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Fifty-six phages designated the U-series and 34 phages designated the Ph-series were carefully examined. The spectrum of activity was established for 183 strains of Staphylococcus epidermidis from different countries and for 258 strains of Staphylococcus aureus. All 90 phages were active against strains of both species, but some differences in sensitivity were noted. Sixteen of the 90 phages were selected for phage typing of S. epidermidis. With use of a routine test dilution of phage (the highest dilution that yields confluent lysis of the propagation strain), 71.6% of 183 coagulase-negative staphylococci tested were sensitive to the phages; 42 phage patterns were observed. The results indicate that phage typing of S. epidermidis can be recommended for epidemiological and ecological purposes.

Concerning the chemical induction of lysogeny of Staphylococcus aureus only little is known. Therefore, we performed induction experiments on 43 Staph, aureus strains using nine mutagenic substances and 15 chemotherapeutics. Only three of the nine mutagenic substances (beta-propiolacton, nitrosoguanidin and mitomycin C) and six of the 15 chemotherapeutics (penicillin G, ampicillin, cephalothin, nebacetin, novobiocin and nalidixie acid) showed inducing effects. Our results demonstrated furtheron that the lysogeny inducing ability is dependent on strains and substances used.

Ps. aeruginosa strains--a frequement resuet of an irresponsible antibiotic therapy--represent a common agent of nosocomial infektions. At the same time, gravity of Pseudomonas diseases is also increasing. Lysogeny, bacteriocinogeny and frequent occurrence of autoplaques are the lytic manifestations of Pseudomonas aeruginosa strains which play a great role in the complexity of solving diagnostic, epidemiological end therapeutical problems connected with infections induced by these microbes. A survey is presented of the importance and utilization of the lytic properties of bacterial strains of Pseudomonas aeruginosa during the differentiation, epidemiological typing and further expansion of therapeutical possibilities in infections caused by Pseudomonas aeruginosa bacteria.

Versuche uber Inaktivierung von Staphylokokkenphagen durch Hydroxylamin. Das Resultat wird auch durch die Wahl des Wirtsorganismus bestimmt.

Lysogeny after Mitomycin C- and UV-induction was studied on 127 pathogenic strains of the speciesStaphylococcus albus. A lysogeny indicator set of 24Staphylococcus albus strains was used. All 127 examinedStaphylococcus albus strains could be shown to be lysogenic, sometimes even multilysogenic.