19 results on '"Matos, Sérgio A."'
Search Results
2. Understanding Depression from Psycholinguistic Patterns in Social Media Texts
- Author
-
Trifan, Alina, Antunes, Rui, Matos, Sérgio, Oliveira, Jose Luís, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Jose, Joemon M., editor, Yilmaz, Emine, editor, Magalhães, João, editor, Castells, Pablo, editor, Ferro, Nicola, editor, Silva, Mário J., editor, and Martins, Flávio, editor
- Published
- 2020
- Full Text
- View/download PDF
3. Improving Document Prioritization for Protein-Protein Interaction Extraction Using Shallow Linguistics and Word Embeddings
- Author
-
Matos, Sérgio, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Fdez-Riverola, Florentino, editor, Mohamad, Mohd Saberi, editor, Rocha, Miguel, editor, De Paz, Juan F., editor, and Pinto, Tiago, editor
- Published
- 2017
- Full Text
- View/download PDF
4. Protein-Protein Interaction Article Classification Using a Convolutional Recurrent Neural Network with Pre-trained Word Embeddings
- Author
-
Matos Sérgio and Antunes Rui
- Subjects
literature retrieval ,protein-protein interactions ,machine learning ,recurrent neural networks ,word embeddings ,Biotechnology ,TP248.13-248.65 - Abstract
Curation of protein interactions from scientific articles is an important task, since interaction networks are essential for the understanding of biological processes associated with disease or pharmacological action for example. However, the increase in the number of publications that potentially contain relevant information turns this into a very challenging and expensive task. In this work we used a convolutional recurrent neural network for identifying relevant articles for extracting information regarding protein interactions. Using the BioCreative III Article Classification Task dataset, we achieved an area under the precision-recall curve of 0.715 and a Matthew’s correlation coefficient of 0.600, which represents an improvement over previous works.
- Published
- 2017
- Full Text
- View/download PDF
5. An Intelligent Cloud Storage Gateway for Medical Imaging
- Author
-
Viana-Ferreira, Carlos, Guerra, António, Silva, João F., Matos, Sérgio, and Costa, Carlos
- Published
- 2017
- Full Text
- View/download PDF
6. Process of Learning from Demonstration with Paraconsistent Artificial Neural Cells for Application in Linear Cartesian Robots.
- Author
-
Da Silva Filho, João Inácio, Fernandes, Cláudio Luís Magalhães, Silveira, Rodrigo Silvério da, Gomes, Paulino Machado, Matos, Sérgio Luiz da Conceição, Santo, Leonardo do Espirito, Nunes, Vander Célio, Côrtes, Hyghor Miranda, Lopes, William Aparecido Celestino, Mario, Mauricio Conceição, Garcia, Dorotéa Vilanova, Torres, Cláudio Rodrigo, Abe, Jair Minoro, and Lambert-Torres, Germano
- Subjects
INDUSTRIAL robots ,ARTIFICIAL cells ,ARTIFICIAL neural networks ,NONLINEAR dynamical systems ,MACHINE learning ,MOBILE robots - Abstract
Paraconsistent Annotated Logic (PAL) is a type of non-classical logic based on concepts that allow, under certain conditions, for one to accept contradictions without invalidating conclusions. The Paraconsistent Artificial Neural Cell of Learning (lPANCell) algorithm was created from PAL-based equations. With its procedures for learning discrete patterns being represented by values contained in the closed interval between 0 and 1, the lPANCell algorithm presents responses similar to those of nonlinear dynamical systems. In this work, several tests were carried out to validate the operation of the lPANCell algorithm in a learning from demonstration (LfD) framework applied to a linear Cartesian robot (gantry robot), which was moving rectangular metallic workpieces. For the LfD process used in the teaching of trajectories in the x and y axes of the linear Cartesian robot, a Paraconsistent Artificial Neural Network (lPANnet) was built, which was composed of eight lPANCells. The results showed that lPANnet has dynamic properties with a robustness to disturbances, both in the learning process by demonstration, as well as in the imitation process. Based on this work, paraconsistent artificial neural networks of a greater complexity, which are composed of lPANCells, can be formed. This study will provide a strong contribution to research regarding learning from demonstration frameworks being applied in robotics. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. The CHEMDNER corpus of chemicals and drugs and its annotation principles
- Author
-
Krallinger, Martin, Rabal, Obdulia, Leitner, Florian, Vazquez, Miguel, Salgado, David, Lu, Zhiyong, Leaman, Robert, Lu, Yanan, Ji, Donghong, Lowe, Daniel M, Sayle, Roger A, Batista-Navarro, Riza Theresa, Rak, Rafal, Huber, Torsten, Rocktäschel, Tim, Matos, Sérgio, Campos, David, Tang, Buzhou, Xu, Hua, Munkhdalai, Tsendsuren, Ryu, Keun Ho, Ramanan, SV, Nathan, Senthil, Žitnik, Slavko, Bajec, Marko, Weber, Lutz, Irmer, Matthias, Akhondi, Saber A, Kors, Jan A, Xu, Shuo, An, Xin, Sikdar, Utpal Kumar, Ekbal, Asif, Yoshioka, Masaharu, Dieb, Thaer M, Choi, Miji, Verspoor, Karin, Khabsa, Madian, Giles, C Lee, Liu, Hongfang, Ravikumar, Komandur Elayavilli, Lamurias, Andre, Couto, Francisco M, Dai, Hong-Jie, Tsai, Richard Tzong-Han, Ata, Caglar, Can, Tolga, Usié, Anabel, Alves, Rui, Segura-Bedmar, Isabel, Martínez, Paloma, Oyarzabal, Julen, and Valencia, Alfonso
