1. Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome.
- Author
-
Hagelstrom RT, Ford J, Reiser GM, Nelson M, Pickering DL, Althof PA, Sanger WG, and Coccia PF
- Subjects
- Adult, Child, Hamartoma Syndrome, Multiple genetics, Humans, Male, Pedigree, Breast Neoplasms, Male complications, Hamartoma Syndrome, Multiple complications, Lymphoma, Non-Hodgkin complications
- Abstract
Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2016
- Full Text
- View/download PDF