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This study leverages the DCTPep database, a comprehensive repository of cancer therapy peptides, to explore the application of machine learning in accelerating cancer research. We applied Principal Component Analysis (PCA) and K-means clustering to categorize cancer therapy peptides based on their physicochemical properties. Our analysis identified three distinct clusters, each characterized by unique features such as sequence length, isoelectric point (pI), net charge, and mass. These findings provide valuable insights into the key properties that influence peptide efficacy, offering a foundation for the design of new therapeutic peptides. Future work will focus on experimental validation and the integration of additional data sources to refine the clustering and enhance the predictive power of the model, ultimately contributing to the development of more effective peptide-based cancer treatments.

This study investigates the forecasting of cardiovascular mortality trends in Greece's elderly population. Utilizing mortality data from 2001 to 2020, we employ two forecasting models: the Autoregressive Integrated Moving Average (ARIMA) and Facebook's Prophet model. Our study evaluates the efficacy of these models in predicting cardiovascular mortality trends over 2020-2030. The ARIMA model showcased predictive accuracy for the general and male population within the 65-79 age group, whereas the Prophet model provided better forecasts for females in the same age bracket. Our findings emphasize the need for adaptive forecasting tools that accommodate demographic-specific characteristics and highlight the role of advanced statistical methods in health policy planning.

In the realm of ophthalmic surgeries, silicone oil is often utilized as a tamponade agent for repairing retinal detachments, but it necessitates subsequent removal. This study harnesses the power of machine learning to analyze the macular and optic disc perfusion changes pre and post-silicone oil removal, using Optical Coherence Tomography Angiography (OCTA) data. Building upon the foundational work of prior research, our investigation employs Gaussian Process Regression (GPR) and Long Short-Term Memory (LSTM) networks to create predictive models based on OCTA scans. We conducted a comparative analysis focusing on the flow in the outer retina and vessel density in the deep capillary plexus (superior-hemi and perifovea) to track perfusion changes across different time points. Our findings indicate that while machine learning models predict the flow in the outer retina with reasonable accuracy, predicting the vessel density in the deep capillary plexus (particularly in the superior-hemi and perifovea regions) remains challenging. These results underscore the potential of machine learning to contribute to personalized patient care in ophthalmology, despite the inherent complexities in predicting ocular perfusion changes.

Background/Objectives: The emergence of antimicrobial resistance (AMR) due to the misuse and overuse of antibiotics has become a critical threat to global public health. There is a dire need to forecast AMR to understand the underlying mechanisms of resistance for the development of effective interventions. This paper explores the capability of machine learning (ML) methods, particularly unsupervised learning methods, to enhance the understanding and prediction of AMR. It aims to determine the patterns from AMR gene data that are clinically relevant and, in public health, capable of informing strategies. Methods: We analyzed AMR gene data in the PanRes dataset by applying unsupervised learning techniques, namely K-means clustering and Principal Component Analysis (PCA). These techniques were applied to identify clusters based on gene length and distribution according to resistance class, offering insights into the resistance genes' structural and functional properties. Data preprocessing, such as filtering and normalization, was conducted prior to applying machine learning methods to ensure consistency and accuracy. Our methodology included the preprocessing of data and reduction of dimensionality to ensure that our models were both accurate and interpretable. Results: The unsupervised learning models highlighted distinct clusters of AMR genes, with significant patterns in gene length, including their associated resistance classes. Further dimensionality reduction by PCA allows for clearer visualizations of relationships among gene groupings. These patterns provide novel insights into the potential mechanisms of resistance, particularly the role of gene length in different resistance pathways. Conclusions: This study demonstrates the potential of ML, specifically unsupervised approaches, to enhance the understanding of AMR. The identified patterns in resistance genes could support clinical decision-making and inform public health interventions. However, challenges remain, particularly in integrating genomic data and ensuring model interpretability. Further research is needed to advance ML applications in AMR prediction and management. [ABSTRACT FROM AUTHOR]