- Published
- 2015
- Full Text
- View/download PDF
8. Predicting the behaviour of water distribution networks with machine learning models
- Author
-
Matos, Pedro, Matos, Sérgio, and Andrade-Campos, A.
- Subjects
Water demand forecasting ,Water supply systems ,Machine learning ,Modelling ,Simulation ,Richmond’s network - Abstract
Water supply systems are indispensable infrastructures in any modern society, considering that a modern house is expected to have running water all the time. Water supply systems must pump water to meet their clients demands and face large cost-efficiency problems related to pumping operations. This work presents and analyses a possible solution to this problem using machine learning to both forecast water demands and simulate the consequent behaviour of the network which enables the optimisation of the energy cost. The study was conducted using data from real water demands from the central region of Portugal and previously modelled networks such as Richmond’s network. The results indicate that Artificial Neural Networks (ANNs) and Recurrent Neural Networks (RNNs) with Gated Recurrent Units (GRUs) are capable of achieving good performance in forecasting water demands, and that it is possible to create a model that mimics the behaviour of a water supply network of reasonable size using ANNs. published
- Published
- 2019
9. Machine learning with word embeddings applied to biomedical concept disambiguation
- Author
-
Antunes, Rui and Matos, Sérgio
- Subjects
Word embeddings ,Machine learning ,Biomedical concept disambiguation - Abstract
Artificial Intelligence (AI) has grown in the last years and it has many applications. Natural Language Processing is one of the AI tasks, which has the objective to endow the machines the capability of understanding human language. This is an important process due to the amount of information stored in textual form. There is a growing need for automatic extraction of knowledge, and NLP comes in this direction helping in tasks such as information extraction and information retrieval. Word sense disambiguation is an important NLP subtask, which is responsible for assigning the proper concept to an ambiguous word or term. In this paper, we present results obtained from applying supervised machine learning algorithms with local features, and word embeddings as global features extracted from Wikipedia and PubMed knowledge sources. These results indicate that word embeddings features are informative and may improve the biomedical word disambiguation accuracy. published
- Published
- 2016
10. BioCreative V BioC track overview: collaborative biocurator assistant task for BioGRID.
- Author
-
Sun Kim, Doğan, Rezarta Islamaj, Chatr-Aryamontri, Andrew, Chang, Christie S., Oughtred, Rose, Rust, Jennifer, Batista-Navarro, Riza, Carter, Jacob, Ananiadou, Sophia, Matos, Sérgio, Santos, André, Campos, David, Oliveira, José Luís, Singh, Onkar, Jonnagaddala, Jitendra, Hong-Jie Dai, Su, Emily Chia-Yu, Yung-Chun Chang, Yu-Chen Su, and Chun-Han Chu
- Subjects
INTERNETWORKING ,DATA curation ,XML (Extensible Markup Language) ,MACHINE learning ,BIOLOGICAL databases - Abstract
BioC is a simple XML format for text, annotations and relations, and was developed to achieve interoperability for biomedical text processing. Following the success of BioC in BioCreative IV, the BioCreative V BioC track addressed a collaborative task to build an assistant system for BioGRID curation. In this paper, we describe the framework of the collaborative BioC task and discuss our findings based on the user survey. This track consisted of eight subtasks including gene/protein/organism named entity recognition, protein-protein/genetic interaction passage identification and annotation visualization. Using BioC as their data-sharing and communication medium, nine teams, world-wide, participated and contributed either new methods or improvements of existing tools to address different subtasks of the BioC track. Results from different teams were shared in BioC and made available to other teams as they addressed different subtasks of the track. In the end, all submitted runs were merged using a machine learning classifier to produce an optimized output. The biocurator assistant system was evaluated by four BioGRID curators in terms of practical usability. The curators' feedback was overall positive and highlighted the user-friendly design and the convenient gene/protein curation tool based on text mining. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
