1. Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV.
- Author
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Schnittman SR, Talathi R, Wilks MQ, Hedgire S, Lu MT, Fourman LT, Alagpulinsa DA, Stockman SL, White KS, Wallis ZK, Autissier P, Stanley TL, Lee H, Honigberg MC, El-Fakhri G, Williams KC, Zanni MV, Grinspoon SK, and Toribio M more...
- Subjects
- Humans, Male, Female, Middle Aged, Adult, Arteries pathology, Arteries immunology, HIV Infections immunology, HIV Infections complications, Macrophages immunology, T-Lymphocyte Subsets immunology
- Abstract
People with human immunodeficiency virus (HIV, PWH) face an increased risk of cardiovascular disease (CVD) compared to the general population. We previously demonstrated that people with (versus without) HIV have higher macrophage-specific arterial infiltration in relation to systemic monocyte activation. We now show that select T lymphocyte subpopulations (naïve CD4 + , effector memory CD4 + , and central memory CD8 + ) are differentially associated with macrophage-specific arterial infiltration among participants with versus without HIV, with evidence of interaction by HIV status. Our results suggest that among PWH, circulating T lymphocytes associate with macrophage-specific arterial infiltration, of relevance to atherogenesis and CVD risk., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) more...
- Published
- 2024
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