Search

Purpose: To test an integrated "AC/DC" array approach at 7T, where B 0 inhomogeneity poses an obstacle for functional imaging, diffusion-weighted MRI, MR spectroscopy, and other applications., Methods: A close-fitting 7T 31-channel (31-ch) brain array was constructed and tested using combined Rx and ΔB 0 shim channels driven by a set of rapidly switchable current amplifiers. The coil was compared to a shape-matched 31-ch reference receive-only array for RF safety, signal-to-noise ratio (SNR), and inter-element noise correlation. We characterize the coil array's ability to provide global and dynamic (slice-optimized) shimming using ΔB 0 field maps and echo planar imaging (EPI) acquisitions., Results: The SNR and average noise correlation were similar to the 31-ch reference array. Global and slice-optimized shimming provide 11% and 40% improvements respectively compared to baseline second-order spherical harmonic shimming. Birdcage transmit coil efficiency was similar for the reference and AC/DC array setups., Conclusion: Adding ΔB 0 shim capability to a 31-ch 7T receive array can significantly boost 7T brain B 0 homogeneity without sacrificing the array's rdiofrequency performance, potentially improving ultra-high field neuroimaging applications that are vulnerable to off-resonance effects., (© 2021 International Society for Magnetic Resonance in Medicine.)

Events are often remembered as having occurred in a specific order, but almost nothing is known about how the brain encodes this temporal information. It is commonly assumed that temporal information is encoded via a single mechanism, based either on the temporal context in which the event occurred or inferred from the strength of the memory trace itself. By analyzing time-dependent changes in activity patterns, we show that the distinctiveness of contextual representations in the hippocampus and anterior and medial prefrontal cortex was associated with accurate recency memory. In contrast, overall activation in the perirhinal and lateral prefrontal cortices predicted whether an object would be judged more recent, regardless of accuracy. These results demonstrate that temporal information was encoded through at least two complementary neural mechanisms.

The hippocampus is critical for human episodic memory, but its role remains controversial. One fundamental question concerns whether the hippocampus represents specific objects or assigns context-dependent representations to objects. Here, we used multivoxel pattern similarity analysis of fMRI data during retrieval of learned object sequences to systematically investigate hippocampal coding of object and temporal context information. Hippocampal activity patterns carried information about the temporal positions of objects in learned sequences, but not about objects or temporal positions in random sequences. Hippocampal activity patterns differentiated between overlapping object sequences and between temporally adjacent objects that belonged to distinct sequence contexts. Parahippocampal and perirhinal cortex showed different pattern information profiles consistent with coding of temporal position and object information, respectively. These findings are consistent with models proposing that the hippocampus represents objects within specific temporal contexts, a capability that might explain its critical role in episodic memory.

Purpose: To test an integrated "AC/DC" array approach at 7T, where B0 inhomogeneity poses an obstacle for functional imaging, diffusion‐weighted MRI, MR spectroscopy, and other applications. Methods: A close‐fitting 7T 31‐channel (31‐ch) brain array was constructed and tested using combined Rx and ΔB0 shim channels driven by a set of rapidly switchable current amplifiers. The coil was compared to a shape‐matched 31‐ch reference receive‐only array for RF safety, signal‐to‐noise ratio (SNR), and inter‐element noise correlation. We characterize the coil array's ability to provide global and dynamic (slice‐optimized) shimming using ΔB0 field maps and echo planar imaging (EPI) acquisitions. Results: The SNR and average noise correlation were similar to the 31‐ch reference array. Global and slice‐optimized shimming provide 11% and 40% improvements respectively compared to baseline second‐order spherical harmonic shimming. Birdcage transmit coil efficiency was similar for the reference and AC/DC array setups. Conclusion: Adding ΔB0 shim capability to a 31‐ch 7T receive array can significantly boost 7T brain B0 homogeneity without sacrificing the array's rdiofrequency performance, potentially improving ultra‐high field neuroimaging applications that are vulnerable to off‐resonance effects. [ABSTRACT FROM AUTHOR]

One of the defining features of episodic long-term memory is that it includes information about the temporal context in which an event occurred. Little is known about the regions that support the encoding of temporal information in the human brain, although previous work has suggested a role for the lateral prefrontal cortex (PFC) and medial temporal lobes (MTL). Here we used event-related fMRI to examine the relationship between activity at encoding and subsequent memory for temporal context. Participants were scanned while performing a serial order working memory task with pictures of common objects and were later tested for temporal memory at two different timescales. In the coarse temporal memory test, participants viewed one object from each trial and indicated approximately when during the course of the experiment it had appeared. In the fine temporal memory test, participants were shown the remaining objects from each trial and asked to recall the order in which they had been originally presented. Activity in the parahippocampal cortex predicted subsequent fine temporal accuracy, whereas coarse temporal accuracy was predicted by activity in several regions of the PFC, as well as in the hippocampus. Additional multivoxel pattern analyses revealed evidence implicating the rostrolateral PFC in the representation of time-varying contextual states in a manner similar to that proposed by computational theories of temporal context memory. These results highlight MTL and PFC contributions to temporal memory at the time of encoding and suggest a particular role for the rostrolateral PFC in encoding coarse temporal context. [ABSTRACT FROM AUTHOR]

Converging behavioral and neuroimaging evidence indicates that culture influences the processing of complex visual scenes. Whereas Westerners focus on central objects and tend to ignore context, East Asians process scenes more holistically, attending to the context in which objects are embedded. We investigated cultural differences in contextual processing by manipulating the congruence of visual scenes presented in an fMR-adaptation paradigm. We hypothesized that East Asians would show greater adaptation to incongruent scenes, consistent with their tendency to process contextual relationships more extensively than Westerners. Sixteen Americans and 16 native Chinese were scanned while viewing sets of pictures consisting of a focal object superimposed upon a background scene. In half of the pictures objects were paired with congruent backgrounds, and in the other half objects were paired with incongruent backgrounds. We found that within both the right and left lateral occipital complexes, Chinese participants showed significantly greater adaptation to incongruent scenes than to congruent scenes relative to American participants. These results suggest that Chinese were more sensitive to contextual incongruity than were Americans and that they reacted to incongruent object/background pairings by focusing greater attention on the object. [ABSTRACT FROM PUBLISHER]