11. An Overview of Biomolecular Event Extraction from Scientific Documents.
- Author
-
Vanegas, Jorge A., Matos, Sérgio, González, Fabio, and Oliveira, José L.
- Subjects
- *
TRANSCRIPTION factors , *MOLECULAR recognition , *BIOMOLECULES , *NATURAL language processing , *MACHINE learning - Abstract
This paper presents a review of state-of-the-art approaches to automatic extraction of biomolecular events from scientific texts. Events involving biomolecules such as genes, transcription factors, or enzymes, for example, have a central role in biological processes and functions and provide valuable information for describing physiological and pathogenesis mechanisms. Event extraction from biomedical literature has a broad range of applications, including support for information retrieval, knowledge summarization, and information extraction and discovery. However, automatic event extraction is a challenging task due to the ambiguity and diversity of natural language and higher-level linguistic phenomena, such as speculations and negations, which occur in biological texts and can lead to misunderstanding or incorrect interpretation. Many strategies have been proposed in the last decade, originating from different research areas such as natural language processing, machine learning, and statistics. This review summarizes the most representative approaches in biomolecular event extraction and presents an analysis of the current state of the art and of commonly used methods, features, and tools. Finally, current research trends and future perspectives are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
12. Twitter: A Good Place to Detect Health Conditions.
- Author
-
Prieto, Víctor M., Matos, Sérgio, Álvarez, Manuel, Cacheda, Fidel, and Oliveira, José Luís
- Subjects
- *
MEDICAL informatics , *MACHINE learning , *WEB-based user interfaces , *NATURAL language processing , *ONLINE social networks , *SOCIAL epidemiology - Abstract
With the proliferation of social networks and blogs, the Internet is increasingly being used to disseminate personal health information rather than just as a source of information. In this paper we exploit the wealth of user-generated data, available through the micro-blogging service Twitter, to estimate and track the incidence of health conditions in society. The method is based on two stages: we start by extracting possibly relevant tweets using a set of specially crafted regular expressions, and then classify these initial messages using machine learning methods. Furthermore, we selected relevant features to improve the results and the execution times. To test the method, we considered four health states or conditions, namely flu, depression, pregnancy and eating disorders, and two locations, Portugal and Spain. We present the results obtained and demonstrate that the detection results and the performance of the method are improved after feature selection. The results are promising, with areas under the receiver operating characteristic curve between 0.7 and 0.9, and f-measure values around 0.8 and 0.9. This fact indicates that such approach provides a feasible solution for measuring and tracking the evolution of health states within the society. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
