1. Outcome and toxicity associated with a dose-intensified, maintenance-free CHOP-based chemotherapy protocol in canine lymphoma: 130 cases.
- Author
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Sorenmo K, Overley B, Krick E, Ferrara T, LaBlanc A, and Shofer F
- Subjects
- Animals, Asparaginase administration & dosage, Asparaginase adverse effects, Cyclophosphamide adverse effects, Cyclophosphamide therapeutic use, Dog Diseases mortality, Dogs, Doxorubicin adverse effects, Doxorubicin therapeutic use, Female, Lymphoma drug therapy, Lymphoma mortality, Male, Methotrexate administration & dosage, Methotrexate adverse effects, Neoplasm Staging, Prednisone adverse effects, Prednisone therapeutic use, Prognosis, Retrospective Studies, Survival Analysis, Treatment Outcome, Vincristine adverse effects, Vincristine therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Dog Diseases drug therapy, Lymphoma veterinary
- Abstract
A dose-intensified/dose-dense chemotherapy protocol for canine lymphoma was designed and implemented at the Veterinary Hospital of the University of Pennsylvania. In this study, we describe the clinical characteristics, prognostic factors, efficacy and toxicity in 130 dogs treated with this protocol. The majority of the dogs had advanced stage disease (63.1% stage V) and sub-stage b (58.5%). The median time to progression (TTP) and lymphoma-specific survival were 219 and 323 days, respectively. These results are similar to previous less dose-intense protocols. Sub-stage was a significant negative prognostic factor for survival. The incidence of toxicity was high; 53.9 and 45% of the dogs needed dose reductions and treatment delays, respectively. Dogs that required dose reductions and treatment delays had significantly longer TTP and lymphoma-specific survival times. These results suggest that dose density is important, but likely relative, and needs to be adjusted according to the individual patient's toxicity for optimal outcome.
- Published
- 2010
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