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In order to analyze the involvement of γδ T cells in the immune surveillance against B cell lymphomas (BCL), we investigated the proportion of circulating γδ T cells in 52 BCL patients using two-color flow cytometry, together with tumor-infiltrating γδ T cells in 22 of those patients. We found that the proportion of tumor-infiltrating γδ T cells in BCL patients was not different from that of lymph node γδ T cells in reactive hyperplasia patients. However, a decreased percentage of circulating γδ T cells were observed in indolent lymphoma (IL) and limited aggressive lymphoma (AL) patients when compared with normal controls. In contrast, as a result of a histogram, advanced AL patients were divided into two subgroups: the patients with increased circulating γδ T cells and those without any increase. However, there was no difference in the clinical features of between the two AL subgroups. [ABSTRACT FROM AUTHOR]

A case of marginal zone B cell lymphoma of MALT type arising in the uvula and breast is reported. The patient, a 30-year-old woman who delivered a child and lactated in 1997, was suffering from Sjögren syndrome (SS). She was diagnosed with MALT lymphoma after a biopsy of the right breast and uvula. To investigate the relationship of the delivery, lactation and MALT lymphoma, we examined the immunohistochemical analysis of hormone receptors. As a result, lymphoid cells of the breast were stained with anti-progesterone receptor antibodies in the cytoplasm. Consequently, the MALT lymphoma of the uvula appeared to be associated with SS. Moreover, hormones such as progesterone may have influenced the breast involvement of MALT lymphoma in our case. [ABSTRACT FROM AUTHOR]