13. Harmonization of gene/protein annotations: towards a gold standard MEDLINE.
- Author
-
Campos, David, Matos, Sérgio, Lewin, Ian, Oliveira, José Luís, and Rebholz-Schuhmann, Dietrich
- Subjects
- *
GOLD standard , *MEDLINE , *MACHINE learning , *JAVA programming language , *BIOINFORMATICS , *GENES , *PROTEINS , *MONETARY systems - Abstract
Motivation: The recognition of named entities (NER) is an elementary task in biomedical text mining. A number of NER solutions have been proposed in recent years, taking advantage of available annotated corpora, terminological resources and machine-learning techniques. Currently, the best performing solutions combine the outputs from selected annotation solutions measured against a single corpus. However, little effort has been spent on a systematic analysis of methods harmonizing the annotation results and measuring against a combination of Gold Standard Corpora (GSCs).Results: We present Totum, a machine learning solution that harmonizes gene/protein annotations provided by heterogeneous NER solutions. It has been optimized and measured against a combination of manually curated GSCs. The performed experiments show that our approach improves the F-measure of state-of-the-art solutions by up to 10% (achieving ≈70%) in exact alignment and 22% (achieving ≈82%) in nested alignment. We demonstrate that our solution delivers reliable annotation results across the GSCs and it is an important contribution towards a homogeneous annotation of MEDLINE abstracts.Availability and implementation: Totum is implemented in Java and its resources are available at http://bioinformatics.ua.pt/totumContact: david.campos@ua.pt; rebholz@ebi.ac.ukSupplementary information: Supplementary data are available at Bioinformatics online. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
- Full Text
- View/download PDF
14. Predicting the behaviour of water distribution networks with machine learning methods
- Author
-
Matos, Pedro Guilherme Silva, Matos, Sérgio Guilherme Aleixo de, and Campos, António Gil d'Orey de Andrade
- Subjects
Water distribution systems ,Water demand forecasting ,Machine learning ,Modelling ,Simulation - Abstract
Water supply systems are indispensable infrastructures in any modern civilisation. Any modern house has running water at all time. People are so dependent on this essential good that today it is unthinkable for any social environment to live without water supply. Supply systems are responsible for maintaining the constant supply of water to homes, hospitals, industries, etc., and, consequently, are also responsible for maintaining the functioning of society. Since these systems are so indispensable in daily life, the costs associated with their operation are not taken into account. These systems have to pump water to meet their customers’ demands and face major energy cost-efficiency issues related to pumping operations. This work presents and analyses a possible solution to this problem using a decision support system that takes advantage of variations in the energy tariff throughout the day to optimise energy costs. It uses machine learning methods to predict future water demands and simulate the consequent behaviour of the networks, thus allowing the scheduling of pumping operations to coincide with the period when the tariff is cheaper. The results indicate that Artificial Neural Networks, Extreme Learning Machines and Recurrent Neural Networks with Gated Recurrent Units are capable of achieving a good performance forecasting water demands. It was also possible to create a model that accurately reproduces the behaviour of a water supply network of reasonable size using Artificial Neural Networks. Os sistemas de abastecimento de água são infraestruturas indispensáveis em qualquer civilização moderna. Qualquer casa moderna tem sempre água corrente. As pessoas estão de tal maneira dependentes deste bem essencial que hoje em dia é impensável qualquer meio social viver sem abastecimento de água. Os sistemas de abastecimento são responsáveis por manter o constante fornecimento de água a casas, hospitais, indústrias, etc., e, consequentemente, também são responsáveis por manter o funcionamento da sociedade. Como são sistemas indispensáveis no quotidiano não se tem tanto em consideração os custos associados com o seu funcionamento. Estes sistemas têm de bombear água para satisfazer os consumos dos seus clientes e enfrentam grandes problemas de custos energéticos relacionados com as operações de bombeamento. Este trabalho apresenta e analisa uma possível solução para este problema utilizando um sistema de apoio à decisão que tira partido da variação da tarifa energética ao longo do dia para fazer a otimização dos custos energéticos. A solução apresentada utiliza métodos de aprendizagem automática para prever consumos de água e simular o consequente comportamento das redes possibilitando assim o agendamento das operações de bombeamento para que coincidam com o período em que a tarifa é mais barata. Os resultados indicam que Redes Neuronais, Máquinas de Aprendizagem Extrema e Redes Neuronais Recurrentes com Gated Recurrent Units são capazes de alcançar um bom desempenho na previsão de consumos de água. Também foi possível criar um modelo que reproduz com precisão o comportamento de uma rede de abastecimento de água de médio tamanho usando Redes Neuronais. Mestrado em Engenharia Informática