Background/Objectives: Carbapenem resistance poses a significant threat to public health by undermining the efficacy of one of the last lines of antibiotic defense. Addressing this challenge requires innovative approaches that can enhance our understanding and ability to combat resistant pathogens. This review aims to explore the integration of machine learning (ML) and epidemiological approaches to understand, predict, and combat carbapenem-resistant pathogens. It examines how leveraging large datasets and advanced computational techniques can identify patterns, predict outbreaks, and inform targeted intervention strategies. Methods: The review synthesizes current knowledge on the mechanisms of carbapenem resistance, highlights the strengths and limitations of traditional epidemiological methods, and evaluates the transformative potential of ML. Real-world applications and case studies are used to demonstrate the practical benefits of combining ML and epidemiology. Technical and ethical challenges, such as data quality, model interpretability, and biases, are also addressed, with recommendations provided for overcoming these obstacles. Results: By integrating ML with epidemiological analysis, significant improvements can be made in predictive accuracy, identifying novel patterns in disease transmission, and designing effective public health interventions. Case studies illustrate the benefits of interdisciplinary collaboration in tackling carbapenem resistance, though challenges such as model interpretability and data biases must be managed. Conclusions: The combination of ML and epidemiology holds great promise for enhancing our capacity to predict and prevent carbapenem-resistant infections. Future research should focus on overcoming technical and ethical challenges to fully realize the potential of these approaches. Interdisciplinary collaboration is key to developing sustainable strategies to combat antimicrobial resistance (AMR), ultimately improving patient outcomes and safeguarding public health. [ABSTRACT FROM AUTHOR]

The process of aging leads to a progressive decline in the immune system function, known as immunosenescence, which compromises both innate and adaptive responses. This includes impairments in phagocytosis and decreased production, activation, and function of T- and B-lymphocytes, among other effects. Bacteria exploit immunosenescence by using various virulence factors to evade the host's defenses, leading to severe and often life-threatening infections. This manuscript explores the complex relationship between immunosenescence and bacterial virulence, focusing on the underlying mechanisms that increase vulnerability to bacterial infections in the elderly. Additionally, it discusses how machine learning methods can provide accurate modeling of interactions between the weakened immune system and bacterial virulence mechanisms, guiding the development of personalized interventions. The development of vaccines, novel antibiotics, and antivirulence therapies for multidrug-resistant bacteria, as well as the investigation of potential immune-boosting therapies, are promising strategies in this field. Future research should focus on how machine learning approaches can be integrated with immunological, microbiological, and clinical data to develop personalized interventions that improve outcomes for bacterial infections in the growing elderly population. [ABSTRACT FROM AUTHOR]

Antibiotic resistance presents a critical challenge in healthcare, particularly among the elderly, where multidrug-resistant organisms (MDROs) contribute to increased morbidity, mortality, and healthcare costs. This review focuses on the mechanisms underlying resistance in key bacterial pathogens and highlights how aging-related factors like immunosenescence, frailty, and multimorbidity increase the burden of infections from MDROs in this population. Novel strategies to mitigate resistance include the development of next-generation antibiotics like teixobactin and cefiderocol, innovative therapies such as bacteriophage therapy and antivirulence treatments, and the implementation of antimicrobial stewardship programs to optimize antibiotic use. Furthermore, advanced molecular diagnostic techniques, including nucleic acid amplification tests and next-generation sequencing, allow for faster and more precise identification of resistant pathogens. Vaccine development, particularly through innovative approaches like multi-epitope vaccines and nanoparticle-based platforms, holds promise in preventing MDRO infections among the elderly. The role of machine learning (ML) in predicting resistance patterns and aiding in vaccine and antibiotic development is also explored, offering promising solutions for personalized treatment and prevention strategies in the elderly. By integrating cutting-edge diagnostics, therapeutic innovations, and ML-based approaches, this review underscores the importance of multidisciplinary efforts to address the global challenge of antibiotic resistance in aging populations. [ABSTRACT FROM AUTHOR]

