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In patients with acute acetic acid intoxication the diminution of degree and velocity of thrombocytes aggregation against the background of their amount attenuation in peripheral blood is established. The significant augmentation of amount of lymphocytic thrombocytic complexes and -dimers concentration in blood is revealed. The most marked alterations are determined on first and second days in patients with severe degree of intoxication.

The patients experiencing severe acute poisoning with acetic acid were divided into 2 groups with and without exotoxic shock to study platelet aggregation capacity and lymphocyte-platelet adhesion. The data obtained were used to develop exotoxic shock probability coefficient for patients with acute poisoning.

Disseminated intravascular coagulation is a menacing complication due to acute acetic acid poisoning. However, many key mechanisms of this condition remain to be not clearly understood. The authors have studied lymphocyte-platelet adhesion and D-dimer concentrations in the blood. The most pronounced changes were observed in patients with severe poisoning in the first 24 hours, which were characterized by a significant increase in the number of lymphocyte-platelet complexes and D-dimer concentrations in the blood. A statistically significant correlation was established between the parameters being studied.