- Published
- 2019
15. Previsão do comportamento de redes de distribuição de água com métodos de aprendizagem automática
- Author
-
Matos, Pedro Guilherme Silva, Matos, Sérgio Guilherme Aleixo de, and Campos, António Gil d'Orey de Andrade
- Subjects
Water distribution systems ,Water demand forecasting ,Machine learning ,Modelling ,Simulation - Abstract
Submitted by Marisa Figueiredo (marisa@ua.pt) on 2020-10-30T14:57:01Z No. of bitstreams: 1 Documento_Pedro_Matos.pdf: 3394533 bytes, checksum: 79e65a30cac00c78a759ca4dd392168e (MD5) Made available in DSpace on 2020-10-30T14:57:01Z (GMT). No. of bitstreams: 1 Documento_Pedro_Matos.pdf: 3394533 bytes, checksum: 79e65a30cac00c78a759ca4dd392168e (MD5) Previous issue date: 2019-07 Mestrado em Engenharia Informática
- Published
- 2019
16. Deep learning for identification of pathogenic genetic mutations
- Author
-
Vieira, Pedro Gabriel Fernandes and Matos, Sérgio Guilherme Aleixo de
- Subjects
Codons ,Aprendizagem automática ,Machine learning ,Deep learning ,Doenças genéticas ,Bioinformática ,Genetic mutation ,Desoxyribonucleic acid ,Pathogenicity prediction ,Engenharia de computadores e telemática - Abstract
Mestrado em Engenharia de Computadores e Telemática Nowadays, in which the world is highly developed technologically, is possible to perform several tasks in certain areas that aim to help the world’s population. One of the areas where it has invested more in technological resources is in bioinformatics area. The growth in this area is a signal of improvement in quality of life of population, and this improvement may pass through an analysis of genetic code, alerting her of possible genetic changes or even the appearing of the diseases. This dissertation aims to perform an analysis to genetic code in order to know if an change may be pathogenic or not. In a first step, are performed tests with classical classifiers, to know their behaviour. Then, are performed new tests but this time using different models based on convolutional neural networks to get a better prediction and results of the same. Lastly, is done a comparison between each adopted classifier in order to be applied in the future the respective models in bioinformatics area. Nos dias de hoje,no qual o mundo está muito desenvolvido tecnologicamente, é possível efectuar várias tarefas em determinadas áreas que visam a ajudar a população mundial. Uma das áreas onde se tem investido mais em recursos tecnológicos é na área da bio informática. O crescimento desta área é sinal de melhoria na qualidadede vida da população, e essa melhoria pode passar por uma análise ao código genético, alertando-a de possíveis alterações genéticas ou até mesmo o aparecimento de doenças. Esta dissertação tem como objectivo efectuar uma análise ao código genético a fim de saber se uma alteração pode ser patogénica ou não. Numa primeira fase, são efectuados testes com classificadores clássicos, para saber qual o seu comportamento. De seguida, são efectuados novos testes mas desta vez usando modelos diferentes baseados em redes neuronais convolucionais para obter uma melhor previsão e resultados da mesma. Por fim, é feita a comparação entre cada um dos modelos adoptados para no futuro serem aplicados os respectivos modelos na área da bioinformática.
- Published
- 2017
17. Deep learning para identificação de mutações genéticas patogénicas
- Author
-
Vieira, Pedro Gabriel Fernandes and Matos, Sérgio Guilherme Aleixo de
- Subjects
Codons ,Aprendizagem automática ,Machine learning ,Deep learning ,Doenças genéticas ,Bioinformática ,Genetic mutation ,Desoxyribonucleic acid ,Pathogenicity prediction ,Engenharia de computadores e telemática - Abstract
Mestrado em Engenharia de Computadores e Telemática Submitted by Patrícia Correia (patriciacorreia@ua.pt) on 2018-06-12T11:58:05Z No. of bitstreams: 1 tese.pdf: 3157810 bytes, checksum: 3a261e03881ad4f1f09098759c04fd40 (MD5) Made available in DSpace on 2018-06-12T11:58:05Z (GMT). No. of bitstreams: 1 tese.pdf: 3157810 bytes, checksum: 3a261e03881ad4f1f09098759c04fd40 (MD5) Previous issue date: 2017
- Published
- 2017
18. Computational methods for gene characterization and genomic knowledge extraction
- Author
-
Gaspar, Paulo Miguel da Silva, Oliveira, José Luís Guimarães, and Matos, Sérgio Guilherme Aleixo de
- Subjects
Computational biology ,Optimization ,Genome ,Bioinformatics ,Diagnóstico ,Genoma humano ,Machine learning ,Ciências da computação ,Bioinformática ,Variome ,Pathogenicity prediction ,Gene ,Data mining - Abstract