Greek giant beans, also known as "Gigantes Elefantes" (elephant beans, Phaseolus vulgaris L.,) are a traditional and highly cherished culinary delight in Greek cuisine, contributing significantly to the economic prosperity of local producers. However, the issue of food fraud associated with these products poses substantial risks to both consumer safety and economic stability. In the present study, multi-elemental analysis combined with decision tree learning algorithms were investigated for their potential to determine the multi-elemental profile and discriminate the origin of beans collected from the two geographical areas. Ensuring the authenticity of agricultural products is increasingly crucial in the global food industry, particularly in the fight against food fraud, which poses significant risks to consumer safety and economic stability. To ascertain this, an extensive multi-elemental analysis (Ag, Al, As, B, Ba, Be, Ca, Cd, Co, Cr, Cs, Cu, Fe, Ga, Ge, K, Li, Mg, Mn, Mo, Na, Nb, Ni, P, Pb, Rb, Re, Se, Sr, Ta, Ti, Tl, U, V, W, Zn, and Zr) was performed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Bean samples originating from Kastoria and Prespes (products with Protected Geographical Indication (PGI) status) were studied, focusing on the determination of elemental profiles or fingerprints, which are directly related to the geographical origin of the growing area. In this study, we employed a decision tree algorithm to classify Greek "Gigantes Elefantes" beans based on their multi-elemental composition, achieving high performance metrics, including an accuracy of 92.86%, sensitivity of 87.50%, and specificity of 96.88%. These results demonstrate the model's effectiveness in accurately distinguishing beans from different geographical regions based on their elemental profiles. The trained model accomplished the discrimination of Greek "Gigantes Elefantes" beans from Kastoria and Prespes, with remarkable accuracy, based on their multi-elemental composition. [ABSTRACT FROM AUTHOR]

Aging is a fundamental biological process characterized by a progressive decline in physiological functions and an increased susceptibility to diseases. Understanding aging at the molecular level is crucial for developing interventions that could delay or reverse its effects. This review explores the integration of machine learning (ML) with multi-omics technologies—including genomics, transcriptomics, epigenomics, proteomics, and metabolomics—in studying the molecular hallmarks of aging to develop personalized medicine interventions. These hallmarks include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Using ML to analyze big and complex datasets helps uncover detailed molecular interactions and pathways that play a role in aging. The advances of ML can facilitate the discovery of biomarkers and therapeutic targets, offering insights into personalized anti-aging strategies. With these developments, the future points toward a better understanding of the aging process, aiming ultimately to promote healthy aging and extend life expectancy. [ABSTRACT FROM AUTHOR]

Featured Application: Machine-Learning Support for Hospital Admission Decisions. The study explores the application of automated machine learning (AutoML) using the MIMIC-IV-ED database to enhance decision-making in emergency department (ED) triage. We developed a predictive model that utilizes triage data to forecast hospital admissions, aiming to support medical staff by providing an advanced decision-support system. The model, powered by H2O.ai's AutoML platform, was trained on approximately 280,000 preprocessed records from the Beth Israel Deaconess Medical Center collected between 2011 and 2019. The selected Gradient Boosting Machine (GBM) model demonstrated an AUC ROC of 0.8256, indicating its efficacy in predicting patient dispositions. Key variables such as acuity and waiting hours were identified as significant predictors, emphasizing the model's capability to integrate critical triage metrics into its predictions. However, challenges related to the complexity and heterogeneity of medical data, privacy concerns, and the need for model interpretability were addressed through the incorporation of Explainable AI (XAI) techniques. These techniques ensure the transparency of the predictive processes, fostering trust and facilitating ethical AI use in clinical settings. Future work will focus on external validation and expanding the model to include a broader array of variables from diverse healthcare environments, enhancing the model's utility and applicability in global emergency care contexts. [ABSTRACT FROM AUTHOR]

The COVID-19 infection is still a serious threat to public health and healthcare systems. Numerous practical machine learning applications have been investigated in this context to support clinical decision-making, forecast disease severity and admission to the intensive care unit, as well as to predict the demand for hospital beds, equipment, and staff in the future. We retrospectively analyzed demographics, and routine blood biomarkers from consecutive Covid-19 patients admitted to the intensive care unit (ICU) of a public tertiary hospital, during a 17- month period, relative to the outcome, in order to build a prognostic model. We used the Google Vertex AI platform, on the one hand, to evaluate its performance in predicting ICU mortality, and on the other hand to show the ease with which even non-experts can make prognostic models. The model’s performance regarding the area under the receiver operating characteristic curve (AUC-ROC) was 0.955. The six highest-ranked predictors of mortality in the prognostic model were age, serum urea, platelets, C-reactive protein, hemoglobin, and SGOT. [ABSTRACT FROM AUTHOR]

