1. Relation Between N-Terminal Pro-Brain Natriuretic Peptide and Cardiac Remodeling and Function Assessed by Cardiovascular Magnetic Resonance Imaging in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
- Author
-
Jianmin Chu, Jing Wang, Cuihong Hou, Xuhua Chen, Sanjay K Prasad, Shihua Zhao, Gang Yin, Huaibing Cheng, Minjie Lu, Jielin Pu, and Shu Zhang
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.drug_class ,Sensitivity and Specificity ,Right ventricular cardiomyopathy ,Interquartile range ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Natriuretic peptide ,Humans ,In patient ,cardiovascular diseases ,Ventricular remodeling ,Arrhythmogenic Right Ventricular Dysplasia ,Retrospective Studies ,Ventricular Remodeling ,medicine.diagnostic_test ,business.industry ,Cardiac muscle ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Peptide Fragments ,medicine.anatomical_structure ,Ventricular Function, Right ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,hormones, hormone substitutes, and hormone antagonists ,N-terminal pro-Brain Natriuretic Peptide - Abstract
Although N-terminal pro-brain natriuretic peptide (NT-proBNP) is a useful screening test of impaired right ventricular (RV) function in conditions affecting the right-sided cardiac muscle, the role of NT-proBNP remains unclear in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study was designed to clarify the relation between the plasma NT-proBNP level and the RV function evaluated by cardiovascular magnetic resonance (CMR) imaging. We selected 56 patients with confirmed ARVC only when their blood specimens for NT-proBNP measurements were collected within 48 hours of a CMR scan. The NT-proBNP level was significantly higher in patients with RV dysfunction than in patients without RV dysfunction (median of 655.3 [interquartile range 556.4 to 870.0] vs 347.0 [interquartile range 308.0 to 456.2] pmol/L, p0.001). The NT-proBNP levels were positively correlated with RV end-diastolic and end-systolic volume indices (r = 0.49 and 0.70, respectively) and negatively correlated with RV ejection fraction (r = -0.76, all p0.001), which remained significant after adjustment for age, gender, and body mass index. The area under the receiver-operating characteristic curve for NT-proBNP was 0.91 (95% confidence interval 0.80 to 0.97, p0.001). The cut-off value of NT-proBNP (458 pmol/L) was associated with sensitivity, specificity, and positive and negative predictive values of 91%, 89%, 67%, and 98%, respectively. In conclusion, NT-proBNP is a useful marker for the detection of RV dysfunction and associated with extent of RV dilatation and dysfunction determined by CMR in patients with ARVC.
- Published
- 2015