Doutoramento conjunto MAPi em Ciências da Computação Motivation: Medicine and health sciences are changing from the classical symptom-based to a more personalized and genetics-based paradigm, with an invaluable impact in health-care. While advancements in genetics were already contributing significantly to the knowledge of the human organism, the breakthrough achieved by several recent initiatives provided a comprehensive characterization of the human genetic differences, paving the way for a new era of medical diagnosis and personalized medicine. Data generated from these and posterior experiments are now becoming available, but its volume is now well over the humanly feasible to explore. It is then the responsibility of computer scientists to create the means for extracting the information and knowledge contained in that data. Within the available data, genetic structures contain significant amounts of encoded information that has been uncovered in the past decades. Finding, reading and interpreting that information are necessary steps for building computational models of genetic entities, organisms and diseases; a goal that in due course leads to human benefits. Aims: Numerous patterns can be found within the human variome and exome. Exploring these patterns enables the computational analysis and manipulation of digital genomic data, but requires specialized algorithmic approaches. In this work we sought to create and explore efficient methodologies to computationally calculate and combine known biological patterns for various purposes, such as the in silico optimization of genetic structures, analysis of human genes, and prediction of pathogenicity from human genetic variants. Results: We devised several computational strategies to evaluate genes, explore genomes, manipulate sequences, and analyze patients’ variomes. By resorting to combinatorial and optimization techniques we were able to create and combine sequence redesign algorithms to control genetic structures; by combining the access to several web-services and external resources we created tools to explore and analyze available genetic data and patient data; and by using machine learning we developed a workflow for analyzing human mutations and predicting their pathogenicity. Motivação: A medicina e as ciências da saúde estão atualmente num processo de alteração que muda o paradigma clássico baseado em sintomas para um personalizado e baseado na genética. O valor do impacto desta mudança nos cuidados da saúde é inestimável. Não obstante as contribuições dos avanços na genética para o conhecimento do organismo humano até agora, as descobertas realizadas recentemente por algumas iniciativas forneceram uma caracterização detalhada das diferenças genéticas humanas, abrindo o caminho a uma nova era de diagnóstico médico e medicina personalizada. Os dados gerados por estas e outras iniciativas estão disponíveis mas o seu volume está muito para lá do humanamente explorável, e é portanto da responsabilidade dos cientistas informáticos criar os meios para extrair a informação e conhecimento contidos nesses dados. Dentro dos dados disponíveis estão estruturas genéticas que contêm uma quantidade significativa de informação codificada que tem vindo a ser descoberta nas últimas décadas. Encontrar, ler e interpretar essa informação são passos necessários para construir modelos computacionais de entidades genéticas, organismos e doenças; uma meta que, em devido tempo, leva a benefícios humanos. Objetivos: É possível encontrar vários padrões no varioma e exoma humano. Explorar estes padrões permite a análise e manipulação computacional de dados genéticos digitais, mas requer algoritmos especializados. Neste trabalho procurámos criar e explorar metodologias eficientes para o cálculo e combinação de padrões biológicos conhecidos, com a intenção de realizar otimizações in silico de estruturas genéticas, análises de genes humanos, e previsão da patogenicidade a partir de diferenças genéticas humanas. Resultados: Concebemos várias estratégias computacionais para avaliar genes, explorar genomas, manipular sequências, e analisar o varioma de pacientes. Recorrendo a técnicas combinatórias e de otimização criámos e conjugámos algoritmos de redesenho de sequências para controlar estruturas genéticas; através da combinação do acesso a vários web-services e recursos externos criámos ferramentas para explorar e analisar dados genéticos, incluindo dados de pacientes; e através da aprendizagem automática desenvolvemos um procedimento para analisar mutações humanas e prever a sua patogenicidade.
- Published
- 2014
19. Métodos computacionais para a caracterização de genes e extração de conhecimento genómico
- Author
-
Gaspar, Paulo Miguel da Silva, Oliveira, José Luís Guimarães, and Matos, Sérgio Guilherme Aleixo de
- Subjects
Computational biology ,Optimization ,Genome ,Bioinformatics ,Diagnóstico ,Genoma humano ,Machine learning ,Ciências da computação ,Bioinformática ,Variome ,Pathogenicity prediction ,Gene ,Data mining - Abstract
Doutoramento conjunto MAPi em Ciências da Computação Submitted by Daisy Tavares (daisytavares@ua.pt) on 2015-04-28T11:20:51Z No. of bitstreams: 1 Tese.pdf: 5809132 bytes, checksum: 2034485a6ba0189983a262e54e94950f (MD5) Made available in DSpace on 2015-04-28T11:20:51Z (GMT). No. of bitstreams: 1 Tese.pdf: 5809132 bytes, checksum: 2034485a6ba0189983a262e54e94950f (MD5) Previous issue date: 2014
- Published
- 2014
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.