Machine learning (ML) algorithms are increasingly applied in medical research and in healthcare, gradually improving clinical practice. Among various applications of these novel methods, their usage in the combat against antimicrobial resistance (AMR) is one of the most crucial areas of interest, as increasing resistance to antibiotics and management of difficult-to-treat multidrug-resistant infections are significant challenges for most countries worldwide, with life-threatening consequences. As antibiotic efficacy and treatment options decrease, the need for implementation of multimodal antibiotic stewardship programs is of utmost importance in order to restrict antibiotic misuse and prevent further aggravation of the AMR problem. Both supervised and unsupervised machine learning tools have been successfully used to predict early antibiotic resistance, and thus support clinicians in selecting appropriate therapy. In this paper, we reviewed the existing literature on machine learning and artificial intelligence (AI) in general in conjunction with antimicrobial resistance prediction. This is a narrative review, where we discuss the applications of ML methods in the field of AMR and their value as a complementary tool in the antibiotic stewardship practice, mainly from the clinician's point of view. [ABSTRACT FROM AUTHOR]

Attrition is one of the main concerns in distance learning due to the impact on the incomes and institutions reputation. Timely identification of students at risk has high practical value in effective students' retention services. Big Data mining and machine learning methods are applied to manipulate, analyze, and predict students' failure, supporting self-directed learning. Despite the extensive application of data mining to education, the imbalance problem in minority classes of students' attrition is often overlooked in conventional models. This document proposes a large data frame using the Hadoop ecosystem and the application of machine learning techniques to different datasets of an academic year at the Hellenic Open University. Datasets were divided into 35 weeks; 32 classifiers were created, compared and statistically analyzed to address the minority classes' imbalance of student's failure. The algorithms MetaCost-SMO and C4.5 provide the most accurate performance for each target class. Early predictions of timeframes determine a remarkable performance, while the importance of written assignments and specific quizzes is noticeable. The models' performance in any week is exploited by developing a prediction tool for student attrition, contributing to timely and personalized intervention. [ABSTRACT FROM AUTHOR]

Attrition is one of the main concerns in distance learning due to the impact on the incomes and institutions reputation. Timely identification of students at risk has high practical value in effective students' retention services. Big Data mining and machine learning methods are applied to manipulate, analyze and predict students' failure, supporting self-directed learning. Despite the extensive application of data mining to education, the imbalance problem in minority classes of students' attrition is often overlooked in conventional models. This document proposes a large data frame using the Hadoop ecosystem and the application of machine learning techniques to different datasets of an academic year at the Hellenic Open University. Datasets were divided into thirty-five weeks. Thirty-two classifiers were created, compared and statistical analyzed to address the minority classes' imbalance of student's failure. The algorithms metacost-SMO, and C4.5 provide the most accurate performance for each target class. Early predictions of timeframes determine a remarkable performance, while the importance of written assignments and specific quizzes is noticeable. The models' performance in any week is exploited by developing a prediction tool for student attrition, contributing to timely and personalized intervention. [ABSTRACT FROM AUTHOR]

Data sharing among different entities in the healthcare domain has become an increasingly common practice, where each entity would most likely want to prevent indirect data disclosure via inference channels. The Local Distortion Hiding (LDH) algorithm has been developed to protect sensitive decision tree (DT) rules, which are chosen not to be disclosed when DT construction techniques are applied to the data. This article presents eight experiments using a Java-based prototype that implements the LDH algorithm in a diabetes data set. Our experiments test the ability of the LDH algorithm in two ways, firstly in inference control and secondly in maintaining the structure and the performance metrics of the resulting DT. Our experiments on hiding eight terminal nodes in a diabetes data set using a Java-based prototype that implements the LDH algorithm, yield satisfactory results. [ABSTRACT FROM AUTHOR]

