1. Imatinib-Responsive Hypereosinophilia in a Patient with B Cell ALL.
- Author
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Robyn, Jamie, Noel, Pierre, Wlodarska, Iwona, Choksi, Mamta, O'Neal, Patricia, Arthur, Diane C., Dunbar, Cynthia, Nutman, Thomas B., and Klion, Amy D.
- Subjects
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LYMPHOCYTIC leukemia , *LYMPHOPROLIFERATIVE disorders , *EOSINOPHILIA , *LEUCOCYTOSIS , *B cells , *BONE marrow - Abstract
Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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