arthritis diagnosis , *DISEASE progression ,DIAGNOSIS of bone diseases - Abstract
Abstract: Objectives: To evaluate the utility of sequentially acquired, post hoc fused, magnetic resonance imaging (MRI) and multi-pinhole single photon emission computed tomography (MPH-SPECT) with technetium-99m-labeled disphosphonates (Tc99m-DPD) for the identification of finger joints with later erosive progression in early rheumatoid arthritis (ERA) patients. Methods: Ten consecutive ERA patients prospectively underwent MPH-SPECT and MRI of metacarpophalangeal (MCP) joints prior to and after 6 months methotrexate therapy. Tc99m-DPD uptake was measured at proximal and distal MCP sites using regional analysis. The course of joint pathologies was scored according to the Rheumatoid Arthritis MRI Score (RAMRIS) criteria. Results: The frequency of increased Tc99m-DPD uptake, synovitis and bone marrow edemadecreased under MTX therapy; but the number of bone erosions increased. Joints with progressive and new erosions on follow-up had a higher baseline Tc99m-DPD uptake (2.64±1.23 vs. 1.43±0.91) (p =0.02). Conclusions: Joints with erosive progression are characterized by an early increased Tc99m-DPD uptake, even in absence of MRI bone pathologies. Tc99m-DPD MPH-SPECT might thus be of additional value to morphological MRI for the identification of RA patients with a high risk for erosive progression. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
25. Evaluation of the volumes of cranial cavities in Cavalier King Charles Spaniels with Chiari-like malformation and other brachycephalic dogs as measured via computed tomography.
- Author
-
Schmidt, Martin J., Biel, Miriam, Klumpp, Stephan, Schneider, Matthias, and Kramer, Martin
- Subjects
- *
CAVALIER King Charles spaniel , *CEREBELLUM abnormalities , *ABNORMALITIES in dogs , *VETERINARY tomography , *MAGNETIC resonance imaging - Abstract
Objective--To measure the absolute and relative volumes of cranial vaults of Cavalier King Charles Spaniels (CKCSs) and other brachycephalic dogs for the purpose of evaluating a possible association between the volume of the caudal fossa (fossa caudalis cerebri; CF) and existence of Chiari-like malformation (CLM) and syringohydromyelia in CKCSs. Animals--40 CKCSs and 25 brachycephalic dogs. Procedures--The intracranial vault of all dogs was evaluated via computed tomography followed by magnetic resonance imaging. Volumes of the CF and the rostral and medial fossa (fossa rostralis et medialis cerebri) were determined. The ratio of the absolute volumes was calculated as the volume index (VI). Results--All CKCSs had cranial characteristics consistent with CLM. There were no significant differences between CKCSs and brachycephalic dogs with respect to the VI and absolute volumes of the CF and rostral and medial fossas. The CKCSs without syringohydromyelia (n = 26) had a median VI of 0.1842, and CKCSs with syringohydromyelia (14) had a median VI of 0.1805. The median VI of other brachycephalic dogs was 0.1864. The VI did not differ among these 3 groups. Conclusions and Clinical Relevance--Results of this study suggested that descent of the cerebellum into the foramen magnum and the presence of syringohydromyelia in CKCSs are not necessarily associated with a volume reduction in the CF of the skull. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.