Educational Data Mining has turned into an effective technique for revealing relationships hidden in educational data and predicting students' learning outcomes. One can analyze data extracted from the students' activity, educational and social behavior, and academic background. The outcomes which are produced are, the following: A personalized learning procedure, a feasible engagement with students' behavior, a predictable interaction of the students with the learning processes and data. In the current work, we apply several supervised methods aiming at predicting the students' academic performance. We prove that the use of the default parameters of learning algorithms on a voting generalization procedure of the three most accurate classifiers, can produce better results than any single tuned learning algorithm. [ABSTRACT FROM AUTHOR]

The lack of physical contact and the demanding need for personalized services has prompted stakeholders in distance learning to benefit from the enormous volume of students' online traces in the Learning Management Systems. Data mining methodologies are widely applied to analyze data logs and predict trends for early and efficient interventions. Thus, the retention of students in the educational process can be achieved with positive effects on the reputation and finances of the institutions. This work divides the moodle data sets from six different sections of an annual postgraduate program at the Hellenic Open University in six periods for each section, due to the number of written assignments. Then it implements data mining techniques to analyze the activity, polarity and emotions of tutors and students in order to predict students' grades. The results indicate the algorithm with the highest precision in each prediction. In addition, the research concludes that polarity and emotions as independent variables provide better performance in comparative models. Moreover, tutors' variables are highlighted as an important factor for more accurate predictions of student grades. Finally, a comparison of actual and predicted grades indicates which students have used a third party to fulfill their assignments. [ABSTRACT FROM AUTHOR]

In this AI-focused era, researchers are delving into AI applications in healthcare, with ChatGPT being a primary focus. This Greek study involved 182 doctors from various regions, utilizing a custom web application connected to ChatGPT 4.0. Doctors from diverse departments and experience levels engaged with ChatGPT, which provided tailored responses. Over a month, data was collected using a form with a 1-to-5 rating scale. The results showed varying satisfaction levels across four criteria: clarity, response time, accuracy, and overall satisfaction. ChatGPT's response speed received high ratings (3.85/5.0), whereas clarity of information was moderately rated (3.43/5.0). A significant observation was the correlation between a doctor's experience and their satisfaction with ChatGPT. More experienced doctors (over 21 years) reported lower satisfaction (2.80–3.74/5.0) compared to their less experienced counterparts (3.43–4.20/5.0). At the medical field level, Internal Medicine showed higher satisfaction in evaluation criteria (ranging from 3.56 to 3.88), compared to other fields, while Psychiatry scored higher overall, with ratings from 3.63 to 5.00. The study also compared two departments: Urology and Internal Medicine, with the latter being more satisfied with the accuracy, and clarity of provided information, response time, and overall compared to Urology. These findings illuminate the specific needs of the health sector and highlight both the potential and areas for improvement in ChatGPT's provision of specialized medical information. Despite current limitations, ChatGPT, in its present version, offers a valuable resource to the medical community, signaling further advancements and potential integration into healthcare practices. • Greek doctors evaluate ChatGPT 4.0 nationwide via a custom web app. • ChatGPT earns high marks for speed; clarity scores are moderate. • More experienced doctors report lower satisfaction. • Doctors in Internal Medicine and Psychiatry show higher satisfaction than those in Surgery or Special Treatment Units. • Findings underscore ChatGPT's potential and improvement areas in healthcare. [ABSTRACT FROM AUTHOR]

Abstract: The process of identifying which records in two or more databases correspond to the same entity is an important aspect of data quality activities such as data pre-processing and data integration. Known as record linkage, data matching or entity resolution, this process has attracted interest from researchers in fields such as databases and data warehousing, data mining, information systems, and machine learning. Record linkage has various challenges, including scalability to large databases, accurate matching and classification, and privacy and confidentiality. The latter challenge arises because commonly personal identifying data, such as names, addresses and dates of birth of individuals, are used in the linkage process. When databases are linked across organizations, the issue of how to protect the privacy and confidentiality of such sensitive information is crucial to successful application of record linkage. In this paper we present an overview of techniques that allow the linking of databases between organizations while at the same time preserving the privacy of these data. Known as ‘privacy-preserving record linkage’ (PPRL), various such techniques have been developed. We present a taxonomy of PPRL techniques to characterize these techniques along 15 dimensions, and conduct a survey of PPRL techniques. We then highlight shortcomings of current techniques and discuss avenues for future research. [Copyright &y& Elsevier]