1. TiO2 microspheres containing magnetic nanoparticles for intra-arterial hyperthermia
- Author
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Kanetaka, Hiroyasu, Liu, Gengci, Li, Zhixia, Miyazaki, Toshiki, Furuya, Maiko, Kudo, Tada-aki, and Kaw, Masakazu
- Subjects
magnetic nanoparticles ,microspheres ,TiO2 ,equipment and supplies ,hyperthermia - Abstract
Magnetic microspheres measuring 15–35 µm in diameter are believed to be useful for intra-arterial hyperthermia. In this study, we attempted to prepare titanium dioxide (TiO2) microspheres containing magnetic nanoparticles (MNPs). MNP-containing TiO2 microspheres with diameters of approximately 30 µm were successfully obtained by sol–gel reaction of titanium tetraisopropoxide in a water-in-oil emulsion with added cosurfactant of 1-butanol and subsequent heat treatment at 200°C. The microspheres showed ferrimagnetism owing to high content of MNPs in approximately 60 wt % and had a low-crystalline TiO2 matrix. Furthermore, the agar phantom was heated to above 43°C after approximately 1 min under an alternating magnetic field of 100 kHz and 300 Oe and showed in vitro biocompatibility similar to that of MNP-free TiO2 microspheres. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2308–2314, 2017.
- Published
- 2016